Shiwen Koay
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View article: Cardiovascular autonomic failure correlates with cutaneous autonomic denervation in PD and MSA
Cardiovascular autonomic failure correlates with cutaneous autonomic denervation in PD and MSA Open
Purpose Cardiovascular autonomic failure and neurogenic orthostatic hypotension (nOH) are common and disabling in Parkinson’s disease (PD) and multiple system atrophy (MSA). Recent studies have shown evidence of postganglionic autonomic de…
View article: Multimodal Autonomic Biomarkers Predict Phenoconversion in Pure Autonomic Failure
Multimodal Autonomic Biomarkers Predict Phenoconversion in Pure Autonomic Failure Open
Background Pure autonomic failure (PAF) presents with autonomic failure without other neurological features. A third develop central neurological features, fulfilling criteria for multiple system atrophy (MSA) and Lewy body diseases (LBD),…
View article: Pure autonomic failure: a natural history study of the Queen Square cohort
Pure autonomic failure: a natural history study of the Queen Square cohort Open
The current research challenge in pure autonomic failure (PAF) lies in identifying specific biomarkers that can differentiate it from the other Lewy body disorders (Parkinson’s disease, Parkinson’s disease dementia, dementia with Lewy bodi…
View article: Mycophenolate Facilitates Improvement in Outcome Measures in Treatment Resistant Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Mycophenolate Facilitates Improvement in Outcome Measures in Treatment Resistant Chronic Inflammatory Demyelinating Polyradiculoneuropathy Open
Introduction/Aims Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a potentially disabling autoimmune neuropathy. Approximately 20% of patients are refractory to first‐line treatments necessitating second‐line options wi…
View article: Safety and Cost Analysis of Immunoglobulin Cessation Trials in Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Safety and Cost Analysis of Immunoglobulin Cessation Trials in Chronic Inflammatory Demyelinating Polyradiculoneuropathy Open
Background and Aims Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is the most common chronic autoimmune neuropathy worldwide. A significant proportion of CIDP patients enter spontaneous or medication‐related remission, r…
View article: Bing-Neel Syndrome - a Case Series of 46 Patients from the United Kingdom
Bing-Neel Syndrome - a Case Series of 46 Patients from the United Kingdom Open
Background Central nervous system involvement with Waldenstrom's Macroglobulinaemia (WM) or lymphoplasmacytic lymphoma (LPL) is termed Bing-Neel syndrome (BNS). An infrequent complication, it nevertheless causes significant morbidity. Opti…
View article: Cardiovascular autonomic failure correlates with cutaneous autonomic devervation in PD and MSA
Cardiovascular autonomic failure correlates with cutaneous autonomic devervation in PD and MSA Open
Background Cardiovascular autonomic failure and neurogenic orthostatic hypotension (nOH) are common and disabling in Parkinson’s disease (PD) and multiple system atrophy (MSA). Recent studies have shown evidence of postganglionic denervati…
View article: Cardiovascular autonomic failure in hereditary transthyretin amyloidosis and TTR carriers is an early and progressive disease marker
Cardiovascular autonomic failure in hereditary transthyretin amyloidosis and TTR carriers is an early and progressive disease marker Open
Background. The cardiomyopathic and neuropathic phenotype of hereditary transthyretin amyloidosis are well recognized. Cardiovascular autonomic dysfunction is less systematically and objectively assessed. Methods. Autonomic and clinical fe…
View article: Abnormal dopamine transporter imaging in pure autonomic failure: a potential biomarker of central nervous system involvement
Abnormal dopamine transporter imaging in pure autonomic failure: a potential biomarker of central nervous system involvement Open
Background and purpose Pure autonomic failure (PAF) is a rare progressive neurodegenerative disease characterized by neurogenic orthostatic hypotension at presentation, without other neurological abnormalities. Some patients may develop ot…
View article: Diagnosing Premotor Multiple System Atrophy
Diagnosing Premotor Multiple System Atrophy Open
Almost one-third of patients with MSA presented with nonmotor features, which could predate motor symptoms by up to 6 years. Cardiovascular autonomic failure and early urinary catheterization were predictors of poorer outcomes. A normal su…
View article: Postganglionic Sudomotor Assessment in Early Stage of Multiple System Atrophy and Parkinson Disease
Postganglionic Sudomotor Assessment in Early Stage of Multiple System Atrophy and Parkinson Disease Open
This study provides Class II evidence that postganglionic sudomotor morpho-functional assessment accurately distinguish patients with PD from patients with MSA-P.