Shiwen Wu
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View article: Integrated analysis of transcriptomic and metabolomic reveal insights into low-temperature stress in sainfoin (Onobrychis viciifolia) seedlings
Integrated analysis of transcriptomic and metabolomic reveal insights into low-temperature stress in sainfoin (Onobrychis viciifolia) seedlings Open
Background Sainfoin, a valuable native legume forage grass in northwest China, is commonly used as livestock feed and exhibits resistance to environmental stressors. Although sainfoin displays some resistance, low temperature remains a sig…
View article: Confirmatory long-term efficacy and safety results of ataluren in patients with nmDMD from Study 041, an international, randomized, double-blind, placebo-controlled, Phase III trial
Confirmatory long-term efficacy and safety results of ataluren in patients with nmDMD from Study 041, an international, randomized, double-blind, placebo-controlled, Phase III trial Open
Aim: To report the efficacy and safety of ataluren in patients with nonsense mutation Duchenne muscular dystrophy (nmDMD) from the phase III, 72-week, placebo-controlled period of Study 041. Materials & methods: Inclusion criteria: boys wi…
View article: Association between triglycerides and remnant cholesterol levels and spine bone mineral density in Duchenne muscular dystrophy
Association between triglycerides and remnant cholesterol levels and spine bone mineral density in Duchenne muscular dystrophy Open
Lipid abnormalities, particularly elevated TG and RC levels, were significantly associated with lower bone mineral density in patients with DMD. These findings suggest that lipid abnormalities are involved in bone health impairment in DMD,…
View article: Clinical Characteristics and Risk Factors for Blood Culture-Positive Klebsiella pneumoniae Liver Abscess: A Retrospective Study
Clinical Characteristics and Risk Factors for Blood Culture-Positive Klebsiella pneumoniae Liver Abscess: A Retrospective Study Open
Patients with underlying diabetes mellitus are more prone to developing blood culture-positive KPLA. PCT demonstrates better predictive performance for blood culture-positive KPLA, and patients with PCT levels ≥4.97 ng/mL have a higher lik…
View article: Effects of Alfalfa–Grass Mixed Sowing on Grass Yield and Rhizosphere Soil Characteristics
Effects of Alfalfa–Grass Mixed Sowing on Grass Yield and Rhizosphere Soil Characteristics Open
This research investigated the impact of various mixed sowing combinations on soil nutrients and grass yield within the rhizosphere across different seasons. Three varieties of leguminous forages—Medicago sativa ‘Gannong No. 3’ (GN3), M. s…
View article: Analysis of clinical characteristics of elderly patients with blood culture-positive bacterial liver abscess
Analysis of clinical characteristics of elderly patients with blood culture-positive bacterial liver abscess Open
Objective To analyze the clinical features of elderly patients with blood culture-positive bacterial liver abscess (BLA) and improve diagnostic and treatment strategies. Methods Elderly BLA patients admitted to our hospital from December 2…
View article: Activation of endogenous full-length utrophin by MyoAAV-UA as a therapeutic approach for Duchenne muscular dystrophy
Activation of endogenous full-length utrophin by MyoAAV-UA as a therapeutic approach for Duchenne muscular dystrophy Open
Activation of endogenous full-length utrophin, a dystrophin homolog, presents an attractive therapeutic strategy for Duchenne muscular dystrophy (DMD), regardless of mutation types and loci. However, current dCas9-based activators are too …
View article: Endotoxin tolerance inhibits NLRP3 inflammasome activation in macrophages of septic mice by restoring autophagic flux through TRIM26
Endotoxin tolerance inhibits NLRP3 inflammasome activation in macrophages of septic mice by restoring autophagic flux through TRIM26 Open
Objective Endotoxin tolerance (ET) has been demonstrated to attenuate the inflammatory response in murine models of sepsis. This study seeks to elucidate the underlying mechanisms by which ET modulates inflammation in sepsis, with a partic…
View article: Small vessel disease burden and prognosis of recent subcortical ischaemic stroke differ by parent artery atherosclerosis
Small vessel disease burden and prognosis of recent subcortical ischaemic stroke differ by parent artery atherosclerosis Open
Background and purpose Parent artery atherosclerosis is an important aetiology of recent subcortical ischaemic stroke (RSIS). However, comparisons of RSIS with different degrees of parent artery atherosclerosis are lacking. Methods Prospec…
View article: Transcriptomic and metabolomic analyses of the response of sainfoin (Onobrychis viciifolia) seedings to low-temperature stress
Transcriptomic and metabolomic analyses of the response of sainfoin (Onobrychis viciifolia) seedings to low-temperature stress Open
Sainfoin (Onobrychis viciifolia) is a valuable native legume forage in northwest China and is commonly used as fodder for livestock. However, low temperatures (LW) not only affect the yield and quality of sainfoin but also its geographical…
View article: A novel approach to evaluation of tumor response for advanced pulmonary adenocarcinoma using the intertumoral heterogeneity response score
A novel approach to evaluation of tumor response for advanced pulmonary adenocarcinoma using the intertumoral heterogeneity response score Open
Treatment response and prognosis estimation in advanced pulmonary adenocarcinoma are challenged by the significant heterogeneity of the disease. The current Response Evaluation Criteria in Solid Tumors (RECIST) criteria, despite providing …
View article: Metabolomics reveal root differential metabolites of different root-type alfalfa under drought stress
Metabolomics reveal root differential metabolites of different root-type alfalfa under drought stress Open
Introduction Alfalfa ( Medicago sativa L.) is the favored premium feed ingredient in animal husbandry production which is in serious jeopardy due to soil moisture shortages. It is largely unknown how different root types of alfalfa respond…
View article: Fabrication of flexible and durable functional fabric with high electromagnetic shielding performances based on MXene
Fabrication of flexible and durable functional fabric with high electromagnetic shielding performances based on MXene Open
The functional fabric with high electromagnetic shielding (EMI) performance, durability as well as good handle has been drawing increasing attention. Herein, AgNPs@MXene of high conductivity was prepared by in-situ reduction of AgNO 3 onto…
View article: Tuning Optical Properties of Metamaterials by Mie Scattering for Efficient Sub-ambient Daytime Radiative Cooling
Tuning Optical Properties of Metamaterials by Mie Scattering for Efficient Sub-ambient Daytime Radiative Cooling Open
The management of the abundant eggshell biowaste produced worldwide has become a problematic issue due to the generated odor and microorganisms after directly disposing eggshell biowaste in landfills. Herein, we propose a novel method to c…
View article: CD8+ T cell/cancer-associated fibroblast ratio stratifies prognostic and predictive responses to immunotherapy across multiple cancer types
CD8+ T cell/cancer-associated fibroblast ratio stratifies prognostic and predictive responses to immunotherapy across multiple cancer types Open
Background Cancer-associated fibroblasts (CAFs) within the tumor microenvironment (TME) are critical for immune suppression by restricting immune cell infiltration in the tumor stromal zones from penetrating tumor islands and changing thei…
View article: Case report: Five-year periodontal management of a patient with two novel mutation sites in ELANE-induced cyclic neutropenia
Case report: Five-year periodontal management of a patient with two novel mutation sites in ELANE-induced cyclic neutropenia Open
Cyclic neutropenia (CyN) is a rare, ELANE -related neutropenia. Oral manifestations are among the initial signs of CyN and an important reason that leads patients to seek professional help. This case report describes a 12-year-old girl wit…
View article: Heterogeneity of tumor immune microenvironment and real-world analysis of immunotherapy efficacy in lung adenosquamous carcinoma
Heterogeneity of tumor immune microenvironment and real-world analysis of immunotherapy efficacy in lung adenosquamous carcinoma Open
Lung adenosquamous carcinoma (ASC) is an uncommon histological subtype. We aimed to characterize the tumor immune microenvironment (TIME) in lung ASC and estimate patient response to immune checkpoint inhibitors (ICIs), which have never be…
View article: Promising therapeutic approaches of utrophin replacing dystrophin in the treatment of Duchenne muscular dystrophy
Promising therapeutic approaches of utrophin replacing dystrophin in the treatment of Duchenne muscular dystrophy Open
Duchenne muscular dystrophy (DMD) is a serious genetic neuromuscular rare disease that is prevalent and caused by the mutation/deletion of the X-linked DMD gene that encodes dystrophin. Utrophin is a dystrophin homologous protein on human …
View article: Academic Productivity from Rare Neuromuscular Disease Registries: A Systematic Review
Academic Productivity from Rare Neuromuscular Disease Registries: A Systematic Review Open
Background: TREAT-NMD is a global neuromuscular (NM) organization, created to enhance infrastructure to facilitate novel therapeutics reaching patients. One main activity is aimed at supporting NM disease registries. These rare disease reg…
View article: The Black Necrotic Lesion Enhanced Fusarium graminearum Resistance in Wheat
The Black Necrotic Lesion Enhanced Fusarium graminearum Resistance in Wheat Open
Fusarium head blight, mainly incited by Fusarium graminearum , is a devastating wheat disease worldwide. Diverse Fusarium head blight (FHB) resistant sources have been reported, but the resistance mechanisms of these sources remain to be i…
View article: Monogenic basis of young-onset cryptogenic stroke: a multicenter study
Monogenic basis of young-onset cryptogenic stroke: a multicenter study Open
In this study, pathogenic variants were identified in nearly half of the young-onset cryptogenic stroke patients, with genes related to cardiogenic diseases being the most frequently mutated. This may have implications for future clinical …