Shixia Wang
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View article: Chemokine receptors CXCR4 or CXCR5 displayed on nanoparticles are bioactive and able to bind its relevant ligand CXCL12 or CXCL13 3085
Chemokine receptors CXCR4 or CXCR5 displayed on nanoparticles are bioactive and able to bind its relevant ligand CXCL12 or CXCL13 3085 Open
Description The selective chemokine and receptor interactions are critical in inflammatory responses. CXCR4 is a receptor for chemokine CXCL12 and a co-receptor for HIV to infect CD4 T-cells. CXCR5 is a receptor for chemokine CXCL13. The o…
View article: Engineered novel CD4 cis-dimer protein significantly enhances the binding of HIV-1 envelope glycoproteins 3066
Engineered novel CD4 cis-dimer protein significantly enhances the binding of HIV-1 envelope glycoproteins 3066 Open
Description The CD4 molecule on the T-cell surface can present as monomer and dimer forms. Dimeric CD4 can be important for T-cell activation. As the primary receptor of HIV, the interaction between CD4 and HIV envelope glycoprotein (Env) …
View article: Engineered Nectin-4 and CD155 novel cis-dimer proteins significantly enhance the binding of their receptor TIGIT 3056
Engineered Nectin-4 and CD155 novel cis-dimer proteins significantly enhance the binding of their receptor TIGIT 3056 Open
Description Understanding immune checkpoint receptor and ligand interactions is crucial for immuno-oncology. Nectin-4 and CD155 are Nectin/Nectin-like family ligands of TIGIT (an inhibitory receptor on lymphocytes), can form homodimers on …
View article: Environmental Factors Drive the Changes of Bacterial Structure and Functional Diversity in Rhizosphere Soil of Hippophae rhamnoides subsp. sinensis Rousi in Arid Regions of Northwest China
Environmental Factors Drive the Changes of Bacterial Structure and Functional Diversity in Rhizosphere Soil of Hippophae rhamnoides subsp. sinensis Rousi in Arid Regions of Northwest China Open
Hippophae rhamnoides subsp. sinensis Rousi has high ecological and medicinal value, and it is an important plant resource unique to the arid regions of Northwest China. Exploring the influence of climate characteristics and soil factors on…
View article: Safety and immunogenicity of UB-612 heterologous booster in adults primed with mRNA, adenovirus, or inactivated COVID-19 vaccines: a randomized, active-controlled, Phase 3 trial
Safety and immunogenicity of UB-612 heterologous booster in adults primed with mRNA, adenovirus, or inactivated COVID-19 vaccines: a randomized, active-controlled, Phase 3 trial Open
The study was co-funded by the Coalition for Epidemic Preparedness Innovations (CEPI) and Vaxxinity.
View article: Preclinical characterization of an active immunotherapy targeting calcitonin gene-related peptide
Preclinical characterization of an active immunotherapy targeting calcitonin gene-related peptide Open
Background The success of passive immunotherapies targeting Calcitonin gene-related peptide (CGRP) for managing migraine has prompted our efforts towards developing an active immunotherapy that induces the production of endogenous antibodi…
View article: Phase transition, structural stability and electrical properties of V or Mn doped ZnSe composites under high pressure
Phase transition, structural stability and electrical properties of V or Mn doped ZnSe composites under high pressure Open
The structural parameters and enthalpies of pure ZnSe and different concentrations of V/Mn:ZnSe at high pressures were calculated using the first principles calculation method based on density functional theory. The lattice constants and b…
View article: Human CD4-binding site antibody elicited by polyvalent DNA prime-protein boost vaccine neutralizes cross-clade tier-2-HIV strains
Human CD4-binding site antibody elicited by polyvalent DNA prime-protein boost vaccine neutralizes cross-clade tier-2-HIV strains Open
View article: Safety and immunogenicity of a polyvalent DNA–protein HIV vaccine with matched Env immunogens delivered as a prime–boost regimen or coadministered in HIV-uninfected adults in the USA (HVTN 124): a phase 1, placebo-controlled, double-blind randomised controlled trial
Safety and immunogenicity of a polyvalent DNA–protein HIV vaccine with matched Env immunogens delivered as a prime–boost regimen or coadministered in HIV-uninfected adults in the USA (HVTN 124): a phase 1, placebo-controlled, double-blind randomised controlled trial Open
View article: Irreversible pressure effect on phase transitions and bandgap narrowing of layered MoO3
Irreversible pressure effect on phase transitions and bandgap narrowing of layered MoO3 Open
Two-dimensional layered molybdenum trioxide (MoO3) holds significant importance in optoelectronics owing to its unique anisotropic structure and optical properties. Given that changes in structure can profoundly impact physical characteris…
View article: VXX-401, a novel anti-PCSK9 vaccine, reduces LDL-C in cynomolgus monkeys
VXX-401, a novel anti-PCSK9 vaccine, reduces LDL-C in cynomolgus monkeys Open
Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of disease burden in the world and is highly correlated with chronic elevations of LDL-C. LDL-C-lowering drugs, such as statins or monoclonal antibodies against propr…
View article: Revolutionizing Co2 Conversion for Single-Carbon Products: Unveiling the Photocatalytic Magic of M6@Tio2 Via First-Principles Insights
Revolutionizing Co2 Conversion for Single-Carbon Products: Unveiling the Photocatalytic Magic of M6@Tio2 Via First-Principles Insights Open
View article: Irreversible Pressure Effect on Phase Transitions and Bandgap Narrowing of Layered Moo3
Irreversible Pressure Effect on Phase Transitions and Bandgap Narrowing of Layered Moo3 Open
View article: RBD-Protein/Peptide Vaccine UB-612 Elicits Mucosal and Fc-Mediated Antibody Responses against SARS-CoV-2 in Cynomolgus Macaques
RBD-Protein/Peptide Vaccine UB-612 Elicits Mucosal and Fc-Mediated Antibody Responses against SARS-CoV-2 in Cynomolgus Macaques Open
Antibodies provide critical protective immunity against COVID-19, and the Fc-mediated effector functions and mucosal antibodies also contribute to the protection. To expand the characterization of humoral immunity stimulated by subunit pro…
View article: Human CD4-Binding Site Antibody Elicited by Polyvalent DNA Prime-Protein Boost Vaccine Neutralizes Cross-Clade Tier-2-HIV Strains
Human CD4-Binding Site Antibody Elicited by Polyvalent DNA Prime-Protein Boost Vaccine Neutralizes Cross-Clade Tier-2-HIV Strains Open
The vaccine elicitation of HIV-neutralizing antibodies with tier-2-neutralization breadth has been a challenge. Here, we report the isolation and characteristics of a CD4-binding site specific monoclonal antibody, HmAb64, from a human volu…
View article: A novel RBD-protein/peptide vaccine elicits broadly neutralizing antibodies and protects mice and macaques against SARS-CoV-2
A novel RBD-protein/peptide vaccine elicits broadly neutralizing antibodies and protects mice and macaques against SARS-CoV-2 Open
The development of safe and effective vaccines to respond to COVID-19 pandemic/endemic remains a priority. We developed a novel subunit protein-peptide COVID-19 vaccine candidate (UB-612) composed of: (i) receptor binding domain of SARS-Co…
View article: High Neutralizing Antibody Levels Against Severe Acute Respiratory Syndrome Coronavirus 2 Omicron BA.1 and BA.2 After UB-612 Vaccine Booster
High Neutralizing Antibody Levels Against Severe Acute Respiratory Syndrome Coronavirus 2 Omicron BA.1 and BA.2 After UB-612 Vaccine Booster Open
The highly transmissible severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant has caused high rates of breakthrough infections in those previously vaccinated with ancestral strain coronavirus disease 2019 (COVID-19)…
View article: High neutralizing antibody levels against SARS-CoV-2 Omicron BA.1 and BA.2 after UB-612 vaccine booster
High neutralizing antibody levels against SARS-CoV-2 Omicron BA.1 and BA.2 after UB-612 vaccine booster Open
The highly transmissible Omicron variant has caused high rates of breakthrough infections among vaccinated and convalescent individuals. Here, we demonstrate that a booster dose of UB-612 vaccine candidate delivered 7-9 months after primar…
View article: Broadly binding and functional antibodies and persisting memory B cells elicited by HIV vaccine PDPHV
Broadly binding and functional antibodies and persisting memory B cells elicited by HIV vaccine PDPHV Open
Since publishing our original reports on the safety and immunogenicity of a polyvalent DNA prime-protein boost HIV vaccine (PDPHV) which elicited high titer antibody responses with broad specificity, neutralizing activities to multiple HIV…
View article: Non-neutralizing antibodies targeting the immunogenic regions of HIV-1 envelope reduce mucosal infection and virus burden in humanized mice
Non-neutralizing antibodies targeting the immunogenic regions of HIV-1 envelope reduce mucosal infection and virus burden in humanized mice Open
Antibodies are principal immune components elicited by vaccines to induce protection from microbial pathogens. In the Thai RV144 HIV-1 vaccine trial, vaccine efficacy was 31% and the sole primary correlate of reduced risk was shown to be v…
View article: Identification of key genes involved in tamoxifen-resistant breast cancer using bioinformatics analysis
Identification of key genes involved in tamoxifen-resistant breast cancer using bioinformatics analysis Open
A number of significant hub DEGs were identified based on their degree of connectivity in the PPI network, , included MAPK1 (node degree 36), ESR1 (node degree 27), SMARCA4 (node degree 27), RANBP2 (node degree …
View article: Non-neutralizing antibodies targeting the immunogenic regions of HIV-1 envelope reduce mucosal infection and virus burden in humanized mice
Non-neutralizing antibodies targeting the immunogenic regions of HIV-1 envelope reduce mucosal infection and virus burden in humanized mice Open
Antibodies are principal immune components elicited by vaccines to induce protection from microbial pathogens. In the Thai RV144 HIV-1 vaccine trial, vaccine efficacy was 31% and the sole primary correlate of reduced risk was shown to be v…
View article: A novel DNA and protein combination COVID-19 vaccine formulation provides full protection against SARS-CoV-2 in rhesus macaques
A novel DNA and protein combination COVID-19 vaccine formulation provides full protection against SARS-CoV-2 in rhesus macaques Open
The current study aims to develop a safe and highly immunogenic COVID-19 vaccine. The novel combination of a DNA vaccine encoding the full-length Spike (S) protein of SARS-CoV-2 and a recombinant S1 protein vaccine induced high level neutr…
View article: DNA priming immunization is more effective than recombinant protein vaccine in eliciting antigen-specific B cell responses
DNA priming immunization is more effective than recombinant protein vaccine in eliciting antigen-specific B cell responses Open
While DNA prime-protein boost vaccination approach has been widely used in preclinical and clinical studies especially in the field of HIV vaccine development, the exact role of DNA immunization has not been fully identified. Our previous …
View article: Glycan Profiles of gp120 Protein Vaccines from Four Major HIV-1 Subtypes Produced from Different Host Cell Lines under Non-GMP or GMP Conditions
Glycan Profiles of gp120 Protein Vaccines from Four Major HIV-1 Subtypes Produced from Different Host Cell Lines under Non-GMP or GMP Conditions Open
HIV-1 Env protein is a major target for the development of an HIV-1 vaccine. Env is covered with a large number of sugar-based glycan forms; about 50% of the Env molecular weight is composed of glycans. Glycan analysis of recombinant Env i…
View article: The values and limitations of mathematical modelling to COVID-19 in the world: a follow up report
The values and limitations of mathematical modelling to COVID-19 in the world: a follow up report Open
We previously described a mathematical model to simulate the course of the COVID-19 pandemic and try to predict how this outbreak might evolve in the following two months when the pandemic cases will drop significantly. Our original paper …
View article: Mathematic modeling of COVID-19 in the United States
Mathematic modeling of COVID-19 in the United States Open
COVID-19, the worst pandemic in 100 years, has rapidly spread to the entire world in 2 months since its early report in January 2020. Based on the publicly available data sources, we developed a simple mathematic modeling approach to track…
View article: Author Correction: The wide utility of rabbits as models of human diseases
Author Correction: The wide utility of rabbits as models of human diseases Open
Select gp120 V2 domain specific antibodies derived from HIV and SIV infection and vaccination inhibit gp120 binding to α4β7 Open
View article: Structural Comparison of Human Anti-HIV-1 gp120 V3 Monoclonal Antibodies of the Same Gene Usage Induced by Vaccination and Chronic Infection
Structural Comparison of Human Anti-HIV-1 gp120 V3 Monoclonal Antibodies of the Same Gene Usage Induced by Vaccination and Chronic Infection Open
Understanding the structural basis of gene usage and affinity maturation for anti-HIV-1 antibodies may help vaccine design and development. Antibodies targeting the highly immunogenic third variable loop (V3) of HIV-1 gp120 provide a uniqu…