Explanipedia

Viral Metagenomics of the Bharal (<i>Pseudois nayaur</i>) within the Qinghai-Tibet Plateau Revealed Diverse Viruses Open

ERCONG ZHANG, Ga Gong, Shiqin Huang, Yanping Bao, Likai Ji , et al. · 2025

The Qinghai-Tibetan Plateau (QTP) provides a home to diverse flora and fauna, and its ecosystems are unique worldwide. The study focused on the bharal, an endemic species found in the QTP and adjacent regions. We applied viral metagenomics…

Influence of coal gangue-aeolian sand aggregate gradation on rheological properties and pipeline transportation characteristics of filling slurry Open

Bo Liu, Yongbing Zhang, Shixing Yang · 2025

Uneven of filling aggregate gradation may cause transportation problems such as pipe blockage due to segregation and stratification of filling slurry. To study the influence of aggregate gradation on the conveying performance of filler slu…

Zincophilic Polymer Nanofiber Network as Multifunctional Interface Layer to Stabilize Zn Metal Anodes Open

Yan Zhang, Shixing Yang, Xuehua Zhou, Jia Wang, Yong Zhang , et al. · 2025

Gut Virome of Tibetan Pigs Reveals the Diversity, Composition, and Distribution of Potential Novel Viruses/Variants Open

Ga Gong, Shiyin Huang, Shixing Yang, Quan Shen, Xiaochun Wang , et al. · 2025

As a local breed adapted to the extreme environment of the Tibetan Plateau, Tibetan pigs have not yet been systematically characterized in terms of their gut viral communities. In this study, we applied viral metagenomics to sequence fecal…

Comparison of gut viromes from different species of mammals in zoos unveiled the genetic diversity of bacteriophage dark matter and mammalian viruses Open

Juan Lü, Haoning Wang, Chunmei Wang, Juan Xu, Kingsley Ikechukwu Chukwudozie , et al. · 2025

FBXW8 suppresses PDCoV proliferation via the NPD52-dependent autophagic degradation of a viral nucleocapsid protein Open

Likai Ji, Liying Zhou, Ying Wang, Shixing Yang, Yuwei Liu , et al. · 2024

Porcine deltacoronavirus (PDCoV), a newly discovered intestinal coronavirus, has rapidly spread among pigs worldwide and has shown the potential for cross-species infection. However, the interaction mechanism between PDCoV and the host’s a…

Identification of multiple novel viruses in bar-headed goose feces from Tibet of China Open

Yijie Sun, Yan Wang, Ji Li, Yifei Pei, Xiaoyi Sun , et al. · 2024

Introduction The bar-headed goose is a typical high-altitude bird that primarily inhabits alpine lakes and wetlands in Central Asia, with a remarkable ability to adapt to high elevations. Previous studies have shown that they can be infect…

Unveiling the Virome of Wild Birds: Exploring CRESS-DNA Viral Dark Matter Open

Ziyuan Dai, Haoning Wang, Juan Xu, Xiang Lü, Ping Ni , et al. · 2024

Amid global health concerns and the constant threat of zoonotic diseases, this study delves into the diversity of circular replicase-encoding single-stranded DNA (CRESS-DNA) viruses within Chinese wild bird populations. Employing viral met…

Identification and characterization of multiple novel viruses in fecal samples of ruddy shelducks using viral metagenomics methods Open

Ji Li, Yan Wang, Yijie Sun, Likai Ji, Xiaochun Wang , et al. · 2024

The viral metagenomics approach is an effective technique for investigating and analysing both existing and emerging viruses in humans and diverse animal samples. The ruddy shelduck, a nationally protected secondary key species of wild ani…

ChatGPT and similar models in higher medical education of China: refuse or embrace? Open

Quan Shen, Zongzheng Li, Zhengyi Sun, Yonghao LIU, Shixing Yang , et al. · 2024

The development of artificial intelligence (AI) technology is promoting the transformation of medical practice and medical education. Many countries including America and China have incorporated the development of AI into its national stra…

Identification and full-genome characterization of a novel circovirus in giant pandas ( Ailuropoda melanoleuca ) Open

Wen Zhang, Ziyuan Dai, Hao Wang, Zhanghao Feng, Shixing Yang , et al. · 2024

The members of the family Circoviridae are considered to be the smallest autonomously replicating viruses, including two genera, Circovirus and Cyclovirus . Circoviruses have been found in a variety of vertebrates, but whether they infect …

Jujing Zhuyu Decoction Can Improve the Sperm Quality of Rats with Asthenospermia by Activating the Wnt/Β-Catenin Signaling Pathway Through M6a Modification Open

Hongying Li, Menghua Shi, Lei Xu, Yanfang Yang, Tianyu Ma , et al. · 2024

Identification of Multiple Novel Viruses in Fecal Samples of Black-Necked Cranes Using Viral Metagenomic Methods Open

Qifan Zhao, Ran Zhao, Yijie Sun, Ji Li, Xi Yuan , et al. · 2023

The black-necked crane is the only species of crane that lives in the high-altitude region of the Tibet Plateau. At present, there is little research on viral diseases of the black-necked crane (Grus nigricollis). In this study, a viral me…

Metagenomic analysis of herbivorous mammalian viral communities in the Northwest Plateau Open

Jiamin Pan, Likai Ji, Haisheng Wu, Xiaochun Wang, Yan Wang , et al. · 2023

Identification of Multiple Novel Viruses in Fecal Samples of Black-necked Cranes using Viral Metagenomics Methods Open

Qifan Zhao, Ran Zhao, Yijie Sun, Ji Li, Xi Yuan , et al. · 2023

The black-necked crane is the only species that lives in the plateau. At present, there is little re-search on viral diseases of the black-necked crane. In this study, a virus metagenomics approach was employed to investigate the viral com…

SARS-CoV-2 Nsp15 suppresses type I interferon production by inhibiting IRF3 phosphorylation and nuclear translocation Open

Dianqi Zhang, Likai Ji, Xu Chen, HE Yu-min, Yijie Sun , et al. · 2023

Comparison of viral communities in the blood, feces and various tissues of wild brown rats (Rattus norvegicus) Open

Zi Zhuang, Lingling Qian, Juan Lü, Xiaodan Zhang, Asif Mahmood , et al. · 2023

Zika Virus Induces Degradation of the Numb Protein Required through Embryonic Neurogenesis Open

Jia He, Liping Yang, Peixi Chang, Shixing Yang, Yu Wang , et al. · 2023

Zika virus (ZIKV) is a mosquito-borne flavivirus and causes an infection associated with congenital Zika syndrome and Guillain–Barre syndrome. The mechanism of ZIKV-mediated neuropathogenesis is not well understood. In this study, we disco…

Stress-strain relationship and damage constitutive model of wet concrete under uniaxial compression Open

Fan Yang, Shixing Yang, Fu Yuhua, Youfeng Zhang · 2023

The deformation and damage of wet shotcrete under geostress in deep mines is a common issue. To better understand the damage characteristics of rock deformation rates on wet shotcrete, uniaxial compression tests were conducted using an RMT…

Zika Virus Induces the Degradation of the Numb Protein that is Required through Embryonic Neurogenesis Open

Jia He, Liping Yang, Peixi Chang, Shixing Yang, Yu Wang , et al. · 2023

Zika virus (ZIKV) is a mosquito-borne flavivirus and causes an infection that is associated with neurological manifestations, including microcephaly and Guillain-Barre syndrome. The mechanism of ZIKV-mediated neuropathogenesis is not well …

Comparison of gut viral communities in children under 5 years old and newborns Open

Hong Li, Hao Wang, Huimin Ju, Jinquan Lv, Shixing Yang , et al. · 2023

Objectives The gut virome of humans is mainly composed of bacteriophages and their role in shaping the gut microbiome and influencing human health is increasingly recognized. However, little is known about the dynamic changes of the gut vi…

Molecular detection and characterization of three novel parvoviruses belonging to two different subfamilies in zoo birds Open

Yan Wang, Yijie Sun, Xin Li, Rong Chen, Xiaotian Li , et al. · 2023

Birds carry a large number of viruses that may cause diseases in animals or human. At present, virome of zoo birds are limited. In this study, using viral metagenomics method, we investigated the feces virome of zoo birds collected from a …

SARS-CoV-2 Nsp15 Suppresses Type I Interferon Production by Inhibiting IRF3 Phosphorylation And Nuclear Translocation Open

Dianqi Zhang, Likai Ji, Xu Chen, Quan Shen, Xiaochun Wang , et al. · 2023

Diversity of viral communities in faecal samples of farmed red foxes Open

Dianqi Zhang, Yan Wang, Xu Chen, Yumin He, Min Zhao , et al. · 2023

Emerging and existing viruses from various human and animal samples have been studied and analyzed using viral metagenomics, which has proven to be an effective technique. Foxes, as a kind of significant economic animal, are widely raised …

Expanding known viral diversity in plants: virome of 161 species alongside an ancient canal Open

Shixing Yang, Qingqing Mao, Yan Wang, Jingxian He, Jie Yang , et al. · 2022

Study on static and dynamic flocculation settlement characteristics of fine tailings slurry and influence of flocculant on strength of fine tailings backfill Open

Shenghua Yin, Hou Yong-qiang, Shixing Yang, Xin Chen · 2022

In order to study the static and dynamic flocculation settlement characteristics of fine total tailings and the influence law of flocculant on the mechanical properties of fine tailings backfill, the experimental research on the flocculati…

Viral Metagenomics Reveals Diverse Viruses in Tissue Samples of Diseased Pigs Open

Shixing Yang, Dianqi Zhang, Zexuan Ji, Yuyang Zhang, Yan Wang , et al. · 2022

The swine industry plays an essential role in agricultural production in China. Diseases, especially viral diseases, affect the development of the pig industry and threaten human health. However, at present, the tissue virome of diseased p…

Genome Analysis of Goose-Origin Astroviruses Causing Fatal Gout in Shanghai, China Reveals One of Them Belonging to a Novel Type Is a Recombinant Strain Open

Quan Shen, Zi Zhuang, Juan Lü, Lingling Qian, Guangquan Li , et al. · 2022

Since 2014, a goose-origin astroviruses disease, which is characterized by urate precipitation in viscera, has rapidly spread to major commercial goose provinces leading to huge economic losses in the poultry industry of China. In March 20…

Virome in the cloaca of wild and breeding birds revealed a diversity of significant viruses Open

Tongling Shan, Shixing Yang, Haoning Wang, Hao Wang, Ju Zhang , et al. · 2022

Background Wild birds may harbor and transmit viruses that are potentially pathogenic to humans, domestic animals, and other wildlife. Results Using the viral metagenomic approach, we investigated the virome of cloacal swab specimens colle…

Comparison of Gut Viral Communities in Atopic Dermatitis and Healthy Children Open

Xiang Lü, Hao Wang, Jingqi Zhang, Kexin Jin, Ling Ma , et al. · 2022

The immune development and regulation of living individuals are affected by the gut microbiota. The imbalance of gut microbiota is considered to be a key factor that easily induces immune dysregulation and the development of atopic disease…

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