Shixue Chen
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View article: Novel Insights into the Mechanism of Luteolin and its Analogues as Potent Inhibitors of Xanthine Oxidase Activity: Inhibition Thermodynamics, Kinetics and Docking Simulation
Novel Insights into the Mechanism of Luteolin and its Analogues as Potent Inhibitors of Xanthine Oxidase Activity: Inhibition Thermodynamics, Kinetics and Docking Simulation Open
View article: Mechanistic Insight into the Synergistic Inhibition of Myricetin Cooperating Allopurinol on Xanthine Oxidase Activity: Inhibition Thermodynamics, Kinetics, Docking and Molecular Dynamic Simulation
Mechanistic Insight into the Synergistic Inhibition of Myricetin Cooperating Allopurinol on Xanthine Oxidase Activity: Inhibition Thermodynamics, Kinetics, Docking and Molecular Dynamic Simulation Open
View article: An Improved Test Method for Assaying the Inhibition of Bioflavonoids on Xanthine Oxidase Activity <i>in vitro</i>
An Improved Test Method for Assaying the Inhibition of Bioflavonoids on Xanthine Oxidase Activity <i>in vitro</i> Open
The difference on inhibitory effects of bioflavonoids inhibiting XOD activity assayed by varying test methods cause of us to be further in consideration. The reported test method creating a micro‐environment surrounding XOD in the absence …
View article: Optimization of Knobs-into-holes Structure of Bispecific Antibody based on Molecular Dynamics Simulation
Optimization of Knobs-into-holes Structure of Bispecific Antibody based on Molecular Dynamics Simulation Open
Objective: To evaluate the stability and binding efficiency of CH3-CH3 heterodimer assembly generated by knobs-into-holes (KIH) method, and to lay the foundation for designing more stable bispecific antibodies by optimizing the structure. …
View article: Association of Helicobacter pylori infection with survival outcomes in advanced gastric cancer patients treated with immune checkpoint inhibitors
Association of Helicobacter pylori infection with survival outcomes in advanced gastric cancer patients treated with immune checkpoint inhibitors Open
View article: Sustainable Approaches to Selective Conversion of Cellulose Into 5-Hydroxymethylfurfural Promoted by Heterogeneous Acid Catalysts: A Review
Sustainable Approaches to Selective Conversion of Cellulose Into 5-Hydroxymethylfurfural Promoted by Heterogeneous Acid Catalysts: A Review Open
5-Hydroxymethylfurfural (5-HMF) as a triply catalytic product is a value-added refining chemical in industry production. 5-HMF as biomass feedstock enables to be transformed into other high-value industrial compounds, such as 2,5-furandica…
View article: Association of Helicobacter pylori infection with survival outcomes in advanced gastric cancer patients treated with immune checkpoint inhibitors
Association of Helicobacter pylori infection with survival outcomes in advanced gastric cancer patients treated with immune checkpoint inhibitors Open
Background Accumulating evidence has revealed that the gut microbiota influences the effectiveness of immune checkpoint inhibitors (ICIs) in cancer patients. As a part of the human microbiome, Helicobacter pylori (H. pylori) was reported t…
View article: Single cell profiling of bronchoalveolar immune cells in checkpoint inhibitor-related pneumonitis
Single cell profiling of bronchoalveolar immune cells in checkpoint inhibitor-related pneumonitis Open
Immune checkpoint inhibitors (ICIs) therapy induced pneumonitis (CIP) complicates this effective in therapy patients with non-small cell lung cancer (NSCLC), but the underlying mechanisms remain incompletely understood. Here, we implemente…
View article: Response Efficacy of PD-1 and PD-L1 Inhibitors in Clinical Trials: A Systematic Review and Meta-Analysis
Response Efficacy of PD-1 and PD-L1 Inhibitors in Clinical Trials: A Systematic Review and Meta-Analysis Open
Background Immune checkpoint inhibitors targeting the PD-1/PD-L1 pathway have demonstrated promise in treating a variety of advanced cancers; however, little is known regarding their efficacy under various clinical situations, including di…
View article: An Improved System to Evaluate Superoxide‐Scavenging Effects of Bioflavonoids
An Improved System to Evaluate Superoxide‐Scavenging Effects of Bioflavonoids Open
The pyrogallol autoxidation method has been widely utilized to evaluate various antioxidants in antioxidative bioactivities. However, this method is generally not appropriate for estimating the . O 2 − radical scavenging capacity of biofla…
View article: Efficacy and safety of anti-PD-1-based therapy in combination with PARP inhibitors for patients with advanced solid tumors in a real-world setting
Efficacy and safety of anti-PD-1-based therapy in combination with PARP inhibitors for patients with advanced solid tumors in a real-world setting Open
View article: Prognostic value of baseline and change in neutrophil-to-lymphocyte ratio for survival in advanced non-small cell lung cancer patients with poor performance status receiving PD-1 inhibitors
Prognostic value of baseline and change in neutrophil-to-lymphocyte ratio for survival in advanced non-small cell lung cancer patients with poor performance status receiving PD-1 inhibitors Open
High baseline NLR and increased post-treatment NLR might aid in the stratification of high progression and death risk groups in advanced NSCLC patients with poor PS receiving PD-1 inhibitors.
View article: The Synergistic Effect of PARP Inhibitors and Immune Checkpoint Inhibitors
The Synergistic Effect of PARP Inhibitors and Immune Checkpoint Inhibitors Open
Poly (ADP-ribose) polymerase (PARP) inhibitors have demonstrated great promise for treating cancers with homologous recombination (HR) defects, such as germline BRCA1/2 mutation. Further studies suggest that PARP inhibitors (PARPi) can als…
View article: Efficacy and safety of crizotinib plus bevacizumab in <i>ALK/ROS-1/c-MET</i> positive non-small cell lung cancer: an open-label, single-arm, prospective observational study.
Efficacy and safety of crizotinib plus bevacizumab in <i>ALK/ROS-1/c-MET</i> positive non-small cell lung cancer: an open-label, single-arm, prospective observational study. Open
This study demonstrated that crizotinib plus bevacizumab showed benefit in treating naive ALK rearrangement NSCLC patients, and the toxicity was relatively tolerant. Our results suggested that crizotinib plus bevacizumab might be a …
View article: Corrigendum: Evaluation of General Synthesis Procedures for Bioflavonoid–Metal Complexes in Air-Saturated Alkaline Solutions
Corrigendum: Evaluation of General Synthesis Procedures for Bioflavonoid–Metal Complexes in Air-Saturated Alkaline Solutions Open
[This corrects the article DOI: 10.3389/fchem.2020.00589.].
View article: <p>Association of the Pretreatment Lung Immune Prognostic Index with Survival Outcomes in Advanced Hepatocellular Carcinoma Patients Treated with PD-1 Inhibitors</p>
Association of the Pretreatment Lung Immune Prognostic Index with Survival Outcomes in Advanced Hepatocellular Carcinoma Patients Treated with PD-1 Inhibitors Open
Pretreatment LIPI combined with a dNLR ≥ 3 and/or LDH ≥ ULN is associated with poor outcomes in patients with aHCC treated with PD-1 inhibitors. Further validation in large, prospective studies are warranted.
View article: Evaluation of General Synthesis Procedures for Bioflavonoid–Metal Complexes in Air-Saturated Alkaline Solutions
Evaluation of General Synthesis Procedures for Bioflavonoid–Metal Complexes in Air-Saturated Alkaline Solutions Open
The general synthesis methods of bioflavonoid-metal complexes are considered to be unreliable due to the instability of flavonoids in air-saturated alkaline solutions. In this study, dihydromyricetin (DHM), as a representative bioflavonoid…
View article: Immune checkpoint inhibitors combined with chemotherapy for the treatment of advanced pancreatic cancer patients
Immune checkpoint inhibitors combined with chemotherapy for the treatment of advanced pancreatic cancer patients Open
View article: Association of immune-related pneumonitis with the efficacy of PD-1/PD-L1 inhibitors in non-small cell lung cancer
Association of immune-related pneumonitis with the efficacy of PD-1/PD-L1 inhibitors in non-small cell lung cancer Open
Background: Cutaneous adverse events (AEs) have been positively associated with immune checkpoint inhibitor (ICI) efficacy in patients with melanoma, but little is known regarding the association between checkpoint inhibitor pneumonitis (C…
View article: Anti-PD-1 therapy combined with chemotherapy in patients with advanced biliary tract cancer
Anti-PD-1 therapy combined with chemotherapy in patients with advanced biliary tract cancer Open
View article: Immunoglobulin Gamma-Like Therapeutic Bispecific Antibody Formats for Tumor Therapy
Immunoglobulin Gamma-Like Therapeutic Bispecific Antibody Formats for Tumor Therapy Open
Bispecific antibodies (BsAbs) are a sort of dual functional proteins with specific binding to two distinct targets, which have become a focus of interest in antibody engineering and drug development research and have a promising future for…
View article: Nab-Paclitaxel in combination with Cisplatin Versus Docetaxel Plus Cisplatin as First-Line Therapy in Non-small Cell Lung Cancer
Nab-Paclitaxel in combination with Cisplatin Versus Docetaxel Plus Cisplatin as First-Line Therapy in Non-small Cell Lung Cancer Open