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View article: An SH3-binding allosteric modulator stabilizes the global conformation of the AML-associated Src-family kinase, Hck
An SH3-binding allosteric modulator stabilizes the global conformation of the AML-associated Src-family kinase, Hck Open
View article: An SH3-binding allosteric modulator stabilizes the global conformation of the AML-associated Src-family kinase, Hck
An SH3-binding allosteric modulator stabilizes the global conformation of the AML-associated Src-family kinase, Hck Open
While ATP-site inhibitors for protein-tyrosine kinases are often effective drugs, their clinical utility can be limited by off-target activity and acquired resistance mutations due to the conserved nature of the ATP-binding site. However, …
View article: miR-206 as a prognostic and sensitivity biomarker for platinum chemotherapy in epithelial ovarian cancer
miR-206 as a prognostic and sensitivity biomarker for platinum chemotherapy in epithelial ovarian cancer Open
View article: MiR-770-5p inhibits cisplatin chemoresistance in human ovarian cancer by targeting ERCC2
MiR-770-5p inhibits cisplatin chemoresistance in human ovarian cancer by targeting ERCC2 Open
In this study, we examined the role of the miRNA miR-770-5p in cisplatin chemotherapy resistance in ovarian cancer (OVC) patients. miR-770-5p expression was reduced in platinum-resistant patients. Using a 6.128-fold in expression as the cu…