Shiyu Bai
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View article: A high-efficiency CFD simulation strategy for industrial fluidized bed reactors with long solids residence time
A high-efficiency CFD simulation strategy for industrial fluidized bed reactors with long solids residence time Open
View article: Identification of a <i>de novo MYH9</i> mutation in a Chinese family with MYH9-related disease
Identification of a <i>de novo MYH9</i> mutation in a Chinese family with MYH9-related disease Open
Our study suggested that a de novo missense mutation in MYH9 may be causative to MYH9-RD. Furthermore, genetic sequencing is expected to soon become a standard component of the diagnostic evaluation for individuals wit…
View article: The mechanism of resistance to CDK4/6 inhibition and novel combination therapy with RNR inhibition for chemo‐resistant bladder cancer
The mechanism of resistance to CDK4/6 inhibition and novel combination therapy with RNR inhibition for chemo‐resistant bladder cancer Open
Bladder cancer (BCa) is the most prevalent urological cancer worldwide [1]. A significant proportion of BCa (89%) exhibits molecular alterations in the cell cycle pathway, and targeting cyclin-dependent kinases 4 and 6 (CDK4/6) is deemed a…
View article: Motility and tumor infiltration are key aspects of invariant natural killer T cell anti-tumor function
Motility and tumor infiltration are key aspects of invariant natural killer T cell anti-tumor function Open
View article: Cytotoxic Lymphocyte-Monocyte Complex Reflects the Dynamics of Coronavirus Disease 2019 Systemic Immune Response
Cytotoxic Lymphocyte-Monocyte Complex Reflects the Dynamics of Coronavirus Disease 2019 Systemic Immune Response Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes a variety of clinical manifestations, many of which originate from altered immune responses, either locally or systemically. Immune cell cross-talk occurs mainly…
View article: Local electric field in nanocavities dictates the vibrational relaxation dynamics of interfacial molecules
Local electric field in nanocavities dictates the vibrational relaxation dynamics of interfacial molecules Open
The electric field sensed by molecules in nanocavities determines the molecular vibrational energy relaxation dynamics using ultrafast time-resolved sum frequency generation vibrational spectroscopy.
View article: Supplementary Figure 3 from Antigen Priming Induces Functional Reprogramming in iNKT Cells via Metabolic and Epigenetic Regulation: An Insight into iNKT Cell-Based Antitumor Immunotherapy
Supplementary Figure 3 from Antigen Priming Induces Functional Reprogramming in iNKT Cells via Metabolic and Epigenetic Regulation: An Insight into iNKT Cell-Based Antitumor Immunotherapy Open
A, Procedure for TCR signaling priming of human iNKT cells in vitro. B, The TMRM/MitoTracker ratio (n = 4) in control and TCR signaling-primed human iNKT cells, in the presence of ZLN005 or DMSO as control. C, Frequencies of IFN+ cells an…
View article: Supplementary Figure 4 from Antigen Priming Induces Functional Reprogramming in iNKT Cells via Metabolic and Epigenetic Regulation: An Insight into iNKT Cell-Based Antitumor Immunotherapy
Supplementary Figure 4 from Antigen Priming Induces Functional Reprogramming in iNKT Cells via Metabolic and Epigenetic Regulation: An Insight into iNKT Cell-Based Antitumor Immunotherapy Open
Gating strategy for identifying different lymphocytes in tumors.
View article: Supplementary Figure 2 from Antigen Priming Induces Functional Reprogramming in iNKT Cells via Metabolic and Epigenetic Regulation: An Insight into iNKT Cell-Based Antitumor Immunotherapy
Supplementary Figure 2 from Antigen Priming Induces Functional Reprogramming in iNKT Cells via Metabolic and Epigenetic Regulation: An Insight into iNKT Cell-Based Antitumor Immunotherapy Open
A, Procedure for TCR priming in vitro. B-C, Frequencies of IFN+ (B), GzmA+, and GzmB+ (C) naïve and TCR-primed iNKT cells restimulated with anti-CD3 plus anti-CD28 antibodies as indicated in (A) (n = 3). Data are represented as mean ± SD.…
View article: Supplementary Figure 4 from Antigen Priming Induces Functional Reprogramming in iNKT Cells via Metabolic and Epigenetic Regulation: An Insight into iNKT Cell-Based Antitumor Immunotherapy
Supplementary Figure 4 from Antigen Priming Induces Functional Reprogramming in iNKT Cells via Metabolic and Epigenetic Regulation: An Insight into iNKT Cell-Based Antitumor Immunotherapy Open
Gating strategy for identifying different lymphocytes in tumors.
View article: Supplementary Figure 3 from Antigen Priming Induces Functional Reprogramming in iNKT Cells via Metabolic and Epigenetic Regulation: An Insight into iNKT Cell-Based Antitumor Immunotherapy
Supplementary Figure 3 from Antigen Priming Induces Functional Reprogramming in iNKT Cells via Metabolic and Epigenetic Regulation: An Insight into iNKT Cell-Based Antitumor Immunotherapy Open
A, Procedure for TCR signaling priming of human iNKT cells in vitro. B, The TMRM/MitoTracker ratio (n = 4) in control and TCR signaling-primed human iNKT cells, in the presence of ZLN005 or DMSO as control. C, Frequencies of IFN+ cells an…
View article: Supplementary Figure 2 from Antigen Priming Induces Functional Reprogramming in iNKT Cells via Metabolic and Epigenetic Regulation: An Insight into iNKT Cell-Based Antitumor Immunotherapy
Supplementary Figure 2 from Antigen Priming Induces Functional Reprogramming in iNKT Cells via Metabolic and Epigenetic Regulation: An Insight into iNKT Cell-Based Antitumor Immunotherapy Open
A, Procedure for TCR priming in vitro. B-C, Frequencies of IFN+ (B), GzmA+, and GzmB+ (C) naïve and TCR-primed iNKT cells restimulated with anti-CD3 plus anti-CD28 antibodies as indicated in (A) (n = 3). Data are represented as mean ± SD.…
View article: Supplementary Figure Legends from Antigen Priming Induces Functional Reprogramming in iNKT Cells via Metabolic and Epigenetic Regulation: An Insight into iNKT Cell-Based Antitumor Immunotherapy
Supplementary Figure Legends from Antigen Priming Induces Functional Reprogramming in iNKT Cells via Metabolic and Epigenetic Regulation: An Insight into iNKT Cell-Based Antitumor Immunotherapy Open
Supplementary Figure Legends
View article: Data from Antigen Priming Induces Functional Reprogramming in iNKT Cells via Metabolic and Epigenetic Regulation: An Insight into iNKT Cell-Based Antitumor Immunotherapy
Data from Antigen Priming Induces Functional Reprogramming in iNKT Cells via Metabolic and Epigenetic Regulation: An Insight into iNKT Cell-Based Antitumor Immunotherapy Open
Dysfunction of intratumoral invariant natural killer T (iNKT) cells hinders their antitumor efficacy, but the underlying mechanisms and the relationship with endogenous antigen priming remain to be explored. Here, we report that antigen pr…
View article: Supplementary Figure Legends from Antigen Priming Induces Functional Reprogramming in iNKT Cells via Metabolic and Epigenetic Regulation: An Insight into iNKT Cell-Based Antitumor Immunotherapy
Supplementary Figure Legends from Antigen Priming Induces Functional Reprogramming in iNKT Cells via Metabolic and Epigenetic Regulation: An Insight into iNKT Cell-Based Antitumor Immunotherapy Open
Supplementary Figure Legends
View article: Supplementary Figure 1 from Antigen Priming Induces Functional Reprogramming in iNKT Cells via Metabolic and Epigenetic Regulation: An Insight into iNKT Cell-Based Antitumor Immunotherapy
Supplementary Figure 1 from Antigen Priming Induces Functional Reprogramming in iNKT Cells via Metabolic and Epigenetic Regulation: An Insight into iNKT Cell-Based Antitumor Immunotherapy Open
Antigen priming leads to dysfunction in distinct iNKT subsets.
View article: Data from Antigen Priming Induces Functional Reprogramming in iNKT Cells via Metabolic and Epigenetic Regulation: An Insight into iNKT Cell-Based Antitumor Immunotherapy
Data from Antigen Priming Induces Functional Reprogramming in iNKT Cells via Metabolic and Epigenetic Regulation: An Insight into iNKT Cell-Based Antitumor Immunotherapy Open
Dysfunction of intratumoral invariant natural killer T (iNKT) cells hinders their antitumor efficacy, but the underlying mechanisms and the relationship with endogenous antigen priming remain to be explored. Here, we report that antigen pr…
View article: Supplementary Figure 1 from Antigen Priming Induces Functional Reprogramming in iNKT Cells via Metabolic and Epigenetic Regulation: An Insight into iNKT Cell-Based Antitumor Immunotherapy
Supplementary Figure 1 from Antigen Priming Induces Functional Reprogramming in iNKT Cells via Metabolic and Epigenetic Regulation: An Insight into iNKT Cell-Based Antitumor Immunotherapy Open
Antigen priming leads to dysfunction in distinct iNKT subsets.
View article: Table of Contents
Table of Contents Open
View article: PKM2 allosteric converter: A self-assembly peptide for suppressing renal cell carcinoma and sensitizing chemotherapy
PKM2 allosteric converter: A self-assembly peptide for suppressing renal cell carcinoma and sensitizing chemotherapy Open
Stronger intrinsic Warburg effect and resistance to chemotherapy are the responses to high mortality of renal cell carcinoma (RCC). Pyruvate kinase M2 (PKM2) plays an important role in this process. Promoting PKM2 conversion from dimer to …
View article: Vam6 reduces iNKT cell function in tumor via modulating AMPK/mTOR pathways
Vam6 reduces iNKT cell function in tumor via modulating AMPK/mTOR pathways Open
Activation of mTORC1 is essential for anti-tumor function of iNKT cells. The mechanisms underlying impaired mTORC1 activation in intratumoral iNKT cells remain unclear. Via generating Vam6 +/- mice and using flow cytometry, image approach,…
View article: Vam6 upregulated by lactic acid inhibits anti-tumor effects of intratumoral iNKT cells via modulating AMPK/mTOR pathways
Vam6 upregulated by lactic acid inhibits anti-tumor effects of intratumoral iNKT cells via modulating AMPK/mTOR pathways Open
Activation of mTORC1 is essential for anti-tumor function of iNKT cells. The mechanisms underlying impaired mTORC1 activation in intratumoral iNKT cells remain unclear. Here, we showed that lactic acid from tumor cells increased Vam6 expre…
View article: iNKT subsets differ in their developmental and functional requirements on Foxo1
iNKT subsets differ in their developmental and functional requirements on Foxo1 Open
Significance Invariant natural killer T (iNKT) cells participate in the first line of body defense and can be classified into three functional subsets. Differences in their developmental and functional control further contribute to their f…
View article: ASC deglutathionylation is a checkpoint for NLRP3 inflammasome activation
ASC deglutathionylation is a checkpoint for NLRP3 inflammasome activation Open
Activation of NLRP3 inflammasome is precisely controlled to avoid excessive activation. Although multiple molecules regulating NLRP3 inflammasome activation have been revealed, the checkpoints governing NLRP3 inflammasome activation remain…
View article: Circular RNA circ_0111277 attenuates human trophoblast cell invasion and migration by regulating miR-494/HTRA1/Notch-1 signal pathway in pre-eclampsia
Circular RNA circ_0111277 attenuates human trophoblast cell invasion and migration by regulating miR-494/HTRA1/Notch-1 signal pathway in pre-eclampsia Open
Mounting evidence has revealed that impaired spiral artery remodeling, placental dysfunction, and inadequate trophoblast invasion are closely correlated with the etiology and pathogenesis of pre-eclampsia (PE). Moreover, defective trophobl…
View article: Impaired lipid biosynthesis hinders anti-tumor efficacy of intratumoral iNKT cells
Impaired lipid biosynthesis hinders anti-tumor efficacy of intratumoral iNKT cells Open