Sheng‐Cai Lin
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View article: Glucose starvation mimetic aldometanib removes immune barriers permitting mice with hepatocellular carcinoma to live to normal ages
Glucose starvation mimetic aldometanib removes immune barriers permitting mice with hepatocellular carcinoma to live to normal ages Open
View article: Gut bacteria enriched in obese mice produce leucic acid to counter obesity through HCAR2
Gut bacteria enriched in obese mice produce leucic acid to counter obesity through HCAR2 Open
Gut microbiota modulates a wide range of physiological processes in the host. However, whether host genes shape microbial communities to affect host physiology remains poorly explored. Using Aida -/- mice that develop obesity …
View article: Oligodendrocyte precursor cell-specific blocking of low-glucose-induced activation of AMPK ensures myelination and remyelination
Oligodendrocyte precursor cell-specific blocking of low-glucose-induced activation of AMPK ensures myelination and remyelination Open
It has been shown that in most cells, low glucose leads to activation of AMP-activated protein kinase (AMPK) via the lysosomal glucose-sensing pathway, where glycolytic aldolase acts as the glucose sensor. Here, we show that ALDOC (aldolas…
View article: Author Correction: Lithocholic acid phenocopies anti-ageing effects of calorie restriction
Author Correction: Lithocholic acid phenocopies anti-ageing effects of calorie restriction Open
View article: Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK
Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK Open
View article: AMPK acts to remove immune barriers to CD8<sup>+</sup>T cell-mediated immunity against hepatocellular carcinoma
AMPK acts to remove immune barriers to CD8<sup>+</sup>T cell-mediated immunity against hepatocellular carcinoma Open
Dysregulated metabolism in tumor tissues, and para-tumor tissues alike, can lead to immunosuppression, which may underlie cancer development. However, metabolic intervention as a therapeutic strategy has been of no avail. In this study, we…
View article: Lithocholic acid binds TULP3 to activate sirtuins and AMPK to slow down ageing
Lithocholic acid binds TULP3 to activate sirtuins and AMPK to slow down ageing Open
View article: Lithocholic acid phenocopies anti-ageing effects of calorie restriction
Lithocholic acid phenocopies anti-ageing effects of calorie restriction Open
View article: Oral Intake of Collagen and Collagen Hydrolysate From <i>Takifugu bimaculatus</i> Attenuates Ultraviolet‐Induced Skin Photoaging in Mice
Oral Intake of Collagen and Collagen Hydrolysate From <i>Takifugu bimaculatus</i> Attenuates Ultraviolet‐Induced Skin Photoaging in Mice Open
With the rapid emergence of pufferfish aquaculture and processing industries, fish skin is underutilized as a byproduct of processing, leading to resource waste. In this study, Takifugu bimaculatus skin collagen (TBSC) was extracted by ace…
View article: AMPK-PDZD8-GLS1 axis mediates calorie restriction-induced lifespan extension
AMPK-PDZD8-GLS1 axis mediates calorie restriction-induced lifespan extension Open
View article: AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine
AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine Open
The shift of carbon utilization from primarily glucose to other nutrients is a fundamental metabolic adaptation to cope with decreased blood glucose levels and the consequent decline in glucose oxidation. AMP-activated protein kinase (AMPK…
View article: Low glucose metabolite 3-phosphoglycerate switches PHGDH from serine synthesis to p53 activation to control cell fate
Low glucose metabolite 3-phosphoglycerate switches PHGDH from serine synthesis to p53 activation to control cell fate Open
Glycolytic intermediary metabolites such as fructose-1,6-bisphosphate can serve as signals, controlling metabolic states beyond energy metabolism. However, whether glycolytic metabolites also play a role in controlling cell fate remains un…
View article: AMPK targets PDZD8 to trigger carbon source shift to glutamine
AMPK targets PDZD8 to trigger carbon source shift to glutamine Open
The shift of carbon utilisation from glucose to other nutrients is a fundamental metabolic adaptation to cope with the decreased glucose oxidation during fasting or starvation 1 . AMP-activated protein kinase (AMPK) plays crucial roles in …
View article: Data from Daxx Cooperates with the Axin/HIPK2/p53 Complex to Induce Cell Death
Data from Daxx Cooperates with the Axin/HIPK2/p53 Complex to Induce Cell Death Open
Daxx, a death domain–associated protein, has been implicated in proapoptosis, antiapoptosis, and transcriptional regulation. Many factors known to play critically important roles in controlling apoptosis and gene transcription have been sh…
View article: Supplementary Methods and Figure Legends from Daxx Cooperates with the Axin/HIPK2/p53 Complex to Induce Cell Death
Supplementary Methods and Figure Legends from Daxx Cooperates with the Axin/HIPK2/p53 Complex to Induce Cell Death Open
Supplementary Methods and Figure Legends from Daxx Cooperates with the Axin/HIPK2/p53 Complex to Induce Cell Death
View article: Supplementary Figures 1-7 from Daxx Cooperates with the Axin/HIPK2/p53 Complex to Induce Cell Death
Supplementary Figures 1-7 from Daxx Cooperates with the Axin/HIPK2/p53 Complex to Induce Cell Death Open
Supplementary Figures 1-7 from Daxx Cooperates with the Axin/HIPK2/p53 Complex to Induce Cell Death
View article: Supplementary Figures 1-7 from Daxx Cooperates with the Axin/HIPK2/p53 Complex to Induce Cell Death
Supplementary Figures 1-7 from Daxx Cooperates with the Axin/HIPK2/p53 Complex to Induce Cell Death Open
Supplementary Figures 1-7 from Daxx Cooperates with the Axin/HIPK2/p53 Complex to Induce Cell Death
View article: Supplementary Methods and Figure Legends from Daxx Cooperates with the Axin/HIPK2/p53 Complex to Induce Cell Death
Supplementary Methods and Figure Legends from Daxx Cooperates with the Axin/HIPK2/p53 Complex to Induce Cell Death Open
Supplementary Methods and Figure Legends from Daxx Cooperates with the Axin/HIPK2/p53 Complex to Induce Cell Death
View article: Data from Daxx Cooperates with the Axin/HIPK2/p53 Complex to Induce Cell Death
Data from Daxx Cooperates with the Axin/HIPK2/p53 Complex to Induce Cell Death Open
Daxx, a death domain–associated protein, has been implicated in proapoptosis, antiapoptosis, and transcriptional regulation. Many factors known to play critically important roles in controlling apoptosis and gene transcription have been sh…
View article: Supplementary Figure 8 from Daxx Cooperates with the Axin/HIPK2/p53 Complex to Induce Cell Death
Supplementary Figure 8 from Daxx Cooperates with the Axin/HIPK2/p53 Complex to Induce Cell Death Open
Supplementary Figure 8 from Daxx Cooperates with the Axin/HIPK2/p53 Complex to Induce Cell Death
View article: Supplementary Figure 8 from Daxx Cooperates with the Axin/HIPK2/p53 Complex to Induce Cell Death
Supplementary Figure 8 from Daxx Cooperates with the Axin/HIPK2/p53 Complex to Induce Cell Death Open
Supplementary Figure 8 from Daxx Cooperates with the Axin/HIPK2/p53 Complex to Induce Cell Death
View article: Hierarchical inhibition of mTORC1 by glucose starvation-triggered AXIN lysosomal translocation and by AMPK
Hierarchical inhibition of mTORC1 by glucose starvation-triggered AXIN lysosomal translocation and by AMPK Open
When glucose is replete, mammalian/mechanistic target of rapamycin complex 1 (mTORC1) is active and anchored to the lysosomal surface via the two GTPases, Ras-related GTPase (RAG) and Ras homolog enriched in brain (Rheb), which are regulat…
View article: Visualization of the Lenticulostriate artery with 3-dimensional time-of-flight magnetic resonance angiography combined with the compressed sensing technique using a 3-T magnetic resonance imaging system
Visualization of the Lenticulostriate artery with 3-dimensional time-of-flight magnetic resonance angiography combined with the compressed sensing technique using a 3-T magnetic resonance imaging system Open
The lenticulostriate artery (LSA) is a vital perforating cerebral artery, whose occlusion often leads to lacunar infarction. Currently, digital subtraction angiography is mainly used to visualize the LSA in the clinical setting; however, i…
View article: The aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK
The aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK Open
The activity of 5′-adenosine monophosphate-activated protein kinase (AMPK) is inversely correlated with the cellular availability of glucose. When glucose levels are low, the glycolytic enzyme aldolase is not bound to fructose-1,6-bisphosp…
View article: Midkine noncanonically suppresses AMPK activation through disrupting the LKB1-STRAD-Mo25 complex
Midkine noncanonically suppresses AMPK activation through disrupting the LKB1-STRAD-Mo25 complex Open
Midkine (MDK), a secreted growth factor, regulates signal transduction and cancer progression by interacting with receptors, and it can be internalized into the cytoplasm by endocytosis. However, its intracellular function and signaling re…
View article: Identification of serum metabolites enhancing inflammatory responses in COVID-19
Identification of serum metabolites enhancing inflammatory responses in COVID-19 Open
View article: Low-dose metformin targets the lysosomal AMPK pathway through PEN2
Low-dose metformin targets the lysosomal AMPK pathway through PEN2 Open
View article: Midkine noncanonically suppresses AMPK activation through disrupting the LKB1-STRAD-Mo25 complex
Midkine noncanonically suppresses AMPK activation through disrupting the LKB1-STRAD-Mo25 complex Open
Midkine (MDK), an extracellular growth factor, regulates signal transduction and cancer progression by interacting with receptors, and it can be internalized into the cytoplasm by endocytosis. However, its intracellular function and signal…
View article: Nuclear UHRF1 is a gate-keeper of cellular AMPK activity and function
Nuclear UHRF1 is a gate-keeper of cellular AMPK activity and function Open
View article: AIDA directly connects sympathetic innervation to adaptive thermogenesis by UCP1
AIDA directly connects sympathetic innervation to adaptive thermogenesis by UCP1 Open
The sympathetic nervous system-catecholamine-uncoupling protein 1 (UCP1) axis plays an essential role in non-shivering adaptive thermogenesis. However, whether there exists a direct effector that physically connects catecholamine signallin…