Shizhen He
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View article: Long-term exposure to air pollution and metabolites in children and young adults in a Swedish birth cohort
Long-term exposure to air pollution and metabolites in children and young adults in a Swedish birth cohort Open
Background The biochemical dysregulation underlying the adverse health effects of exposure to air pollution (AP) remains unclear. Objective The objective of this study was to explore associations between long-term exposure to AP and the ur…
View article: Impact of ambient temperature exposure on inflammation-related proteins: a repeated measurement study in the BAMSE cohort
Impact of ambient temperature exposure on inflammation-related proteins: a repeated measurement study in the BAMSE cohort Open
Background Short-term exposure to ambient temperature is linked to various health outcomes, raising public health concern in the context of climate change. We aimed to investigate longitudinal associations of temperature exposure with infl…
View article: Air pollution-induced proteomic alterations increase the risk of child respiratory infections
Air pollution-induced proteomic alterations increase the risk of child respiratory infections Open
View article: On‐Demand Regulation of Catalytic DNA Circuits Using Phosphorylated Charge Reversal Peptides
On‐Demand Regulation of Catalytic DNA Circuits Using Phosphorylated Charge Reversal Peptides Open
Catalytic DNA circuits have emerged as a powerful tool for high‐performance biosensing application; however, the establishment of a safe and efficient in vivo delivery system remains a critical bottleneck. Peptides serve as attractive carr…
View article: Long-Term Exposure to Air Pollution is Associated with Urinary Metabolite Shifts in Children and Young Adults in a Swedish Birth Cohort
Long-Term Exposure to Air Pollution is Associated with Urinary Metabolite Shifts in Children and Young Adults in a Swedish Birth Cohort Open
View article: Biological mechanisms behind health effects of air pollution exposure from childhood to adulthood
Biological mechanisms behind health effects of air pollution exposure from childhood to adulthood Open
BACKGROUND: Early life air pollution exposure impairs respiratory health during childhood and up to young adulthood. The proposed mechanism for air pollution adverse health effects includes systemic inflammation and metabolic dysregulation…
View article: Joint association of air pollution exposure and inflammation-related proteins in relation to infant lung function
Joint association of air pollution exposure and inflammation-related proteins in relation to infant lung function Open
Early life air pollution exposure and abnormal inflammation-related protein profiles may interact synergistically towards lower lung function in infants.
View article: Spatiotemporally Programmed Disassembly of Multifunctional Integrated DNAzyme Nanoplatfrom for Amplified Intracellular MicroRNA Imaging
Spatiotemporally Programmed Disassembly of Multifunctional Integrated DNAzyme Nanoplatfrom for Amplified Intracellular MicroRNA Imaging Open
The sensing performance of DNAzymes in live cells is tremendously hampered by the inefficient and inhomogeneous delivery of DNAzyme probes and their incontrollable off‐site activation, originating from their susceptibility to nuclease dige…
View article: Stimuli‐Responsive DNA Circuits for High‐Performance Bioimaging Application
Stimuli‐Responsive DNA Circuits for High‐Performance Bioimaging Application Open
Probing endogenous molecules in living entities is significant to help decipher biological functions and exploit novel theranostics. DNA circuits that can recognize molecular inputs of interest and transduce them into readable signal outpu…
View article: The compact integration of a cascaded HCR circuit for highly reliable cancer cell discrimination
The compact integration of a cascaded HCR circuit for highly reliable cancer cell discrimination Open
A compact and clamped CHA-control-HCR (CCH) circuitry system, specifically for amplified multi-microRNA imaging, is developed to precisely distinguish cancer cells from normal cells.
View article: Efficiency Evaluation of a Forestry Green Economy under a Multi-Dimensional Output Benefit in China—Based on Evidential Reasoning and the Cross Efficiency Model
Efficiency Evaluation of a Forestry Green Economy under a Multi-Dimensional Output Benefit in China—Based on Evidential Reasoning and the Cross Efficiency Model Open
The efficiency evaluation of forestry green economy development is related to the direction of forestry development and plays an important role in balancing the economic and environmental issues within that forestry development. The existi…
View article: Exploring the exposome across the life-course; air pollution, metabolomics and lung function
Exploring the exposome across the life-course; air pollution, metabolomics and lung function Open
Background and Aim. Previous studies have explored relationships of air pollution and metabolic profiles with lung function. However, the metabolites linking air pollution and lung function and associated mechanisms have not been reviewed …
View article: Ambient air pollution and inflammation-related proteins during early childhood
Ambient air pollution and inflammation-related proteins during early childhood Open
Background and aim: Experimental studies show that short-term exposure to air pollution may alter cytokine concentrations. There is, however, a lack of epidemiological studies evaluating the association between long-term air pollution expo…
View article: Ambient air pollution and inflammation-related proteins during early childhood
Ambient air pollution and inflammation-related proteins during early childhood Open
Ambient air pollution exposure influences inflammation-related protein levels already during early childhood. Our results also suggest age- and sex-specific differences in the impact of air pollution on children's inflammatory profiles.
View article: Construction of a Stimuli-Responsive DNAzyme-Braked DNA Nanomachine for the Amplified Imaging of miRNAs in Living Cells and Mice
Construction of a Stimuli-Responsive DNAzyme-Braked DNA Nanomachine for the Amplified Imaging of miRNAs in Living Cells and Mice Open
Open AccessCCS ChemistryRESEARCH ARTICLES6 Oct 2022Construction of a Stimuli-Responsive DNAzyme-Braked DNA Nanomachine for the Amplified Imaging of miRNAs in Living Cells and Mice Yingying Chen†, Mingzhu Yan†, Yushi Wang, Jinhua Shang, Shi…
View article: Air pollution, metabolites and respiratory health across the life-course
Air pollution, metabolites and respiratory health across the life-course Open
Previous studies have explored the relationships of air pollution and metabolic profiles with lung function. However, the metabolites linking air pollution and lung function and the associated mechanisms have not been reviewed from a life-…
View article: Theoretical Study on the Electronic Structure and Magnetic Properties Regulation of Janus Structure of M’MCO2 2D MXenes
Theoretical Study on the Electronic Structure and Magnetic Properties Regulation of Janus Structure of M’MCO2 2D MXenes Open
Motivated by the recent successful synthesis of Janus monolayer of transition metal (TM) dichalcogenides, MXenes with Janus structures are worthy of further study, concerning its electronic structure and magnetic properties. Here, we study…
View article: Construction of a Homogeneous Enzyme-Free Autocatalytic Nucleic Acid Machinery for High-Performance Intracellular Imaging of MicroRNA
Construction of a Homogeneous Enzyme-Free Autocatalytic Nucleic Acid Machinery for High-Performance Intracellular Imaging of MicroRNA Open
Open AccessCCS ChemistryRESEARCH ARTICLE7 Nov 2022Construction of a Homogeneous Enzyme-Free Autocatalytic Nucleic Acid Machinery for High-Performance Intracellular Imaging of MicroRNA Jie Wei†, Jinhua Shang†, Shizhen He, Yu Ouyang, Itamar …
View article: Monitoring and modulating a catalytic hybridization circuit for self-adaptive bioorthogonal DNA assembly
Monitoring and modulating a catalytic hybridization circuit for self-adaptive bioorthogonal DNA assembly Open
A localized catalytic circuit, facilitating the self-assembly of DNA nanosponges, is developed for robust and accurate monitoring of miRNA targets in live cells and mice.
View article: Bioorthogonal regulation of DNA circuits for smart intracellular microRNA imaging
Bioorthogonal regulation of DNA circuits for smart intracellular microRNA imaging Open
An on-site bioorthogonal regulated DNA circuit was developed by introducing an endogenous DNA repairing enzyme-mediated sequential activation strategy to achieve cancer cell-selective microRNA imaging with high anti-interference ability.
View article: Breast Cancer Screening Trends among Lower Income Women of New York: A Time-Series Evaluation of a Population-Based Intervention
Breast Cancer Screening Trends among Lower Income Women of New York: A Time-Series Evaluation of a Population-Based Intervention Open
This study found limited evidence that the Breast Cancer Early Detection Programme significantly contributed to the state-wide increase in mammography screening rate among lower-income women from 1988 to 2010. Future studies should examine…