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View article: Deconvolution in Alzheimer’s disease
Deconvolution in Alzheimer’s disease Open
View article: Effects of Ethanol and Opioid Receptor Antagonists Naltrexone and LY2444296 on the Organization of Cholesterol- and Sphingomyelin-Enriched Plasma Membrane Domains
Effects of Ethanol and Opioid Receptor Antagonists Naltrexone and LY2444296 on the Organization of Cholesterol- and Sphingomyelin-Enriched Plasma Membrane Domains Open
Excessive consumption of alcohol (ethanol (EtOH)) can lead to alcohol use disorder (AUD). While AUD can be managed through behavioral interventions, there is a great need for pharmacological remedies for this condition. To date, only three…
View article: Collaborative Duality of CircGLIS3(2) RNA and Protein in human Wound Repair (Adv. Sci. 25/2025)
Collaborative Duality of CircGLIS3(2) RNA and Protein in human Wound Repair (Adv. Sci. 25/2025) Open
View article: Collaborative Duality of CircGLIS3(2) RNA and Protein in human Wound Repair
Collaborative Duality of CircGLIS3(2) RNA and Protein in human Wound Repair Open
The discovery of an increasing number of translatable circular RNAs (circRNAs) raises the question of whether their coding and non‐coding functions can coexist within the same cell. This study profiles the dynamic expression of circRNAs du…
View article: Celebrating 50 years of fluorescence correlation spectroscopy (FCS): Advancing live-cell massively parallel FCS studies with photostable GFPs, mStayGold and StayGold/E138D
Celebrating 50 years of fluorescence correlation spectroscopy (FCS): Advancing live-cell massively parallel FCS studies with photostable GFPs, mStayGold and StayGold/E138D Open
More than 50 years after its inception, fluorescence correlation spectroscopy (FCS) remains a cornerstone technique for quantitative characterization of the cellular dynamics of molecules and their concentration and interactions in live ce…
View article: Suppressing recurrence in Sonic Hedgehog subgroup medulloblastoma using the OLIG2 inhibitor CT-179
Suppressing recurrence in Sonic Hedgehog subgroup medulloblastoma using the OLIG2 inhibitor CT-179 Open
View article: Publisher Correction: Thioflavin-T: application as a neuronal body and nucleolar stain and the blue light photo enhancement effect
Publisher Correction: Thioflavin-T: application as a neuronal body and nucleolar stain and the blue light photo enhancement effect Open
View article: Naltrexone blocks alcohol-induced effects on kappa-opioid receptors in the plasma membrane
Naltrexone blocks alcohol-induced effects on kappa-opioid receptors in the plasma membrane Open
Naltrexone (NTX), a homolog of the opiate antidote naloxone, is an orally active long-acting general opioid receptor antagonist used in the treatment of opiate dependence. NTX is also found to relieve craving for alcohol and is one of few …
View article: Thioflavin-T: application as a neuronal body and nucleolar stain and the blue light photo enhancement effect
Thioflavin-T: application as a neuronal body and nucleolar stain and the blue light photo enhancement effect Open
Thioflavin-T (THT) is a common and indispensable tool for the study of amyloid pathologies and protein aggregation, both in vitro and for histological samples. In this study we expand the use of THT beyond its canonical usage for staining …
View article: Small Molecule Decoy of Amyloid-β Aggregation Blocks Activation of Microglia-Like Cells
Small Molecule Decoy of Amyloid-β Aggregation Blocks Activation of Microglia-Like Cells Open
Background: Aggregated forms of the amyloid-β (Aβ) peptides which form protofibrils and fibrils in the brain are signatures of Alzheimer’s disease (AD). Aggregates are also recognized by microglia, which in early phases may be protective a…
View article: Small molecular decoys in Alzheimer’s disease
Small molecular decoys in Alzheimer’s disease Open
View article: Mapping the Direction of Nucleocytoplasmic Transport of Glucocorticoid Receptor (GR) in Live Cells Using Two-Foci Cross-Correlation in Massively Parallel Fluorescence Correlation Spectroscopy (mpFCS)
Mapping the Direction of Nucleocytoplasmic Transport of Glucocorticoid Receptor (GR) in Live Cells Using Two-Foci Cross-Correlation in Massively Parallel Fluorescence Correlation Spectroscopy (mpFCS) Open
Nucleocytoplasmic transport of transcription factors is vital for normal cellular function, and its breakdown is a major contributing factor in many diseases. The glucocorticoid receptor (GR) is an evolutionarily conserved, ligand-dependen…
View article: The interwoven fibril-like structure of amyloid-beta plaques in mouse brain tissue visualized using super-resolution STED microscopy
The interwoven fibril-like structure of amyloid-beta plaques in mouse brain tissue visualized using super-resolution STED microscopy Open
Background Standard neuropathologic analysis of Alzheimer’s brain relies on traditional fluorescence microscopy, which suffers from limited spatial resolution due to light diffraction. As a result, it fails to reveal intricate details of a…
View article: Increased intracellular crowding during hyperosmotic stress
Increased intracellular crowding during hyperosmotic stress Open
View article: Naltrexone blocks alcohol-induced effects on kappa-opioid receptors in the plasma membrane
Naltrexone blocks alcohol-induced effects on kappa-opioid receptors in the plasma membrane Open
Naltrexone (NTX), a homologue of the opiate antidote naloxone, is an orally active long-acting mu-opioid receptor (MOP) antagonist used in the treatment of opiate dependence. NTX is also found to relieve craving for alcohol and is one of t…
View article: Interactions of ultrashort laser pulses with hemoglobin: Photophysical aspects and potential applications
Interactions of ultrashort laser pulses with hemoglobin: Photophysical aspects and potential applications Open
View article: Preventing recurrence in Sonic Hedgehog Subgroup Medulloblastoma using OLIG2 inhibitor CT-179
Preventing recurrence in Sonic Hedgehog Subgroup Medulloblastoma using OLIG2 inhibitor CT-179 Open
View article: Small Molecule Decoys of Aggregation for Elimination of Aβ-Peptide Toxicity
Small Molecule Decoys of Aggregation for Elimination of Aβ-Peptide Toxicity Open
Several lines of evidence suggest that a characteristic of the neuropathology of Alzheimer's disease (AD) is the aggregation of the amyloid beta peptides (Aβ), fragments of the human amyloid precursor protein (hAPP). The dominating species…
View article: Increased intracellular crowding during hyperosmotic stress
Increased intracellular crowding during hyperosmotic stress Open
Hyperosmotic stress activates in live cells numerous processes and also promotes intracellular protein/RNA aggregation and phase separation. However, the time course and the extent of these changes remain largely uncharacterized. To invest…
View article: Cytosolic GPR37, but not GPR37L1, multimerization and its reversal by Parkin: A live cell imaging study
Cytosolic GPR37, but not GPR37L1, multimerization and its reversal by Parkin: A live cell imaging study Open
Biochemical data have shown aggregated G protein‐coupled receptor 37 (GPR37) in the cytoplasm and Lewy bodies in Parkinson's disease (PD). Properly folded GPR37 at the plasma membrane appears to be neuroprotective. GPR37, and its homologue…
View article: Dynamic Cellular Cartography: Mapping the Local Determinants of Oligodendrocyte Transcription Factor 2 (OLIG2) Function in Live Cells Using Massively Parallel Fluorescence Correlation Spectroscopy Integrated with Fluorescence Lifetime Imaging Microscopy (mpFCS/FLIM)
Dynamic Cellular Cartography: Mapping the Local Determinants of Oligodendrocyte Transcription Factor 2 (OLIG2) Function in Live Cells Using Massively Parallel Fluorescence Correlation Spectroscopy Integrated with Fluorescence Lifetime Imaging Microscopy (mpFCS/FLIM) Open
Compartmentalization and integration of molecular processes through diffusion are basic mechanisms through which cells perform biological functions. To characterize these mechanisms in live cells, quantitative and ultrasensitive analytical…
View article: Mapping the Spatiotemporal Heterogeneity of Biomolecules Concentration, Mobility and Local Environment in Live Cells using Quantitative Time-Resolved Confocal Fluorescence Microscopy Imaging Without Scanning and Fluorescence Lifetime Imaging Microscopy
Mapping the Spatiotemporal Heterogeneity of Biomolecules Concentration, Mobility and Local Environment in Live Cells using Quantitative Time-Resolved Confocal Fluorescence Microscopy Imaging Without Scanning and Fluorescence Lifetime Imaging Microscopy Open
View article: A strategy for designing allosteric modulators of transcription factor dimerization
A strategy for designing allosteric modulators of transcription factor dimerization Open
Significance Transcription factors in the bHLH family are potentially relevant for tumor growth. Activation requires homodimerization or heterodimerization. Thus, the dimerization step is a likely significant drug target. The oligodendrocy…
View article: Relationship Between Homodimeric Glucocorticoid Receptor and Transcriptional Regulation Assessed via an In Vitro Fluorescence Correlation Spectroscopy-Microwell System
Relationship Between Homodimeric Glucocorticoid Receptor and Transcriptional Regulation Assessed via an In Vitro Fluorescence Correlation Spectroscopy-Microwell System Open
View article: A Quantitative Study of Internal and External Interactions of Homodimeric Glucocorticoid Receptor Using Fluorescence Cross-Correlation Spectroscopy in a Live Cell
A Quantitative Study of Internal and External Interactions of Homodimeric Glucocorticoid Receptor Using Fluorescence Cross-Correlation Spectroscopy in a Live Cell Open