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View article: Maternal Renal Function During Pregnancy and the Early Postpartum Period in Normotensive and Hypertensive Pregnancies
Maternal Renal Function During Pregnancy and the Early Postpartum Period in Normotensive and Hypertensive Pregnancies Open
Aim We aimed to assess renal function trends during pregnancy and the early postpartum period and establish trimester‐specific reference ranges for maternal renal function parameters in Japan, including comparisons with pregnancies complic…
View article: Quantitative assessment of placental alpha macroglobulin‐1 for predicting impending preterm delivery in asymptomatic women with a short cervix
Quantitative assessment of placental alpha macroglobulin‐1 for predicting impending preterm delivery in asymptomatic women with a short cervix Open
Aims Preterm delivery (PTD) is a leading cause of neonatal morbidity and mortality. Accurate prediction is crucial for optimizing clinical outcomes, particularly in women with a short cervix. Although fetal fibronectin (FFN) is widely used…
View article: Antenatal corticosteroid treatment for women with hypertensive disorders of pregnancy: A population‐based study in Japan
Antenatal corticosteroid treatment for women with hypertensive disorders of pregnancy: A population‐based study in Japan Open
Aim This study aimed to evaluate the current antenatal corticosteroid (ACS) treatment practices for hypertensive disorders of pregnancy (HDP) in Japan, by evaluating annual trends and identifying clinical disparities and factors influencin…
View article: Butyrate-Producing Bacteria in Pregnancy Maintenance: Mitigating Dysbiosis-Induced Preterm Birth
Butyrate-Producing Bacteria in Pregnancy Maintenance: Mitigating Dysbiosis-Induced Preterm Birth Open
Background: Preterm birth (PTB) is a major contributor to neonatal morbidity, mortality, and long-term health complications. Despite advances in perinatal care, PTB rates remain high, and its multifactorial etiology is not fully understood…
View article: Dietary supplements and prevention of preeclampsia
Dietary supplements and prevention of preeclampsia Open
Preeclampsia (PE) is a common pregnancy complication characterized by hypertension, proteinuria, and end-organ dysfunction. However, to date, no effective treatment has been established other than iatrogenic delivery, and the importance of…
View article: Patient awareness of long‐term cardiovascular and metabolic disease risks after hypertensive disorders of pregnancy in Japan
Patient awareness of long‐term cardiovascular and metabolic disease risks after hypertensive disorders of pregnancy in Japan Open
Aim Given the increasing recognition of the importance of postpartum follow‐up care for women with a history of hypertensive disorders of pregnancy (HDP) to mitigate their future risk of cardiovascular and metabolic diseases, here we aimed…
View article: Visualizing risk modification of hypertensive disorders of pregnancy: development and validation of prediction model for personalized interpregnancy weight management
Visualizing risk modification of hypertensive disorders of pregnancy: development and validation of prediction model for personalized interpregnancy weight management Open
The growing recognition of the importance of interpregnancy weight management in reducing hypertensive disorders of pregnancy (HDP) underscores the importance of effective preventive strategies. However, developing effective systems remain…
View article: Histology-specific long-term oncologic outcomes in patients with epithelial ovarian cancer who underwent complete tumor resection: The implication of occult seeds after initial surgery
Histology-specific long-term oncologic outcomes in patients with epithelial ovarian cancer who underwent complete tumor resection: The implication of occult seeds after initial surgery Open
Objective Assessing the histology-specific prognosis of epithelial ovarian cancer (OvCa) is clinically challenging, especially in a patient population with a favorable prognosis. This study investigated the histology-specific long-term onc…
View article: Aging affects regrowth of stealthperitoneal dissemination of advanced ovarian cancer: a multicenter retrospective cohort study
Aging affects regrowth of stealthperitoneal dissemination of advanced ovarian cancer: a multicenter retrospective cohort study Open
Ovarian cancer (OvCa) is one of the most lethal gynecological malignancies, and most patients are diagnosed at advanced stage with peritoneal dissemination. Although age at diagnosis is considered an independent prognostic factor, its impa…
View article: Elevated levels of apolipoprotein A4 in umbilical cord serum from the maternal major depressive disorder
Elevated levels of apolipoprotein A4 in umbilical cord serum from the maternal major depressive disorder Open
Aim Prenatal maternal depression is known to affect the neurodevelopment of offspring. This study aimed to investigate the profile of umbilical cord serum in mothers with major depressive disorder (MDD). Methods Liquid chromatography–tande…
View article: Impact of antenatal corticosteroids-to-delivery interval on very preterm neonatal outcomes: a retrospective study in two tertiary centers in Japan
Impact of antenatal corticosteroids-to-delivery interval on very preterm neonatal outcomes: a retrospective study in two tertiary centers in Japan Open
An ACS-to-delivery interval of 1-7 days achieved the lowest incidence of several complications in preterm neonates born at < 32 weeks of gestational age. Some of the favorable effects of ACS seem to continue even beyond ≥ 8 days from admin…
View article: Impact of antenatal corticosteroids on subcortical volumes in preterm infants at term-equivalent age: A retrospective observational study
Impact of antenatal corticosteroids on subcortical volumes in preterm infants at term-equivalent age: A retrospective observational study Open
ACS was associated with smaller volumes of the bilateral amygdalae and caudate nuclei at term-equivalent age. This association was observed exclusively in infants born at 28 weeks of gestation or later.
View article: Identifying the high-benefit population for weight management-based cardiovascular disease prevention in Japan
Identifying the high-benefit population for weight management-based cardiovascular disease prevention in Japan Open
These findings underscore the importance of weight management under age 60, especially in women.
View article: Amniotic fluid‐derived small extracellular vesicles for predicting postnatal severe outcome of congenital diaphragmatic hernia
Amniotic fluid‐derived small extracellular vesicles for predicting postnatal severe outcome of congenital diaphragmatic hernia Open
Congenital diaphragmatic hernia (CDH) is a life‐threatening condition with high morbidity and mortality rates. The survival rate of neonates with severe CDH is reportedly only 10%–15%. However, prenatal prediction of severe cases is diffic…
View article: TJP1 suppresses trophoblast cell invasion by expressing E2F8 in the human placenta
TJP1 suppresses trophoblast cell invasion by expressing E2F8 in the human placenta Open
Adequate extravillous trophoblast (EVT) invasion into the maternal decidua is important for human placental development. We identified that E2F transcription factor 8 (E2F8) suppresses EVT invasion, and that tight junction protein-1 (TJP1)…
View article: Practical weight management to minimize pregnancy complications and promote women's health: the possibility of interpregnancy care.
Practical weight management to minimize pregnancy complications and promote women's health: the possibility of interpregnancy care. Open
Pregnancy is an excellent opportunity to provide medical interventions to women. It is also a stress test used to predict health. Numerous studies have demonstrated that the pre-pregnancy body mass index (BMI) and gestational weight gain (…
View article: Predicting preterm birth within 2 weeks in asymptomatic women with a short cervix: <scp>Combined</scp> effects of cervicovaginal fluid cytokine levels and fetal fibronectin test
Predicting preterm birth within 2 weeks in asymptomatic women with a short cervix: <span>Combined</span> effects of cervicovaginal fluid cytokine levels and fetal fibronectin test Open
Aims To predict preterm birth (PTB) accurately, we conducted a comprehensive cytokine assay using cervicovaginal fluid (CVF) and evaluated the additive effects of cytokine levels on the fetal fibronectin (fFN) test. Methods A total of 645 …
View article: Risk factors for non‐previa placenta accreta spectrum in pregnancies conceived through frozen embryo transfer during a hormone replacement cycle in Japan
Risk factors for non‐previa placenta accreta spectrum in pregnancies conceived through frozen embryo transfer during a hormone replacement cycle in Japan Open
Purpose Non‐previa placenta accreta spectrum (PAS) is associated with assisted reproductive technology (ART), particularly frozen embryo transfer during hormone replacement therapy (HRC‐FET). We especially aimed to evaluate the prevalence …
View article: Possible Efficacy of Vaginal Progesterone on Asymptomatic Women with a Short Cervix after 24 Weeks of Gestation: A Historical Cohort Study in Japan
Possible Efficacy of Vaginal Progesterone on Asymptomatic Women with a Short Cervix after 24 Weeks of Gestation: A Historical Cohort Study in Japan Open
The VD treatment can prevent PTD in asymptomatic women with sCX diagnosed after 24 weeks of gestation. Although further validation is warranted, these findings may contribute to expanding the use of VD treatment in Japanese clinical practi…