Shobbir Hussain
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View article: On the modelling of variance components in classical twin studies
On the modelling of variance components in classical twin studies Open
Classical twin studies can be used to disentangle the extent to which phenotypic variance of a given complex trait is determined by genetic and environmental variance. The designs widely employ ‘ACDE’ structural equation models where parti…
View article: A dominance-assimilated liability model for complex fitness traits
A dominance-assimilated liability model for complex fitness traits Open
Opposing explanations for the evolution of dominance effects observed in genetic traits were first proposed by Fisher and Wright around a century ago. Over the last few decades, while Wright’s theory and extensions of it have reached the s…
View article: A modeling of complex trait phenotypic variance determinants
A modeling of complex trait phenotypic variance determinants Open
Studies have now shown that the heritability of some complex traits, such as human height, can be virtually fully captured via potential use of sufficiently powered approaches that can characterize the associated collective common- and rar…
View article: A junction coverage compatibility score to quantify the reliability of transcript abundance estimates and annotation catalogs
A junction coverage compatibility score to quantify the reliability of transcript abundance estimates and annotation catalogs Open
Most methods for statistical analysis of RNA-seq data take a matrix of abundance estimates for some type of genomic features as their input, and consequently the quality of any obtained results is directly dependent on the quality of these…
View article: Impaired hippocampal NMDAR-LTP in a transgenic model of NSUN2-deficiency
Impaired hippocampal NMDAR-LTP in a transgenic model of NSUN2-deficiency Open
View article: The Emerging Roles of Cytosine-5 Methylation in mRNAs
The Emerging Roles of Cytosine-5 Methylation in mRNAs Open
View article: Sequence- and structure-specific cytosine-5 mRNA methylation by NSUN6
Sequence- and structure-specific cytosine-5 mRNA methylation by NSUN6 Open
The highly abundant N6-methyladenosine (m6A) RNA modification affects most aspects of mRNA function, yet the precise function of the rarer 5-methylcytidine (m5C) remains largely unknown. Here, we map m5C in the human transcriptome using me…
View article: Sequence- and structure-specific cytosine-5 mRNA methylation by NSUN6
Sequence- and structure-specific cytosine-5 mRNA methylation by NSUN6 Open
Methylation is the most common internal modification in mRNA. While the highly abundant N6-methyladonsine (m 6 A) modification affects most aspects of mRNA function, the precise functions of the rarer 5-methylcytosine (m 5 C) remains large…
View article: Masthead
Masthead Open
SCOPE-IEEE Industrial Electronics Magazine (IEM)publishes peer-reviewed articles that present emerging trends and practices in industrial electronics product research and development, key insights, and tutorial surveys in the field of inte…
View article: Advanced Communication and Control Methods for Future Smartgrids
Advanced Communication and Control Methods for Future Smartgrids Open
Proliferation of distributed generation and the increased ability to monitor different parts of the electrical grid offer unprecedented opportunities for consumers and grid operators. Energy can be generated near the consumption points, wh…
View article: A comprehensive examination of Nanopore native RNA sequencing for characterization of complex transcriptomes
A comprehensive examination of Nanopore native RNA sequencing for characterization of complex transcriptomes Open
View article: FICC-Seq: a method for enzyme-specified profiling of methyl-5-uridine in cellular RNA
FICC-Seq: a method for enzyme-specified profiling of methyl-5-uridine in cellular RNA Open
Methyl-5-uridine (m5U) is one the most abundant non-canonical bases present in cellular RNA, and in yeast is found at position U54 of tRNAs where modification is catalysed by the methyltransferase Trm2. Although the mammalian enzymes that …
View article: A comprehensive examination of Nanopore native RNA sequencing for characterization of complex transcriptomes
A comprehensive examination of Nanopore native RNA sequencing for characterization of complex transcriptomes Open
A platform for highly parallel direct sequencing of native RNA strands was recently described by Oxford Nanopore Technologies (ONT); in order to assess overall performance in transcript-level investigations, the technology was applied for …
View article: A junction coverage compatibility score to quantify the reliability of transcript abundance estimates and annotation catalogs
A junction coverage compatibility score to quantify the reliability of transcript abundance estimates and annotation catalogs Open
Most methods for statistical analysis of RNA-seq data take a matrix of abundance estimates for some type of genomic features as their input, and consequently the quality of any obtained results is directly dependent on the quality of these…
View article: Catalytic crosslinking-based methods for enzyme-specified profiling of RNA ribonucleotide modifications
Catalytic crosslinking-based methods for enzyme-specified profiling of RNA ribonucleotide modifications Open
View article: Robust long-read native DNA sequencing using the ONT CsgG Nanopore system
Robust long-read native DNA sequencing using the ONT CsgG Nanopore system Open
Background: The ability to obtain long read lengths during DNA sequencing has several potentially important practical applications. Especially long read lengths have been reported using the Nanopore sequencing method, currently commerciall…
View article: A junction coverage compatibility score to quantify the reliability of transcript abundance estimates and annotation catalogs
A junction coverage compatibility score to quantify the reliability of transcript abundance estimates and annotation catalogs Open
Most methods for statistical analysis of RNA-seq data take a matrix of abundance estimates for some type of genomic features as their input, and consequently the quality of any obtained results are directly dependent on the quality of thes…
View article: Shaping and Reshaping Transcriptome Plasticity during Evolution
Shaping and Reshaping Transcriptome Plasticity during Evolution Open
View article: Robust long-read native DNA sequencing using the ONT CsgG Nanopore system
Robust long-read native DNA sequencing using the ONT CsgG Nanopore system Open
Background: The ability to obtain long read lengths during DNA sequencing has several potentially important practical applications. Especially long read lengths have been reported using the Nanopore sequencing method, currently commerciall…
View article: Robust long-read native DNA sequencing using the ONT CsgG Nanopore system
Robust long-read native DNA sequencing using the ONT CsgG Nanopore system Open
Background: The ability to obtain long read lengths during DNA sequencing has several potentially important practical applications. Especially long read lengths have been reported using the Nanopore sequencing method, currently commerciall…
View article: Deficient methylation and formylation of mt-tRNAMet wobble cytosine in a patient carrying mutations in NSUN3
Deficient methylation and formylation of mt-tRNAMet wobble cytosine in a patient carrying mutations in NSUN3 Open
View article: Stem cell function and stress response are controlled by protein synthesis
Stem cell function and stress response are controlled by protein synthesis Open
View article: A new conceptual framework for investigating complex genetic disease
A new conceptual framework for investigating complex genetic disease Open
Some common diseases are known to have an inherited component, however, their population- and familial-incidence patterns do not conform to any known monogenic Mendelian pattern of inheritance and instead they are currently much better exp…
View article: The epitranscriptome in modulating spatiotemporal RNA translation in neuronal post-synaptic function
The epitranscriptome in modulating spatiotemporal RNA translation in neuronal post-synaptic function Open
The application of next-generation-sequencing based methods has recently allowed the sequence-specific occurrence of RNA modifications to be investigated in transcriptome-wide settings. This has led to the emergence of a new field of molec…