Shuji Kojima
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View article: Tri-system integration in metal-oxide nanocomposites via in-situ solution-processed method for ultrathin flexible transparent electrodes
Tri-system integration in metal-oxide nanocomposites via in-situ solution-processed method for ultrathin flexible transparent electrodes Open
For stable operation of ultrathin flexible transparent electrodes (uFTEs), it is critical to implement effective risk management during concurrent multi-loading operation of electrical bias and mechanical folding cycles in high-humidity en…
View article: Involvement of TRPV1 and TRPV4 Channels in Enhancement of Metastatic Ability Induced by γ-Irradiation in Human Lung Cancer A549 Cells
Involvement of TRPV1 and TRPV4 Channels in Enhancement of Metastatic Ability Induced by γ-Irradiation in Human Lung Cancer A549 Cells Open
Radiation therapy is an important local treatment for malignant tumors, but ionizing radiation may also facilitate tumor invasion and metastasis. The transient receptor potential (TRP) superfamily, which is a diverse group of ion channels …
View article: Radon Therapy Is Very Promising as a Primary or an Adjuvant Treatment for Different Types of Cancers: 4 Case Reports
Radon Therapy Is Very Promising as a Primary or an Adjuvant Treatment for Different Types of Cancers: 4 Case Reports Open
We report on the application of radon inhalation therapy to patients with 4 types of cancer: colon, uterine, lung, and liver cell. The radon treatments were given to improve the efficacy of chemotherapy and were potent in all 4 cases. Mark…
View article: Radon Therapy for Autoimmune Diseases Pemphigus and Diabetes: 2 Case Reports
Radon Therapy for Autoimmune Diseases Pemphigus and Diabetes: 2 Case Reports Open
We report on the application of radon therapy to relieve the suffering of 2 patients with autoimmune diseases, one with pemphigus with an old myocardial infarction and diabetes mellitus and the other with type I diabetes. We include a leng…
View article: Recovery From Rheumatoid Arthritis Following 15 Months of Therapy With Low Doses of Ionizing Radiation: A Case Report
Recovery From Rheumatoid Arthritis Following 15 Months of Therapy With Low Doses of Ionizing Radiation: A Case Report Open
Rheumatoid arthritis (RA) is an inflammatory autoimmune disease that occurs commonly in old people. Hot spring radon therapy is widely practiced in Central Europe and Japan for relief from the painful symptoms. The usual duration of a spa …
View article: The Lowest Radiation Dose Having Molecular Changes in the Living Body
The Lowest Radiation Dose Having Molecular Changes in the Living Body Open
We herein attempted to identify the lowest radiation dose causing molecular changes in the living body. We investigated the effects of radiation in human cells, animals, and humans. DNA double-strand breaks (DSBs) formed in cells at γ- or …
View article: A Novel Mechanism of γ-Irradiation-Induced IL-6 Production Mediated by P2Y11 Receptor in Epidermal Keratinocytes
A Novel Mechanism of γ-Irradiation-Induced IL-6 Production Mediated by P2Y11 Receptor in Epidermal Keratinocytes Open
Skin inflammation is caused by excessive production of cytokines and chemokines in response to an external stimulus, such as radiation, but the mechanisms involved are not completely understood. Here, we report a novel mechanism of γ-irrad…
View article: Present and Future Prospects of Radiation Therapy Using α-Emitting Nuclides
Present and Future Prospects of Radiation Therapy Using α-Emitting Nuclides Open
Therapy with α-radiation has issues associated with internal exposure; its clinical use has been avoided. However, phase III clinical tests of the α-emitting nuclide 223 Ra on patients with cancer have been conducted, and results were repo…
View article: Treatment of Cancer and Inflammation With Low-Dose Ionizing Radiation
Treatment of Cancer and Inflammation With Low-Dose Ionizing Radiation Open
There is considerable evidence from experimental studies in animals, as well as from clinical reports, that low-dose radiation hormesis is effective for the treatment of cancer and ulcerative colitis. In this study, we present 3 case repor…
View article: Role of ATP as a Key Signaling Molecule Mediating Radiation-Induced Biological Effects
Role of ATP as a Key Signaling Molecule Mediating Radiation-Induced Biological Effects Open
Adenosine triphosphate (ATP) serves as a signaling molecule for adaptive responses to a variety of cytotoxic agents and plays an important role in mediating the radiation stress-induced responses that serve to mitigate or repair the injuri…
View article: Radiosensitizing Effect of TRPV1 Channel Inhibitors in Cancer Cells
Radiosensitizing Effect of TRPV1 Channel Inhibitors in Cancer Cells Open
Radiosensitizers are used in cancer therapy to increase the γ-irradiation susceptibility of cancer cells, including radioresistant hypoxic cancer cells within solid tumors, so that radiotherapy can be applied at doses sufficiently low to m…
View article: Involvement of released ATP in UVA-induced IL-6 production.
Involvement of released ATP in UVA-induced IL-6 production. Open
(A) Cells were pre-incubated with apyrase (10 U/mL), CBX (20 μM), FFA (50 μM), probenecid (500 μM), LaCl3 (200 μM), trovafloxacin (30 μM) or AZ11645373 (10 μM) for 30 min, and irradiated with 2.5 J/cm2. (B) Cells were…
View article: ATP release from UVA-irradiated HaCaT cells.
ATP release from UVA-irradiated HaCaT cells. Open
(A) Cells were irradiated with 2.5 J/cm2 UVA and then incubated for the indicated times. (B) Cells were irradiated with 2.5 J/cm2 UVA after pretreatment with GdCl3 (50 μM), glibenclamide (100 μM), bafilomyc…
View article: Involvement of elevation of intracellular Ca<sup>2+</sup> in UVA-induced IL-6 production.
Involvement of elevation of intracellular Ca<sup>2+</sup> in UVA-induced IL-6 production. Open
Cells were pre-incubated with (A) U73122 (10 μM) or BAPTA-AM (50 μM) or (B) SQ22536 (10 μM), and irradiated with 2.5 J/cm2. After incubation for 24 h, the culture supernatants were harvested and the concentration of IL-6 was mea…
View article: UVA-induced increase in IL-6 mRNA and protein levels in HaCaT cells.
UVA-induced increase in IL-6 mRNA and protein levels in HaCaT cells. Open
(A) Cells were irradiated with 2.5–10 J/cm2 and incubated for 4 h. (B) Cells were irradiated with 2.5 J/cm2 and incubated for the indicated times. In both experiments, IL-6 mRNA levels were analyzed by RT-PCR as descr…
View article: Extracellular ATP induces unconventional release of glyceraldehyde-3-phosphate dehydrogenase from microglial cells
Extracellular ATP induces unconventional release of glyceraldehyde-3-phosphate dehydrogenase from microglial cells Open
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a key glycolytic enzyme that is predominantly localized in the cytoplasm. However, recent studies have suggested that GAPDH is released by various cells and that extracellular GAPDH is in…
View article: Autocrine Regulation of UVA-Induced IL-6 Production via Release of ATP and Activation of P2Y Receptors
Autocrine Regulation of UVA-Induced IL-6 Production via Release of ATP and Activation of P2Y Receptors Open
Extracellular nucleotides, such as ATP, are released from cells in response to various stimuli and act as intercellular signaling molecules through activation of P2 receptors. Exposure to the ultraviolet radiation A (UVA) component of sunl…
View article: Brain-Specific Superoxide Dismutase 2 Deficiency Causes Perinatal Death with Spongiform Encephalopathy in Mice
Brain-Specific Superoxide Dismutase 2 Deficiency Causes Perinatal Death with Spongiform Encephalopathy in Mice Open
Oxidative stress is believed to greatly contribute to the pathogenesis of various diseases, including neurodegeneration. Impairment of mitochondrial energy production and increased mitochondrial oxidative damage are considered early pathol…
View article: Purinergic signaling mediates oxidative stress in UVA-exposed THP-1 cells
Purinergic signaling mediates oxidative stress in UVA-exposed THP-1 cells Open
Ultraviolet A (UVA) radiation, the major UV component of solar radiation, can penetrate easily to the dermis, where it causes significant damage to cellular components by inducing formation of reactive oxygen species (ROS). On the other ha…