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View article: Minimally invasive measurement of carotid artery and brain temperature in the mouse
Minimally invasive measurement of carotid artery and brain temperature in the mouse Open
Purpose Brain temperature is tightly regulated and reflects a balance between cerebral metabolic heat production and heat transfer between the brain, blood, and external environment. Blood temperature and flow are critical to the regulatio…
View article: Altered adult brain morphology in a mouse model of late-onset fetal growth restriction
Altered adult brain morphology in a mouse model of late-onset fetal growth restriction Open
Late-onset fetal growth restriction (FGR) from placental insufficiency results in progressive fetal hypoxia and is often associated with poor neurodevelopmental outcomes. In response to hypoxia, fetal brain sparing physiology is activated …
View article: Post‐mortem MR imaging of tau pathology – a pilot study
Post‐mortem MR imaging of tau pathology – a pilot study Open
Background In‐vivo detection of neuropathology is critical for early diagnosis of neurodegenerative diseases. Post‐mortem brain magnetic resonance imaging (MRI) of pathological protein inclusions could further our ability to detect them in…
View article: Impact of prenatal delta-9-tetrahydrocannabinol exposure on mouse brain development: a fetal-to-adulthood magnetic resonance imaging study
Impact of prenatal delta-9-tetrahydrocannabinol exposure on mouse brain development: a fetal-to-adulthood magnetic resonance imaging study Open
While cannabis use during pregnancy is often perceived as harmless, little is known about its consequences on offspring neurodevelopment. There is an urgent need to map the effects of prenatal cannabis exposure on the brain through the cou…
View article: Sex chromosomes and hormones independently influence healthy brain development but act similarly after cranial radiation
Sex chromosomes and hormones independently influence healthy brain development but act similarly after cranial radiation Open
The course of normal development and response to pathology are strongly influenced by biological sex. For instance, female childhood cancer survivors who have undergone cranial radiation therapy (CRT) tend to display more pronounced cognit…
View article: Deficiency of the histone lysine demethylase KDM5B causes autism-like phenotypes via increased NMDAR signalling
Deficiency of the histone lysine demethylase KDM5B causes autism-like phenotypes via increased NMDAR signalling Open
Loss-of-function mutations in genes encoding lysine methyltransferases (KMTs) and demethylases (KDMs) responsible for regulating the trimethylation of histone 3 on lysine 4 (H3K4me3) are associated with neurodevelopmental conditions, inclu…
View article: TDP-43-M323K causes abnormal brain development and progressive cognitive and motor deficits associated with mislocalised and increased levels of TDP-43
TDP-43-M323K causes abnormal brain development and progressive cognitive and motor deficits associated with mislocalised and increased levels of TDP-43 Open
TDP-43 pathology is found in several neurodegenerative disorders, collectively referred to as “TDP-43 proteinopathies”. Aggregates of TDP-43 are present in the brains and spinal cords of >97% of amyotrophic lateral sclerosis (ALS), and in …
View article: Mutation in the FUS nuclear localisation signal domain causes neurodevelopmental and systemic metabolic alterations
Mutation in the FUS nuclear localisation signal domain causes neurodevelopmental and systemic metabolic alterations Open
Variants in the ubiquitously expressed DNA/RNA-binding protein FUS cause aggressive juvenile forms of amyotrophic lateral sclerosis (ALS). Most FUS mutation studies have focused on motor neuron degeneration; little is known about wider sys…
View article: FUSDelta14 mutation impairs normal brain development and causes systemic metabolic alterations
FUSDelta14 mutation impairs normal brain development and causes systemic metabolic alterations Open
FUS (Fused in sarcoma) is a ubiquitously expressed DNA/RNA binding protein. Mutations in FUS cause aggressive juvenile forms of amyotrophic lateral sclerosis (ALS), as in the case with the FUSDelta14 mutation. While most studies have focus…
View article: Maternal exposure to polystyrene nanoplastics impacts developmental milestones and brain structure in mouse offspring
Maternal exposure to polystyrene nanoplastics impacts developmental milestones and brain structure in mouse offspring Open
Maternal exposure to polystyrene nanoplastics impact postnatal brain development in mouse offspring. This work motivates further studies to determine the levels of nanoplastics in the environment.
View article: Structural brain abnormalities in endothelial nitric oxide synthase‐deficient mice revealed by high‐resolution magnetic resonance imaging
Structural brain abnormalities in endothelial nitric oxide synthase‐deficient mice revealed by high‐resolution magnetic resonance imaging Open
Introduction Endothelial nitric oxide synthase (eNOS) produces nitric oxide, which is essential for a variety of physiological functions in the brain. Previous work has demonstrated the detrimental effects of eNOS deficiency on brain funct…
View article: Age-dependent gray matter demyelination is associated with leptomeningeal neutrophil accumulation
Age-dependent gray matter demyelination is associated with leptomeningeal neutrophil accumulation Open
People living with multiple sclerosis (MS) experience episodic CNS white matter lesions instigated by autoreactive T cells. With age, patients with MS show evidence of gray matter demyelination and experience devastating nonremitting sympt…
View article: Differential effects of early or late exposure to prenatal maternal immune activation on mouse embryonic neurodevelopment
Differential effects of early or late exposure to prenatal maternal immune activation on mouse embryonic neurodevelopment Open
Significance Prenatal exposure to maternal infection increases the risk of developing mental health disorders, such as schizophrenia and autism spectrum disorder. Exposure to maternal immune activation has been associated with a number of …
View article: Age-related susceptibility to grey matter demyelination and neurodegeneration is associated with meningeal neutrophil accumulation in an animal model of Multiple Sclerosis
Age-related susceptibility to grey matter demyelination and neurodegeneration is associated with meningeal neutrophil accumulation in an animal model of Multiple Sclerosis Open
People living with multiple sclerosis (MS) experience episodic central nervous system (CNS) white matter lesions instigated by autoreactive T cells. With age, MS patients show evidence of grey matter demyelination and experience devastatin…
View article: Subtle alterations in neonatal neurodevelopment following early or late exposure to prenatal maternal immune activation
Subtle alterations in neonatal neurodevelopment following early or late exposure to prenatal maternal immune activation Open
Prenatal exposure to maternal immune activation (MIA) is a risk factor for a variety of neurodevelopmental and psychiatric disorders. The timing of MIA-exposure has been shown to affect adolescent and adult offspring neurodevelopment, howe…
View article: Differential effects of early or late exposure to prenatal maternal immune activation on mouse embryonic neurodevelopment
Differential effects of early or late exposure to prenatal maternal immune activation on mouse embryonic neurodevelopment Open
Exposure to maternal immune activation (MIA) in utero is a risk factor for neurodevelopmental and psychiatric disorders. MIA-induced deficits in adolescent and adult offspring have been well characterized, however, less is known about the …
View article: Differential effects of early or late exposure to prenatal maternal immune activation on mouse embryonic neurodevelopment
Differential effects of early or late exposure to prenatal maternal immune activation on mouse embryonic neurodevelopment Open
Exposure to maternal immune activation (MIA) in utero is a risk factor for neurodevelopmental and psychiatric disorders. MIA-induced deficits in adolescent and adult offspring have been well characterized, however, less is known about the …
View article: Differential effects of early or late exposure to prenatal maternal immune activation on mouse embryonic neurodevelopment
Differential effects of early or late exposure to prenatal maternal immune activation on mouse embryonic neurodevelopment Open
Exposure to maternal immune activation (MIA) in utero is a risk factor for neurodevelopmental and psychiatric disorders. MIA-induced deficits in adolescent and adult offspring have been well characterized, however, less is known about the …
View article: Mouse models of immune dysfunction: Their neuroanatomical differences reflect their anxiety-behavioural phenotype
Mouse models of immune dysfunction: Their neuroanatomical differences reflect their anxiety-behavioural phenotype Open
Extensive evidence supports the role of the immune system in modulating brain function and behaviour. However, past studies have revealed striking heterogeneity in behavioural phenotypes produced from immune system dysfunction. Using magne…
View article: Exposure to maternal high-fat diet induces extensive changes in the brain of adult offspring
Exposure to maternal high-fat diet induces extensive changes in the brain of adult offspring Open
Maternal environmental exposures, such as high-fat diets, diabetes and obesity, can induce long-term effects in offspring. These effects include increased risk of neurodevelopmental disorders (NDDs) including autism spectrum disorder (ASD)…
View article: Peroxisome Proliferator-Activated Receptor-δ Deficiency in Microglia Results in Exacerbated Axonal Injury and Tissue Loss in Experimental Autoimmune Encephalomyelitis
Peroxisome Proliferator-Activated Receptor-δ Deficiency in Microglia Results in Exacerbated Axonal Injury and Tissue Loss in Experimental Autoimmune Encephalomyelitis Open
Peroxisome proliferator-activated receptor (PPAR)-δ is a nuclear receptor that functions to maintain metabolic homeostasis, regulate cell growth, and limit the development of excessive inflammation during immune responses. Previously, we r…
View article: Exposure to maternal high-fat diet induces extensive changes in the brain of adult offspring
Exposure to maternal high-fat diet induces extensive changes in the brain of adult offspring Open
Maternal environmental exposures, such as high-fat diets, diabetes and obesity, can induce long term effects in offspring. These effects include increased risk of neurodevelopmental disorders (NDDs) including autism spectrum disorder (ASD)…