Shou-Ching Jaminet
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View article: Cable Cars to the Nucleus: TM4SF1-Enriched Microdomains Conduct Signaling in Endothelial Cells for Blood Vessel Formation
Cable Cars to the Nucleus: TM4SF1-Enriched Microdomains Conduct Signaling in Endothelial Cells for Blood Vessel Formation Open
Endothelial cell proliferation, migration, and intercellular interactions for blood vessel formation require coordinated signaling by a myriad of molecules. Following endothelial cell activation by growth factors and cytokines, a variety o…
View article: Cable cars to the nucleus: TM4SF1-enriched microdomains and cell signaling
Cable cars to the nucleus: TM4SF1-enriched microdomains and cell signaling Open
Proliferating cells with volumes of 2,000–4,000 μm3 contain about ten billion protein molecules, making it challenging, in a crowded cellular environment filled with vesicles and organelles, for proteins to find their interaction partners …
View article: Transmembrane-4 L-Six Family Member-1 Is Essential for Embryonic Blood Vessel Development
Transmembrane-4 L-Six Family Member-1 Is Essential for Embryonic Blood Vessel Development Open
Transmembrane-4 L-six family member-1 (TM4SF1) is a small cell surface glycoprotein that is highly and selectively expressed on endothelial cell and mesenchymal stem cell surfaces. TM4SF1 regulates cellular functions by forming protein com…
View article: TM4SF1 is a molecular facilitator that distributes cargo proteins intracellularly in endothelial cells in support of blood vessel formation
TM4SF1 is a molecular facilitator that distributes cargo proteins intracellularly in endothelial cells in support of blood vessel formation Open
Transmembrane‐4 L‐six family member‐1 (TM4SF1) is an atypical tetraspanin that is highly and selectively expressed in proliferating endothelial cells and plays an essential role in blood vessel development. TM4SF1 forms clusters on the cel…
View article: TM4SF1 is essential for embryonic blood vessel development
TM4SF1 is essential for embryonic blood vessel development Open
Transmembrane-4 L-six family member-1 (TM4SF1) is a small cell surface glycoprotein that is highly and selectively expressed on endothelial cells and mesenchymal stem cells. TM4SF1 regulates cellular functions by forming protein complexes …
View article: Supplementary Figures S1-S6 from Novel Anti-TM4SF1 Antibody–Drug Conjugates with Activity against Tumor Cells and Tumor Vasculature
Supplementary Figures S1-S6 from Novel Anti-TM4SF1 Antibody–Drug Conjugates with Activity against Tumor Cells and Tumor Vasculature Open
Supplementary Figures S1-S6. Supplementary Figure S1. Liquid chromatography electrospray ionization tandem mass spectrometry analysis; Supplementary Figure S2. TM4SF1 expression in human breast and colon cancers; Supplementary Figure S3A. …
View article: Data from Novel Anti-TM4SF1 Antibody–Drug Conjugates with Activity against Tumor Cells and Tumor Vasculature
Data from Novel Anti-TM4SF1 Antibody–Drug Conjugates with Activity against Tumor Cells and Tumor Vasculature Open
Antibody–drug conjugates (ADC) represent a promising therapeutic modality for managing cancer. Here, we report a novel humanized ADC that targets the tetraspanin-like protein TM4SF1. TM4SF1 is highly expressed on the plasma membranes of ma…
View article: Supplementary Methods from Novel Anti-TM4SF1 Antibody–Drug Conjugates with Activity against Tumor Cells and Tumor Vasculature
Supplementary Methods from Novel Anti-TM4SF1 Antibody–Drug Conjugates with Activity against Tumor Cells and Tumor Vasculature Open
Supplementary Methods
View article: Supplementary Figures S1-S6 from Novel Anti-TM4SF1 Antibody–Drug Conjugates with Activity against Tumor Cells and Tumor Vasculature
Supplementary Figures S1-S6 from Novel Anti-TM4SF1 Antibody–Drug Conjugates with Activity against Tumor Cells and Tumor Vasculature Open
Supplementary Figures S1-S6. Supplementary Figure S1. Liquid chromatography electrospray ionization tandem mass spectrometry analysis; Supplementary Figure S2. TM4SF1 expression in human breast and colon cancers; Supplementary Figure S3A. …
View article: Data from Novel Anti-TM4SF1 Antibody–Drug Conjugates with Activity against Tumor Cells and Tumor Vasculature
Data from Novel Anti-TM4SF1 Antibody–Drug Conjugates with Activity against Tumor Cells and Tumor Vasculature Open
Antibody–drug conjugates (ADC) represent a promising therapeutic modality for managing cancer. Here, we report a novel humanized ADC that targets the tetraspanin-like protein TM4SF1. TM4SF1 is highly expressed on the plasma membranes of ma…
View article: Supplementary Methods from Novel Anti-TM4SF1 Antibody–Drug Conjugates with Activity against Tumor Cells and Tumor Vasculature
Supplementary Methods from Novel Anti-TM4SF1 Antibody–Drug Conjugates with Activity against Tumor Cells and Tumor Vasculature Open
Supplementary Methods
View article: Supplemental Figure Legends from Stromal-Based Signatures for the Classification of Gastric Cancer
Supplemental Figure Legends from Stromal-Based Signatures for the Classification of Gastric Cancer Open
These are the figure legends for the supplemental figures and tables.
View article: Supplemental Figures 1 through 9 and Supplemental Tables 1 and 2 from Stromal-Based Signatures for the Classification of Gastric Cancer
Supplemental Figures 1 through 9 and Supplemental Tables 1 and 2 from Stromal-Based Signatures for the Classification of Gastric Cancer Open
These figures contain extensions of data that would not fit in the primary manuscript but are important for a complete understanding of the work. These include analysis of other data sets, correlations between genomic profiling our stromal…
View article: Supplemental Methods from Stromal-Based Signatures for the Classification of Gastric Cancer
Supplemental Methods from Stromal-Based Signatures for the Classification of Gastric Cancer Open
This file contains details too lengthy to put in the primary manuscript file as well as methods for supplemental data
View article: Data from Stromal-Based Signatures for the Classification of Gastric Cancer
Data from Stromal-Based Signatures for the Classification of Gastric Cancer Open
Treatment of metastatic gastric cancer typically involves chemotherapy and monoclonal antibodies targeting HER2 (ERBB2) and VEGFR2 (KDR). However, reliable methods to identify patients who would benefit most from a combination of treatment…
View article: Supplemental Figures from Stromal-Based Signatures for the Classification of Gastric Cancer
Supplemental Figures from Stromal-Based Signatures for the Classification of Gastric Cancer Open
These figures contain extensions of data that would not fit in the primary manuscript but are important for a complete understanding of the work. These include analysis of other data sets, correlations between genomic profiling our stromal…
View article: Supplemental Figures from Stromal-Based Signatures for the Classification of Gastric Cancer
Supplemental Figures from Stromal-Based Signatures for the Classification of Gastric Cancer Open
These figures contain extensions of data that would not fit in the primary manuscript but are important for a complete understanding of the work. These include analysis of other data sets, correlations between genomic profiling our stromal…
View article: Supplemental Methods from Stromal-Based Signatures for the Classification of Gastric Cancer
Supplemental Methods from Stromal-Based Signatures for the Classification of Gastric Cancer Open
This file contains details too lengthy to put in the primary manuscript file as well as methods for supplemental data
View article: Supplemental Figures 1 through 9 and Supplemental Tables 1 and 2 from Stromal-Based Signatures for the Classification of Gastric Cancer
Supplemental Figures 1 through 9 and Supplemental Tables 1 and 2 from Stromal-Based Signatures for the Classification of Gastric Cancer Open
These figures contain extensions of data that would not fit in the primary manuscript but are important for a complete understanding of the work. These include analysis of other data sets, correlations between genomic profiling our stromal…
View article: Data from Stromal-Based Signatures for the Classification of Gastric Cancer
Data from Stromal-Based Signatures for the Classification of Gastric Cancer Open
Treatment of metastatic gastric cancer typically involves chemotherapy and monoclonal antibodies targeting HER2 (ERBB2) and VEGFR2 (KDR). However, reliable methods to identify patients who would benefit most from a combination of treatment…
View article: Supplemental Figure Legends from Stromal-Based Signatures for the Classification of Gastric Cancer
Supplemental Figure Legends from Stromal-Based Signatures for the Classification of Gastric Cancer Open
These are the figure legends for the supplemental figures and tables.
View article: Stromal-Based Signatures for the Classification of Gastric Cancer
Stromal-Based Signatures for the Classification of Gastric Cancer Open
Treatment of metastatic gastric cancer typically involves chemotherapy and monoclonal antibodies targeting HER2 (ERBB2) and VEGFR2 (KDR). However, reliable methods to identify patients who would benefit most from a combination of treatment…
View article: Activation of the Nrf2 Cell Defense Pathway by Ancient Foods: Disease Prevention by Important Molecules and Microbes Lost from the Modern Western Diet
Activation of the Nrf2 Cell Defense Pathway by Ancient Foods: Disease Prevention by Important Molecules and Microbes Lost from the Modern Western Diet Open
The Nrf2 (NFE2L2) cell defense pathway protects against oxidative stress and disorders including cancer and neurodegeneration. Although activated modestly by oxidative stress alone, robust activation of the Nrf2 defense mechanism requires …
View article: Novel Anti-TM4SF1 Antibody–Drug Conjugates with Activity against Tumor Cells and Tumor Vasculature
Novel Anti-TM4SF1 Antibody–Drug Conjugates with Activity against Tumor Cells and Tumor Vasculature Open
Antibody–drug conjugates (ADC) represent a promising therapeutic modality for managing cancer. Here, we report a novel humanized ADC that targets the tetraspanin-like protein TM4SF1. TM4SF1 is highly expressed on the plasma membranes of ma…
View article: NFAT1 promotes intratumoral neutrophil infiltration by regulating IL8 expression in breast cancer
NFAT1 promotes intratumoral neutrophil infiltration by regulating IL8 expression in breast cancer Open
NFAT transcription factors are key regulators of gene expression in immune cells. In addition, NFAT1‐induced genes play diverse roles in mediating the progression of various solid tumors. Here we show that NFAT1 induces the expression of t…