Shoucheng Chen
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View article: Elastic Membranes Induce Macrophage-Mediated Pmscs Activation For Bone Regeneration
Elastic Membranes Induce Macrophage-Mediated Pmscs Activation For Bone Regeneration Open
Aim or purpose: Traditional collagen membranes used in guided bone regeneration (GBR) act only as passive barriers, lacking active bone-regenerative properties. This study explores optimizing collagen membranes' elastic modulus to regulate…
View article: Fluorine-Incorporated Biogenic Hydroxyapatite Enhances Socket Bone Healing via Addressing Macrophage-Mediated Inflammatory Response
Fluorine-Incorporated Biogenic Hydroxyapatite Enhances Socket Bone Healing via Addressing Macrophage-Mediated Inflammatory Response Open
Biological hydroxyapatite (BHA) has been extensively employed in alveolar socket preservation, yet its clinical application is often compromised by delayed bone healing triggered by macrophage-mediated pro-inflammatory responses. Building …
View article: Fluorinated Porcine Bone-Derived Hydroxyapatite Promotes Vascularized Osteogenesis by Coordinating Human Bone Marrow Mesenchymal Stem Cell/Human Umbilical Vein Endothelial Cell Complexes
Fluorinated Porcine Bone-Derived Hydroxyapatite Promotes Vascularized Osteogenesis by Coordinating Human Bone Marrow Mesenchymal Stem Cell/Human Umbilical Vein Endothelial Cell Complexes Open
Biogenic hydroxyapatite is known for its osteoinductive potential due to its similarity to human bone and biocompatibility, but insufficient vascularization compared to autogenous bone during early implantation limits bone integration and …
View article: Enhanced Binding Affinity of 2-Deoxyglucose-6Phosphate to Hexokinase I: Insights from Molecular Simulations
Enhanced Binding Affinity of 2-Deoxyglucose-6Phosphate to Hexokinase I: Insights from Molecular Simulations Open
2-deoxyglucose (2-DG), targeting Hexokinase I (HKI) to inhibit glycolysis in cancer cells, has inspired drug design. Increasing evidence suggests that its phosphorylated form, 2-deoxyglucose-6-phosphate (2-DG-6-P), may inhibit HKI more eff…
View article: Mapping Connective Tissue Molecular Blueprints to Illuminate Human Keratinized and Non-Keratinized Oral Mucosa
Mapping Connective Tissue Molecular Blueprints to Illuminate Human Keratinized and Non-Keratinized Oral Mucosa Open
A fundamental question in oral science is elucidating the factors that underpin the distinct tissue characteristics of human keratinized and non-keratinized mucosa. Clinical autotransplantation and large animal studies have observed that i…
View article: Unveiling the governing role of ‘remodeling triangle area’ in soft-hard tissue interface equilibrium for metal implants advancement
Unveiling the governing role of ‘remodeling triangle area’ in soft-hard tissue interface equilibrium for metal implants advancement Open
Metal implants holds significant promise for diverse fixed prostheses. However, their long-term reliability and broader application are hindered by challenges related to the disequilibrium at the soft-hard tissue interface. By using anti-i…
View article: A Standardized Rat Model to Study Peri-implantitis of Transmucosal Osseointegrated Implants
A Standardized Rat Model to Study Peri-implantitis of Transmucosal Osseointegrated Implants Open
With the high incidence rate, distinctive implant characteristic and unique infection pattern, peri-implantitis (PI) requires a specially designed implant animal model for the researches on the pathogenesis and treatments. Previous small-a…
View article: Influences of Adenoid Hypertrophy on Children’s Maxillofacial Development
Influences of Adenoid Hypertrophy on Children’s Maxillofacial Development Open
This study aims to investigate the association between adenoid hypertrophy and facial development. A total of 388 children aged 1–13 years old who had undergone head MRI in Foshan Maternal and Child Health Hospital were collected, includin…
View article: A Standardized Rat Model to Study Percutaneous/permucosal Osseointegrated Implants Peri-implantitis
A Standardized Rat Model to Study Percutaneous/permucosal Osseointegrated Implants Peri-implantitis Open
Background:Percutaneous/permucosal osseointegrated implants(POI) are increasingly utilized in clinical practices. However, POI peri-implantitis because of bacterial colonization remains an unsolved problem. With the high incidence rate, di…
View article: Optimized osteogenesis of porcine bone-derived xenograft through surface coating of magnesium-doped nanohydroxyapatite
Optimized osteogenesis of porcine bone-derived xenograft through surface coating of magnesium-doped nanohydroxyapatite Open
As one of the key factors influencing the outcome of guided bone regeneration, the currently used xenografts possess insufficient capability in osteogenesis. With the aim of improving the osteogenic performance of xenografts, porcine bone-…
View article: 2-DG Regulates Immune Imbalance on the Titanium Surface after Debridement
2-DG Regulates Immune Imbalance on the Titanium Surface after Debridement Open
Peri-implantitis requires clinical treatments comprised of mechanical and chemical debridement to remove bacterial biofilms. Bone regeneration on the titanium surface after debridement has been a topical issue of peri-implantitis treatment…
View article: Tailoring the multiscale mechanics of tunable decellularized extracellular matrix (dECM) for wound healing through immunomodulation
Tailoring the multiscale mechanics of tunable decellularized extracellular matrix (dECM) for wound healing through immunomodulation Open
With the discovery of the pivotal role of macrophages in tissue regeneration through shaping the tissue immune microenvironment, various immunomodulatory strategies have been proposed to modify traditional biomaterials. Decellularized extr…
View article: Optimizing the biodegradability and osteogenesis of biogenic collagen membrane via fluoride-modified polymer-induced liquid precursor process
Optimizing the biodegradability and osteogenesis of biogenic collagen membrane via fluoride-modified polymer-induced liquid precursor process Open
Biogenic collagen membranes (BCM) have been widely used in guided bone regeneration (GBR) owing to their biodegradability during tissue integration. However, their relatively high degradation rate and lack of pro-osteogenic properties limi…
View article: Immunomodulation-based development engineering for advancing metal soft tissue implants
Immunomodulation-based development engineering for advancing metal soft tissue implants Open
Metal materials have been widely applied clinically due to their superior mechanical properties. However, the integration of metallic implants with surrounding soft tissue remains challenging and may lead to severe infections and failure o…
View article: Plasma polymerized bio-interface directs fibronectin adsorption and functionalization to enhance “epithelial barrier structure” formation via FN-ITG β1-FAK-mTOR signaling cascade
Plasma polymerized bio-interface directs fibronectin adsorption and functionalization to enhance “epithelial barrier structure” formation via FN-ITG β1-FAK-mTOR signaling cascade Open
Background Transepithelial medical devices are increasing utilized in clinical practices. However, the damage of continuous natural epithelial barrier has become a major risk factor for the failure of epithelium-penetrating implants. How t…
View article: Optimizing the bio-degradability and biocompatibility of a biogenic collagen membrane through cross-linking and zinc-doped hydroxyapatite
Optimizing the bio-degradability and biocompatibility of a biogenic collagen membrane through cross-linking and zinc-doped hydroxyapatite Open
Biogenic collagen membranes have been widely used as soft tissue barriers in guided bone regeneration (GBR) and guided tissue regeneration (GTR). Nevertheless, their clinical performance remains unsatisfactory because of their low mechanic…
View article: Immunomodulation‐Based Strategy for Improving Soft Tissue and Metal Implant Integration and Its Implications in the Development of Metal Soft Tissue Materials
Immunomodulation‐Based Strategy for Improving Soft Tissue and Metal Implant Integration and Its Implications in the Development of Metal Soft Tissue Materials Open
The difficulties associated with metal implants and soft tissue integration have significantly affected the applications of metal implants in soft‐tissue‐related areas. Prompted by the close association between soft tissue integration and …