Shouying Xu
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View article: GPR137-RAB8A activation promotes ovarian cancer development via the Hedgehog pathway
GPR137-RAB8A activation promotes ovarian cancer development via the Hedgehog pathway Open
Background Ovarian cancer (OC) progression is one of the commonest cause of female cancer death. While treatments in clinic includes primary surgery and targeted chemotherapy, curative and survival trends in OC have not significantly impro…
View article: ARID1A restrains EMT and stemness of ovarian cancer cells through the Hippo pathway
ARID1A restrains EMT and stemness of ovarian cancer cells through the Hippo pathway Open
Genes encoding subunits of SWI/SNF (BAF) chromatin‑remodeling complexes are recurrently mutated in a broad array of tumor types, and among the subunits, ARID1A is the most frequent target with mutations. In the present study, it was report…
View article: Function and regulation of Rab GTPases in cancers
Function and regulation of Rab GTPases in cancers Open
View article: GPR137 inactivates Hippo signaling to promote gastric cancer cell malignancy
GPR137 inactivates Hippo signaling to promote gastric cancer cell malignancy Open
As the fifth most common cancer in the world, gastric cancer (GC) ranks as the third major cause of cancer-related death globally. Although surgical resection and chemotherapy still remains the mainstay of potentially curative treatment fo…
View article: PUS1 is a novel biomarker for evaluating malignancy of human renal cell carcinoma
PUS1 is a novel biomarker for evaluating malignancy of human renal cell carcinoma Open
Renal cell carcinoma (RCC) is one of the most common malignancies. Despite the rapid development of the oncology research and surgical treatment, the prognosis of RCC has not significantly improved. Thus, exploration of the pathological mo…
View article: RGS2 promotes estradiol biosynthesis by trophoblasts during human pregnancy
RGS2 promotes estradiol biosynthesis by trophoblasts during human pregnancy Open
View article: Micro-RNAs in Human Placenta: Tiny Molecules, Immense Power
Micro-RNAs in Human Placenta: Tiny Molecules, Immense Power Open
Micro-RNAs (miRNAs) are short non-coding single-stranded RNAs that modulate the expression of various target genes after transcription. The expression and distribution of kinds of miRNAs have been characterized in human placenta during dif…
View article: Cholesterol and Hedgehog Signaling: Mutual Regulation and Beyond
Cholesterol and Hedgehog Signaling: Mutual Regulation and Beyond Open
The Hedgehog (HH) signaling is one of the key agents that govern the precisely regulated developmental processes of multicellular organisms in vertebrates and invertebrates. The HH pathway in the receiving cell includes Patched1, a twelve-…
View article: Tianma Gouteng Decoction Exerts Pregnancy-Protective Effects Against Preeclampsia via Regulation of Oxidative Stress and NO Signaling
Tianma Gouteng Decoction Exerts Pregnancy-Protective Effects Against Preeclampsia via Regulation of Oxidative Stress and NO Signaling Open
Preeclampsia (PE), a pregnancy-specific syndrome with the major molecular determinants of placenta-borne oxidative stress and consequently impaired nitric oxide (NO) generation, has been considered to be one of the leading causes of matern…
View article: Hedgehog signaling is controlled by Rac1 activity
Hedgehog signaling is controlled by Rac1 activity Open
Rationale: The nuclear translocation of transcriptional factor Gli is indispensable for Hedgehog (Hh) signaling activation, whose deregulation causes cancer progressions; however, the mechanisms governing Gli nuclear translocation a…
View article: The Role of ARID1A in Tumors: Tumor Initiation or Tumor Suppression?
The Role of ARID1A in Tumors: Tumor Initiation or Tumor Suppression? Open
Genes encoding subunits of SWItch/Sucrose Non-Fermenting (SWI/SNF) chromatin remodeling complexes are collectively mutated in 20% of all human cancers, among which the AT-rich interacting domain−containing protein 1A ( ARID1A , also known …
View article: MicroRNA-3935 promotes human trophoblast cell epithelial-mesenchymal transition through tumor necrosis factor receptor-associated factor 6/regulator of G protein signaling 2 axis
MicroRNA-3935 promotes human trophoblast cell epithelial-mesenchymal transition through tumor necrosis factor receptor-associated factor 6/regulator of G protein signaling 2 axis Open
View article: Human HAND1 inhibits the conversion of cholesterol to steroids in trophoblasts
Human HAND1 inhibits the conversion of cholesterol to steroids in trophoblasts Open
Steroidogenesis from cholesterol in placental trophoblasts is fundamentally involved in the establishment and maintenance of pregnancy. The transcription factor gene heart and neural crest derivatives expressed 1 (Hand1) promotes different…
View article: Rab34 small GTPase is required for Hedgehog signaling and an early step of ciliary vesicle formation in mouse
Rab34 small GTPase is required for Hedgehog signaling and an early step of ciliary vesicle formation in mouse Open
The primary cilium is a microtubule-based organelle that protrudes from the cell surface and plays essential roles in embryonic development. Ciliogenesis begins with the successive fusion of preciliary vesicles to form ciliary vesicles, wh…