Shovan Naskar
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View article: An enhancer-AAV toolbox to target and manipulate distinct interneuron subtypes
An enhancer-AAV toolbox to target and manipulate distinct interneuron subtypes Open
SUMMARY In recent years, we and others have identified a number of enhancers that, when incorporated into rAAV vectors, can restrict the transgene expression to particular neuronal populations. Yet, viral tools to access and manipulate spe…
View article: Loss of Ezh2 in the medial ganglionic eminence alters interneuron fate, cell morphology and gene expression profiles
Loss of Ezh2 in the medial ganglionic eminence alters interneuron fate, cell morphology and gene expression profiles Open
Introduction Enhancer of zeste homolog 2 (Ezh2) is responsible for trimethylation of histone 3 at lysine 27 (H3K27me3), resulting in repression of gene expression. Here, we explore the role of Ezh2 in forebrain GABAergic interneuron develo…
View article: Loss of Ezh2 in the medial ganglionic eminence alters interneuron fate, cell morphology and gene expression profiles
Loss of Ezh2 in the medial ganglionic eminence alters interneuron fate, cell morphology and gene expression profiles Open
SUMMARY Enhancer of zeste homolog 2 (Ezh2) is responsible for trimethylation of histone 3 at lysine 27 (H3K27me3), resulting in gene repression. Here, we explore the role of Ezh2 in forebrain GABAergic interneuron development. Loss of Ezh2…
View article: Posteromedial thalamic nucleus activity significantly contributes to perceptual discrimination
Posteromedial thalamic nucleus activity significantly contributes to perceptual discrimination Open
Higher-order sensory thalamic nuclei are densely connected with multiple cortical and subcortical areas, yet the role of these nuclei remains elusive. The posteromedial thalamic nucleus (POm), the higher-order thalamic nucleus in the roden…
View article: Posteromedial thalamic nucleus activity significantly contributes to perceptual discrimination
Posteromedial thalamic nucleus activity significantly contributes to perceptual discrimination Open
Higher-order sensory thalamic nuclei are densely connected with multiple cortical and subcortical areas, yet the role of these nuclei remains elusive. The posteromedial (POm) thalamic nucleus, the higher-order thalamic nucleus in the roden…
View article: Cell-type-specific recruitment of GABAergic interneurons in the primary somatosensory cortex by long-range inputs
Cell-type-specific recruitment of GABAergic interneurons in the primary somatosensory cortex by long-range inputs Open
Extensive hierarchical yet highly reciprocal interactions among cortical areas are fundamental for information processing. However, connectivity rules governing the specificity of such corticocortical connections, and top-down feedback pro…
View article: The development of synaptic transmission is time-locked to early social behaviors in rats
The development of synaptic transmission is time-locked to early social behaviors in rats Open
The development of functional synapses is a sequential process preserved across many brain areas. Here, we show that glutamatergic postsynaptic currents anticipated GABAergic currents in Layer II/III of the rat neocortex, in contrast to th…