Shreesh Ojha
YOU?
Author Swipe
View article: Mollugin: A Comprehensive Review of Its Multifaceted Pharmacological Properties and Therapeutic Potential
Mollugin: A Comprehensive Review of Its Multifaceted Pharmacological Properties and Therapeutic Potential Open
The substantial interest in plant-based drugs or plant-derived phytocompounds drives researchers to conduct comprehensive investigations on their therapeutic properties. Mollugin, one of the major active constituents of Rubia cardifolia, h…
View article: Therapeutic Potentials of Phytochemicals in Pancreatitis: Targeting Calcium Signaling, Ferroptosis, microRNAs, and Inflammation with Drug-Likeness Evaluation
Therapeutic Potentials of Phytochemicals in Pancreatitis: Targeting Calcium Signaling, Ferroptosis, microRNAs, and Inflammation with Drug-Likeness Evaluation Open
Background: Pancreatitis, encompassing acute (AP), severe acute (SAP), and chronic (CP) forms, is a life-threatening inflammatory disorder with limited therapeutic options. Current management is largely supportive, highlighting the urgent …
View article: Adropin modulates pancreatic cell proliferation and glutathione levels in an animal model of type 1 diabetes mellitus
Adropin modulates pancreatic cell proliferation and glutathione levels in an animal model of type 1 diabetes mellitus Open
Background Diabetes mellitus (DM), a metabolic disorder that leads to chronic hyperglycemia, is one of the topmost global public health concerns according to the International Diabetes Federation. Adropin is a peptide hormone that is prima…
View article: Biochemical Properties of Banana and Pineapple Intercropped in Organically Managed Young Arecanut Based Cropping System
Biochemical Properties of Banana and Pineapple Intercropped in Organically Managed Young Arecanut Based Cropping System Open
The present investigation was carried out at the instructional and research field of the Department of Plantation Crops and Processing, Faculty of Horticulture, Uttar Banga Krishi Viswavidyalaya, Pundibari during the Month of March 2019–20…
View article: β-Caryophyllene Ameliorates Thioacetamide-Induced Liver Fibrosis in Rats: A Preventative Approach
β-Caryophyllene Ameliorates Thioacetamide-Induced Liver Fibrosis in Rats: A Preventative Approach Open
Liver fibrosis is associated with increased rates of morbidity and mortality. At present, there are no specific treatments that can directly reverse hepatic fibrosis. The endocannabinoid system has been found to play a significant role in …
View article: α-Bisabolol, a Dietary Bioactive Terpene Attenuates Oxidative Stress and Inflammation in Colonic Mucosa of Acetic Acid-Induced Colitis in Rats
α-Bisabolol, a Dietary Bioactive Terpene Attenuates Oxidative Stress and Inflammation in Colonic Mucosa of Acetic Acid-Induced Colitis in Rats Open
Inflammatory bowel diseases (IBDs), such as ulcerative colitis, and Crohn’s disease are chronic idiopathic inflammatory diseases of the gastrointestinal system involving interaction between genetic and environmental factors mediating the o…
View article: Natural compounds targeting inflammation and oxidative stress in intestinal ischemia-reperfusion injury: a comprehensive review
Natural compounds targeting inflammation and oxidative stress in intestinal ischemia-reperfusion injury: a comprehensive review Open
Background: Intestinal ischemia-reperfusion (I/R) injury is a severe condition characterized by significant morbidity and mortality, caused by the temporary disruption of blood supply to the intestines followed by reperfusion. This patholo…
View article: Molecular Docking, Dynamics, and Preclinical Studies Reveal Morin Hydrate as a Potent <scp>PPARγ</scp> and Nrf2 Agonist That Mitigates Colon Inflammation
Molecular Docking, Dynamics, and Preclinical Studies Reveal Morin Hydrate as a Potent <span>PPARγ</span> and Nrf2 Agonist That Mitigates Colon Inflammation Open
Peroxisome proliferator‐activated receptors (PPARs), functioning as nuclear receptors, regulate the expression of genes associated with inflammation, lipid metabolism, and glucose metabolism. The primary isotypes of PPARs are PPARα , PPARβ…
View article: The Multifaceted Role of Neuroprotectin D1: Physiological, Pathophysiological, and Pharmacological Insights in Neurodegenerative Diseases
The Multifaceted Role of Neuroprotectin D1: Physiological, Pathophysiological, and Pharmacological Insights in Neurodegenerative Diseases Open
Neuroprotectin D1 (NPD1) has emerged as an integral lipid mediator with significant implications for maintaining neurological health. Being derived from docosahexaenoic acid (DHA), NPD1 is a specialized pro-resolving lipid mediator (SPM), …
View article: Efflux pump modulation by Montelukast and its roles in restoring antibiotic susceptibility in multidrug-resistant Staphylococcus aureus
Efflux pump modulation by Montelukast and its roles in restoring antibiotic susceptibility in multidrug-resistant Staphylococcus aureus Open
The study was supported by SERB-DST, India (CRG/2021/005069), and the BRIC-ILS core.
View article: Targeted nanoliposomes for precision rheumatoid arthritis therapy: a review on mechanisms and <i>in vivo</i> potential
Targeted nanoliposomes for precision rheumatoid arthritis therapy: a review on mechanisms and <i>in vivo</i> potential Open
Rheumatoid arthritis (RA) is an inflammatory immune-triggered disease that causes synovitis, cartilage degradation, and joint injury. In nanotechnology, conventional liposomes were extensively investigated for RA. However, they frequently …
View article: Thermodynamics Properties of Leucine and Isoleucine Peptides in Water
Thermodynamics Properties of Leucine and Isoleucine Peptides in Water Open
Thermodynamic properties of amino acids explore the ideas about the energetic contribution in biomolecular interfaces. In our work, we have estimated the solvation free energy of leucine and isoleucine peptides with the variation of chain …
View article: A Case Study of Ayurvedic Treatment of Vitiligo (Shwitra) in Child
A Case Study of Ayurvedic Treatment of Vitiligo (Shwitra) in Child Open
The skin is the largest and most visible organ of the human body, playing a vital role in overall health. Any anomalies in the skin can create both physical and psychological problems for an individual, primarily due to cosmetic concerns. …
View article: Bioactive peptides with potential anticancer properties from various food protein sources: status of recent research, production technologies, and developments
Bioactive peptides with potential anticancer properties from various food protein sources: status of recent research, production technologies, and developments Open
Recently, bioactive peptides, from natural resources, have attracted remarkable attention as nutraceutical treasures and the health benefits of their consumption have extensively been studied. Therapies based on bioactive peptides have bee…
View article: Isoproterenol mechanisms in inducing myocardial fibrosis and its application as an experimental model for the evaluation of therapeutic potential of phytochemicals and pharmaceuticals
Isoproterenol mechanisms in inducing myocardial fibrosis and its application as an experimental model for the evaluation of therapeutic potential of phytochemicals and pharmaceuticals Open
Cardiac injury initiates repair mechanisms and results in cardiac remodeling and fibrosis, which appears to be a leading cause of cardiovascular diseases. Cardiac fibrosis is characterized by the accumulation of extracellular matrix protei…
View article: Phytochemical Compounds as Promising Therapeutics for Intestinal Fibrosis in Inflammatory Bowel Disease: A Critical Review
Phytochemical Compounds as Promising Therapeutics for Intestinal Fibrosis in Inflammatory Bowel Disease: A Critical Review Open
Background/Objective: Intestinal fibrosis, a prominent consequence of inflammatory bowel disease (IBD), presents considerable difficulty owing to the absence of licensed antifibrotic therapies. This review assesses the therapeutic potentia…
View article: Therapeutic potential of agents targeting cannabinoid type 2 receptors in organ fibrosis
Therapeutic potential of agents targeting cannabinoid type 2 receptors in organ fibrosis Open
The endocannabinoid system has garnered attention as a potential therapeutic target in a range of pathological disorders. Cannabinoid receptors type 2 (CB2) are a class of G protein‐coupled receptors responsible for transmitting intracellu…
View article: Nanotechnology-assisted combination drug delivery: a progressive approach for the treatment of acute myeloid leukemia
Nanotechnology-assisted combination drug delivery: a progressive approach for the treatment of acute myeloid leukemia Open
Acute myeloid leukemia (AML), a heterogeneous hematopoietic cancer prevalent in adults, has been a leading cause of leukemia-associated deaths for decades. Despite advancements in understanding its pathology and pharmacological targets, th…
View article: α-Bisabolol: A Dietary Sesquiterpene that Attenuates Apoptotic and Nonapoptotic Cell Death Pathways by Regulating the Mitochondrial Biogenesis and Endoplasmic Reticulum Stress–Hippo Signaling Axis in Doxorubicin-Induced Acute Cardiotoxicity in Rats
α-Bisabolol: A Dietary Sesquiterpene that Attenuates Apoptotic and Nonapoptotic Cell Death Pathways by Regulating the Mitochondrial Biogenesis and Endoplasmic Reticulum Stress–Hippo Signaling Axis in Doxorubicin-Induced Acute Cardiotoxicity in Rats Open
The potential for multiorgan toxicities is a significant barrier to the therapeutic use of doxorubicin (DOX) in cancer treatment. With regard to DOX-induced acute cardiotoxicity in rats, the current investigation sought to assess the cardi…
View article: Quality-by-Design-Driven Nanostructured Lipid Scaffold of Apixaban: Optimization, Characterization, and Pharmacokinetic Evaluation
Quality-by-Design-Driven Nanostructured Lipid Scaffold of Apixaban: Optimization, Characterization, and Pharmacokinetic Evaluation Open
Apixaban, an anticoagulant, is limited in its efficacy due to poor solubility, low bioavailability, and extensive metabolism. This study investigates the application of nanostructured lipid carriers (NLCs) to enhance the bioavailability of…
View article: Targeting Microglia in Neuroinflammation: H3 Receptor Antagonists as a Novel Therapeutic Approach for Alzheimer’s Disease, Parkinson’s Disease, and Autism Spectrum Disorder
Targeting Microglia in Neuroinflammation: H3 Receptor Antagonists as a Novel Therapeutic Approach for Alzheimer’s Disease, Parkinson’s Disease, and Autism Spectrum Disorder Open
Histamine performs dual roles as an immune regulator and a neurotransmitter in the mammalian brain. The histaminergic system plays a vital role in the regulation of wakefulness, cognition, neuroinflammation, and neurogenesis that are subst…
View article: Mechanistic insights into the potential role of dietary polyphenols and their nanoformulation in the management of Alzheimer’s disease
Mechanistic insights into the potential role of dietary polyphenols and their nanoformulation in the management of Alzheimer’s disease Open
Alzheimer's disease (AD) is a very common neurodegenerative disorder associated with memory loss and a progressive decline in cognitive activity. The two major pathophysiological factors responsible for AD are amyloid plaques (comprising a…
View article: CB2 Cannabinoid Receptor as a Potential Target in Myocardial Infarction: Exploration of Molecular Pathogenesis and Therapeutic Strategies
CB2 Cannabinoid Receptor as a Potential Target in Myocardial Infarction: Exploration of Molecular Pathogenesis and Therapeutic Strategies Open
The lipid endocannabinoid system has recently emerged as a novel therapeutic target for several inflammatory and tissue-damaging diseases, including those affecting the cardiovascular system. The primary targets of cannabinoids are cannabi…
View article: Does Hypertension Affect the Recovery of Renal Functions after Reversal of Unilateral Ureteric Obstruction?
Does Hypertension Affect the Recovery of Renal Functions after Reversal of Unilateral Ureteric Obstruction? Open
Research has demonstrated that hypertension can lead to an exaggeration in the renal functional and histological changes caused by ureteral obstruction. These changes were particularly observed shortly after the release of a relatively bri…