Shruti Menon
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View article: Ground-based Reconnaissance Observations of 21 Exoplanet Atmospheres with the Exoplanet Transmission Spectroscopy Imager
Ground-based Reconnaissance Observations of 21 Exoplanet Atmospheres with the Exoplanet Transmission Spectroscopy Imager Open
One of the most prolific methods of studying exoplanet atmospheres is transmission spectroscopy, which measures the difference between the depth of an exoplanet's transit signal at various wavelengths and attempts to correlate the depth ch…
View article: Development of a novel wireless telemetric brain stimulator for behavioral studies in rodents
Development of a novel wireless telemetric brain stimulator for behavioral studies in rodents Open
Brain simulators are moving the field of neuroscience at a rapid pace due to their wide applicability in treating neurodegenerative disorders. Although continuing advances in the field have made significant breakthroughs, most brain simula…
View article: Pneumonia Unveiled A Comprehensive Exploration of Causes, Symptoms, and Prevention
Pneumonia Unveiled A Comprehensive Exploration of Causes, Symptoms, and Prevention Open
A major contributor to atypical community-acquired pneumonia, Mycoplasma pneumoniae poses a special challenge in the clinical and scientific arenas because of its unique features, which include its tiny genome size, absence of a cell wall,…
View article: Genetic Predisposition Analysis of the Fshr Gene in Pcos: Insights From a South Indian Population
Genetic Predisposition Analysis of the Fshr Gene in Pcos: Insights From a South Indian Population Open
Purpose: In genetic studies, ethnic variations and the heterogeneous nature of PCOS attributed to inconclusive results. Despite being one of the most populated and diverse countries in the world, there is an absence of polymorphisms study …
View article: Emergent metabolic interactions in resistance to<i>Clostridioides difficile</i>invasion
Emergent metabolic interactions in resistance to<i>Clostridioides difficile</i>invasion Open
Commensal gut bacteria are key contributors to the resilience against pathogen invasion. This is exemplified by the success of fecal microbiota transplantation in treating recurrent Clostridioides difficile infection. Yet, characteristics …
View article: Clinical and Economic Burden of Severe Asthma With Low Blood Eosinophil Counts
Clinical and Economic Burden of Severe Asthma With Low Blood Eosinophil Counts Open
Most patients managed in primary care experienced infrequent exacerbations, whereas UKSAR patients had frequent exacerbations. Large proportions of both patient groups had poor symptom control and continued to receive high levels of mainte…
View article: Factors associated with non-fatal heart failure and atrial fibrillation or flutter within the first 30 days post COPD exacerbation: a nested case-control study
Factors associated with non-fatal heart failure and atrial fibrillation or flutter within the first 30 days post COPD exacerbation: a nested case-control study Open
Background An immediate, temporal risk of heart failure and arrhythmias after a Chronic Obstructive Pulmonary Disease (COPD) exacerbation has been demonstrated, particularly in the first month post-exacerbation. However, the clinical profi…
View article: Characteristics and outcomes of patients enrolled in the Connect 360 benralizumab patient support programme in the UK: a retrospective cohort study
Characteristics and outcomes of patients enrolled in the Connect 360 benralizumab patient support programme in the UK: a retrospective cohort study Open
Background Patient support programmes (PSPs) allow patients with chronic diseases to receive treatment and support at home. This study describes the Connect 360 PSP delivery and impact on patient-reported outcomes, satisfaction and adheren…
View article: Temporal Risk of Nonfatal Cardiovascular Events After Chronic Obstructive Pulmonary Disease Exacerbation: A Population-based Study
Temporal Risk of Nonfatal Cardiovascular Events After Chronic Obstructive Pulmonary Disease Exacerbation: A Population-based Study Open
Rationale: Cardiovascular events after chronic obstructive pulmonary disease (COPD) exacerbations are recognized. Studies to date have been post hoc analyses of trials, did not differentiate exacerbation severity, included death in the car…
View article: S86 Factors associated with non-fatal atrial fibrillation or flutter within the first 30 days post-exacerbation of COPD: a nested case-control study
S86 Factors associated with non-fatal atrial fibrillation or flutter within the first 30 days post-exacerbation of COPD: a nested case-control study Open
Background Few observational studies have explored the relationship between exacerbations of COPD and atrial fibrillation (AF) or flutter, specifically developing AF/flutter in the first 30 days following a COPD exacerbation. Methods We co…
View article: FET fusion oncoproteins disrupt physiologic DNA repair and create a targetable opportunity for ATR inhibitor therapy
FET fusion oncoproteins disrupt physiologic DNA repair and create a targetable opportunity for ATR inhibitor therapy Open
In cancers with genetic loss of specific DNA damage response (DDR) genes (i.e., BRCA1/2 tumor suppressor mutations), synthetic lethal targeting of compensatory DDR pathways has translated into clinical benefit for patients. Whether and how…
View article: Identification of key opportunities for optimising the management of high-risk COPD patients in the UK using the CONQUEST quality standards: an observational longitudinal study
Identification of key opportunities for optimising the management of high-risk COPD patients in the UK using the CONQUEST quality standards: an observational longitudinal study Open
This study is conducted by the Observational & Pragmatic Research International Ltd and was co-funded by Optimum Patient Care and AstraZeneca. No funding was received by the Observational & Pragmatic Research Institute Pte Ltd (OPRI) for i…
View article: Immunoassay to categorize chlamydial inflammatory disease in women to develop biomarker from peptide derived stimulant and its response to cytokine
Immunoassay to categorize chlamydial inflammatory disease in women to develop biomarker from peptide derived stimulant and its response to cytokine Open
Chlamydia trachomatis infection in women can result in serious sequelae such as pelvic inflammatory disease and infertility. Previous research has suggested that peptide epitopes from HtrA and HSP60 are potential biomarkers for immune cell…
View article: How Do We Find the Source of Foodborne Superbug Outbreaks?
How Do We Find the Source of Foodborne Superbug Outbreaks? Open
Lately, there have been more foodborne “superbug” outbreaks than ever before, which creates a problem because superbugs are antibiotic-resistant bacteria that are difficult to treat. To reduce such outbreaks, better ways of finding the sou…
View article: Kinase-mediated RAS signaling via membraneless cytoplasmic protein granules
Kinase-mediated RAS signaling via membraneless cytoplasmic protein granules Open
Receptor tyrosine kinase (RTK)-mediated activation of downstream effector pathways such as the RAS GTPase/MAP kinase (MAPK) signaling cascade is thought to occur exclusively from lipid membrane compartments in mammalian cells. Here, we unc…
View article: Structure and Metal Binding Properties of <i>Chlamydia trachomatis</i> YtgA
Structure and Metal Binding Properties of <i>Chlamydia trachomatis</i> YtgA Open
Chlamydia trachomatis is the most common bacterial sexually transmitted infection in developed countries, with an estimated global prevalence of 4.2% in the 15- to 49-year age group. Although infection is asymptomatic in more than 80% of i…
View article: Sero-epidemiological assessment of Chlamydia trachomatis infection and sub-fertility in Samoan women
Sero-epidemiological assessment of Chlamydia trachomatis infection and sub-fertility in Samoan women Open
The high prevalence of chlamydial infection and of positive chlamydial sub-fertility results suggests that CT is an important and frequent contributory factor to sub-fertility in this population.