Shreyans K. Jain
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View article: Effect of Stress-WIN, a novel polyherbal formulation, on DOCA-salt-induced hypertensive Wistar rats
Effect of Stress-WIN, a novel polyherbal formulation, on DOCA-salt-induced hypertensive Wistar rats Open
Hypertension is a multifactorial disorder and one of the most important risk factors and a leading cause of stroke, heart disease, and end-organ damage. Hypertension leads to the production of high levels of pro-inflammatory cytokines and …
View article: Pharmacological Evaluation of Bakuchiol From <i>Psoralea corylifolia</i> L. as Potent Antimicrobial Agent Against <i>Staphylococcus aureus</i>
Pharmacological Evaluation of Bakuchiol From <i>Psoralea corylifolia</i> L. as Potent Antimicrobial Agent Against <i>Staphylococcus aureus</i> Open
The surge in multidrug resistance in Staphylococcus aureus is the pressing need to identify novel alternatives to combat antimicrobial resistance effectively. Bakuchiol is a bioactive prenylated phenolic meroterpene largely abundant in the…
View article: WavShadow: Wavelet Based Shadow Segmentation and Removal
WavShadow: Wavelet Based Shadow Segmentation and Removal Open
Shadow removal and segmentation remain challenging tasks in computer vision, particularly in complex real world scenarios. This study presents a novel approach that enhances the ShadowFormer model by incorporating Masked Autoencoder (MAE) …
View article: Semisynthesis: Bridging natural products and novel anticancer therapies
Semisynthesis: Bridging natural products and novel anticancer therapies Open
Natural products (NPs) have played a central role in drug discovery particularly in therapeutic areas like oncology, and infectious diseases. Despite their pharmacological potential, natural products present some significant challenges for…
View article: An Optimized Method for LC–MS-Based Quantification of Endogenous Organic Acids: Metabolic Perturbations in Pancreatic Cancer
An Optimized Method for LC–MS-Based Quantification of Endogenous Organic Acids: Metabolic Perturbations in Pancreatic Cancer Open
Accurate and reliable quantification of organic acids with carboxylic acid functional groups in complex biological samples remains a major analytical challenge in clinical chemistry. Issues such as spontaneous decarboxylation during ioniza…
View article: An Optimized Method for LC-MS Based Quantification of Endogenous Organic Acids: Metabolic Perturbations in Pancreatic Cancer
An Optimized Method for LC-MS Based Quantification of Endogenous Organic Acids: Metabolic Perturbations in Pancreatic Cancer Open
Metabolomics profiling for accurate and reliable quantification of organic acids that carry a carboxylic acid functional group in complex biological samples, remains a major analytical challenge in clinical chemistry research. Several proc…
View article: Antioxident and Anticancer Potency of Hydro-Alcoholic Ingudi (Balanites aegyptiaca Linn. Delile) Seed Extract
Antioxident and Anticancer Potency of Hydro-Alcoholic Ingudi (Balanites aegyptiaca Linn. Delile) Seed Extract Open
Balanites aegyptiaca is a well-known medicinal plant, which has been traditionally used by local communities to treat various human ailments such as antibacterial, skin diseases, wound healing, and antioxidant properties. This study, exami…
View article: Unveiling the healing properties of 2,3-dehydrosilychristin: a potential silymarin-derived flavonolignan from <i>Vitex negundo</i>
Unveiling the healing properties of 2,3-dehydrosilychristin: a potential silymarin-derived flavonolignan from <i>Vitex negundo</i> Open
The compound 2,3-dehydrosilychristin, a flavonolignan linked to silychristin and silymarin, remains intriguing due to its challenging isolation from silymarin. While silymarin has been the exclusive source of flavonolignans – silybin, sily…
View article: Mahamanalactone A, a new triterpenoid from <i>Dysoxylum malabaricum</i> bark: a case study for rapid identification of new metabolites via LC-HRMS profiling and database mining strategy
Mahamanalactone A, a new triterpenoid from <i>Dysoxylum malabaricum</i> bark: a case study for rapid identification of new metabolites via LC-HRMS profiling and database mining strategy Open
In this recent investigation, the focus centred on exploring the potential phytoconstituents within the bark of Dysoxylum malabaricum. A profiling strategy employing LC-HRMS (Liquid Chromatography-High Resolution Mass Spectrometry) was imp…
View article: <i>In silico</i> analysis, isolation, and cytotoxicity evaluation of the coumestans from <i>Cullen corylifolium</i> (L.) Medik
<i>In silico</i> analysis, isolation, and cytotoxicity evaluation of the coumestans from <i>Cullen corylifolium</i> (L.) Medik Open
Cullen corylifolium is well known for diverse phytoconstituents that possess multifaceted pharmacology, and one such less explored class is coumestans, which have not been well explored for their anticancer activities. One of the popular c…
View article: Phytochemical and Pharmacological Aspects of Psoralen – A Bioactive Furanocoumarin from<i>Psoralea corylifolia</i>Linn.
Phytochemical and Pharmacological Aspects of Psoralen – A Bioactive Furanocoumarin from<i>Psoralea corylifolia</i>Linn. Open
Since long ago, medicinal plants have played a vital role in drug discovery. Being blessed and rich in chemovars with diverse scaffolds, they have unique characteristics of evolving based on the need. The World Health Organization also men…
View article: Impact of Nitrogen Levels on the Growth and Medicinal Properties of Periwinkle (Catharanthus roseus) in an Inceptisol of Varanasi, India
Impact of Nitrogen Levels on the Growth and Medicinal Properties of Periwinkle (Catharanthus roseus) in an Inceptisol of Varanasi, India Open
Aims: Periwinkle (Catharanthus roseus), is a perennial herbaceous, belongs to the Apocynaceae family. The medicinal poperties are more economically important than the yield of the plant. Nitrogen is the main nutrient affect the medicinal p…
View article: Correction to “LC–PDA–MS/MS-Based Dereplication Guided Isolation of a New Optical Isomer of 19,20-Epoxycytochalasin-N and Its Cytotoxic Activity”
Correction to “LC–PDA–MS/MS-Based Dereplication Guided Isolation of a New Optical Isomer of 19,20-Epoxycytochalasin-N and Its Cytotoxic Activity” Open
[This corrects the article DOI: 10.1021/acsomega.2c03037.].
View article: Antiproliferative Potential of Gloriosine: A Lead for Anticancer Drug Development
Antiproliferative Potential of Gloriosine: A Lead for Anticancer Drug Development Open
Gloriosine, a colchicine-like natural product, is widely obtained from Gloriosa superba roots. Despite having remarkable anticancer potential, colchicine could not pave its way to the clinic, while gloriosine is yet to be investigated for …
View article: LC–PDA–MS/MS-Based Dereplication Guided Isolation of a New Optical Isomer of 19,20-Epoxycytochalasin-N and Its Cytotoxic Activity
LC–PDA–MS/MS-Based Dereplication Guided Isolation of a New Optical Isomer of 19,20-Epoxycytochalasin-N and Its Cytotoxic Activity Open
The Rosellinia sanctae-cruciana extract was subjected to detailed liquid chromatography tandem mass spectrometry studies. A total of 38 peaks were annotated to m/z 508.26, m/z 510.28, m/z 524.26, m/z 526.28, m/z 540.26, m/z 542.27, and m/z…
View article: Exploring the Potential of Chemical Inhibitors for Targeting Post-translational Glycosylation of Coronavirus (SARS-CoV-2)
Exploring the Potential of Chemical Inhibitors for Targeting Post-translational Glycosylation of Coronavirus (SARS-CoV-2) Open
The Spike (S) protein of SARS-CoV-2 expressed on the viral cell surface is of particular importance as it facilitates viral entry into the host cells. The S protein is heavily glycosylated with 22 N-glycosylation sites and a few N-glycosyl…
View article: Low expression of TMPRSS2–a SARS-CoV-2 internalization protease–associates with basal subtype of head and neck squamous cell carcinoma
Low expression of TMPRSS2–a SARS-CoV-2 internalization protease–associates with basal subtype of head and neck squamous cell carcinoma Open
SARS-CoV-2 is a single-stranded RNA virus that has caused the ongoing COVID-19 pandemic. ACE2 and other genes utilized by SARS-CoV-2 to enter human cells have been shown to express in Head and Neck Squamous Cell Carcinoma (HNSCC) patients.…
View article: Iodine-mediated one-step synthesis of ipomone from gibberellic acid
Iodine-mediated one-step synthesis of ipomone from gibberellic acid Open
A fast and efficient method for synthesising ipomone (4), a bicyclo[3.2.1]octanone containing aromatised derivative, from gibberellic acid (1) has been developed using molecular iodine as a mild and effective mediator under heating conditi…
View article: Correction: Chrysomycins A–C, antileukemic naphthocoumarins from <i>Streptomyces sporoverrucosus</i>
Correction: Chrysomycins A–C, antileukemic naphthocoumarins from <i>Streptomyces sporoverrucosus</i> Open
Correction for ‘Chrysomycins A–C, antileukemic naphthocoumarins from Streptomyces sporoverrucosus ’ by Shreyans K. Jain et al. , RSC Adv. , 2013, 3 , 21046–21053, https://doi.org/10.1039/c3ra42884b.
View article: TGFβ Drives Metabolic Perturbations during Epithelial Mesenchymal Transition in Pancreatic Cancer: TGFβ Induced EMT in PDAC
TGFβ Drives Metabolic Perturbations during Epithelial Mesenchymal Transition in Pancreatic Cancer: TGFβ Induced EMT in PDAC Open
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy wherein a majority of patients present metastatic disease at diagnosis. Although the role of epithelial to mesenchymal transition (EMT), mediated by transforming growth …
View article: A comprehensive review on chemistry and pharmacology of marine bioactives as antimetastatic agents
A comprehensive review on chemistry and pharmacology of marine bioactives as antimetastatic agents Open
Metastasis by and large is responsible for the worldwide deaths associated with various types of cancers. The metastatic variant of cancer cells generated due to the cellular heterogeneity and abnormal activation of various signaling pathw…
View article: Pharmacokinetic Assessment of Rottlerin from <i>Mallotus philippensis</i> Using a Highly Sensitive Liquid Chromatography–Tandem Mass Spectrometry-Based Bioanalytical Method
Pharmacokinetic Assessment of Rottlerin from <i>Mallotus philippensis</i> Using a Highly Sensitive Liquid Chromatography–Tandem Mass Spectrometry-Based Bioanalytical Method Open
Rottlerin is a key bioactive phytoconstituent present in the pericarp of Mallotus philippensis. It shows promising multifaceted pharmacological actions against cancer. However, there is hardly any report for the quantification of rottlerin…
View article: Identification and Evaluation of Apoptosis-Inducing Activity of Ipomone from <i>Ipomoea nil</i>: A Novel, Unusual Bicyclo-[3.2.1] Octanone Containing Gibberic Acid Diterpenoid
Identification and Evaluation of Apoptosis-Inducing Activity of Ipomone from <i>Ipomoea nil</i>: A Novel, Unusual Bicyclo-[3.2.1] Octanone Containing Gibberic Acid Diterpenoid Open
Ipomone (1), a novel diterpenoid along with seven known compounds (2-8), was isolated for the first time from the acidified hydroalcoholic extract of Ipomoea nil seeds. The structures of the isolated compounds were elucidated via comprehen…
View article: Tandem MS-Based Metabolite Profiling of 19,20-Epoxycytochalasin C Reveals the Importance of a Hydroxy Group at the C7 Position for Biological Activity
Tandem MS-Based Metabolite Profiling of 19,20-Epoxycytochalasin C Reveals the Importance of a Hydroxy Group at the C7 Position for Biological Activity Open
Seven cytochalasins, 19,20-epoxycytochalasin N, cytochalasin P1, deacetyl 19,20-epoxycytochalasin C, 19,20-epoxycytochalasin D, 19,20-epoxycytochalasin C, cytochalasin D, and cytochalasin C, were isolated from a fungal (Rosellinia sanctae-…
View article: Developing Multimodal Logistics Parks in India
Developing Multimodal Logistics Parks in India Open
This publication discusses the potential of multimodal logistics parks (MMLPs) to support supply chains in India. It also presents findings of studies on the feasibility of MMLPs in Bengaluru and Guwahati.
View article: Transformation of Santonin to a Naproxen Analogue with Anti-Inflammatory Activity
Transformation of Santonin to a Naproxen Analogue with Anti-Inflammatory Activity Open
Santonin, a natural product, was aromatized with molecular iodine as the catalyst. The new compound was characterized as ( S)-methyl-2-(7-hydroxy-5,8-dimethylnaphthalen-2-yl) propanoate (2) based on 2D NMR spectroscopic data. Structurally,…
View article: Liquid Chromatography–Mass Spectrometry-Based Metabolomics of Nonhuman Primates after 4 Gy Total Body Radiation Exposure: Global Effects and Targeted Panels
Liquid Chromatography–Mass Spectrometry-Based Metabolomics of Nonhuman Primates after 4 Gy Total Body Radiation Exposure: Global Effects and Targeted Panels Open
Rapid assessment of radiation signatures in noninvasive biofluids may aid in assigning proper medical treatments for acute radiation syndrome (ARS) and delegating limited resources after a nuclear disaster. Metabolomic platforms allow for …
View article: Metabolomics based predictive classifier for early detection of pancreatic ductal adenocarcinoma
Metabolomics based predictive classifier for early detection of pancreatic ductal adenocarcinoma Open
The availability of robust classification algorithms for the identification of high risk individuals with resectable disease is critical to improving early detection strategies and ultimately increasing survival rates in PC. We leveraged h…