Shruthi Venugopal
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View article: MRCKα/CDC42BPA Is a Suppressor of Gef-H1/RhoA/MRTF Signaling in Tubular Cells
MRCKα/CDC42BPA Is a Suppressor of Gef-H1/RhoA/MRTF Signaling in Tubular Cells Open
Pro-fibrotic mediators derived from tubular cells have a central role in he development of kidney fibrosis. Our previous studies revealed that GEF-H1 (ARHGEF2)/RhoA signalling is a crucial regulator of tubular mediator release. Fibrotic st…
View article: M-Motif, a potential non-conventional NLS in YAP/TAZ and other cellular and viral proteins that inhibits classic protein import
M-Motif, a potential non-conventional NLS in YAP/TAZ and other cellular and viral proteins that inhibits classic protein import Open
Multiple mechanisms were proposed to mediate the nuclear import of TAZ/YAP, transcriptional co-activators regulating organ growth and regeneration. Our earlier observations showed that TAZ/YAP harbor a C-terminal, unconventional nuclear lo…
View article: review on diabetes associated with psychological disorders among elderly people
review on diabetes associated with psychological disorders among elderly people Open
People over the age of 65 who have diabetes are more likely to have mental health issues. Chronic illness might have a direct or indirect impact on this outcome. Diabetic complications can also play a role. The goal of this study is to exa…
View article: Myocardin-related transcription factor and serum response factor regulate cilium turnover by both transcriptional and local mechanisms
Myocardin-related transcription factor and serum response factor regulate cilium turnover by both transcriptional and local mechanisms Open
Turnover of the primary cilium (PC) is critical for proliferation and tissue homeostasis. Each key component of the PC resorption machinery, the HEF1/Aurora kinase A (AurA)/HDAC6 pathway harbors cis-elements potentially targeted by the tra…
View article: Myocardin-Related Transcription Factor and Serum Response Factor Regulate Cilium Resorption and Ciliogenesis by Both Transcriptional and Local Mechanisms
Myocardin-Related Transcription Factor and Serum Response Factor Regulate Cilium Resorption and Ciliogenesis by Both Transcriptional and Local Mechanisms Open
View article: Claudin-2: Roles beyond Permeability Functions
Claudin-2: Roles beyond Permeability Functions Open
Claudin-2 is expressed in the tight junctions of leaky epithelia, where it forms cation-selective and water permeable paracellular channels. Its abundance is under fine control by a complex signaling network that affects both its synthesis…
View article: Claudin-2 suppresses GEF-H1, RHOA, and MRTF, thereby impacting proliferation and profibrotic phenotype of tubular cells
Claudin-2 suppresses GEF-H1, RHOA, and MRTF, thereby impacting proliferation and profibrotic phenotype of tubular cells Open
View article: Cell confluence regulates claudin-2 expression: possible role for ZO-1 and Rac
Cell confluence regulates claudin-2 expression: possible role for ZO-1 and Rac Open
Claudin-2 (Cldn-2) is a channel-forming tight junction (TJ) protein in the proximal tubules that mediates paracellular Na + transport and has also emerged as a regulator of proliferation and migration. Expression of Cldn-2 is altered by nu…