Shruti Dharmaraj
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View article: Cargo-less itaconate-based nanoparticles mitigate allergic airway inflammation 3726
Cargo-less itaconate-based nanoparticles mitigate allergic airway inflammation 3726 Open
Description Allergic diseases affect over 50 million annually in the U.S., with standard treatments being non-curative. Allergen-specific immunotherapies represent an antigen (Ag)-specific approach to modulate Th2 dysregulation in allergy,…
View article: Lipid nanoparticles from L. meyenii Walp mitigate sepsis through multimodal protein corona formation
Lipid nanoparticles from L. meyenii Walp mitigate sepsis through multimodal protein corona formation Open
View article: Microfluidics-generated PLA nanoparticles: impact of purification method on macrophage interactions, anti-inflammatory effects, biodistribution, and protein corona formation
Microfluidics-generated PLA nanoparticles: impact of purification method on macrophage interactions, anti-inflammatory effects, biodistribution, and protein corona formation Open
This study identifies TFF as an efficient method for scalable NP purification compared to centrifugation, though it alters biological properties that should be evaluated case-by-case.
View article: Lipid Nanoparticles from<i>L. meyenii</i>Walp Mitigate Sepsis through Multimodal Protein Corona Formation
Lipid Nanoparticles from<i>L. meyenii</i>Walp Mitigate Sepsis through Multimodal Protein Corona Formation Open
Background Plant-derived nanoparticles (PDNP) are nano-sized particles isolated from various edible plants that contain bioactive components involved in regulating cellular immune responses against pathogenic intrusion and inflammation. Pu…
View article: Impact of antigen loading in tolerogenic nanoparticles to mitigate Th2-mediated allergic lung inflammation
Impact of antigen loading in tolerogenic nanoparticles to mitigate Th2-mediated allergic lung inflammation Open
View article: Cell and biomaterial delivery strategies to induce immune tolerance
Cell and biomaterial delivery strategies to induce immune tolerance Open
View article: Multimodal nanoparticle‐containing modified suberoylanilide hydroxamic acid polymer conjugates to mitigate immune dysfunction in severe inflammation
Multimodal nanoparticle‐containing modified suberoylanilide hydroxamic acid polymer conjugates to mitigate immune dysfunction in severe inflammation Open
Excessive immune activation and immunosuppression are opposing factors that contribute to the dysregulated innate and adaptive immune responses seen in severe inflammation and sepsis. Here, a novel analog of the histone deacetylase inhibit…
View article: Intranasally Administered MSC-Derived Extracellular Vesicles Reverse Cisplatin-Induced Cognitive Impairment
Intranasally Administered MSC-Derived Extracellular Vesicles Reverse Cisplatin-Induced Cognitive Impairment Open
Neurotoxic side effects of chemotherapy include deficits in attention, memory, and executive functioning. Currently, there are no FDA-approved therapies. In mice, cisplatin causes long-term cognitive deficits, white matter damage, mitochon…
View article: Poly(lactic acid)-based immunomodulatory nanoparticles promote survival in a polymicrobial mouse model of sepsis
Poly(lactic acid)-based immunomodulatory nanoparticles promote survival in a polymicrobial mouse model of sepsis Open
Sepsis is a life-threatening multifactorial organ dysfunction caused by a dysregulated host response to infection. Despite being recognized as a global health priority, current therapeutic approaches for sepsis have yet to demonstrate sign…
View article: Immunomodulatory Nanoparticles as a Multimodal Approach to Attenuate Immune Dysregulation in Severe Inflammation and Sepsis
Immunomodulatory Nanoparticles as a Multimodal Approach to Attenuate Immune Dysregulation in Severe Inflammation and Sepsis Open
View article: Nasal administration of mesenchymal stem cells prevents accelerated age-related tauopathy after chemotherapy in mice
Nasal administration of mesenchymal stem cells prevents accelerated age-related tauopathy after chemotherapy in mice Open
Background There is increasing concern that cancer and cancer treatment accelerate aging and the associated cognitive decline. We showed recently that treatment of 9-month-old male mice with cisplatin causes cognitive deficits that are ass…
View article: Excipient-Free Ionizable Polyester Nanoparticles for Lung-Selective and Innate Immune Cell Plasmid DNA and mRNA Transfection
Excipient-Free Ionizable Polyester Nanoparticles for Lung-Selective and Innate Immune Cell Plasmid DNA and mRNA Transfection Open
Extrahepatic nucleic acid delivery using polymers typically requires the synthesis and purification of custom monomers, post-synthetic modifications, and incorporation of additional excipients to augment their stability, endosomal escape, …
View article: Targeting the A3 adenosine receptor to prevent and reverse chemotherapy-induced neurotoxicities in mice
Targeting the A3 adenosine receptor to prevent and reverse chemotherapy-induced neurotoxicities in mice Open
View article: Additional file 2 of Targeting the A3 adenosine receptor to prevent and reverse chemotherapy-induced neurotoxicities in mice
Additional file 2 of Targeting the A3 adenosine receptor to prevent and reverse chemotherapy-induced neurotoxicities in mice Open
Additional file 2: Table S2. Differentially expressed genes (Cisplatin vs Cisplatin + MRS5980).
View article: Additional file 1 of Targeting the A3 adenosine receptor to prevent and reverse chemotherapy-induced neurotoxicities in mice
Additional file 1 of Targeting the A3 adenosine receptor to prevent and reverse chemotherapy-induced neurotoxicities in mice Open
Additional file1: Table S1. Differentially expressed genes (PBS vs Cisplatin).
View article: HDAC6 inhibition reverses long-term doxorubicin-induced cognitive dysfunction by restoring microglia homeostasis and synaptic integrity
HDAC6 inhibition reverses long-term doxorubicin-induced cognitive dysfunction by restoring microglia homeostasis and synaptic integrity Open
Breast cancer is the most common female malignancy in both the developed and developing world. Doxorubicin is one of the most commonly used chemotherapies for breast cancer. Unfortunately, up to 60% of survivors report long-term chemothera…
View article: Fate of nanoparticles in the central nervous system after intrathecal injection in healthy mice
Fate of nanoparticles in the central nervous system after intrathecal injection in healthy mice Open