Shruti S. Bhise
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View article: Multimodal single-cell analyses reveal distinct fusion-regulated transcriptional programs in Ewing sarcoma
Multimodal single-cell analyses reveal distinct fusion-regulated transcriptional programs in Ewing sarcoma Open
Ewing sarcoma (EwS) is a fusion-driven malignancy, peaking in adolescence. Although EwS tumors are driven uniquely by EWS::FLI1 and related fusions, patient outcomes vary greatly. If and how tumor plasticity of EWS::FLI1-regulated transcri…
View article: Multimodal single-cell analyses reveal distinct fusion-regulated transcriptional programs in Ewing sarcoma
Multimodal single-cell analyses reveal distinct fusion-regulated transcriptional programs in Ewing sarcoma Open
Ewing sarcoma (EwS) is a fusion-driven malignancy, peaking in adolescence. Although EwS tumors are driven uniquely by EWS::FLI1 and related fusions, patient outcomes vary greatly. If and how tumor plasticity of EWS::FLI1-regulated transcri…
View article: Multi-omic single cell sequencing reveals discordant MRD and mechanisms of relapse in pediatric AML
Multi-omic single cell sequencing reveals discordant MRD and mechanisms of relapse in pediatric AML Open
Introduction: Pediatric acute myeloid leukemia (AML) is a biologically heterogeneous disease. Prognosis is determined by risk of relapse, and the most powerful prognostic marker is measurable residual disease (MRD) at the end of induction …
View article: Quantifying HLA transcripts by genotype in chimeric mixtures at single-cell resolution
Quantifying HLA transcripts by genotype in chimeric mixtures at single-cell resolution Open
Gene products from the highly variable major histocompatibility locus, including HLA, are essential for self-recognition and immune surveillance of malignancy. Following allogeneic hematopoietic cell transplantation (alloHCT), genetic and …
View article: Multimodal single-cell analyses reveal distinct fusion-regulated transcriptional programs in Ewing sarcoma
Multimodal single-cell analyses reveal distinct fusion-regulated transcriptional programs in Ewing sarcoma Open
Ewing sarcoma (EwS) is a fusion-driven malignancy, peaking in adolescence. Although EwS tumors are driven uniquely by EWS::FLI1 and related fusions, patient outcomes vary greatly. If and how tumor plasticity of EWS::FLI1-regulated transcri…
View article: Modulating AP-1 enables CAR-T cells to establish an intratumoral PD-1<sup>+</sup>Tcf1<sup>+</sup>stem-like reservoir and overcomes resistance to PD-1 axis blockade
Modulating AP-1 enables CAR-T cells to establish an intratumoral PD-1<sup>+</sup>Tcf1<sup>+</sup>stem-like reservoir and overcomes resistance to PD-1 axis blockade Open
PD-1 + Tcf1 + stem-like cells are critical mediators of endogenous T cell responses to PD-1/PD-L1 blockade and are maintained by MHC-dependent interactions with professional antigen-presenting cells ( APCs ). Unlike conventional T cells, C…
View article: IFN-γ and donor leukocyte infusions for relapsed myeloblastic malignancies after allogeneic hematopoietic stem cell transplantation
IFN-γ and donor leukocyte infusions for relapsed myeloblastic malignancies after allogeneic hematopoietic stem cell transplantation Open
BACKGROUNDThe graft-versus-leukemia (GVL) effect contributes to the efficacy of allogeneic stem cell transplantation (alloSCT). However, relapse, indicative of GVL failure, is the greatest single cause of treatment failure. Based on precli…
View article: Defining pathogenic IL-17 and CSF-1 gene expression signatures in chronic graft-versus-host disease
Defining pathogenic IL-17 and CSF-1 gene expression signatures in chronic graft-versus-host disease Open
Chronic graft-versus-host disease (cGVHD) remains the leading cause of nonrelapse morbidity and mortality after allogeneic hematopoietic cell transplantation (HCT). Effective therapeutic agents targeting dysregulated cytokines including in…
View article: Supplemental Figure S3 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment
Supplemental Figure S3 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment Open
Supplemental Figure S3. Spatial heterogeneity of CD73+ tumor cells and ECM deposition in additional xenograft and PDX-derived models. Related to Figure 3.
View article: Supplementary Table 6 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment
Supplementary Table 6 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment Open
Supplemental Table 6. List of genes that positively correlate with NT5E expression in 3 independent patient tumor cohorts.
View article: Supplementary Table 7 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment
Supplementary Table 7 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment Open
Supplemental Table 7. Clinical information and CD73 IHC score for patient tumor tissue microarray.
View article: Supplemental Figure S1 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment
Supplemental Figure S1 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment Open
Supplemental Figure S1. CD73+ EwS cells retain proliferative and tumorigenic capacity. Related to Figure 1.
View article: Supplementary Table 5 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment
Supplementary Table 5 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment Open
Supplemental Table 5. Q3 normalized gene expression counts for CHLA10 xenograft digital spatial profiling.
View article: Supplementary Table 2 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment
Supplementary Table 2 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment Open
Supplemental Table 2. 52 genes overlapping between markers of cells with high GO:BP Mesenchymal Development from A673 and CHLA10 single cell sequencing and EWS::FLI1 repressed gene set.
View article: Supplementary Table 7 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment
Supplementary Table 7 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment Open
Supplemental Table 7. Clinical information and CD73 IHC score for patient tumor tissue microarray.
View article: Supplemental Figure S1 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment
Supplemental Figure S1 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment Open
Supplemental Figure S1. CD73+ EwS cells retain proliferative and tumorigenic capacity. Related to Figure 1.
View article: Supplemental Table 3 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment
Supplemental Table 3 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment Open
Supplemental Table 3. RNAseq-derived gene expression data for CD73- and CD73+ A673 and CHLA10 cells.
View article: Supplementary Table 2 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment
Supplementary Table 2 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment Open
Supplemental Table 2. 52 genes overlapping between markers of cells with high GO:BP Mesenchymal Development from A673 and CHLA10 single cell sequencing and EWS::FLI1 repressed gene set.
View article: Supplemental Figure S5 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment
Supplemental Figure S5 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment Open
Supplemental Figure S5. Patient tumor gene expression microarrays display heterogeneity of expression of NT5E and associated mesenchymal gene signature. Related to Figure 5.
View article: Supplemental Figure S2 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment
Supplemental Figure S2 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment Open
Supplemental Figure S2. CD73+ cells are enriched in EMT and ECM gene expression. Related to Figure 2.
View article: Supplemental Figure S6 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment
Supplemental Figure S6 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment Open
Supplemental Figure S6. Intertumoral heterogeneity of CD73+ tumor cells and ECM deposition in patient biopsies. Related to Figure 6.
View article: Supplemental Figure S5 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment
Supplemental Figure S5 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment Open
Supplemental Figure S5. Patient tumor gene expression microarrays display heterogeneity of expression of NT5E and associated mesenchymal gene signature. Related to Figure 5.
View article: Supplementary Table 1 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment
Supplementary Table 1 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment Open
Supplemental Table 1. Table of selected reagents and resources used.
View article: Data from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment
Data from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment Open
Purpose: Despite limited genetic and histologic heterogeneity, Ewing sarcoma (EwS) tumor cells are transcriptionally heterogeneous and display varying degrees of mesenchymal lineage specification in vitro. In this study, we investigated if…
View article: Supplementary Table 5 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment
Supplementary Table 5 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment Open
Supplemental Table 5. Q3 normalized gene expression counts for CHLA10 xenograft digital spatial profiling.
View article: Supplemental Figure S6 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment
Supplemental Figure S6 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment Open
Supplemental Figure S6. Intertumoral heterogeneity of CD73+ tumor cells and ECM deposition in patient biopsies. Related to Figure 6.
View article: Supplementary Table 6 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment
Supplementary Table 6 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment Open
Supplemental Table 6. List of genes that positively correlate with NT5E expression in 3 independent patient tumor cohorts.
View article: Supplementary Table 4 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment
Supplementary Table 4 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment Open
Supplemental Table 4. Top 200 markers of NT5E+ cells (by fold change vs. NT5E- cells) from nine EwS cell lines by single cell sequencing.
View article: Supplemental Figure S3 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment
Supplemental Figure S3 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment Open
Supplemental Figure S3. Spatial heterogeneity of CD73+ tumor cells and ECM deposition in additional xenograft and PDX-derived models. Related to Figure 3.
View article: Supplemental Figure S2 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment
Supplemental Figure S2 from Cancer-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment Open
Supplemental Figure S2. CD73+ cells are enriched in EMT and ECM gene expression. Related to Figure 2.