Shruti Sinha
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View article: Global prevalence of post-miscarriage anxiety, depression, and stress: a systematic review and meta-analysis
Global prevalence of post-miscarriage anxiety, depression, and stress: a systematic review and meta-analysis Open
PROSPERO: CRD42024578605.
View article: Long Read genomic and epigenomic profiling enhances timely comprehensive variant discovery in hypotonia and muscle weakness
Long Read genomic and epigenomic profiling enhances timely comprehensive variant discovery in hypotonia and muscle weakness Open
Background Identifying the genetic basis of hypotonia and muscle weakness is critical for patient management and family counseling. However, diagnosis is often hindered by diverse genomic alterations, including repeat expansions, structura…
View article: Genetic dissection of leaf rust resistance in a diversity panel of tetraploid wheat (Triticum turgidum)
Genetic dissection of leaf rust resistance in a diversity panel of tetraploid wheat (Triticum turgidum) Open
Our study provides a comprehensive understanding of the genetic basis underlying leaf rust resistance in a diverse tetraploid wheat germplasm panel. It has also revealed novel candidate genomic regions for leaf rust resistance. These genom…
View article: Long read sequencing enhances pathogenic and novel variation discovery in patients with rare diseases
Long read sequencing enhances pathogenic and novel variation discovery in patients with rare diseases Open
With ongoing improvements in the detection of complex genomic and epigenomic variations, long-read sequencing (LRS) technologies could serve as a unified platform for clinical genetic testing, particularly in rare disease settings, where n…
View article: Genome-wide identification and characterization of the WRKY gene family in lentil (Lens culinaris Medikus)
Genome-wide identification and characterization of the WRKY gene family in lentil (Lens culinaris Medikus) Open
The WRKY gene family plays a very important role in plant growth, development, and response to both biotic and abiotic stresses. Despite its importance, WRKY gene family is yet to be explored in lentil (Lentil culinaris Medikus), an import…
View article: Pathogenic variation underlying rare diseases in an Arab Population: implications for screening programs
Pathogenic variation underlying rare diseases in an Arab Population: implications for screening programs Open
Background Genetic variation underlying rare diseases in Arab populations is poorly understood, limiting effective carrier screening for recessive disorders which are prevalent due to high consanguineous rates. Methods Using the ACMG/AMP g…
View article: <i>FBXO22</i>deficiency defines a pleiotropic syndrome of growth restriction and multi-system anomalies associated with a unique epigenetic signature
<i>FBXO22</i>deficiency defines a pleiotropic syndrome of growth restriction and multi-system anomalies associated with a unique epigenetic signature Open
FBXO22 encodes an F-box protein which acts as a substrate-recognition component of the SKP1-CUL1-F-box (SCF) E3 ubiquitin ligase complex. Despite its known roles in the post-translational ubiquitination and degradation of specific substrat…
View article: Understanding the essentials of photodynamic therapy for dental practitioners: Shining a spotlight
Understanding the essentials of photodynamic therapy for dental practitioners: Shining a spotlight Open
Background: Oral disorders, including tooth decay, periodontal disease, and endodontic infections, are prevalent worldwide. The escalating issue of antibiotic resistance exacerbates the need for alternative treatment modalities. Aim: This …
View article: Management of oral aphthous ulcer: A review
Management of oral aphthous ulcer: A review Open
Aphthous ulcers, also known as canker sores, are a common oral condition characterized by recurrent, painful, small ulcers that typically arise on the non-keratinized mucous membranes within the mouth. Although the pathogenesis of aphthous…
View article: Comparison of Clinical Characteristics and Biomarkers in Culture-Positive and Culture-Negative Sepsis Patients
Comparison of Clinical Characteristics and Biomarkers in Culture-Positive and Culture-Negative Sepsis Patients Open
It can be concluded that CRP and PCT can be used as clinically reliable sepsis biomarkers in both culture-positive and culture-negative patients. The study found that culture-negative sepsis is more prevalent and that there are substantial…
View article: Long read sequencing enhances pathogenic and novel variation discovery in patients with rare diseases
Long read sequencing enhances pathogenic and novel variation discovery in patients with rare diseases Open
With ongoing improvements in accuracy and capacity to detect complex genomic and epigenomic variations, long-read sequencing (LRS) technologies could serve as a unified platform for clinical genetic testing, particularly in rare disease se…
View article: A dual-mode targeted Nanopore sequencing assay for comprehensive<i>SMN1</i>and<i>SMN2</i>variant analysis
A dual-mode targeted Nanopore sequencing assay for comprehensive<i>SMN1</i>and<i>SMN2</i>variant analysis Open
Background Spinal Muscular Atrophy (SMA) is one of the most common recessive disorders for which several life-saving treatment options are currently available. It is essential to establish universal SMA screening and diagnostic programs us…
View article: Effect of different density of lac insect (Kerria lacca) infestation on host plant Flemingia macrophylla growth and photosynthetic pigments
Effect of different density of lac insect (Kerria lacca) infestation on host plant Flemingia macrophylla growth and photosynthetic pigments Open
Lac insect life cycle is entirely dependent upon host plants. Its production relies on host plant sustenance of the insect to harvest economic yield. However insect attachment causes fitness cost to host plants. The present study identifie…
View article: Does the Role of Family Assisted Cognitive Remediation Therapy Still Exists in Modern Era of Artificial Intelligence: A Randomized Case-control Study for Schizophrenia Patients from Rural Background
Does the Role of Family Assisted Cognitive Remediation Therapy Still Exists in Modern Era of Artificial Intelligence: A Randomized Case-control Study for Schizophrenia Patients from Rural Background Open
Background: Last decade showed promising evidences of computer based therapies, incorporating either an in-patient or home-based computer model for training the family members. The crux of all these studies focuses on the role of “family”.…
View article: Pyrogenium: A Homoeopathic Antibiotic
Pyrogenium: A Homoeopathic Antibiotic Open
An antibiotic is one of the types of antimicrobial substances that are active against bacteria and helpful either by killing the bacteria or by inhibiting the growth of bacteria, thereby preventing and controlling the infection caused by b…
View article: Targeting Apoptotic Pathway of Cancer Cells with Phytochemicals and Plant-Based Nanomaterials
Targeting Apoptotic Pathway of Cancer Cells with Phytochemicals and Plant-Based Nanomaterials Open
Apoptosis is the elimination of functionally non-essential, neoplastic, and infected cells via the mitochondrial pathway or death receptor pathway. The process of apoptosis is highly regulated through membrane channels and apoptogenic prot…
View article: Lactoferrin and Activated Protein C: Potential Role in Prevention of Cancer Progression and Recurrence.
Lactoferrin and Activated Protein C: Potential Role in Prevention of Cancer Progression and Recurrence. Open
Existing therapeutic interventions for controlling cancer are limited and associated with side effects. Furthermore, the recurrence of cancer poses a significant challenge to the cure of cancer. Therefore, avenues are wanted to find novel …
View article: A case report of rare occurance of pyogenic granuloma at an unusual site – Mapping of its diagnosis and treatment plan
A case report of rare occurance of pyogenic granuloma at an unusual site – Mapping of its diagnosis and treatment plan Open
Pyogenic granuloma is an acquired, benign, common, non-neoplastic, and vascular reactive lesion, occurring in the oral cavity. It is a localized granulation tissue overgrowth symbolizing an exuberant tissue reaction to a trauma or local ir…
View article: Replication Package for: "Partial Identification in Matching Models for the Marriage Market"
Replication Package for: "Partial Identification in Matching Models for the Marriage Market" Open
This is the replication package for "Partial Identification in Matching Models for the Marriage Market," accepted in 2022 by the Journal of Political Economy.
View article: Analysis of microarray data by genetic algorithm
Analysis of microarray data by genetic algorithm Open
Microarray gene expression data is used to understand the actions of thousands of genes. Just a few genes out of thousands have a significant impact in any cancer process. Finding these defective genes using experimental data is impractica…
View article: Type-I Interferon Signaling in Fanconi Anemia
Type-I Interferon Signaling in Fanconi Anemia Open
Fanconi Anemia (FA) is a genome instability syndrome caused by mutations in one of the 23 repair genes of the Fanconi pathway. This heterogenous disease is usually characterized by congenital abnormalities, premature ageing and bone marrow…
View article: Extracting the candidate genes for cancer from the microarray gene expression data by stochastic computation
Extracting the candidate genes for cancer from the microarray gene expression data by stochastic computation Open
Microarray gene expression data provides a simultaneous gene expression profile of thousands of genes. A handful of genes among the thousands of genes play dominant roles in a disease process. It is impractical to find these faulty genes f…
View article: Early maternal care restores LINE-1 methylation and enhances neurodevelopment in preterm infants
Early maternal care restores LINE-1 methylation and enhances neurodevelopment in preterm infants Open
Background Preterm birth affects almost 9–11% of newborns and is one of the leading causes of childhood neurodevelopmental disabilities; the underlying molecular networks are poorly defined. In neurons, retrotransposons LINE-1 (L1) are an …
View article: SNAKE BITE PRESENTING AS INTRACRANIAL BLEED WITH NORMAL COAGULATION PARAMETERS
SNAKE BITE PRESENTING AS INTRACRANIAL BLEED WITH NORMAL COAGULATION PARAMETERS Open
Snakebite being commonly encountered emergency in our country and most dreaded one too. It has been estimated that as many as 2.8 million people are bitten by snakes, and 45 900 people die from snakebite every year in India1. The most comm…
View article: Child abuse: A concealed sin prevailing in the society
Child abuse: A concealed sin prevailing in the society Open
Child abuse is a globally prevalent phenomenon. The child may face abuse which can be physical, emotional, sexual or in the form of neglect. It is the violation of the basic human rights of a child. Root cause of abuse can be family proble…
View article: Understanding genomic diversity, pan-genome, and evolution of SARS-CoV-2
Understanding genomic diversity, pan-genome, and evolution of SARS-CoV-2 Open
Coronovirus disease 2019 (COVID-19) infection, which originated from Wuhan, China, has seized the whole world in its grasp and created a huge pandemic situation before humanity. Since December 2019, genomes of numerous isolates have been s…
View article: Dataset related to article "TNF-Stimulated Gene-6 Is a Key Regulator in Switching Stemness and Biological Properties of Mesenchymal Stem Cells."
Dataset related to article "TNF-Stimulated Gene-6 Is a Key Regulator in Switching Stemness and Biological Properties of Mesenchymal Stem Cells." Open
Mesenchymal stem cells (MSCs) are well established to have promising therapeutic properties. TNF-stimulated gene-6 (TSG-6), a potent tissue-protective and anti-inflammatory factor, has been demonstrated to be responsible for a significant …