Shrutika Wankhade
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View article: Identification of Mitapivat's In Vivo Metabolites in the Rat Model by Quadrupole‐Time‐of‐Flight (Q‐TOF) Mass Spectrometry
Identification of Mitapivat's In Vivo Metabolites in the Rat Model by Quadrupole‐Time‐of‐Flight (Q‐TOF) Mass Spectrometry Open
Mitapivat is a novel, first‐in‐class, allosteric activator of pyruvate kinase enzyme. It has been approved by the US FDA in February 2022 for disease modifying treatment of haemolytic anaemia in adults. In the current study, the in vivo me…
View article: Stability Indicating Assay Method for Quantification of Hypoxia‐Inducible Factor Inhibitor Daprodustat: Characterization of Novel Degradation Products by Quadrupole Time‐of‐Flight (Q‐TOF) Mass Spectrometry and In Silico Toxicity Thereof
Stability Indicating Assay Method for Quantification of Hypoxia‐Inducible Factor Inhibitor Daprodustat: Characterization of Novel Degradation Products by Quadrupole Time‐of‐Flight (Q‐TOF) Mass Spectrometry and In Silico Toxicity Thereof Open
A selective stability‐indicating HPLC method was developed for daprodustat. Among the stress conditions involving acid hydrolysis, base hydrolysis, and oxidation, the drug was found to degrade under acid and base hydrolysis. Whereas it was…
View article: Identification and in vitro genotoxicity assessment of forced degradation products of glimepiride and glyburide using HEK cell‐based COMET assay
Identification and in vitro genotoxicity assessment of forced degradation products of glimepiride and glyburide using HEK cell‐based COMET assay Open
This study focuses on characterizing the forced degradation products of antidiabetic drugs glimepiride (GMD) and glyburide (GBD), with previously unexplored genotoxicity. Drugs underwent stress induced by acid, base, and hydrogen peroxide.…