Wangshu Xu
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View article: <sup>18</sup> F‐ FDG PET Reveals a Nucleus Accumbens‐Centered Metabolic Network Correlating With Clinical Severity in Anti‐LGI1 Encephalitis
<sup>18</sup> F‐ FDG PET Reveals a Nucleus Accumbens‐Centered Metabolic Network Correlating With Clinical Severity in Anti‐LGI1 Encephalitis Open
The metabolic signature of anti‐leucine‐rich glioma‐inactivated 1 (anti‐LGI1) autoimmune encephalitis remains poorly defined. We sought to delineate disease‐specific 18 F‐FDG PET patterns and assess their relationships with clinical severi…
View article: <scp> <sup>18</sup> F </scp> ‐ <scp>FDG PET</scp> / <scp>CT</scp> Reveals Characteristic Prefrontal‐Posterior Cingulate Hypometabolism in <scp>anti‐AMPAR</scp> Encephalitis to Understand Cerebral Function: Insights From an Eight‐Patient Cohort
<span> <sup>18</sup> F </span> ‐ <span>FDG PET</span> / <span>CT</span> Reveals Characteristic Prefrontal‐Posterior Cingulate Hypometabolism in <span>anti‐AMPAR</span> Encephalitis to Understand Cerebral Function: Insights From an Eight‐Patient Cohort Open
Purpose Anti‐AMPAR encephalitis is a rare antibody‐mediated disorder, and its clinicoradiological profile is incompletely defined. We aimed to characterize the clinical presentation and cerebral metabolic patterns of Chinese adults with an…
View article: Targeting serum phosphate trajectory stratification to improve outcomes in high-risk Cardiovascular-Kidney-Metabolic-Sepsis cohorts
Targeting serum phosphate trajectory stratification to improve outcomes in high-risk Cardiovascular-Kidney-Metabolic-Sepsis cohorts Open
Background Sepsis patients exhibit complex clinical conditions, frequently complicated with metabolic dysregulation. Cardiovascular-Kidney-Metabolic Syndrome (C-K-M) is classified as below: stage 0, no C-K-M risk factors; stage 1, excess o…
View article: CIRCULATING INFLAMMATORY PROTEINS IN DRUG-INDUCED ANAPHYLACTIC SHOCK: EVIDENCE FROM MULTIVARIABLE MENDELIAN RANDOMIZATION AND MULTIOMICS INTEGRATION
CIRCULATING INFLAMMATORY PROTEINS IN DRUG-INDUCED ANAPHYLACTIC SHOCK: EVIDENCE FROM MULTIVARIABLE MENDELIAN RANDOMIZATION AND MULTIOMICS INTEGRATION Open
Background : Drug-induced anaphylactic shock (DIAS) remained a critical clinical challenge due to increased drug use and novel hypersensitivity mechanisms. The role of circulating inflammatory proteins in DIAS remained unclear. Methods: We…
View article: Multifactorial analysis of clinical prognosis in patients with anti‐N‐methyl‐D‐aspartate receptor encephalitis: a single‐centre cohort study
Multifactorial analysis of clinical prognosis in patients with anti‐N‐methyl‐D‐aspartate receptor encephalitis: a single‐centre cohort study Open
Background This retrospective cohort study investigated the clinical characteristics, treatment regimens and prognostic factors of anti‐N‐methyl‐D‐aspartate receptor (NMDAR) encephalitis in a single‐centre setting between January 2019 and …
View article: Brain lesion characteristics in Chinese multiple sclerosis patients: A <scp>7‐T MRI</scp> cohort study
Brain lesion characteristics in Chinese multiple sclerosis patients: A <span>7‐T MRI</span> cohort study Open
Objective Prevalence, susceptibility genes, and clinical and radiological features may differ across different ethnic groups of multiple sclerosis (MS). We aim to characterize brain lesions in Chinese patients with MS by use of 7‐T MRI. Me…
View article: Development of a novel nomogram for predicting prognosis of North Chinese with autoimmune cerebellar ataxia
Development of a novel nomogram for predicting prognosis of North Chinese with autoimmune cerebellar ataxia Open
We successfully developed a nomogram to predict poor prognosis for ACA patients using risk factors of age, elevated CSF-ALB and abnormal MRI.
View article: CCL4 as a potential serum factor in differential diagnosis of central nervous system inflammatory diseases and gliomas
CCL4 as a potential serum factor in differential diagnosis of central nervous system inflammatory diseases and gliomas Open
Computed tomography (CT) scans and magnetic resonance imaging (MRI) are commonly utilized to detect brain gliomas and central nervous system inflammation diseases. However, there are instances where depending solely on medical imaging for …
View article: Targeting chemoattractant chemokine (C–C motif) ligand 2 derived from astrocytes is a promising therapeutic approach in the treatment of neuromyelitis optica spectrum disorders
Targeting chemoattractant chemokine (C–C motif) ligand 2 derived from astrocytes is a promising therapeutic approach in the treatment of neuromyelitis optica spectrum disorders Open
Introduction Aquaporin-4 immunoglobulin G (AQP4-IgG)-induced astrocytes injury is a key mechanism in the pathogenesis of neuromyelitis spectrum disorder (NMOSD), and although CCL2 is involved, its specific role has not been reported. We ai…
View article: Soluble TREM2 is a potential biomarker for the severity of primary angiitis of the CNS
Soluble TREM2 is a potential biomarker for the severity of primary angiitis of the CNS Open
Background Primary angiitis of the central nervous system (PACNS) is a severe inflammatory disease, and soluble triggering receptor expressed on myeloid cells 2 (sTREM2) has been reported to be associated with inflammation of the CNS. Howe…
View article: Efficient and stable carbon-based CsPbBr<sub>3</sub> solar cells added with PEABr additive
Efficient and stable carbon-based CsPbBr<sub>3</sub> solar cells added with PEABr additive Open
In recent years, organic-inorganic hybrid perovskite solar cells have become a research hotspot in the photovoltaic field because of their excellent power conversion efficiency. However, this hybrid perovskite material's intrinsic instabil…
View article: Novel Mutation of SIK1 Gene Causing a Mild Form of Pediatric Epilepsy in a Chinese Family
Novel Mutation of SIK1 Gene Causing a Mild Form of Pediatric Epilepsy in a Chinese Family Open
Objective: Early infantile epileptic encephalopathy (EIEE) is a group of disorders affecting children at early stages of infancy, which is characterized by frequent seizures, epileptiform activity on EEG, and developmental retardation or r…
View article: A Radiomics Approach for Prediction of PD-L1 Expression in Cervical Cancer Patients: An Initial Result
A Radiomics Approach for Prediction of PD-L1 Expression in Cervical Cancer Patients: An Initial Result Open
Programmed death ligand 1 (PD-L1) expression level plays an important role in guiding immune therapy for cervical cancer patients according to the latest version of NCCN (Version 3. 2019). We aimed to assess if quantitative radiomic featur…
View article: Cortical Thinning and Ventricle Enlargement in Neuromyelitis Optica Spectrum Disorders
Cortical Thinning and Ventricle Enlargement in Neuromyelitis Optica Spectrum Disorders Open
Background: In neuromyelitis optica spectrum disorders (NMOSDs), inflammation is not the sole driver of accumulation of disability; neurodegeneration is another important pathological process. We aim to explore different patterns of cortic…
View article: Anti-NMDA receptor encephalitis concomitant with myelin oligodendrocyte glycoprotein antibody diseases
Anti-NMDA receptor encephalitis concomitant with myelin oligodendrocyte glycoprotein antibody diseases Open
Anti-N-methyl-D-aspartate receptor encephalitis (NMDARe) can coexist with myelin oligodendrocyte glycoprotein antibody (MOG-ab) disease.To characterize MOG-ab disease during NMDARe, we analyzed all the patients with MOG-ab disease and NMDA…
View article: Persistently Gadolinium Enhancing Lesion is Predictor of Poor Prognosis in NMOSD Attack: A Clinical Trial
Persistently Gadolinium Enhancing Lesion is Predictor of Poor Prognosis in NMOSD Attack: A Clinical Trial Open
Background: Gadolinium (Gd)-contrast MRI, reliable detecting blood-brain barrier (BBB) breakdown, is widely used in neuromyelitis optica spectrum disorder (NMOSD) attack. To investigate the predictive value of persistently Gadolinium-enhan…
View article: C1Q/TNF-related protein 4 expression correlates with herpes simplex encephalitis progression
C1Q/TNF-related protein 4 expression correlates with herpes simplex encephalitis progression Open
Our findings suggest that CTRP4 is highly expressed in HSE and is closely related to the progression of HSE. Thus, CTRP4 may serve as a potential severity index for HSE and targeting CTRP4 might be a promising therapeutic strategy against …
View article: CSF-S100B Is a Potential Candidate Biomarker for Neuromyelitis Optica Spectrum Disorders
CSF-S100B Is a Potential Candidate Biomarker for Neuromyelitis Optica Spectrum Disorders Open
Astrocytic impairment is a pathologic feature of neuromyelitis optica spectrum disorder (NMOSD). S100B and glial fibrillary acidic protein (GFAP) are the two most commonly used astrocytic markers. The aim of this study was to evaluate whet…
View article: Bumetanide promotes neural precursor cell regeneration and dendritic development in the hippocampal dentate gyrus in the chronic stage of cerebral ischemia
Bumetanide promotes neural precursor cell regeneration and dendritic development in the hippocampal dentate gyrus in the chronic stage of cerebral ischemia Open
Bumetanide has been shown to lessen cerebral edema and reduce the infarct area in the acute stage of cerebral ischemia. Few studies focus on the effects of bumetanide on neuroprotection and neurogenesis in the chronic stage of cerebral isc…