Xintao Shuai
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View article: Tirzepatide retention in iWAT with mesoporous polydopamine encapsulation enhances weight loss through leptin receptor signaling
Tirzepatide retention in iWAT with mesoporous polydopamine encapsulation enhances weight loss through leptin receptor signaling Open
These findings indicate that the retention of TZP in iWAT via MPDA encapsulation amplified its effect on weight loss in mice through leptin receptor signaling compared with TZP alone, which provides new insights into the tissue-specific me…
View article: A Multifunctional Molecular Probe for Multimodal Imaging‐Guided Potent Photothermal/Photodynamic Therapy of Endometriosis
A Multifunctional Molecular Probe for Multimodal Imaging‐Guided Potent Photothermal/Photodynamic Therapy of Endometriosis Open
Multifunctional small‐molecule theranostic agents hold significant clinical potential for non‐invasive endometriosis (EMS) management. Current EMS treatment faces challenges due to imprecise lesion localization and therapy‐associated side …
View article: Engineering Mesenchymal Stem Cells with Antioxidant Catalase‐Loaded Metal–Organic Frameworks for Targeted Spinal Cord Injury Therapy
Engineering Mesenchymal Stem Cells with Antioxidant Catalase‐Loaded Metal–Organic Frameworks for Targeted Spinal Cord Injury Therapy Open
Spinal cord injury (SCI) therapy is challenging because of the associated irreversible neurological deficits. These deficits are caused by primary damage and secondary pathological processes such as oxidative stress and inflammation. Altho…
View article: Harnessing PD-1-overexpressing macrophage membrane for preparation of lenvatinib-loaded vesicles to boost immunotherapy against HCC recurrence after radiofrequency ablation
Harnessing PD-1-overexpressing macrophage membrane for preparation of lenvatinib-loaded vesicles to boost immunotherapy against HCC recurrence after radiofrequency ablation Open
Hepatocellular carcinoma (HCC) is characterized by high malignancy, high recurrence rate and poor prognosis. Radiofrequency ablation (RFA) is the first-line curative treatment for early-stage HCC. Yet, effective inhibition of local recurre…
View article: Reprogramming Glucose Metabolism of Macrophage for Acute Liver Failure Therapy with Itaconate Lipo‐Nanodrug
Reprogramming Glucose Metabolism of Macrophage for Acute Liver Failure Therapy with Itaconate Lipo‐Nanodrug Open
Acute liver failure (ALF) is a life‐threatening disease featuring comprehensive inflammatory response and metabolic disorders in which macrophages exert central roles. A glucose metabolism mediator of macrophages, itaconate, has demonstrat…
View article: Dual-Targeting Nanoparticles Enhance Microglial P2Y12R Expression to Promote Neuronal Mitophagy for Repairing Spinal Cord Injury
Dual-Targeting Nanoparticles Enhance Microglial P2Y12R Expression to Promote Neuronal Mitophagy for Repairing Spinal Cord Injury Open
Spinal cord injury (SCI) leads to severe mitochondrial dysfunction and ROS cascade, with microglia playing a dual role in both exacerbating damage and providing neuroprotection. Recent evidence has highlighted the importance of P2Y12R in m…
View article: The hybrid lipoplex induces cytoskeletal rearrangement via autophagy/RhoA signaling pathway for enhanced anticancer gene therapy
The hybrid lipoplex induces cytoskeletal rearrangement via autophagy/RhoA signaling pathway for enhanced anticancer gene therapy Open
Delivering plasmid DNA (pDNA) to solid tumors remains a significant challenge due to the requirement for multiple transport steps and the need to promote delivery efficiency. Herein, we present a virus-mimicking hybrid lipoplex, composed o…
View article: Harnessing Pd-1-Overexpressing Macrophage Membrane for Preparation of Lenvatinib-Loaded Vesicles to Boost Immunotherapy Against Hcc Recurrence after Radiofrequency Ablation
Harnessing Pd-1-Overexpressing Macrophage Membrane for Preparation of Lenvatinib-Loaded Vesicles to Boost Immunotherapy Against Hcc Recurrence after Radiofrequency Ablation Open
View article: Biomimetic nanostructural materials based on placental amniotic membrane-derived nanofibers for self-healing and anti-adhesion during cesarean section
Biomimetic nanostructural materials based on placental amniotic membrane-derived nanofibers for self-healing and anti-adhesion during cesarean section Open
Cesarean section (CS) is highly prevalent surgery among females. However, current absorbable anti-adhesion membranes used clinically can partially prevent postoperative adhesions but show limited efficacy in tissue regeneration, leaving po…
View article: γ-Glutamyl transpeptidase-activable nanoprobe crosses the blood-brain barrier for immuno-sonodynamic therapy of glioma
γ-Glutamyl transpeptidase-activable nanoprobe crosses the blood-brain barrier for immuno-sonodynamic therapy of glioma Open
View article: Bionanoparticles with In Situ Nitric Oxide Release for Precise Modulation of ER‐TRPV1 Ion Channels in Multimodal Killing of Glioblastoma
Bionanoparticles with In Situ Nitric Oxide Release for Precise Modulation of ER‐TRPV1 Ion Channels in Multimodal Killing of Glioblastoma Open
Glioblastoma (GBM) with highly immunosuppressive tumor microenvironment is a significant factor contributing to its treatment resistance and low survival rate. The activation of the transient receptor potential vanilloid 1 (TRPV1) ion chan…
View article: Mesoporous Polydopamine Nanotherapeutics for MRI-Guided Cancer Photothermal and Anti-Inflammatory Therapy
Mesoporous Polydopamine Nanotherapeutics for MRI-Guided Cancer Photothermal and Anti-Inflammatory Therapy Open
The incorporation of Arg doping into MAGM NPs was intended to boost its photothermal conversion efficiency and reactive oxygen species (ROS) scavenging ability. Additionally, synergizing with the anti-inflammatory agent meloxicam (MX) with…
View article: <sup>19</sup> F MRI/CEUS Dual Imaging‐Guided Sonodynamic Therapy Enhances Immune Checkpoint Blockade in Triple‐Negative Breast Cancer
<sup>19</sup> F MRI/CEUS Dual Imaging‐Guided Sonodynamic Therapy Enhances Immune Checkpoint Blockade in Triple‐Negative Breast Cancer Open
Treatment of highly aggressive triple‐negative breast cancer (TNBC) in the clinic is challenging. Here, a liposome nanodrug (LP@PFH@HMME) integrating imaging agents and therapeutic agents for bimodal imaging‐guided sonodynamic therapy (SDT…
View article: Black phosphorus quantum dots prevent atherosclerosis in high-fat diet-fed apolipoprotein E knockout mice
Black phosphorus quantum dots prevent atherosclerosis in high-fat diet-fed apolipoprotein E knockout mice Open
Atherosclerosis (AS) is the main pathological basis of cardiovascular diseases such as coronary heart disease. Black phosphorus quantum dots (BPQDs) are a novel nanomaterial with good optical properties and biocompatibility, which was appl…
View article: Blood Brain Barrier‐Crossing Delivery of Felodipine Nanodrug Ameliorates Anxiety‐Like Behavior and Cognitive Impairment in Alzheimer's Disease
Blood Brain Barrier‐Crossing Delivery of Felodipine Nanodrug Ameliorates Anxiety‐Like Behavior and Cognitive Impairment in Alzheimer's Disease Open
Alzheimer's disease (AD) is the most common age‐related neurodegenerative disorder leading to cognitive decline. Excessive cytosolic calcium (Ca 2+ ) accumulation plays a critical role in the pathogenesis of AD since it activates the NOD‐l…
View article: Multifunctional Nanodrug‐Mediated Immunotherapy in Microsatellite Stable Colorectal Cancer via Promoting m6A Modification and M1‐Like Tumor‐Associated Macrophages Polarization
Multifunctional Nanodrug‐Mediated Immunotherapy in Microsatellite Stable Colorectal Cancer via Promoting m6A Modification and M1‐Like Tumor‐Associated Macrophages Polarization Open
Immunotherapy has made great progress in various solid tumors. However, the “cold” tumor immune microenvironment of microsatellite stable subtype colorectal cancer (MSS‐CRC) hinders the effectiveness of immunotherapy. Therefore, reshaping …
View article: Inside Back Cover: Twins‐like nanodrugs synchronously transport in blood and coalesce inside tumors for sensitive ultrasound imaging and triggerable penetrative drug delivery
Inside Back Cover: Twins‐like nanodrugs synchronously transport in blood and coalesce inside tumors for sensitive ultrasound imaging and triggerable penetrative drug delivery Open
View article: Black Phosphorus Microbubbles Combined with Ultrasound for Treating Parkinson's Disease (Adv. Therap. 5/2024)
Black Phosphorus Microbubbles Combined with Ultrasound for Treating Parkinson's Disease (Adv. Therap. 5/2024) Open
View article: Author Correction: Chromosomal translocation-derived aberrant Rab22a drives metastasis of osteosarcoma
Author Correction: Chromosomal translocation-derived aberrant Rab22a drives metastasis of osteosarcoma Open
View article: Twins‐like nanodrugs synchronously transport in blood and coalesce inside tumors for sensitive ultrasound imaging and triggerable penetrative drug delivery
Twins‐like nanodrugs synchronously transport in blood and coalesce inside tumors for sensitive ultrasound imaging and triggerable penetrative drug delivery Open
Nanodrugs capable of aggregating in the tumor microenvironment (TME) have demonstrated great efficiency in improving the therapeutic outcome. Among various approaches, the strategy utilizing electrostatic interaction as a driving force to …
View article: Contents list
Contents list Open
An international high impact journal exploring the underlying science behind the function, interactions and design of biomaterials rsc.li/biomaterials-scienceThe Royal Society of Chemistry is the world's leading chemistry community.Through…
View article: Correction: MnO<sub>2</sub>/Ce6 microbubble-mediated hypoxia modulation for enhancing sono-photodynamic therapy against triple negative breast cancer
Correction: MnO<sub>2</sub>/Ce6 microbubble-mediated hypoxia modulation for enhancing sono-photodynamic therapy against triple negative breast cancer Open
Correction for ‘MnO 2 /Ce6 microbubble-mediated hypoxia modulation for enhancing sono-photodynamic therapy against triple negative breast cancer’ by Ping Li et al. , Biomater. Sci. , 2024, https://doi.org/10.1039/d3bm00931a.
View article: Real-Time ROS Monitoring-Guided Tumor Electrodynamic Therapy Using a Metal Microneedle Array System
Real-Time ROS Monitoring-Guided Tumor Electrodynamic Therapy Using a Metal Microneedle Array System Open
View article: MnO<sub>2</sub>/Ce6 microbubble-mediated hypoxia modulation for enhancing sono-photodynamic therapy against triple negative breast cancer
MnO<sub>2</sub>/Ce6 microbubble-mediated hypoxia modulation for enhancing sono-photodynamic therapy against triple negative breast cancer Open
Sono-photodynamic therapy (SPDT) has emerged as a promising treatment modality for triple negative breast cancer (TNBC).
View article: Anchoring Microbubbles on Cerebrovascular Endothelium as a New Strategy Enabling Low‐Energy Ultrasound‐Assisted Delivery of Varisized Agents Across Blood‐Brain Barrier
Anchoring Microbubbles on Cerebrovascular Endothelium as a New Strategy Enabling Low‐Energy Ultrasound‐Assisted Delivery of Varisized Agents Across Blood‐Brain Barrier Open
The protective blood‐brain barrier (BBB) prevents most therapeutic agents from entering the brain. Currently, focused ultrasound (FUS) is mostly employed to create microbubbles that induce a cavitation effect to open the BBB. However, micr…
View article: Saponin‐Encapsulated Microbubbles Protect Dopaminergic Neurons from MPTP‐Induced Oxidative Stress Injury (Adv. Therap. 10/2023)
Saponin‐Encapsulated Microbubbles Protect Dopaminergic Neurons from MPTP‐Induced Oxidative Stress Injury (Adv. Therap. 10/2023) Open
Ginsenoside Rb3 nanoparticles (Rb3NPs) is a potential antioxidant for Parkinson's disease (PD) treatment. In Article 2300056, Xintao Shuai, Jie Shi, Yun Chen, Tingting Zheng, and co-workers introduce phospholipid microbubbles encapsulated …
View article: Nanodrug removes physical barrier to promote T-cell infiltration for enhanced cancer immunotherapy
Nanodrug removes physical barrier to promote T-cell infiltration for enhanced cancer immunotherapy Open
The dense extracellular matrix (ECM) is a key barrier to tumor infiltration of cytotoxic T lymphocytes (CTLs), which greatly compromises T cell-dependent immunotherapy of hepatocellular carcinoma (HCC). Herein, hyaluronidase (HAase), IL-12…
View article: Stiffness-tuned and ROS-sensitive hydrogel incorporating complement C5a receptor antagonist modulates antibacterial activity of macrophages for periodontitis treatment
Stiffness-tuned and ROS-sensitive hydrogel incorporating complement C5a receptor antagonist modulates antibacterial activity of macrophages for periodontitis treatment Open
View article: Holmium (Iii)-Doped Multifunctional Nanotheranostic Agent for Ultra-High-Field Magnetic Resonance Imaging-Guided Chemo-Photothermal Tumor Therapy
Holmium (Iii)-Doped Multifunctional Nanotheranostic Agent for Ultra-High-Field Magnetic Resonance Imaging-Guided Chemo-Photothermal Tumor Therapy Open
View article: Multifunctional Nanodrug Performs Sonodynamic Therapy and Inhibits TGF-β to Boost Immune Responses Against Colorectal Cancer and Liver Metastasis
Multifunctional Nanodrug Performs Sonodynamic Therapy and Inhibits TGF-β to Boost Immune Responses Against Colorectal Cancer and Liver Metastasis Open