Shuaiya Ma
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View article: Soluble Tim-3 serves as a tumor prognostic marker and therapeutic target for CD8+ T cell exhaustion and anti-PD-1 resistance
Soluble Tim-3 serves as a tumor prognostic marker and therapeutic target for CD8+ T cell exhaustion and anti-PD-1 resistance Open
Resistance to PD-1 blockade in onco-immunotherapy greatly limits its clinical application. T cell immuno- globulin and mucin domain containing-3 (Tim-3), a promising immune checkpoint target, is cleaved by ADAM10/17 to produce its soluble …
View article: Urolithin A Hijacks ERK1/2‐ULK1 Cascade to Improve CD8<sup>+</sup> T Cell Fitness for Antitumor Immunity
Urolithin A Hijacks ERK1/2‐ULK1 Cascade to Improve CD8<sup>+</sup> T Cell Fitness for Antitumor Immunity Open
According to the latest evidence, the microbial metabolite Urolithin A (UA), known for its role in promoting cellular health, modulates CD8 + T cell‐mediated antitumor activity. However, the direct target protein of UA and its underlying m…
View article: Cover Image, Volume 42, Issue 8
Cover Image, Volume 42, Issue 8 Open
The cover image is based on the Correspondence Intrinsic PD‐L1 promotes antitumor activity of CD8(+) cytotoxic T lymphocytes via in cis interaction with CD80 by Yuming Ding et al., https://doi.org/10.1002/cac2.12337. [Image: see text]
View article: Intrinsic PD‐L1 promotes antitumor activity of CD8<sup>+</sup> cytotoxic T lymphocytes via <i>in cis</i> interaction with CD80
Intrinsic PD‐L1 promotes antitumor activity of CD8<sup>+</sup> cytotoxic T lymphocytes via <i>in cis</i> interaction with CD80 Open
Dear Editor, Programmed cell death-ligand 1 (PD-L1) on tumor cells can inhibit CD8+ cytotoxic T lymphocyte (CTL)-mediated antitumor response by trans-engagement with programmed death protein 1 (PD-1). Besides tumor cells, PD-L1 is expresse…