Shuang‐Jiang Liu
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View article: Shared Gut Microbial and Functional Signatures Linking Parkinson’s Disease and Type 2 Diabetes Revealed by Function-Anchored Metagenomics
Shared Gut Microbial and Functional Signatures Linking Parkinson’s Disease and Type 2 Diabetes Revealed by Function-Anchored Metagenomics Open
Parkinson’s disease (PD) and type 2 diabetes mellitus (T2DM) exhibit increasing comorbidity, yet the shared contribution of gut microbiota remains unclear. To investigate parallel microbial and functional alterations underlying PD, T2DM, a…
View article: A nonenzymatic effector disrupts <i>Bacteroides</i> cell wall homeostasis via OmpA targeting to mediate interbacterial competition
A nonenzymatic effector disrupts <i>Bacteroides</i> cell wall homeostasis via OmpA targeting to mediate interbacterial competition Open
The human gut microbiome is a dynamic ecosystem where bacteria engage in interspecies competition using molecular weapons such as the type VI secretion system (T6SS). Here, we characterize BteO–BtiO, a unique effector–immunity pair in Bact…
View article: Shaping the future of probiotics, live biotherapeutic products, and fecal microbiota transplantation: 30 scientific recommendations from the CHINAGUT Conference
Shaping the future of probiotics, live biotherapeutic products, and fecal microbiota transplantation: 30 scientific recommendations from the CHINAGUT Conference Open
The 2025 CHINAGUT Conference has assembled a panel of 63 experts (30 scientists, 26 physicians, and 7 corporate R&D personnel) collaborated in three groups to present 30 scientific recommendations to advance probiotics, live biotherapeutic…
View article: Heterotrophic ammonia oxidation by <i>Alcaligenes</i> balances ROS generation and terminal electron transport
Heterotrophic ammonia oxidation by <i>Alcaligenes</i> balances ROS generation and terminal electron transport Open
Heterotrophic nitrifiers are bacteria that aerobically oxidize ammonia in the presence of organic carbon sources, which differs from autotrophic nitrifiers that extract energy from ammonia oxidation for cell metabolism and growth. The phys…
View article: <i>Akkermansia muciniphila</i>‐derived hypoacylated rough‐type lipopolysaccharides alleviate diet‐induced obesity via activation of TLR4−IL‐23−IL‐22 immune axis
<i>Akkermansia muciniphila</i>‐derived hypoacylated rough‐type lipopolysaccharides alleviate diet‐induced obesity via activation of TLR4−IL‐23−IL‐22 immune axis Open
Lipopolysaccharides (LPS) derived from intestinal symbionts plays a critical role in modulating and maintaining mucosal immunity. In this study, we investigated the chemical characteristics and antiobesity properties of Akkermansia mucinip…
View article: Flavonifractor porci sp. nov. and Flintibacter porci sp. nov., two novel butyrate-producing bacteria of the family Oscillospiraceae
Flavonifractor porci sp. nov. and Flintibacter porci sp. nov., two novel butyrate-producing bacteria of the family Oscillospiraceae Open
Two Gram-stain-negative, strictly anaerobic, non-motile, non-spore-forming and rod-shaped bacterial strains, namely, P01024 T and P01025 T , were isolated from piglet manure. The strains P01024 T and P01025 T fermented glucose to acetate …
View article: Mechanosensory Piezo2 regulated by gut microbiota participates in the development of visceral hypersensitivity and intestinal dysmotility
Mechanosensory Piezo2 regulated by gut microbiota participates in the development of visceral hypersensitivity and intestinal dysmotility Open
The gut microbiota plays a crucial role in the manifestation of intestinal dysfunction associated with irritable bowel syndrome (IBS). The mechanosensory Piezo2 has been implicated in the regulation of intestinal function. However, it rema…
View article: Potential pitfalls in claiming novel taxa
Potential pitfalls in claiming novel taxa Open
Prokaryotic taxonomy based on short 16S rRNA sequences may lead to an overestimation of microbial diversity. In addition, a lack of sufficient coverage of previously reported taxa may lead to repetition or overestimation of novel taxa. In …
View article: Identification and Characterization of Two Novel Members of the Family Eubacteriaceae, Anaerofustis butyriciformans sp. nov. and Pseudoramibacter faecis sp. nov., Isolated from Human Feces
Identification and Characterization of Two Novel Members of the Family Eubacteriaceae, Anaerofustis butyriciformans sp. nov. and Pseudoramibacter faecis sp. nov., Isolated from Human Feces Open
Members of Eubacteriaceae are involved in host health and diseases. Two Gram-stain-positive, strictly anaerobic, non-motile, non-spore-forming, and rod-shaped bacterial strains, HA2171T and HA2172T, were isolated from the feces of Chinese …
View article: Cross-feeding-based rational design of a probiotic combination of <i>Bacterides xylanisolvens</i> and <i>Clostridium butyricum</i> therapy for metabolic diseases
Cross-feeding-based rational design of a probiotic combination of <i>Bacterides xylanisolvens</i> and <i>Clostridium butyricum</i> therapy for metabolic diseases Open
The human gut microbiota has gained interest as an environmental factor that contributes to health or disease. The development of next-generation live biotherapeutic products (LBPs) is a promising strategy to modulate the gut microbiota an…
View article: Unusual MurC Ligase and Peptidoglycan Discovered in Lachnospiraceae Using a Fluorescent L‐Amino Acid Based Selective Labeling Probe
Unusual MurC Ligase and Peptidoglycan Discovered in Lachnospiraceae Using a Fluorescent L‐Amino Acid Based Selective Labeling Probe Open
Developing selective labeling probes for specific bacterial taxa can not only facilitate the study of target bacteria but also deepen our understanding of the microbial diversity at structural and molecular levels. The availability of such…
View article: Unusual MurC Ligase and Peptidoglycan Discovered in Lachnospiraceae Using a Fluorescent L‐Amino Acid Based Selective Labeling Probe
Unusual MurC Ligase and Peptidoglycan Discovered in Lachnospiraceae Using a Fluorescent L‐Amino Acid Based Selective Labeling Probe Open
Developing selective labeling probes for specific bacterial taxa can not only facilitate the study of target bacteria but also deepen our understanding of the microbial diversity at structural and molecular levels. The availability of such…
View article: <b>Berberrubine Inhibits <i>Helicobacter pylori</i> by Inducing Oxidative Stress</b>
<b>Berberrubine Inhibits <i>Helicobacter pylori</i> by Inducing Oxidative Stress</b> Open
Helicobacter pylori is a prevalent pathogen that colonizes the pylorus and contributes to the pathogenesis of gastric cancer. The increasing antibiotic resistance in H. pylori presents a substantial challenge for effective eradication, mak…
View article: Characterization of Tetrathionate Hydrolase from Acidothermophilic Sulfur-Oxidizing Archaeon Metallosphaera cuprina Ar-4
Characterization of Tetrathionate Hydrolase from Acidothermophilic Sulfur-Oxidizing Archaeon Metallosphaera cuprina Ar-4 Open
Tetrathionate hydrolase (TTH) is a key enzyme for the oxidation of reduced inorganic sulfur compounds (RISCs) with the S4I pathway, which is distributed in autotrophic or facultative autotrophic sulfur-oxidizing bacteria and archaea. In th…
View article: Structural basis for the ligand-dependent activation of heterodimeric AHR-ARNT complex
Structural basis for the ligand-dependent activation of heterodimeric AHR-ARNT complex Open
The aryl hydrocarbon receptor (AHR) possesses an extraordinary capacity to sense and respond to a wide range of small-molecule ligands, ranging from polycyclic aromatic hydrocarbons to endogenous compounds. Upon ligand binding, AHR translo…
View article: Characterization of Tetrathionate Hydrolase from Acidothermophilic Sulfur-oxidizing <em>Archaeon Metallosphaera cuprina</em> Ar-4
Characterization of Tetrathionate Hydrolase from Acidothermophilic Sulfur-oxidizing <em>Archaeon Metallosphaera cuprina</em> Ar-4 Open
Tetrathionate hydrolase (TTH) is a key enzyme for oxidation of reduced inorganic sulfur compounds (RISCs) with S4I pathway, which is distributed in autotrophic or facultative auto-trophic sulfur-oxidizing bacteria and archaea. In this stud…
View article: Clostridium lapidicellarium sp. nov. and Clostridium moutaii sp. nov., two species isolated from fermentation cellar-producing sauce-flavour Chinese baijiu
Clostridium lapidicellarium sp. nov. and Clostridium moutaii sp. nov., two species isolated from fermentation cellar-producing sauce-flavour Chinese baijiu Open
Clostridium is an important microbial component in pit mud due to its ability to produce alcohol and short-chain fatty acids. This study presents the characterization and taxonomy of two Gram-stain-positive, strictly anaerobic, rod-shaped …
View article: The rheumatoid arthritis gut microbial biobank reveals core microbial species that associate and effect on host inflammation and autoimmune responses
The rheumatoid arthritis gut microbial biobank reveals core microbial species that associate and effect on host inflammation and autoimmune responses Open
Gut microbiota dysbiosis has been implicated in rheumatoid arthritis (RA) and influences disease progression. Although molecular and culture‐independent studies revealed RA patients harbored a core microbiome and had characteristic bacteri…
View article: Limosilactobacillus reuteri Alleviates Anxiety-like Behavior and Intestinal Symptoms in Two Stressed Mouse Models
Limosilactobacillus reuteri Alleviates Anxiety-like Behavior and Intestinal Symptoms in Two Stressed Mouse Models Open
Background/Objectives: Limosilactobacillus (Lm.) reuteri is a widely utilized probiotic, recognized for its significant role in alleviating symptoms associated with gastrointestinal and psychiatric disorders. However, the effectiveness of …
View article: The Ambiguous Correlation of Blautia with Obesity: A Systematic Review
The Ambiguous Correlation of Blautia with Obesity: A Systematic Review Open
Obesity is a complex and multifactorial disease with global epidemic proportions, posing significant health and economic challenges. Whilst diet and lifestyle are well-established contributors to the pathogenesis, the gut microbiota’s role…
View article: Acutalibacter caecimuris sp. nov., Acutalibacter intestini sp. nov. and Neglectibacter caecimuris sp. nov., three novel species of the family Oscillospiraceae isolated from caecal contents of C57BL/6J mice
Acutalibacter caecimuris sp. nov., Acutalibacter intestini sp. nov. and Neglectibacter caecimuris sp. nov., three novel species of the family Oscillospiraceae isolated from caecal contents of C57BL/6J mice Open
The intestines of mice are colonized by diverse, as-yet-uncultivated bacteria. In this report, we describe the isolation, culture, genotypic and phenotypic characterization, as well as taxonomic classification of three novel anaerobic bact…
View article: Acidithiobacillus acidisediminis sp. nov., an acidophilic sulphur-oxidizing chemolithotroph isolated from acid mine drainage sediment
Acidithiobacillus acidisediminis sp. nov., an acidophilic sulphur-oxidizing chemolithotroph isolated from acid mine drainage sediment Open
Strain S30A2 T , isolated from the acid mine drainage sediment of Mengzi Copper Mine, Yunnan, is proposed to represent a novel species of the sulphur-oxidizing genus Acidithiobacillus . Cells were Gram-stain-negative, non-endospore forming…
View article: Lacticaseibacillus rhamnosus Strains for Alleviation of Irritable Bowel Disease and Chronic Fatigue Syndrome
Lacticaseibacillus rhamnosus Strains for Alleviation of Irritable Bowel Disease and Chronic Fatigue Syndrome Open
Lacticaseibacillus rhamnosus is applied as a probiotic to alleviate various metabolic, gastrointestinal, and psychological symptoms and diseases, and its probiotic effectiveness is strain-specific. In this study, we obtained 21 strains of …
View article: Advancements in prokaryotic systematics and the role of Bergey's International Society for Microbial Systematicsin addressing challenges in the meta-data era
Advancements in prokaryotic systematics and the role of Bergey's International Society for Microbial Systematicsin addressing challenges in the meta-data era Open
Prokaryotes are ubiquitous in the biosphere, important for human health and drive diverse biological and environmental processes. Systematics of prokaryotes, whose origins can be traced to the discovery of microorganisms in the 17th centur…