Shuangshuang Jia
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View article: Protective Effects of <i> <scp>HLA</scp> ‐ <scp>DRB1</scp> *08:03 </i> and <i> <scp>HLA</scp> ‐ <scp>DQA1</scp> *01:03 </i> Alleles for Alloanti‐D Immunisation in the Southern Chinese D‐Negative Pregnant Women
Protective Effects of <i> <span>HLA</span> ‐ <span>DRB1</span> *08:03 </i> and <i> <span>HLA</span> ‐ <span>DQA1</span> *01:03 </i> Alleles for Alloanti‐D Immunisation in the Southern Chinese D‐Negative Pregnant Women Open
Alloanti‐D is still one of the most common causes of severe hemolytic disease of the fetus and newborn in China, as rhesus immunoglobulin (RhIG) prophylaxis is not a routine practice throughout China. HLA plays an important role in the sus…
View article: Partial s antigen expression in GP(B-A-B) hybrid glycophorins and the corresponding in vitro expression study.
Partial s antigen expression in GP(B-A-B) hybrid glycophorins and the corresponding in vitro expression study. Open
The results demonstrated partial s antigen expression on GP(B-A-B) RBCs. In addition to p.Thr48, p.Asn45 is also important for the epitope expression of s antigen detected by IgM anti-s (P3BER). To avoid false negative serologic typing, it…
View article: Identification of a novel variant (c.1‐<scp>111A</scp>>G) located in <scp>GATA</scp>‐1 motif of <scp><i>RHCE</i></scp> proximal promoter in two Chinese patients with the rare D‐‐ phenotype
Identification of a novel variant (c.1‐<span>111A</span>>G) located in <span>GATA</span>‐1 motif of <span><i>RHCE</i></span> proximal promoter in two Chinese patients with the rare D‐‐ phenotype Open
Background D‐‐ is a rare phenotype lacking the expression of the C, c, E, and e antigens and several high‐frequency antigens on the red cells. Anti‐Rh17 (Hr0) could be developed in individuals with the D‐‐ phenotype to cause hemolytic tran…
View article: Characterisation of the Novel <scp><i>HLA‐DPB1*1781:01</i></scp> Allele Using Oxford Nanopore Sequencing Technology
Characterisation of the Novel <span><i>HLA‐DPB1*1781:01</i></span> Allele Using Oxford Nanopore Sequencing Technology Open
HLA‐DPB1*1781:01 differs from HLA‐DPB1*03:01:01:01 by one nonsynonymous nucleotide substitution in codon 5 in exon 1.
View article: Dapagliflozin-affected endothelial dysfunction and altered gut microbiota in mice with heart failure
Dapagliflozin-affected endothelial dysfunction and altered gut microbiota in mice with heart failure Open
Aim To investigate the potential microbiome profile of a mouse model with heart failure (HF) during dapagliflozin treatment. Method An HF model was constructed in 8-week-old male mice, and cardiac tissues were analyzed using histological s…
View article: The High Value of External Anal- and Urethral-Sphincter Electromyography in Differential Diagnosis with MSA-P, PD, and PSP
The High Value of External Anal- and Urethral-Sphincter Electromyography in Differential Diagnosis with MSA-P, PD, and PSP Open
Objective: It is a challenge to differentiate multiple system atrophy parkinsonism (MSA-P), Parkinson’s disease (PD), and progressive supranuclear palsy (PSP). We aimed to explore the value of external anal-sphincter electromyography (EAS-…
View article: Patients with Asian-type DEL can safely be transfused using RhD-positive blood
Patients with Asian-type DEL can safely be transfused using RhD-positive blood Open
Red blood cells (RBCs) of the Asian-type DEL phenotype express few RhD proteins and are typed as serologic RhD-negative (D-) in routine testing. RhD-positive (D+) RBC transfusion for Asian-type DEL patients has been proposed but has not be…
View article: The Characteristics of Cognitive Proficiency in Patients with Acute Neuromyelitis Optica Spectrum Disease and its Correlation with Serum Aquaporin-4 Antibody Titer
The Characteristics of Cognitive Proficiency in Patients with Acute Neuromyelitis Optica Spectrum Disease and its Correlation with Serum Aquaporin-4 Antibody Titer Open
Objective: To explore the characteristics and dynamic evolution of cognitive impairment in patients with neuromyelitis optica spectrum disorder (NMOSD). Methods: Twenty-five patients with acute NMOSD and 30 age-matched healthy individuals …
View article: Chromosome 1q21 gain is an adverse prognostic factor for newly diagnosed multiple myeloma patients treated with bortezomib-based regimens
Chromosome 1q21 gain is an adverse prognostic factor for newly diagnosed multiple myeloma patients treated with bortezomib-based regimens Open
Chromosome 1q21 aberration is one of the most common cytogenetic abnormalities in multiple myeloma, and is considered an important prognostic factor. The present study analyzed the clinical relevance and prognostic impact of 1q21 gain in 1…
View article: Fluorescence imaging-guided photothermal therapy of asymmetric water-soluble pentamethine cyanine for colorectal cancer
Fluorescence imaging-guided photothermal therapy of asymmetric water-soluble pentamethine cyanine for colorectal cancer Open
The combination of advanced optical technology and tumor treatment has developed into a selectively targeted tumor therapy strategy. Near-infrared (NIR) cyanine derivative has recently received increasing attention in photothermal therapy …
View article: Systematic analysis of prognostic significance, functional enrichment and immune implication of STK10 in acute myeloid leukemia
Systematic analysis of prognostic significance, functional enrichment and immune implication of STK10 in acute myeloid leukemia Open
Background Despite deeper understanding of the genetic landscape of acute myeloid leukemia (AML), the improvement of survival is still a great challenge. STK10 is overexpressed in several cancers with functions varying according to cancer …
View article: Development and Validation of a Novel Prognostic Model for Overall Survival in Newly Diagnosed Multiple Myeloma Integrating Tumor Burden and Comorbidities
Development and Validation of a Novel Prognostic Model for Overall Survival in Newly Diagnosed Multiple Myeloma Integrating Tumor Burden and Comorbidities Open
Background Multiple myeloma (MM) is a highly heterogeneous disease with enormously variable outcomes. It remains to be a major challenge to conduct a more precise estimation of the survival of MM patients. The existing stratifications atta…
View article: HMGB1 Promotes Lymphangiogenesis through the Activation of RAGE on M2 Macrophages in Laryngeal Squamous Cell Carcinoma
HMGB1 Promotes Lymphangiogenesis through the Activation of RAGE on M2 Macrophages in Laryngeal Squamous Cell Carcinoma Open
Background. Receptor for advanced glycation end products (RAGE) is implicated in tumor biology. Released high mobility group box protein 1 (HMGB1) ligand binding to RAGE receptor in tumor cells promotes tumor progression. The mechanisms of…
View article: Heptamethine Cyanine–Based Application for Cancer Theranostics
Heptamethine Cyanine–Based Application for Cancer Theranostics Open
Cancer is the most common life-threatening malignant disease. The future of personalized cancer treatments relies on the development of functional agents that have tumor-targeted anticancer activities and can be detected in tumors through …
View article: Additional file 3 of Systematic analysis of prognostic significance, functional enrichment and immune implication of STK10 in acute myeloid leukemia
Additional file 3 of Systematic analysis of prognostic significance, functional enrichment and immune implication of STK10 in acute myeloid leukemia Open
Additional file 3. The correlation of STK10 with other genes analyzed by the Spearman’s test.
View article: Additional file 2 of Systematic analysis of prognostic significance, functional enrichment and immune implication of STK10 in acute myeloid leukemia
Additional file 2 of Systematic analysis of prognostic significance, functional enrichment and immune implication of STK10 in acute myeloid leukemia Open
Additional file 2. The differential expressed RNA between STK10high and STK10low groups identified by R and limma.
View article: Insight into the Double-Edged Role of Ferroptosis in Disease
Insight into the Double-Edged Role of Ferroptosis in Disease Open
Ferroptosis, a newly described type of iron-dependent programmed cell death that is distinct from apoptosis, necroptosis, and other types of cell death, is involved in lipid peroxidation (LP), reactive oxygen species (ROS) production, and …
View article: Genome-Wide Characterization of HSP90 Gene Family in Cucumber and Their Potential Roles in Response to Abiotic and Biotic Stresses
Genome-Wide Characterization of HSP90 Gene Family in Cucumber and Their Potential Roles in Response to Abiotic and Biotic Stresses Open
Heat shock protein 90 (HSP90) possesses critical functions in plant developmental control and defense reactions. The HSP90 gene family has been studied in various plant species. However, the HSP90 gene family in cucumber has not been chara…
View article: A variant RhAG protein encoded by the <i>RHAG*572A</i> allele causes serological weak D expression while maintaining normal RhCE phenotypes
A variant RhAG protein encoded by the <i>RHAG*572A</i> allele causes serological weak D expression while maintaining normal RhCE phenotypes Open
BACKGROUND The molecular events resulting in a weak D phenotype include missense mutations, in‐frame insertion, or deletion mutations of the RHD gene and hybrid RHD‐CE‐D hybrid alleles. Mutations in genes encoding the proteins that are req…
View article: Immunolocalization of CD163+ Tumor-Associated Macrophages and Symmetric Proliferation of Ki-67 as Biomarkers to Differentiate New Different Grades of Laryngeal Dysplasia
Immunolocalization of CD163+ Tumor-Associated Macrophages and Symmetric Proliferation of Ki-67 as Biomarkers to Differentiate New Different Grades of Laryngeal Dysplasia Open
CD163+ TAMs infiltrating the epithelium and Ki-67 overexpression in the basal layer may serve as biomarkers to differentiate low-grade dysplasia from high-grade dysplasia of the larynx. A symmetric proliferative pattern was observed during…