Shuangshuang Zheng
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View article: The Impact of Asthma Control on the Clinical and Depressive Symptoms in Pediatric Asthma Patients
The Impact of Asthma Control on the Clinical and Depressive Symptoms in Pediatric Asthma Patients Open
Background: Asthma is a common chronic respiratory disease that severely affects children’s health and leads to anxiety and depressive symptoms. Therefore, this study aims to investigate the correlation between asthma control status and de…
View article: Associations between renal function, hippocampal volume, and cognitive impairment in 544 outpatients
Associations between renal function, hippocampal volume, and cognitive impairment in 544 outpatients Open
Background Cognitive impairment and brain atrophy are common in chronic kidney disease patients. It remains unclear whether differences in renal function, even within normal levels, influence hippocampal volume (HCV) and cognition. We aime…
View article: Trend of Mortality Due to Congenital Anomalies in Children Younger Than 5 Years in Eastern China, 2012-2021: Surveillance Data Analysis
Trend of Mortality Due to Congenital Anomalies in Children Younger Than 5 Years in Eastern China, 2012-2021: Surveillance Data Analysis Open
Background As one of the leading causes of child mortality, deaths due to congenital anomalies (CAs) have been a prominent obstacle to meet Sustainable Development Goal 3.2. Objective We conducted this study to understand the death burden …
View article: A real-world study on the changing characteristics of measles antibodies in premature infants in China
A real-world study on the changing characteristics of measles antibodies in premature infants in China Open
The waning of maternal antibodies may cause infants to lose protection against measles before receiving measles-containing vaccine (MCV). The aim of this study is to investigate the changing characteristics and influencing factors of measl…
View article: Associations of PD-1 and PD-L1 gene polymorphisms with cancer risk: a meta-analysis based on 50 studies
Associations of PD-1 and PD-L1 gene polymorphisms with cancer risk: a meta-analysis based on 50 studies Open
Programmed death-1 and its ligand-1 (PD-1/PD-L1), immune checkpoints proteins, play a crucial role in anti-tumor responses. A large number of studies have evaluated the relationships of PD-1/PD-L1 polymorphisms with risk of cancer, but evi…
View article: Monosaccharide transporter <i>OsMST6</i> is activated by transcription factor OsERF120 to enhance chilling tolerance in rice seedlings
Monosaccharide transporter <i>OsMST6</i> is activated by transcription factor OsERF120 to enhance chilling tolerance in rice seedlings Open
Chilling stress caused by extreme weather is threatening global rice (Oryza sativa L.) production. Identifying components of the signal transduction pathways underlying chilling tolerance in rice would advance molecular breeding. Here, we …
View article: GDF11 slows excitatory neuronal senescence and brain ageing by repressing p21
GDF11 slows excitatory neuronal senescence and brain ageing by repressing p21 Open
As a major neuron type in the brain, the excitatory neuron (EN) regulates the lifespan in C. elegans. How the EN acquires senescence, however, is unknown. Here, we show that growth differentiation factor 11 (GDF11) is predominantly express…
View article: The association between parental risks and childhood development: findings from a community-based survey in East China
The association between parental risks and childhood development: findings from a community-based survey in East China Open
Background Nurturing care is necessary for optimal early childhood development. This study aimed to investigate the prevalence of parental risks in rural East China and assess their impacts on early development in children younger than thr…
View article: The association between parental risks and childhood development: findings from a community-based survey in East China
The association between parental risks and childhood development: findings from a community-based survey in East China Open
Background: Nurturing care is necessary for optimal early childhood development. This study aimed to investigate the prevalence of parental risks in rural East China and assess its impacts on the early neurodevelopment of children younger …
View article: Inhibition of RIPK1 by ZJU-37 promotes oligodendrocyte progenitor proliferation and remyelination via NF-κB pathway
Inhibition of RIPK1 by ZJU-37 promotes oligodendrocyte progenitor proliferation and remyelination via NF-κB pathway Open
Receptor interacting serine/threonine protein kinase 1 (RIPK1) activation and necroptosis have been genetically and mechanistically linked with human multiple sclerosis and neurodegenerative diseases for which demyelination is a common key…
View article: Preparation and Properties of Decellularized Sheep Kidney Derived Matrix Scaffolds
Preparation and Properties of Decellularized Sheep Kidney Derived Matrix Scaffolds Open
Scaffolds from tissues or organs have nanoscale microstructures. Derived matrix scaffolds prepared by decellularized method can provide more cell attachment sites, which is conducive to cell adhesion, proliferation, differentiation and oth…
View article: A prospective study on physical performance of Chinese chronic obstructive pulmonary disease males with type 2 diabetes
A prospective study on physical performance of Chinese chronic obstructive pulmonary disease males with type 2 diabetes Open
Currently no research is available on muscle and functional performance of chronic obstructive pulmonary disease (COPD) patients with type 2 diabetes (T2DM) in China, even though both diseases have been reported to damage motor function. T…
View article: Effects of Infant Formula Supplemented With Prebiotics and OPO on Infancy Fecal Microbiota: A Pilot Randomized Clinical Trial
Effects of Infant Formula Supplemented With Prebiotics and OPO on Infancy Fecal Microbiota: A Pilot Randomized Clinical Trial Open
Several lines of evidence suggest that the intestinal microbiota plays crucial roles in infant development, and that it is highly influenced by extrinsic and intrinsic factors. Prebiotic-containing infant formula may increase gastrointesti…
View article: Coordinated cytokinin signaling and auxin biosynthesis mediates arsenate-induced root growth inhibition
Coordinated cytokinin signaling and auxin biosynthesis mediates arsenate-induced root growth inhibition Open
Interactions between plant hormones and environmental signals are important for the maintenance of root growth plasticity under ever-changing environmental conditions. Here, we demonstrate that arsenate (AsV), the most prevalent form of ar…
View article: [Mechanisms underlying remyelination with special focus on demyelination models of multiple sclerosis].
[Mechanisms underlying remyelination with special focus on demyelination models of multiple sclerosis]. Open
Failure to remyelinate and rewrap the demyelinated axons has been revealed as the major hurdle for treatment of multiple sclerosis (MS), and the bottleneck is the inability of oligodendrocyte progenitor cell (OPC) to differentiate into mat…
View article: Identification of Genes Involved in Root Growth Inhibition Under Lead Stress by Transcriptome Profiling in Arabidopsis
Identification of Genes Involved in Root Growth Inhibition Under Lead Stress by Transcriptome Profiling in Arabidopsis Open
Lead (Pb) is a heavy metal with high toxicity to plants. Root is the major organ to respond to Pb stress. However, little is known about how plant roots perceive Pb stress signaling. Here, we describe the transcriptome of Arabidopsis root …
View article: Advances in the Research of Bioinks Based on Natural Collagen, Polysaccharide and Their Derivatives for Skin 3D Bioprinting
Advances in the Research of Bioinks Based on Natural Collagen, Polysaccharide and Their Derivatives for Skin 3D Bioprinting Open
The skin plays an important role in protecting the human body, and wound healing must be set in motion immediately following injury or trauma to restore the normal structure and function of skin. The extracellular matrix component of the s…
View article: Toxicity Evaluation of Geniposide on MCF-7 Cancer Cells
Toxicity Evaluation of Geniposide on MCF-7 Cancer Cells Open
As one of the adjuvant treatments for cancer treatment, traditional Chinese medicine treatment has a wide range of cancer treatments, such as preventing metastasis and relapse, improving the efficacy of radiotherapy and chemotherapy, reduc…
View article: A new branched proximity hybridization assay for the quantification of nanoscale protein–protein proximity
A new branched proximity hybridization assay for the quantification of nanoscale protein–protein proximity Open
Membrane proteins are organized in nanoscale compartments. Their reorganization plays a crucial role in receptor activation and cell signaling. To monitor the organization and reorganization of membrane proteins, we developed a new branche…
View article: 3D Bio-Printing of CS/Gel/HA/Gr Hybrid Osteochondral Scaffolds
3D Bio-Printing of CS/Gel/HA/Gr Hybrid Osteochondral Scaffolds Open
Cartilage is an important tissue contributing to the structure and function of support and protection in the human body. There are many challenges for tissue cartilage repair. However, 3D bio-printing of osteochondral scaffolds provides a …
View article: Evaluation of ionic liquid “greenness”-cytotoxicity of ionic liquids
Evaluation of ionic liquid “greenness”-cytotoxicity of ionic liquids Open
Ionic liquids have become a hot spot in research and application due to their own superiority. At the same time, the “risk” of ionic liquids has attracted more and more attention. The toxicity of ionic liquids varies according to the targe…
View article: The Application of Multi-Walled Carbon Nanotubes in Bone Tissue Repair Hybrid Scaffolds and the Effect on Cell Growth In Vitro
The Application of Multi-Walled Carbon Nanotubes in Bone Tissue Repair Hybrid Scaffolds and the Effect on Cell Growth In Vitro Open
In this study, composite scaffolds with different multi-walled carbon nanotubes (MWCNTs) content were prepared by freeze-drying. These scaffolds were characterized by scanning electron microscope (SEM), energy dispersive spectroscopy (EDS)…
View article: Mediator subunit MED31 is required for radial patterning of <i>Arabidopsis</i> roots
Mediator subunit MED31 is required for radial patterning of <i>Arabidopsis</i> roots Open
Significance SHORTROOT (SHR) and SCARECROW (SCR) orchestrate a transcriptional program that is essential for ground tissue patterning. The regulation of the transcriptional output of SHR/SCR remains unclear. We show that MED31, a subunit o…