Snehali Majumder
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View article: PEaRL: Pathway-Enhanced Representation Learning for Gene and Pathway Expression Prediction from Histology
PEaRL: Pathway-Enhanced Representation Learning for Gene and Pathway Expression Prediction from Histology Open
Integrating histopathology with spatial transcriptomics (ST) provides a powerful opportunity to link tissue morphology with molecular function. Yet most existing multimodal approaches rely on a small set of highly variable genes, which lim…
View article: Femtosecond laser micromachining of barbed sutures
Femtosecond laser micromachining of barbed sutures Open
View article: Novel Transcriptomic Signatures in Fibrostenotic Crohn’s Disease: Dysregulated Pathways, Promising Biomarkers, and Putative Therapeutic Targets
Novel Transcriptomic Signatures in Fibrostenotic Crohn’s Disease: Dysregulated Pathways, Promising Biomarkers, and Putative Therapeutic Targets Open
Background Fibrosis is a common complication in Crohn’s disease (CD), often leading to intestinal strictures. This study aims to explore the transcriptomic signature of fibrostenotic ileal CD for a comprehensive characterization of biologi…
View article: Ultrashort Pulse Laser Fabrication and Evaluation of Innovative Resorbable Barbed Sutures
Ultrashort Pulse Laser Fabrication and Evaluation of Innovative Resorbable Barbed Sutures Open
Laser micro-machining is a rapidly growing technique to create, manufacture and fabricate microstructures on different materials ranging from metals and ceramics to polymers. Micro- and nano-machining on different materials has been helpfu…
View article: Rediscovering histology – the application of artificial intelligence in inflammatory bowel disease histologic assessment
Rediscovering histology – the application of artificial intelligence in inflammatory bowel disease histologic assessment Open
Integrating artificial intelligence (AI) into histologic disease assessment is transforming the management of inflammatory bowel disease (IBD). AI-aided histology enables precise, objective evaluations of disease activity by analysing whol…
View article: Predicting Heart Disease Risk with Lifestyle Factors: Uncovering Vital Predictors via Feature Selection and Machine Learning Techniques
Predicting Heart Disease Risk with Lifestyle Factors: Uncovering Vital Predictors via Feature Selection and Machine Learning Techniques Open
View article: P431 Assessing intestinal barrier healing by fusing ultra-high magnification endoscope and automated spatial multispectral imaging analysis in PSC-colitis patients
P431 Assessing intestinal barrier healing by fusing ultra-high magnification endoscope and automated spatial multispectral imaging analysis in PSC-colitis patients Open
Background PSC colitis is associated with an increased risk of colorectal carcinoma. Endoscopic monitoring is crucial since endoscopic and histological activity can persist in PSC even during clinical remission. Recent evidence suggests th…
View article: DOP61 Up-regulated Gremlin 1 in fibroblasts from Crohn’s Disease fibrotic strictures: A potential therapeutic target
DOP61 Up-regulated Gremlin 1 in fibroblasts from Crohn’s Disease fibrotic strictures: A potential therapeutic target Open
Background Fibrosis is a common complication in Crohn’s disease (CD), often leading to intestinal strictures that are refractory to available biologic drugs and require surgery. Addressing this complication remains a significant unmet need…
View article: OP30 Endothelial cell-mediated smooth muscle hyperplasia in Crohn’s disease intestinal strictures: Caveolin 1 as a potential therapeutic target
OP30 Endothelial cell-mediated smooth muscle hyperplasia in Crohn’s disease intestinal strictures: Caveolin 1 as a potential therapeutic target Open
Background Intestinal stricture is a severe and common complication of Crohn’s disease (CD). Current therapies offer limited success and surgery is often needed. Smooth muscle hyperplasia and hypertrophy play a key role in CD stricture dev…
View article: Neutrophil-only Histological Assessment of Ulcerative Colitis Correlates with Endoscopic Activity and Predicts Long-term Outcomes in a Multicentre Study
Neutrophil-only Histological Assessment of Ulcerative Colitis Correlates with Endoscopic Activity and Predicts Long-term Outcomes in a Multicentre Study Open
Backgrounds and Aims Absence of neutrophils is the minimum standard to consider histological remission of ulcerative colitis [UC]. The PICaSSO Histological Remission Index [PHRI] is a new simple index for UC, based only on the detection of…
View article: P122 External validation of the Picasso Histological Remission Index (PHRI) to assess endoscopic and histological remission and predict long-term outcome in Ulcerative Colitis: A multicentre prospective study.
P122 External validation of the Picasso Histological Remission Index (PHRI) to assess endoscopic and histological remission and predict long-term outcome in Ulcerative Colitis: A multicentre prospective study. Open
Background The PICaSSO Histological remission Index (PHRI) is a simple histological index for assessing ulcerative colitis (UC) based only on the presence or absence of neutrophils in the lamina propria, superficial and cryptal epithelium …
View article: P699 Ustekinumab therapy after biologic failure in patients with Crohn’s Disease – A real-world single centre experience
P699 Ustekinumab therapy after biologic failure in patients with Crohn’s Disease – A real-world single centre experience Open
Background Patients with Crohn’s disease (CD) often require multiple biological therapies due to loss of response. Anti-TNF drugs are generally used as first-line biologics followed by a switch of class. Ustekinumab (UST), an IL-12/23p40 a…
View article: P209 Delayed IBD diagnosis increases risk of requiring biologics in first 4-years - an Inception cohort study
P209 Delayed IBD diagnosis increases risk of requiring biologics in first 4-years - an Inception cohort study Open
Background Delays in diagnosis can be due to patient and health-system related factors. The impact of such delays in Inflammatory Bowel Diseases (IBD), particularly on biological therapies, continues to be of interest. The aim of the study…
View article: P263 Raman spectroscopy analysis of saliva combined with an artificial neural network algorithm could discriminate between Ulcerative Colitis and Crohn’s disease
P263 Raman spectroscopy analysis of saliva combined with an artificial neural network algorithm could discriminate between Ulcerative Colitis and Crohn’s disease Open
Background Early and accurate detection of inflammatory bowel disease (IBD) is crucial for proper intervention.The IBD diagnostic process can be both time-consuming and invasive and lacks a gold standard in disease differentiation. Saliva …