Divyanshu Dubey
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View article: Testicular Cancer–Associated Paraneoplastic Neurologic Syndromes
Testicular Cancer–Associated Paraneoplastic Neurologic Syndromes Open
This cohort study examines the oncological, neurological, and serological profiles of adult male patients with testicular germ cell tumors and paraneoplastic neurologic syndromes.
View article: Outcomes in Patients With Immune Checkpoint Inhibitor–Related Myopathy and Prolonged Follow-Up
Outcomes in Patients With Immune Checkpoint Inhibitor–Related Myopathy and Prolonged Follow-Up Open
Approximately half of the patients with ICI-related myopathy and long-term follow-up had some residual symptoms/signs, despite good functional outcomes. Symptoms continue to improve over 12 months regardless of immunosuppressive/immunomodu…
View article: Epilepsy Care in the Real World of Multiple Medical Considerations
Epilepsy Care in the Real World of Multiple Medical Considerations Open
Similar to the general population, people with epilepsy (PWE) will often have multiple medical issues that may impact their care. It is therefore important for epilepsy clinicians to be aware of these issues to optimize treatment and quali…
View article: <scp>CIDP</scp> Treatment Outcomes Correlation With First Nerve Conduction Changes: Ascertainment of Initial and Long‐Term Responders
<span>CIDP</span> Treatment Outcomes Correlation With First Nerve Conduction Changes: Ascertainment of Initial and Long‐Term Responders Open
Background and Aims Nerve conduction studies (NCS) are integral to diagnosing chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), but their role in predicting treatment outcomes remains underexplored. This study evaluates NCS…
View article: The Clinical Trial Landscape in Autoimmune Encephalitis
The Clinical Trial Landscape in Autoimmune Encephalitis Open
Autoimmune encephalitis (AE) is an important cause of neurologic morbidity and mortality. Treatment algorithms are primarily based on observational studies, retrospective series, and expert opinion. Despite clinical improvement with empiri…
View article: Automated Detection of Faciobrachial Dystonic Seizures Related Events in LGI1 Autoimmune Encephalitis Patients with Wearables
Automated Detection of Faciobrachial Dystonic Seizures Related Events in LGI1 Autoimmune Encephalitis Patients with Wearables Open
Objective To evaluate the potential of wrist-worn wearable devices to detect and quantify Faciobrachial Dystonic Seizures (FBDS) and related events associated with leucine-rich glioma Inactivated-1 (LGI1)-IgG autoimmune encephalitis (LGI1 …
View article: Paraneoplastic Leucine Zipper 4 <scp>IgG</scp> Associated Motor‐Predominant Polyradiculoneuropathy
Paraneoplastic Leucine Zipper 4 <span>IgG</span> Associated Motor‐Predominant Polyradiculoneuropathy Open
Background and Aims Leucine Zipper 4 (LUZP4)‐immunoglobulin G (IgG) is a novel antibody implicated in germ cell tumor‐related paraneoplastic neurologic syndrome. We report a case of painful, progressive tetraparesis associated with testicu…
View article: Clinical Manifestations and Treatment Responses in Pediatric Neurofascin 155-IgG4 Autoimmune Nodopathy
Clinical Manifestations and Treatment Responses in Pediatric Neurofascin 155-IgG4 Autoimmune Nodopathy Open
This study provides Class IV evidence that in pediatric patients with NF155-IgG4 AN who are refractory to IVIG, rituximab treatment provided some benefit.
View article: A case of chronic lymphocytic leukemia with a paraneoplastic neurologic syndrome and leptomeningeal disease
A case of chronic lymphocytic leukemia with a paraneoplastic neurologic syndrome and leptomeningeal disease Open
Purpose Chronic lymphocytic leukemia (CLL) is a hematologic malignancy characterized by overproduction of monoclonal B cells. Paraneoplastic neurologic syndrome (PNS) and leptomeningeal disease (LMD) associated with CLL are both rare entit…
View article: Pre-existing Lambert-Eaton Myasthenic Syndrome and Scleroderma in a Patient with Neuroendocrine Carcinoma Undergoing Immune Checkpoint Inhibitor Cancer Immunotherapy
Pre-existing Lambert-Eaton Myasthenic Syndrome and Scleroderma in a Patient with Neuroendocrine Carcinoma Undergoing Immune Checkpoint Inhibitor Cancer Immunotherapy Open
This case highlights the challenges of managing pre-existing PNS during ICI therapy, emphasizing the need for a multidisciplinary approach and the consideration of unusual clinical presentations in therapeutic decision-making.
View article: B-080 Development and Validation of a GQ1b IgG ELISA as a Diagnostic Aid for Subacute Demyelinating Polyneuropathies
B-080 Development and Validation of a GQ1b IgG ELISA as a Diagnostic Aid for Subacute Demyelinating Polyneuropathies Open
Background Autoimmunity targeting GQ1b is associated with group of disorders that includes Miller-Fisher Syndrome (MFS), Bickerstaff Brainstem Encephalitis (BBE) and classic Guillain Barre Syndrome (GBS) with ophthalmoplegia. Collectively …
View article: Comprehensive Analysis of Paraneoplastic Neurologic Syndrome and PNS-CARE Diagnostic Criteria in Clinical Practice
Comprehensive Analysis of Paraneoplastic Neurologic Syndrome and PNS-CARE Diagnostic Criteria in Clinical Practice Open
Our study validates the PNS-CARE score. A clearer understanding of typical PNS presentation and common underlying malignancies and autoantibodies can aid in earlier and more accurate diagnosis, which is crucial for downstream clinical deci…
View article: Cerebrospinal Fluid Cytokine and Chemokine Profiles in Central Nervous System Sarcoidosis: Diagnostic and Immunopathologic Insights
Cerebrospinal Fluid Cytokine and Chemokine Profiles in Central Nervous System Sarcoidosis: Diagnostic and Immunopathologic Insights Open
Objective To evaluate the cerebrospinal fluid (CSF) cytokine/chemokine profile of central nervous system (CNS) neurosarcoidosis (NS), and its utility in differential diagnosis, treatment, and prognostication. Methods In this case–control s…
View article: Seizure-Related Falls and Near Falls in LGI1-IgG Autoimmune Encephalitis
Seizure-Related Falls and Near Falls in LGI1-IgG Autoimmune Encephalitis Open
Our study demonstrates that seizure-related falls and near falls are common in LGI1-IgG autoimmune encephalitis. Early diagnosis, prompt immunotherapy initiation, and proper counseling are key to improving functional outcomes and preventin…
View article: Diagnostic Utility of <scp>MOG</scp> Antibody Testing in Cerebrospinal Fluid
Diagnostic Utility of <span>MOG</span> Antibody Testing in Cerebrospinal Fluid Open
Objective The aim of this study was to assess the diagnostic utility of cerebrospinal fluid (CSF) myelin oligodendrocyte glycoprotein antibodies (MOG‐IgG) testing. Methods We retrospectively identified patients for CSF MOG‐IgG testing from…
View article: Magnetic Resonance Imaging Characteristics of LGI1-Antibody and CASPR2-Antibody Encephalitis
Magnetic Resonance Imaging Characteristics of LGI1-Antibody and CASPR2-Antibody Encephalitis Open
Importance Rapid and accurate diagnosis of autoimmune encephalitis encourages prompt initiation of immunotherapy toward improved patient outcomes. However, clinical features alone may not sufficiently narrow the differential diagnosis, and…
View article: Immune Checkpoint Inhibitor-Associated Kelch-Like Protein-11 IgG Brainstem Encephalitis
Immune Checkpoint Inhibitor-Associated Kelch-Like Protein-11 IgG Brainstem Encephalitis Open
We report KLHL11-IgG rhombencephalitis associated with poorly differentiated esophageal cancer as a novel nirAE. Tumor staining revealed KLHL11 immunoreactivity, supporting a cancer-antigen-driven ICI-associated paraneoplastic syndrome. Re…
View article: Pearls & Oy-sters: KLHL11 IgG Paraneoplastic–Associated Hearing Loss and Rhombencephalitis in a Woman With Metastatic Müllerian Tumor
Pearls & Oy-sters: KLHL11 IgG Paraneoplastic–Associated Hearing Loss and Rhombencephalitis in a Woman With Metastatic Müllerian Tumor Open
Kelch-like protein-11 (KLHL11) immunoglobulin G (IgG) is a recently reported paraneoplastic autoantibody associated with rhombencephalitis, which commonly presents with ataxia, diplopia, vertigo, hearing loss, tinnitus, and gaze palsies. T…
View article: Neurological autoimmunity in patients with non‐pulmonary neuroendocrine neoplasms: clinical manifestations and neural autoantibody profiles
Neurological autoimmunity in patients with non‐pulmonary neuroendocrine neoplasms: clinical manifestations and neural autoantibody profiles Open
Background and purpose Paraneoplastic neurological autoimmunity is well described with small‐cell lung cancer, but information is limited for other neuroendocrine neoplasms (NENs). Methods Adult patients with histopathologically confirmed …
View article: Peripheral nervous system manifestations of MOG antibody associated disease
Peripheral nervous system manifestations of MOG antibody associated disease Open
Recent studies have reported the involvement of peripheral nervous system (PNS) in association with MOG‐IgG, including isolated neuropathies. In this retrospective study we characterized the PNS involvement in MOG antibody associated disea…