Shu‐Chen Wei
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View article: Prevalence and Outcomes of Primary Sclerosing Cholangitis in Inflammatory Bowel Disease: A Multinational Study Across Asia
Prevalence and Outcomes of Primary Sclerosing Cholangitis in Inflammatory Bowel Disease: A Multinational Study Across Asia Open
PSC is less prevalent among Asian IBD patients than in Western populations. The increased use of MRCP may enable earlier detection, contributing to milder disease severity and improved clinical outcomes in recent years.
View article: Efficacy and safety of filgotinib in the treatment of ulcerative colitis with a focus on rapid and sustained efficacy: a narrative review
Efficacy and safety of filgotinib in the treatment of ulcerative colitis with a focus on rapid and sustained efficacy: a narrative review Open
The rising incidence of ulcerative colitis (UC) globally highlights the necessity for treatment strategies that extend beyond symptom control to include inducing and maintaining remission, achieving biochemical and endoscopic remission, an…
View article: The prevalence of chronic obstructive pulmonary disease in high-altitude areas of China: a systematic review and meta-analysis
The prevalence of chronic obstructive pulmonary disease in high-altitude areas of China: a systematic review and meta-analysis Open
The prevalence of COPD in high-altitude areas of China is 10%, which is closely related to aging and smoking. It is necessary to promote clean energy and strengthen health education for targeted intervention. In the future, priority should…
View article: Demodicosis Mimics Acneiform Eruptions in Patients With Inflammatory Bowel Disease Receiving Upadacitinib
Demodicosis Mimics Acneiform Eruptions in Patients With Inflammatory Bowel Disease Receiving Upadacitinib Open
INTRODUCTION: Acne is a common side effect of inflammatory bowel disease (IBD) treatment. We investigated the role of demodicosis in acne development in patients with IBD. METHODS: From 2019 to 2021, IBD patients with acneiform eruptions w…
View article: Decoding Musical Origins: Distinguishing Human and AI Composers
Decoding Musical Origins: Distinguishing Human and AI Composers Open
With the rapid advancement of Large Language Models (LLMs), AI-driven music generation has become a vibrant and fruitful area of research. However, the representation of musical data remains a significant challenge. To address this, a nove…
View article: Asia Pacific association of gastroenterology consensus statements on histopathological evaluation of inflammatory bowel diseases
Asia Pacific association of gastroenterology consensus statements on histopathological evaluation of inflammatory bowel diseases Open
Background: Mucosal histological activity is increasingly valued as a treatment endpoint in inflammatory bowel diseases (IBD). In the Asia Pacific region, the utility and acceptability of IBD histology as a treatment endpoint are uncertain…
View article: 245. USING CLASSIFICATION AND REGRESSION TREE MODELLING TO INVESTIGATE LOW-DOSE KETAMINE’S EFFECT ON REMISSION OF SUICIDAL SYMPTOMS AMONG PATIENTS WITH TREATMENT-RESISTANT DEPRESSION AND STRONG SUICIDAL THOUGHT
245. USING CLASSIFICATION AND REGRESSION TREE MODELLING TO INVESTIGATE LOW-DOSE KETAMINE’S EFFECT ON REMISSION OF SUICIDAL SYMPTOMS AMONG PATIENTS WITH TREATMENT-RESISTANT DEPRESSION AND STRONG SUICIDAL THOUGHT Open
Background As accumulating evidence suggests ketamine's antisuicidal properties, there has been growing interest in elucidating its underlying mechanisms and predictive factors for treatment response. However, the predictive power of sever…
View article: Lifestyle restrictions are associated with impaired quality of life but not reduction in relapse in ulcerative colitis
Lifestyle restrictions are associated with impaired quality of life but not reduction in relapse in ulcerative colitis Open
Lifestyle restrictions were not associated with relapse reduction in patients with UC; however, they were associated with impaired QOL. Clinicians should engage in evidence-based discussions with patients with UC in remission regarding lif…
View article: Generation of maternally semi-cloned mice
Generation of maternally semi-cloned mice Open
Semi-cloning technology has made a series of advances in studying gene function and building disease models. Maternally semi-cloned mice ( MSCM ) have completely identical maternal genome. MSCM are typically produced by injecting sperm int…
View article: RNA interference-mediated osteoprotegerin silencing increases the receptor activator of nuclear factor-kappa B ligand/osteoprotegerin ratio and promotes osteoclastogenesis
RNA interference-mediated osteoprotegerin silencing increases the receptor activator of nuclear factor-kappa B ligand/osteoprotegerin ratio and promotes osteoclastogenesis Open
BACKGROUND In vivo degradation of bone scaffolds is significantly influenced by osteoclast (OC) activity, which is orchestrated by the interplay between receptor activator of nuclear factor-kappa B ligand (RANKL) and osteoprotegerin (OPG).…
View article: Triple-network model–based graph theory analysis of the effectiveness of low-dose ketamine in patients with treatment-resistant depression: two resting-state functional MRI clinical trials
Triple-network model–based graph theory analysis of the effectiveness of low-dose ketamine in patients with treatment-resistant depression: two resting-state functional MRI clinical trials Open
Background Evidence suggests the crucial role of dysfunctional default mode (DMN), salience and frontoparietal (FPN) networks, collectively termed the triple network model, in the pathophysiology of treatment-resistant depression (TRD). Ai…
View article: A Case of Uterine Adenosarcoma and Colonic Endometriosis Masquerading as Inflammatory Bowel Disease
A Case of Uterine Adenosarcoma and Colonic Endometriosis Masquerading as Inflammatory Bowel Disease Open
This case underscores the diagnostic and therapeutic challenges of gastrointestinal endometriosis, particularly in the presence of coexisting malignancy. A multidisciplinary approach is essential for early recognition and prompt interventi…
View article: Pregnancy and perinatal outcomes of mothers with inflammatory bowel disease in Taiwan: A national database analysis
Pregnancy and perinatal outcomes of mothers with inflammatory bowel disease in Taiwan: A national database analysis Open
Pregnancy and perinatal outcomes are comparable in Taiwanese women with inflammatory bowel disease and matched healthy counterparts. While no statistically significant differences were observed, the limited statistical power for certain ou…
View article: ASSOCIATION OF NEUROFILAMENT LIGHT CHAIN WITH THE ANTIDEPRESSANT EFFECTS OF LOW-DOSE KETAMINE INFUSION AMONG PATIENTS WITH TREATMENT-RESISTANT DEPRESSION
ASSOCIATION OF NEUROFILAMENT LIGHT CHAIN WITH THE ANTIDEPRESSANT EFFECTS OF LOW-DOSE KETAMINE INFUSION AMONG PATIENTS WITH TREATMENT-RESISTANT DEPRESSION Open
Background The role of neurofilament light chain (NFL) in treatment-resistant depression (TRD) is unclear. Whether baseline NFL concentrations are associated with the antidepressant effects of low- dose ketamine infusion has not been deter…
View article: Short-term and long-term outcomes of acute severe ulcerative colitis in Taiwan: a multicenter study with pre- and post-biologics comparison
Short-term and long-term outcomes of acute severe ulcerative colitis in Taiwan: a multicenter study with pre- and post-biologics comparison Open
This is the first Asian study on ASUC to compare colectomy rates between the prebiologics and post-biologics eras, revealing no significant difference. The recurrent ASUC had a higher colectomy rate than the index ASUC.
View article: Role of 5-aminosalicylic acid in ulcerative colitis management in 8 Asian territories: a physician survey
Role of 5-aminosalicylic acid in ulcerative colitis management in 8 Asian territories: a physician survey Open
Clinical guidelines typically endorse conventional therapies such as 5-aminosalicylic acid (5-ASA) as the mainstay of ulcerative colitis management. However, the degree of adoption and application of guideline recommendations by physicians…
View article: P1169 Guselkumab maintenance treatment improves health-related quality of life in patients with moderately to severely active Ulcerative Colitis: Phase 3 QUASAR maintenance study
P1169 Guselkumab maintenance treatment improves health-related quality of life in patients with moderately to severely active Ulcerative Colitis: Phase 3 QUASAR maintenance study Open
Background Ulcerative colitis (UC) symptoms are associated with impaired health-related quality of life (HRQoL). The Phase 3 QUASAR maintenance study (NCT04033445) evaluated the efficacy and safety of guselkumab (GUS) in participants (pts)…
View article: P0350 Asia Pacific Association of Gastroenterology consensus statements on histopathological evaluation of Inflammatory Bowel Diseases
P0350 Asia Pacific Association of Gastroenterology consensus statements on histopathological evaluation of Inflammatory Bowel Diseases Open
Background Mucosal histological activity is increasingly valued as a treatment endpoint in inflammatory bowel diseases (IBD). In the Asia Pacific region, however, the utility and acceptability of IBD histology as a treatment endpoint is un…
View article: DOP043 Clinical outcomes and predictive factors differ in acute severe ulcerative colitis for East Asian and Western patients
DOP043 Clinical outcomes and predictive factors differ in acute severe ulcerative colitis for East Asian and Western patients Open
Background There are limited comparisons of clinical outcomes of acute severe ulcerative colitis (ASUC) between East Asian (EA) and Western countries and many currently used scoring systems are based on Western populations. We developed a …
View article: P0227 Uncontrolled clinical activity and anti-TNF plus thiopurine combination therapy are predictive factors of 1-year infection risk following acute severe ulcerative colitis: AOCC and ANZIBDC collaboration study
P0227 Uncontrolled clinical activity and anti-TNF plus thiopurine combination therapy are predictive factors of 1-year infection risk following acute severe ulcerative colitis: AOCC and ANZIBDC collaboration study Open
Background Information on infectious complications following acute severe ulcerative colitis (ASUC) is limited. The aim of this study was to determine rates of infections following ASUC treatment and the associated risk factors, using data…
View article: Epidemiology and temporal trends of adult inflammatory bowel disease in Taiwan: Multicenter study from the TSIBD registration
Epidemiology and temporal trends of adult inflammatory bowel disease in Taiwan: Multicenter study from the TSIBD registration Open
In Taiwan, similar to high-income countries, the ratio of UC to CD cases has declined. The reduced of colonic and penetrating CD indicates that diagnostic awareness has improved and colonoscopic examination has become more comprehensive in…
View article: Novel Naphthyridones Targeting Pannexin 1 for Colitis Management
Novel Naphthyridones Targeting Pannexin 1 for Colitis Management Open
Pannexin 1 (PANX1) forms cell‐surface channels capable of releasing signaling metabolites for diverse patho‐physiological processes. While inhibiting dysregulated PANX1 has been proposed as a therapeutic strategy for many pathological cond…
View article: Rapid Antidepressant and Antisuicidal Effects of Low-Dose Ketamine Infusion in Patients With Treatment-Resistant Depression With or Without Low-Grade Inflammation
Rapid Antidepressant and Antisuicidal Effects of Low-Dose Ketamine Infusion in Patients With Treatment-Resistant Depression With or Without Low-Grade Inflammation Open
Low-grade inflammation (LGI) contributes to resistance against traditional antidepressants. However, whether the antidepressant and antisuicidal effects of ketamine on patients with treatment-resistant depression (TRD) differ between those…
View article: Clinical Characteristics, Management, and Outcomes of Colitis-Associated Colorectal Cancer and the Comparison With Sporadic Colorectal Cancer in Taiwan
Clinical Characteristics, Management, and Outcomes of Colitis-Associated Colorectal Cancer and the Comparison With Sporadic Colorectal Cancer in Taiwan Open
INTRODUCTION: We explored the clinical characteristics, treatment, and outcomes of colitis-associated colorectal cancer (CAC) and compared with sporadic colorectal cancer in Taiwan. METHODS: In this retrospective study spanning 1987–2022, …
View article: Knowledge and perspectives towards the use of histology in inflammatory bowel disease by gastroenterologists across the Asia-Pacific region
Knowledge and perspectives towards the use of histology in inflammatory bowel disease by gastroenterologists across the Asia-Pacific region Open
Background/Aims: Recently, histological mucosal assessment has gained momentum as a potential new treatment target for patients with inflammatory bowel disease (IBD) in the Asia-Pacific region. This study aimed to evaluate and compare the …
View article: Optimizing 5-aminosalicylate for moderate ulcerative colitis: expert recommendations from the Asia-Pacific, Middle East, and Africa Inflammatory Bowel Disease Coalition
Optimizing 5-aminosalicylate for moderate ulcerative colitis: expert recommendations from the Asia-Pacific, Middle East, and Africa Inflammatory Bowel Disease Coalition Open
The lack of clear definition and classification for “moderate ulcerative colitis (UC)” creates ambiguity regarding the suitability of step-up versus top-down treatment approaches. In this paper, experts address crucial gaps in assessing an…