Shu-fei Lin
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View article: Mapping Genetic Associations With Functional Brain Area Alterations in Schizophrenia and Implications for Cortical Development
Mapping Genetic Associations With Functional Brain Area Alterations in Schizophrenia and Implications for Cortical Development Open
Background While prior studies have identified regional reduction in gray matter (GM) volume in schizophrenia, it remains unclear whether these alterations are concentrated in specific brain functional areas and how they relate to genetic …
View article: Local cortical structure pattern and genetic links in schizophrenia: An MRI and CRISPR/Cas9 study
Local cortical structure pattern and genetic links in schizophrenia: An MRI and CRISPR/Cas9 study Open
While the etiology of schizophrenia (SZ) remains elusive, its diverse phenotypes suggest the involvement of distinct functional cortical areas, and the heritability of SZ implies the underlying genetic factors. This study aimed to integrat…
View article: Retraction Note: Cannabinoid type 1 receptor availability in the amygdala mediates threat processing in trauma survivors
Retraction Note: Cannabinoid type 1 receptor availability in the amygdala mediates threat processing in trauma survivors Open
View article: First-in-Human Assessment of <sup>11</sup>C-LSN3172176, an M1 Muscarinic Acetylcholine Receptor PET Radiotracer
First-in-Human Assessment of <sup>11</sup>C-LSN3172176, an M1 Muscarinic Acetylcholine Receptor PET Radiotracer Open
This was a first-in-human study of the PET radiotracer 11C-LSN3172176 for the muscarinic acetylcholine receptor subtype M1. The objectives of the study were to determine the appropriate kinetic model to quantify binding of the t…
View article: Feasibility study of PET dynamic imaging of [18F]DHMT for quantification of reactive oxygen species in the myocardium of large animals
Feasibility study of PET dynamic imaging of [18F]DHMT for quantification of reactive oxygen species in the myocardium of large animals Open
View article: Kinetic Modeling and Test–Retest Reproducibility of <sup>11</sup>C-EKAP and <sup>11</sup>C-FEKAP, Novel Agonist Radiotracers for PET Imaging of the κ-Opioid Receptor in Humans
Kinetic Modeling and Test–Retest Reproducibility of <sup>11</sup>C-EKAP and <sup>11</sup>C-FEKAP, Novel Agonist Radiotracers for PET Imaging of the κ-Opioid Receptor in Humans Open
The κ-opioid receptor (KOR) is implicated in various neuropsychiatric disorders. We previously evaluated an agonist tracer, 11C-GR103545, for PET imaging of KOR in humans. Although 11C-GR103545 showed high brain uptak…
View article: Synthesis and in vivo evaluation of [18F]UCB-J for PET imaging of synaptic vesicle glycoprotein 2A (SV2A)
Synthesis and in vivo evaluation of [18F]UCB-J for PET imaging of synaptic vesicle glycoprotein 2A (SV2A) Open
View article: Kappa-opioid receptors, dynorphin, and cocaine addiction: a positron emission tomography study
Kappa-opioid receptors, dynorphin, and cocaine addiction: a positron emission tomography study Open
View article: Evaluation of<sup>11</sup>C-LSN3172176 as a Novel PET Tracer for Imaging M<sub>1</sub>Muscarinic Acetylcholine Receptors in Nonhuman Primates
Evaluation of<sup>11</sup>C-LSN3172176 as a Novel PET Tracer for Imaging M<sub>1</sub>Muscarinic Acetylcholine Receptors in Nonhuman Primates Open
The M1 muscarinic acetylcholine receptor (mAChR) plays an important role in learning and memory, and therefore is a target for development of drugs for treatment of cognitive impairments in Alzheimer disease and schizophrenia. T…
View article: Quantification of Positron Emission Tomography Data Using Simultaneous Estimation of the Input Function: Validation with Venous Blood and Replication of Clinical Studies
Quantification of Positron Emission Tomography Data Using Simultaneous Estimation of the Input Function: Validation with Venous Blood and Replication of Clinical Studies Open
View article: Assessing Synaptic Density in Alzheimer Disease With Synaptic Vesicle Glycoprotein 2A Positron Emission Tomographic Imaging
Assessing Synaptic Density in Alzheimer Disease With Synaptic Vesicle Glycoprotein 2A Positron Emission Tomographic Imaging Open
To our knowledge, this is the first study to investigate synaptic density in vivo in AD using 11C-UCB-J-PET imaging. This approach may provide a direct measure of synaptic density, and it therefore holds promise as an in vivo biomarker for…
View article: 2181 Age-related change in 5-HT6 receptor availability in healthy male volunteers measured with 11C-GSK215083 PET
2181 Age-related change in 5-HT6 receptor availability in healthy male volunteers measured with 11C-GSK215083 PET Open
OBJECTIVES/SPECIFIC AIMS: The serotonin receptor 6 (5-HT6) is a potential therapeutic target given its distribution in brain regions that are important in depression, anxiety, and cognition. This study sought to investigate the effects of …
View article: Age-Related Change in 5-HT<sub>6</sub>Receptor Availability in Healthy Male Volunteers Measured with<sup>11</sup>C-GSK215083 PET
Age-Related Change in 5-HT<sub>6</sub>Receptor Availability in Healthy Male Volunteers Measured with<sup>11</sup>C-GSK215083 PET Open
Serotonin receptor 6 (5-hydroxytrypamine-6, or 5-HT6) is a potential therapeutic target given its distribution in brain regions that are important in depression, anxiety, and cognition. This study sought to investigate the effec…
View article: Dose-Related Target Occupancy and Effects on Circuitry, Behavior, and Neuroplasticity of the Glycine Transporter-1 Inhibitor PF-03463275 in Healthy and Schizophrenia Subjects
Dose-Related Target Occupancy and Effects on Circuitry, Behavior, and Neuroplasticity of the Glycine Transporter-1 Inhibitor PF-03463275 in Healthy and Schizophrenia Subjects Open
View article: Evaluation of (‐)‐[<sup>18</sup><scp>F]F</scp>lubatine‐specific binding: Implications for reference region approaches
Evaluation of (‐)‐[<sup>18</sup><span>F]F</span>lubatine‐specific binding: Implications for reference region approaches Open
We aimed to characterize changes in binding of (‐)‐[ 18 F]Flubatine to α 4 β 2 *‐nicotinic acetylcholine receptors (α 4 β 2 *‐nAChRs) during a tobacco cigarette smoking challenge. Displacement of (‐)‐[ 18 F]Flubatine throughout the brain w…
View article: Evaluation of the Lysophosphatidic Acid Receptor Type 1 Radioligand <sup>11</sup>C-BMT-136088 for Lung Imaging in Rhesus Monkeys
Evaluation of the Lysophosphatidic Acid Receptor Type 1 Radioligand <sup>11</sup>C-BMT-136088 for Lung Imaging in Rhesus Monkeys Open
The lysophosphatidic acid receptor type 1 (LPA1) is 1 of 6 known receptors of the extracellular signaling molecule lysophosphatidic acid. It mediates effects such as cell proliferation, migration, and differentiation. In the lung, LPA1 is …
View article: Kinetic evaluation and test–retest reproducibility of [<sup>11</sup>C]UCB-J, a novel radioligand for positron emission tomography imaging of synaptic vesicle glycoprotein 2A in humans
Kinetic evaluation and test–retest reproducibility of [<sup>11</sup>C]UCB-J, a novel radioligand for positron emission tomography imaging of synaptic vesicle glycoprotein 2A in humans Open
Synaptic vesicle glycoprotein 2A (SV2A) is ubiquitously present in presynaptic terminals. Here we report kinetic modeling and test–retest reproducibility assessment of the SV2A positron emission tomography (PET) radioligand [ 11 C]UCB-J in…
View article: Novel<sup>18</sup>F-Labeled κ-Opioid Receptor Antagonist as PET Radiotracer: Synthesis and In Vivo Evaluation of<sup>18</sup>F-LY2459989 in Nonhuman Primates
Novel<sup>18</sup>F-Labeled κ-Opioid Receptor Antagonist as PET Radiotracer: Synthesis and In Vivo Evaluation of<sup>18</sup>F-LY2459989 in Nonhuman Primates Open
The κ-opioid receptor (KOR) has been implicated in depression, addictions, and other central nervous system disorders and, thus, is an important target for drug development. We previously developed several 11C-labeled PET radiot…
View article: PET Imaging Evaluation of Four σ<sub>1</sub> Radiotracers in Nonhuman Primates
PET Imaging Evaluation of Four σ<sub>1</sub> Radiotracers in Nonhuman Primates Open
The σ1 receptors (S1Rs) are implicated in a variety of diseases including Alzheimer disease and cancer. Previous PET S1R radiotracers are characterized by slow kinetics or off-target binding that impedes their use in humans. Her…
View article: PET imaging of α7 nicotinic acetylcholine receptors: a comparative study of [18F]ASEM and [18F]DBT-10 in nonhuman primates, and further evaluation of [18F]ASEM in humans
PET imaging of α7 nicotinic acetylcholine receptors: a comparative study of [18F]ASEM and [18F]DBT-10 in nonhuman primates, and further evaluation of [18F]ASEM in humans Open
View article: The Search for a Subtype-Selective PET Imaging Agent for the GABA<sub>A</sub>Receptor Complex: Evaluation of the Radiotracer [<sup>11</sup>C]ADO in Nonhuman Primates
The Search for a Subtype-Selective PET Imaging Agent for the GABA<sub>A</sub>Receptor Complex: Evaluation of the Radiotracer [<sup>11</sup>C]ADO in Nonhuman Primates Open
The myriad physiological functions of γ-amino butyric acid (GABA) are mediated by the GABA-benzodiazepine receptor complex comprising of the GABA A , GABA B , and GABA C groups. The various GABA A subunits with region-specific distribution…
View article: Evaluation of pancreatic VMAT2 binding with active and inactive enantiomers of 18 F-FP-DTBZ in baboons
Evaluation of pancreatic VMAT2 binding with active and inactive enantiomers of 18 F-FP-DTBZ in baboons Open
View article: Determination of receptor occupancy in the presence of mass dose: [<sup>11</sup>C]GSK189254 PET imaging of histamine H<sub>3</sub> receptor occupancy by PF-03654746
Determination of receptor occupancy in the presence of mass dose: [<sup>11</sup>C]GSK189254 PET imaging of histamine H<sub>3</sub> receptor occupancy by PF-03654746 Open
Measurements of drug occupancies using positron emission tomography (PET) can be biased if the radioligand concentration exceeds “tracer” levels. Negative bias would also arise in successive PET scans if clearance of the radioligand is slo…
View article: First-in-Human Assessment of the Novel PDE2A PET Radiotracer <sup>18</sup>F-PF-05270430
First-in-Human Assessment of the Novel PDE2A PET Radiotracer <sup>18</sup>F-PF-05270430 Open
(18)F-PF-05270430 shows promise as a PDE2A PET ligand, albeit with low binding potential values.
View article: Synthesis and Preclinical Evaluation of<sup>11</sup>C-UCB-J as a PET Tracer for Imaging the Synaptic Vesicle Glycoprotein 2A in the Brain
Synthesis and Preclinical Evaluation of<sup>11</sup>C-UCB-J as a PET Tracer for Imaging the Synaptic Vesicle Glycoprotein 2A in the Brain Open
(11)C-UCB-J exhibited excellent characteristics as an SV2A PET radiotracer in nonhuman primates. The radiotracer is currently undergoing first-in-human evaluation.
View article: PET imaging evaluation of [18F]DBT-10, a novel radioligand specific to α7 nicotinic acetylcholine receptors, in nonhuman primates
PET imaging evaluation of [18F]DBT-10, a novel radioligand specific to α7 nicotinic acetylcholine receptors, in nonhuman primates Open
View article: Imaging robust microglial activation after lipopolysaccharide administration in humans with PET
Imaging robust microglial activation after lipopolysaccharide administration in humans with PET Open
Significance Neuroinflammation is a brain immune response that is associated with neurodegenerative diseases and is primarily driven by activation of microglia, the brain’s resident macrophages. Dysfunctional microglial activation may cont…
View article: Measurement of <i>B</i><sub>max</sub> and <i>K</i><sub>d</sub> with the Glycine Transporter 1 Radiotracer <sup>18</sup>F-MK6577 using a Novel Multi-Infusion Paradigm
Measurement of <i>B</i><sub>max</sub> and <i>K</i><sub>d</sub> with the Glycine Transporter 1 Radiotracer <sup>18</sup>F-MK6577 using a Novel Multi-Infusion Paradigm Open
Glycine is a co-agonist of glutamate at the NMDA receptor. Glycine transporter 1 (GlyT1) inhibitors are reported to be potential therapeutic agents for schizophrenia. 18 F-MK6577 is a new positron emission tomography (PET) radiotracer usef…
View article: Test–retest reproducibility of the metabotropic glutamate receptor 5 ligand [18F]FPEB with bolus plus constant infusion in humans
Test–retest reproducibility of the metabotropic glutamate receptor 5 ligand [18F]FPEB with bolus plus constant infusion in humans Open
View article: Imaging the Cannabinoid CB1 Receptor in Humans with [<sup>11</sup>C] OMAR: Assessment of Kinetic Analysis Methods, Test–Retest Reproducibility, and Gender Differences
Imaging the Cannabinoid CB1 Receptor in Humans with [<sup>11</sup>C] OMAR: Assessment of Kinetic Analysis Methods, Test–Retest Reproducibility, and Gender Differences Open
The Radiotracer [ 11 C]OMAR was developed for positron emission tomography (PET) imaging of cannabinoid type-1 receptors (CB1R). The objectives of the present study were to evaluate kinetic analysis methods, determine test–retest reliabili…