Shufeng Xie
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View article: Enhancing Anti‐Tumor Effects of Engineered Extracellular Vesicles via Endocytosis Route Switching and Interferon Response Suppression
Enhancing Anti‐Tumor Effects of Engineered Extracellular Vesicles via Endocytosis Route Switching and Interferon Response Suppression Open
Engineered extracellular vesicles (EVs) represent a promising therapeutic strategy with many applications in cancer therapy. EVs derived from engineered tumor‐targeting killer cells, such as chimeric antigen receptor (CAR)‐T cells. However…
View article: Exploring potential causal effects of circulating inflammatory proteins on hematologic malignancies and identifying cross-cancer drug targets: a Mendelian randomization study
Exploring potential causal effects of circulating inflammatory proteins on hematologic malignancies and identifying cross-cancer drug targets: a Mendelian randomization study Open
The results of the study provided possible causal evidence for the involvement of circulating inflammatory proteins in the pathogenesis of eleven hematologic malignancies. Nine proteins with cross-cancer effects were of special interest, a…
View article: Improved CAR internalization and recycling through transmembrane domain optimization reduces CAR-T cytokine release and exhaustion
Improved CAR internalization and recycling through transmembrane domain optimization reduces CAR-T cytokine release and exhaustion Open
Background Anti-CD19 chimeric antigen receptor T (CAR-T) cell therapy has proven effective for treating relapsed or refractory acute B cell leukemia. However, challenges such as cytokine release syndrome, T cell dysfunction, and exhaustion…
View article: The nuclear factor-κ B inhibitor SN50 enhances the efficacy of B-cell maturation antigen-targeted chimeric antigen receptor T-cell therapy
The nuclear factor-κ B inhibitor SN50 enhances the efficacy of B-cell maturation antigen-targeted chimeric antigen receptor T-cell therapy Open
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View article: Novel CAR T-cell therapies for relapsed/refractory B-cell malignancies: latest updates from 2023 ASH annual meeting
Novel CAR T-cell therapies for relapsed/refractory B-cell malignancies: latest updates from 2023 ASH annual meeting Open
Chimeric antigen receptors (CAR) are engineered fusion proteins that target T-cells to specific surface antigens of tumor cells to generate effective anti-tumor responses. CAR T-cell therapy is playing an increasingly important role in the…
View article: Microstructure, Mechanical Properties and Wear Behaviors of Ultrafine-Grain WC-Based Cermets with Different Binder Phases Fabricated by Spark Plasma Sintering
Microstructure, Mechanical Properties and Wear Behaviors of Ultrafine-Grain WC-Based Cermets with Different Binder Phases Fabricated by Spark Plasma Sintering Open
In this work, to explore potential substitutions for the Co binder phase, ultrafine-grain WC-based cermets with various binder phases of Co, Ni and AlCoCrNiFeCu HEA were prepared using the SPS method. Based on SPS, WC-based cermets were fa…
View article: Effect of Al Content on the Long-Term Corrosion Behavior of Arc-Sprayed ZnAl Alloy Coatings
Effect of Al Content on the Long-Term Corrosion Behavior of Arc-Sprayed ZnAl Alloy Coatings Open
The corrosion of steel structures in aggressive marine environments is a vital issue that induces significant degradation of their performance and lifespan. Herein, three arc-sprayed ZnAl coatings with varied Al contents of 0 wt.%, 15 wt.%…
View article: A Novel Identified Necroptosis-Related Risk Signature for Prognosis Prediction and Immune Infiltration Indication in Acute Myeloid Leukemia Patients
A Novel Identified Necroptosis-Related Risk Signature for Prognosis Prediction and Immune Infiltration Indication in Acute Myeloid Leukemia Patients Open
AML ranks second in the most common types of leukemia diagnosed in both adults and children. Necroptosis is a programmed inflammatory cell death form reported to be an innate immune effector against microbial and viral pathogens and recent…
View article: Targeting matrix metallopeptidase 2 by hydroxyurea selectively kills acute myeloid mixed-lineage leukemia
Targeting matrix metallopeptidase 2 by hydroxyurea selectively kills acute myeloid mixed-lineage leukemia Open
Oncogene-induced tumorigenesis results in the variation of epigenetic modifications, and in addition to promoting cell immortalization, cancer cells undergo more intense cellular stress than normal cells and depend on other support genes f…
View article: Excellent energy storage performance of niobate-based glass-ceramics via introduction of nucleating agent
Excellent energy storage performance of niobate-based glass-ceramics via introduction of nucleating agent Open
For glass-ceramics, how to realize the collaborative optimization of BDS and permittivity is the key to improve the energy storage density. In this work, ZrO2 is introduced into BPKNAS glass-ceramics as nucleating agent to promote crystal …
View article: A T-cell independent universal cellular therapy strategy through antigen depletion
A T-cell independent universal cellular therapy strategy through antigen depletion Open
Rationale: T cell therapeutic strategy using CD19-targeting chimeric antigen receptor (CAR) is a revolutionary, novel, and successful treatment for B-cell malignancies. However, the dependency on T-cell mediated cytotoxicity restric…
View article: Crystallization-Temperature Controlled Alkali-Free Niobate Glass-Ceramics with High Energy Storage Density and Actual Discharge Energy Density
Crystallization-Temperature Controlled Alkali-Free Niobate Glass-Ceramics with High Energy Storage Density and Actual Discharge Energy Density Open
View article: Crystallization-Temperature Controlled Alkali-Free Niobate Glass-Ceramics with High Energy Storage Density and Actual Discharge Energy Density
Crystallization-Temperature Controlled Alkali-Free Niobate Glass-Ceramics with High Energy Storage Density and Actual Discharge Energy Density Open
View article: Enhancing Graphene Retention and Electrical Conductivity of Plasma-Sprayed Alumina/Graphene Nanoplatelets Coating by Powder Heat Treatment
Enhancing Graphene Retention and Electrical Conductivity of Plasma-Sprayed Alumina/Graphene Nanoplatelets Coating by Powder Heat Treatment Open
Burning loss of graphene in the high-temperature plasma-spraying process is a critical issue, significantly limiting the remarkable performance improvement in graphene reinforced ceramic coatings. Here, we reported an effective approach to…
View article: A T-cell independent universal cellular therapy strategy through antigen depletion
A T-cell independent universal cellular therapy strategy through antigen depletion Open
CD19-targeting chimeric antigen receptor (CAR) T-cell therapeutics is a revolutionary, novel and successful treatment for B-cell malignancies. However, while CD19-CAR-T therapy can obtain high rates of complete responses in these patients,…
View article: Deubiquitinating enzyme inhibitor alleviates cyclin A1‐mediated proteasome inhibitor tolerance in mixed‐lineage leukemia
Deubiquitinating enzyme inhibitor alleviates cyclin A1‐mediated proteasome inhibitor tolerance in mixed‐lineage leukemia Open
Drug resistance is a significant obstacle to effective cancer treatment. Drug resistance develops from initially reversible drug‐tolerant cancer cells, which offer therapeutic opportunities to impede cancer relapse. The mechanisms of resis…
View article: Deubiquitinating Enzyme Inhibitor Alleviates Cyclin A1-mediated Proteasome Inhibitor Tolerance in Mixed-lineage Leukemia
Deubiquitinating Enzyme Inhibitor Alleviates Cyclin A1-mediated Proteasome Inhibitor Tolerance in Mixed-lineage Leukemia Open
Background: Drug resistance is a significant obstacle to effective cancer treatment. Drug resistance develops from initially reversible drug-tolerant cancer cells, which offers therapeutic opportunities to impede cancer relapse. The mechan…
View article: mTORC1‐mediated amino acid signaling is critical for cell fate determination under transplant‐induced stress
mTORC1‐mediated amino acid signaling is critical for cell fate determination under transplant‐induced stress Open
Transplantation of in vitro ‐manipulated cells is widely used in hematology. While transplantation is well recognized to impose severe stress on transplanted cells, the nature of transplant‐induced stress remains elusive. Here, we propose …