Shuguang Zhang
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View article: Telomere-to-telomere sequencing genome assembly identifies variants and genes associated with lactation and dwarf traits in Bactrian camel
Telomere-to-telomere sequencing genome assembly identifies variants and genes associated with lactation and dwarf traits in Bactrian camel Open
Camels play a crucial role in supporting livelihoods and productivity in desert regions. Despite their importance, and our understanding of their genetic composition remains limited. To address this gap, we constructed a telomere-to-telome…
View article: Co-evolution of alpha-helical transmembrane protein residues: large-scale variant profiling and complete mutational landscape of 2277 known PDB entries representing 504 unique human protein sequences
Co-evolution of alpha-helical transmembrane protein residues: large-scale variant profiling and complete mutational landscape of 2277 known PDB entries representing 504 unique human protein sequences Open
View article: Significantly Improved Protection Performance of Lotus-Leaf-Extract-Modified Mortar Against Chloride Corrosion
Significantly Improved Protection Performance of Lotus-Leaf-Extract-Modified Mortar Against Chloride Corrosion Open
Reinforced concrete structures in harsh environments are highly vulnerable to structural damage caused by rebar corrosion. However, there remains a critical shortage of high-performance, environmentally friendly repair materials that integ…
View article: Transanal irrigation is effective for low anterior resection syndrome: a systematic review and meta-analysis of randomized controlled trials
Transanal irrigation is effective for low anterior resection syndrome: a systematic review and meta-analysis of randomized controlled trials Open
TAI significantly improves bowel function in patients with LARS, as evidenced by reduced LARS and Wexner scores. However, its impact on QoL remains inconclusive. Large-scale RCTs with extended follow-up periods are warranted to validate lo…
View article: 871 | SURGERY IS HIGHLY EFFECTIVE FOR ASYMPTOMATIC MULTICENTRIC CASTLEMAN DISEASE
871 | SURGERY IS HIGHLY EFFECTIVE FOR ASYMPTOMATIC MULTICENTRIC CASTLEMAN DISEASE Open
View article: Towards robust medical machine olfaction: Debiasing GC-MS data enhances prostate cancer diagnosis from urine volatiles
Towards robust medical machine olfaction: Debiasing GC-MS data enhances prostate cancer diagnosis from urine volatiles Open
Prostate cancer (PCa) is a major, and increasingly global, health concern with current screening and diagnostic tools’ severe limitations causing unnecessary, invasive biopsy procedures. While gas chromatography–mass spectrometry (GC-MS) h…
View article: Chloride-induced macro-cell corrosion behavior of a novel alloyed-steel rebar and its inhibition strategy
Chloride-induced macro-cell corrosion behavior of a novel alloyed-steel rebar and its inhibition strategy Open
A new type of corrosion-resistant alloyed-steel rebar, Cr10MoV, was researched using techniques such as corrosion electrochemistry, X-ray computed tomography, and zero resistance ammeter to systematically study the macro-cell corrosion beh…
View article: Influencing Factors and Wavelet Coherence of Waves Generated by Submerged Jet
Influencing Factors and Wavelet Coherence of Waves Generated by Submerged Jet Open
This paper investigates the significance of various physical factors affecting the wave generated by submerged jet and the synchronization relationship between the wave surface process and different fluid dynamic parameters, based on three…
View article: Enhanced Corrosion Resistance of Carbon Steel Rebar in Chloride-Containing Water Solutions: The Role of Lotus Extract in Corrosion Inhibition
Enhanced Corrosion Resistance of Carbon Steel Rebar in Chloride-Containing Water Solutions: The Role of Lotus Extract in Corrosion Inhibition Open
Corrosion inhibitors play a crucial role in the corrosion protection of rebars in reinforced concrete structures under harsh service conditions. However, conventional corrosion inhibitors often suffer from low efficiency and environmental …
View article: Study on the regulation of neural cell activity by music therapy based on biosensor technology
Study on the regulation of neural cell activity by music therapy based on biosensor technology Open
With the deepening of biomechanical research and the transformation of medical paradigms, finding safe and effective methods for neural modulation has become an urgent task. This study combines music therapy with biosensing technology to e…
View article: A bilayer scaffold of collagen and nanohydroxyapatite promotes osteochondral defect repair in rabbit knee joints
A bilayer scaffold of collagen and nanohydroxyapatite promotes osteochondral defect repair in rabbit knee joints Open
Aims A large number of surgical operations are available to treat osteochondral defects of the knee. However, the knee joint arthroplasty materials cannot completely mimic the articular cartilage and subchondral bone, which may bring some …
View article: Structure Bioinformatics of Six Human Integral Transmembrane Enzymes and their AlphaFold3 Predicted Water-Soluble QTY Analogs: Insights into FACE1 and STEA4 Binding Mechanisms
Structure Bioinformatics of Six Human Integral Transmembrane Enzymes and their AlphaFold3 Predicted Water-Soluble QTY Analogs: Insights into FACE1 and STEA4 Binding Mechanisms Open
View article: Structural bioinformatic study of human mitochondrial respiratory integral membrane megacomplex and its AlphaFold3 predicted water-soluble QTY megacomplex analog
Structural bioinformatic study of human mitochondrial respiratory integral membrane megacomplex and its AlphaFold3 predicted water-soluble QTY megacomplex analog Open
Human mitochondrial Complex I is one of the largest multi-subunit membrane protein megacomplexes, which plays a critical role in oxidative phosphorylation and ATP production. It is also involved in many neurodegenerative diseases. However,…
View article: Author comment: Structural bioinformatic study of human mitochondrial respiratory integral membrane megacomplex and its AlphaFold3 predicted water-soluble QTY megacomplex analog — R0/PR1
Author comment: Structural bioinformatic study of human mitochondrial respiratory integral membrane megacomplex and its AlphaFold3 predicted water-soluble QTY megacomplex analog — R0/PR1 Open
View article: Structural bioinformatic study of six human olfactory receptors and their AlphaFold3 predicted water-soluble QTY variants and OR1A2 with an odorant octanoate and TAAR9 with spermidine
Structural bioinformatic study of six human olfactory receptors and their AlphaFold3 predicted water-soluble QTY variants and OR1A2 with an odorant octanoate and TAAR9 with spermidine Open
The molecular mechanism of olfaction, namely, how we smell with limited olfactory receptors to recognize exceedingly diverse and large numbers of scents remains unknown despite the recent advances in chemistry, chemical, structural, and mo…
View article: Structural molecular modeling of bacterial integral membrane protein enzymes and their AlphaFold2 predicted water-soluble QTY variants
Structural molecular modeling of bacterial integral membrane protein enzymes and their AlphaFold2 predicted water-soluble QTY variants Open
Context Beta-barrel enzymes are an important area of study in the field of structural biology. These proteins serve crucial roles, acting as porins, transporters, enzymes, virulence factors, and receptors. Recent research has unveiled a no…
View article: Towards robust medical machine olfaction: debiasing GC-MS data enhances prostate cancer diagnosis from urine volatiles
Towards robust medical machine olfaction: debiasing GC-MS data enhances prostate cancer diagnosis from urine volatiles Open
Prostate cancer (PCa) is a major, and increasingly global, health concern with current screening and diagnostic tools’ severe limitations causing unnecessary, invasive biopsy procedures. While gas chromatography–mass spectrometry (GC-MS) h…
View article: Computational engineering of water-soluble human potassium ion channels through QTY transformation
Computational engineering of water-soluble human potassium ion channels through QTY transformation Open
View article: Inhibitory Potential of the Truncated Isoforms on Glutamate Transporter Oligomerization Identified by Computational Analysis of Gene-Centric Isoform Maps
Inhibitory Potential of the Truncated Isoforms on Glutamate Transporter Oligomerization Identified by Computational Analysis of Gene-Centric Isoform Maps Open
View article: Author comment: Structural bioinformatic study of six human olfactory receptors and their AlphaFold3 predicted water-soluble QTY variants and OR1A2 with an odorant octanoate and TAAR9 with spermidine — R1/PR6
Author comment: Structural bioinformatic study of six human olfactory receptors and their AlphaFold3 predicted water-soluble QTY variants and OR1A2 with an odorant octanoate and TAAR9 with spermidine — R1/PR6 Open
View article: Molecular Dynamic Simulations Reveal that Water-Soluble QTY-Variants of Glutamate Transporters EAA1, EAA2 and EAA3 Retain the Conformational Characteristics of Native Transporters
Molecular Dynamic Simulations Reveal that Water-Soluble QTY-Variants of Glutamate Transporters EAA1, EAA2 and EAA3 Retain the Conformational Characteristics of Native Transporters Open
View article: Author comment: Structural bioinformatic study of six human olfactory receptors and their AlphaFold3 predicted water-soluble QTY variants and OR1A2 with an odorant octanoate and TAAR9 with spermidine — R0/PR1
Author comment: Structural bioinformatic study of six human olfactory receptors and their AlphaFold3 predicted water-soluble QTY variants and OR1A2 with an odorant octanoate and TAAR9 with spermidine — R0/PR1 Open
View article: Friction between a single platelet and fibrinogen
Friction between a single platelet and fibrinogen Open
Friction has been considered to mediate physiological activities of cells, however, the biological friction between a single cell and its ligand-bound surface has not been thoroughly explored. Herein, we established a friction model for si…
View article: Design of a water-soluble transmembrane receptor kinase with intact molecular function by QTY code
Design of a water-soluble transmembrane receptor kinase with intact molecular function by QTY code Open
Membrane proteins are critical to biological processes and central to life sciences and modern medicine. However, membrane proteins are notoriously challenging to study, mainly owing to difficulties dictated by their highly hydrophobic nat…
View article: Comparing Fair Dealing with Fair Use: Why Fair Dealing Can Better Balance Copyright Interests?
Comparing Fair Dealing with Fair Use: Why Fair Dealing Can Better Balance Copyright Interests? Open
This paper conducts a comprehensive comparison of the two pivotal doctrines in copyright law: fair dealing and fair use, highlighting the balance between creators' rights and public access to knowledge. It examines the evolution of these d…
View article: Structural bioinformatics studies of glutamate transporters and their AlphaFold2 predicted water-soluble QTY variants and uncovering the natural mutations of L->Q, I->T, F->Y and Q->L, T->I and Y->F
Structural bioinformatics studies of glutamate transporters and their AlphaFold2 predicted water-soluble QTY variants and uncovering the natural mutations of L->Q, I->T, F->Y and Q->L, T->I and Y->F Open
Glutamate transporters play key roles in nervous physiology by modulating excitatory neurotransmitter levels, when malfunctioning, involving in a wide range of neurological and physiological disorders. However, integral transmembrane prote…
View article: Granulomatous hypophysitis: a case report and literature review
Granulomatous hypophysitis: a case report and literature review Open
Granulomatous hypophysitis (GRH) is an extremely rare inflammatory disease of the pituitary. GRH commonly presents with nonspecific clinical and radiological patterns and is commonly misdiagnosed as pituitary adenoma—a 48-year-old male pat…
View article: Structural bioinformatics studies of serotonin, dopamine and norepinephrine transporters and their AlphaFold2 predicted water-soluble QTY variants and uncovering the natural mutations of L->Q, I->T, F->Y and Q->L, T->I and Y->F
Structural bioinformatics studies of serotonin, dopamine and norepinephrine transporters and their AlphaFold2 predicted water-soluble QTY variants and uncovering the natural mutations of L->Q, I->T, F->Y and Q->L, T->I and Y->F Open
Monoamine transporters including transporters for serotonin, dopamine, and norepinephrine play key roles in monoaminergic synaptic signaling, involving in the molecular etiology of a wide range of neurological and physiological disorders. …
View article: Screening and verification of hub genes in esophageal squamous cell carcinoma by integrated analysis
Screening and verification of hub genes in esophageal squamous cell carcinoma by integrated analysis Open
View article: Structural bioinformatics studies of six human ABC transporters and their AlphaFold2-predicted water-soluble QTY variants
Structural bioinformatics studies of six human ABC transporters and their AlphaFold2-predicted water-soluble QTY variants Open
Human ATP-binding cassette (ABC) transporters are one of the largest families of membrane proteins and perform diverse functions. Many of them are associated with multidrug resistance that often results in cancer treatment with poor outcom…