Shuhan Duan
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View article: Genomic insights into population structure, adaptation, and archaic introgression at the Himalayan–East Asian crossroads
Genomic insights into population structure, adaptation, and archaic introgression at the Himalayan–East Asian crossroads Open
Tibetan-Yi Corridor (TYC) is a crucial agro-pastoral region in the eastern Himalayas, linking Qinghai‒Xizang Plateau with the lowlands of East Asia and facilitating human migration for millennia. However, genomic research on TYC population…
View article: Largest-Scale Genomic Resource Reconstructing the Genetic Origin, Population Structure, and Biological Adaptations of the Hui People
Largest-Scale Genomic Resource Reconstructing the Genetic Origin, Population Structure, and Biological Adaptations of the Hui People Open
Historical and archaeological records indicate that the Maritime and Land Silk Roads played a pivotal role in facilitating Trans-Eurasian migrations and cultural exchanges. However, the extent to which population movements or the spread of…
View article: Next-generation sequencing of mitochondrial DNA reveals pathogenic variants and protective haplogroup D4 in esophageal cancer
Next-generation sequencing of mitochondrial DNA reveals pathogenic variants and protective haplogroup D4 in esophageal cancer Open
Introduction The germline variations in the mitochondrial genome of esophageal cancer (EC) remain uncertain. Our study aimed to explore the distribution and pathogenicity of mitochondrial genome variations in EC, as well as to identify hap…
View article: Genomic insights into population stratification, biological adaptation, and archaic introgression at the crossroads of the Himalayas and lowland East Asia
Genomic insights into population stratification, biological adaptation, and archaic introgression at the crossroads of the Himalayas and lowland East Asia Open
The Tibetan-Yi Corridor (TYC) has been a crucial agro-pastoral region in the eastern Himalayas, linking the Qinghai-Tibet Plateau with the lowlands of East Asia and facilitating human migration over millennia. Despite its significance, gen…
View article: YanHuang Paternal Genomic Resource Suggested A Weakly-Differentiated Multi-Source Admixture Model for the Formation of Han’s Founding Ancestral Lineages
YanHuang Paternal Genomic Resource Suggested A Weakly-Differentiated Multi-Source Admixture Model for the Formation of Han’s Founding Ancestral Lineages Open
The revolution in large-scale human genomics and advancements in statistical methods have profoundly refined our understanding of genetic diversity and structure within human populations. Y-chromosome variations, with their distinct evolut…
View article: High-quality Population-specific Haplotype-resolved Reference Panel in the Genomic and Pangenomic Eras
High-quality Population-specific Haplotype-resolved Reference Panel in the Genomic and Pangenomic Eras Open
Large-scale international and regional human genomic and pangenomic resources derived from population-scale biobanks and ancient DNA sequences have provided significant insights into human evolution and the genetic determinants of complex …
View article: The large-scale whole-genome sequencing era expedited medical discovery and clinical translation
The large-scale whole-genome sequencing era expedited medical discovery and clinical translation Open
Genomic research has been constrained by insufficient diversity over the past two decades, with over 90 % of studies targeting populations of European ancestry. This imbalance has hampered health equity and precision medicine, resulting i…
View article: YHSeqY3000 panel captures all founding lineages in the Chinese paternal genomic diversity database
YHSeqY3000 panel captures all founding lineages in the Chinese paternal genomic diversity database Open
This work successfully integrated Y-chromosome-related basic genomic science with forensic and anthropological translational applications, emphasizing the necessity of comprehensively characterizing Y-chromosome genomic diversity from geno…
View article: Genome-driven Chinese precision medicine: Biobank-scale genomic research as a new paradigm
Genome-driven Chinese precision medicine: Biobank-scale genomic research as a new paradigm Open
Large-scale genomic resources from biobank sequencing projects are crucial for understanding the interplay between environmental and genetic factors in human disease and health traits, as well as for reconstructing human evolutionary histo…
View article: Genetic history and biological adaptive landscape of the Tujia people inferred from shared haplotypes and alleles
Genetic history and biological adaptive landscape of the Tujia people inferred from shared haplotypes and alleles Open
The study unveils significant population movements and genetic admixture among the Tujia and other ethno-linguistically diverse East Asian groups, elucidating the differentiated adaptation processes across geographically diverse population…
View article: Population genetic admixture and evolutionary history in the Shandong Peninsula inferred from integrative modern and ancient genomic resources
Population genetic admixture and evolutionary history in the Shandong Peninsula inferred from integrative modern and ancient genomic resources Open
View article: Multiple Human Population Movements and Cultural Dispersal Events Shaped the Landscape of Chinese Paternal Heritage
Multiple Human Population Movements and Cultural Dispersal Events Shaped the Landscape of Chinese Paternal Heritage Open
Large-scale genomic projects and ancient DNA innovations have ushered in a new paradigm for exploring human evolutionary history. However, the genetic legacy of spatiotemporally diverse ancient Eurasians within Chinese paternal lineages re…
View article: Genetic history of esophageal cancer group in southwestern China revealed by Y‐chromosome STRs and genomic evolutionary connection analysis
Genetic history of esophageal cancer group in southwestern China revealed by Y‐chromosome STRs and genomic evolutionary connection analysis Open
View article: Evolutionary history and biological adaptation of Han Chinese people on the Mongolian Plateau
Evolutionary history and biological adaptation of Han Chinese people on the Mongolian Plateau Open
Complex demographic processes and natural selection pressures are critical to resolving patterns of the molecular genetic basis of adaptative traits or complex diseases. Recent ancient genome data allow us to trace how key traits evolved i…
View article: Malaria resistance-related biological adaptation and complex evolutionary footprints inferred from one integrative Tai-Kadai-related genomic resource
Malaria resistance-related biological adaptation and complex evolutionary footprints inferred from one integrative Tai-Kadai-related genomic resource Open
Pathogen‒host adaptative interactions and complex population demographical processes, including admixture, drift, and Darwen selection, have considerably shaped the Neolithic-to-Modern Western Eurasian population structure and genetic susc…
View article: Differentiated adaptative genetic architecture and language-related demographical history in South China inferred from 619 genomes from 56 populations
Differentiated adaptative genetic architecture and language-related demographical history in South China inferred from 619 genomes from 56 populations Open
View article: Differentiated genomic footprints suggest isolation and long-distance migration of Hmong-Mien populations
Differentiated genomic footprints suggest isolation and long-distance migration of Hmong-Mien populations Open
Background The underrepresentation of Hmong-Mien (HM) people in Asian genomic studies has hindered our comprehensive understanding of the full landscape of their evolutionary history and complex trait architecture. South China is a multi-e…
View article: Paternal genomic resources from the YanHuang cohort suggested a Weakly-Differentiated Multi-source Admixture model for the formation of Han’s founding ancestral lineages
Paternal genomic resources from the YanHuang cohort suggested a Weakly-Differentiated Multi-source Admixture model for the formation of Han’s founding ancestral lineages Open
The large-scale human genome revolution and rapidly advanced statistical innovation have updated our understanding of the fine-scale and complex genetic structure, the entire landscape of genetic diversity and the evolutionary trajectories…
View article: The complex genetic landscape of southwestern Chinese populations contributed to their extensive ethnolinguistic diversity
The complex genetic landscape of southwestern Chinese populations contributed to their extensive ethnolinguistic diversity Open
The comprehensive characterization of the fine-scale genetic background of ethnolinguistically diverse populations can gain new insights into the population admixture processes, which is essential for evolutionary and medical genomic resea…
View article: Distinguished biological adaptation architecture aggravated population differentiation of Tibeto-Burman-speaking people
Distinguished biological adaptation architecture aggravated population differentiation of Tibeto-Burman-speaking people Open
Tibeto-Burman (TB) people have endeavored to adapt to the hypoxic, cold, and high-UV high-altitude environments in the Tibetan Plateau and complex disease exposures in lowland rainforests since the late Paleolithic period. However, the ful…
View article: Ancient farmer and steppe pastoralist-related founding lineages contributed to the complex landscape of episodes in the diversification of Chinese paternal lineages
Ancient farmer and steppe pastoralist-related founding lineages contributed to the complex landscape of episodes in the diversification of Chinese paternal lineages Open
Ancient DNA advances have reported the complex genetic history of Eurasians, but how the knowledge of ancient subsistence strategy shifts and population movements influenced the fine-scale paternal genetic structure in East Asia has not be…
View article: Perspective and Opportunity for forensic integrative genomics in the Human Pangenome Reference sequence era
Perspective and Opportunity for forensic integrative genomics in the Human Pangenome Reference sequence era Open
Human Pangenome Reference Consortium (HPRC) and Chinese Pangenome Consortium (CPC) have pronounced the finish of the pilot work of the Human Pangenome Project, which aimed to build worldwide population-representative high-quality haplotype…
View article: Malaria resistance-related biological adaptation and complex evolutionary footprints of Tai-Kadai people inferred from 796 genomes
Malaria resistance-related biological adaptation and complex evolutionary footprints of Tai-Kadai people inferred from 796 genomes Open
Pathogen-host adaptative interaction and complex population demographical processes, including admixture, drift and Darwen selection, have considerably shaped the Neolithic-to-Modern Western Eurasian population structure and genetic suscep…
View article: Distinguished biological adaptation architecture aggravated population differentiation of Tibeto-Burman-speaking people inferred from 500 whole-genome data from 39 populations
Distinguished biological adaptation architecture aggravated population differentiation of Tibeto-Burman-speaking people inferred from 500 whole-genome data from 39 populations Open
SUMMARY Tibeto-Burman (TB) people have tried to adapt to the hypoxic, cold and high-UV high-altitude Tibetan Plateau and complex disease exposure in the lowland wet and hot rainforest since the late Paleolithic period. However, the full la…
View article: Extensive genetic admixture between Tai-Kadai-speaking people and their neighbours in the northeastern region of the Yungui Plateau inferred from genome-wide variations
Extensive genetic admixture between Tai-Kadai-speaking people and their neighbours in the northeastern region of the Yungui Plateau inferred from genome-wide variations Open
Background Yungui Plateau in Southwest China is characterized by multi-language and multi-ethnic communities and is one of the regions with the wealthiest ethnolinguistic, cultural and genetic diversity in East Asia. There are numerous Tai…
View article: Correction: Genome-wide allele and haplotype-sharing patterns suggested one unique Hmong–Mein-related lineage and biological adaptation history in Southwest China
Correction: Genome-wide allele and haplotype-sharing patterns suggested one unique Hmong–Mein-related lineage and biological adaptation history in Southwest China Open
View article: Multiple founding paternal lineages inferred from the newly-developed 639-plex Y-SNP panel suggested the complex admixture and migration history of Chinese people
Multiple founding paternal lineages inferred from the newly-developed 639-plex Y-SNP panel suggested the complex admixture and migration history of Chinese people Open
View article: Genome-wide allele and haplotype-sharing patterns suggested one unique Hmong–Mein-related lineage and biological adaptation history in Southwest China
Genome-wide allele and haplotype-sharing patterns suggested one unique Hmong–Mein-related lineage and biological adaptation history in Southwest China Open
Background Fine-scale genetic structure of ethnolinguistically diverse Chinese populations can fill the gap in the missing diversity and evolutionary landscape of East Asians, particularly for anthropologically informed Chinese minorities.…
View article: Admixture-introduced complex landscape of genetic diversity contributed to the extensive Southwestern Chinese ethnolinguistic diversity
Admixture-introduced complex landscape of genetic diversity contributed to the extensive Southwestern Chinese ethnolinguistic diversity Open
Fine-scale genetic background characterization of ethnolinguistically diverse populations can gain new insights into the population admixture processes, which is essential for evolutionary and medical genomic research. However, the genetic…
View article: Differentiated genomic footprints and connections inferred from 440 Hmong-Mien genomes suggest their isolation and long-distance migration
Differentiated genomic footprints and connections inferred from 440 Hmong-Mien genomes suggest their isolation and long-distance migration Open
Background The underrepresentation of Hmong-Mien (HM) people in Asian genomic studies has hindered our comprehensive understanding of population history and human health. South China is an ethnolinguistically diverse region and indigenousl…