Shu‐Han Yu
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View article: Comparison of Ahmed Glaucoma Valve Implantation Alone Versus Combined with Phacoemulsification in Chinese Primary Open-Angle Glaucoma
Comparison of Ahmed Glaucoma Valve Implantation Alone Versus Combined with Phacoemulsification in Chinese Primary Open-Angle Glaucoma Open
The surgical outcomes of phaco-AGV showed higher success rates and fewer complications than those of AGV in this 2-year study.
View article: The corneal biomechanics of the posterior staphyloma
The corneal biomechanics of the posterior staphyloma Open
Eyes with posterior staphyloma (PS) exhibit greater corneal deformability, elasticity, and viscoelasticity than controls, independent of PS location. These findings suggest PS impacts the anterior ocular wall, offering insights into PS pat…
View article: Tartrate-resistant acid phosphatase 5 regulates the metabolic flexibility of macrophages in the tumor microenvironment, thereby influencing their functional fate and modulating tumor growth
Tartrate-resistant acid phosphatase 5 regulates the metabolic flexibility of macrophages in the tumor microenvironment, thereby influencing their functional fate and modulating tumor growth Open
Macrophages play a crucial role in anti-tumor immunity, and their dysfunction within the tumor microenvironment contributes to tumor growth and distant metastasis, posing a significant obstacle to cancer immunotherapies. Understanding the …
View article: High-selective HDAC6 inhibitor alleviates bone marrow fibrosis through inhibiting collagen formation and extracellular matrix deposition
High-selective HDAC6 inhibitor alleviates bone marrow fibrosis through inhibiting collagen formation and extracellular matrix deposition Open
View article: A tau class glutathione S-transferase in alfalfa, MsGSTU17, regulates salt tolerance in transgenic <i>Arabidopsis thaliana</i>
A tau class glutathione S-transferase in alfalfa, MsGSTU17, regulates salt tolerance in transgenic <i>Arabidopsis thaliana</i> Open
View article: Atezolizumab, bevacizumab, pemetrexed and platinum for <i>EGFR</i>‐mutant NSCLC patients after EGFR TKI failure: A phase II study with immune cell profile analysis
Atezolizumab, bevacizumab, pemetrexed and platinum for <i>EGFR</i>‐mutant NSCLC patients after EGFR TKI failure: A phase II study with immune cell profile analysis Open
Background Acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) remains a significant hurdle for patients with EGFR ‐mutated non‐small cell lung cancer (NSCLC), particularly those lacking the EGFR …
View article: PD-L1 expression and immune profiling cannot predict osimertinib efficacy in lung cancer with EGFR T790 M mutation: A translational study
PD-L1 expression and immune profiling cannot predict osimertinib efficacy in lung cancer with EGFR T790 M mutation: A translational study Open
PD-L1 expression in pre-treated EGFR T790 M + lung adenocarcinoma is not predictive of osimertinib efficacy, as demonstrated by in vitro, xenograft, and clinical case studies.
View article: The emotion prediction of college students with attention LSTM during the COVID19 epidemic
The emotion prediction of college students with attention LSTM during the COVID19 epidemic Open
During the COVID19 pandemic, there is a pronounced collective mental health issue among college students. Forecasting the trend of emotional changes in on-campus students is crucial to effectively address this issue. This study proposes an…
View article: Glycine-rich peptides from fermented Chenopodium formosanum sprout as an antioxidant to modulate the oxidative stress
Glycine-rich peptides from fermented Chenopodium formosanum sprout as an antioxidant to modulate the oxidative stress Open
Rhizopus oligosporus was utilized in the solid-state fermentation of Chenopodiumformosanumsprouts (FCS) in a bioreactor. Subsequently, the antioxidant activity of food proteins derived from FCS was investigated. Results showed that glycine…
View article: Discovery of HDAC6, HDAC8, and 6/8 Inhibitors and Development of Cell-Based Drug Screening Models for the Treatment of TGF-β-Induced Idiopathic Pulmonary Fibrosis
Discovery of HDAC6, HDAC8, and 6/8 Inhibitors and Development of Cell-Based Drug Screening Models for the Treatment of TGF-β-Induced Idiopathic Pulmonary Fibrosis Open
Idiopathic pulmonary fibrosis is incurable, and its progression is difficult to control and thus can lead to pulmonary deterioration. Pan-histone deacetylase inhibitors such as SAHA have shown potential for modulating pulmonary fibrosis ye…
View article: Effects of selective cyclooxygenase‐2 inhibitor robenacoxib on primary cells derived from feline injection‐site sarcoma
Effects of selective cyclooxygenase‐2 inhibitor robenacoxib on primary cells derived from feline injection‐site sarcoma Open
Feline injection‐site sarcomas (FISSs) are highly invasive malignant mesenchymal neoplasms that arise from injection sites in cats. Although the tumorigenesis of FISSs is still uncertain, there is a consensus that FISS is associated with c…
View article: Genome-Wide Analysis of the Wall-Associated Kinase (WAK) Genes in Medicago truncatula and Functional Characterization of MtWAK24 in Response to Pathogen Infection
Genome-Wide Analysis of the Wall-Associated Kinase (WAK) Genes in Medicago truncatula and Functional Characterization of MtWAK24 in Response to Pathogen Infection Open
The wall-associated kinases (WAKs) can perceive and transmit extracellular signals as one kind of unique receptor-like kinases (RLKs) involved in the regulation of cell expansion, pathogen resistance and abiotic stress tolerance. To unders…
View article: Features of gut microbiota and short-chain fatty acids in patients with first-episode depression and their relationship with the clinical symptoms
Features of gut microbiota and short-chain fatty acids in patients with first-episode depression and their relationship with the clinical symptoms Open
Objective To compare the differences in gut microbiota and short-chain fatty acids (SCFAs; metabolites of gut microbiota) in the serum of patients with first-episode depression and the healthy population and to analyze the relationship bet…
View article: Neoantigen vaccination augments antitumor effects of anti-PD-1 on mouse hepatocellular carcinoma
Neoantigen vaccination augments antitumor effects of anti-PD-1 on mouse hepatocellular carcinoma Open
Immune checkpoint inhibitors are groundbreaking resources for cancer therapy. However, only a few patients with hepatocellular carcinoma (HCC) have shown positive responses to anti-PD-1 therapy. Neoantigens are sequence-altered proteins re…
View article: Supplementary Figure S2 from A Paracrine Role for IL6 in Prostate Cancer Patients: Lack of Production by Primary or Metastatic Tumor Cells
Supplementary Figure S2 from A Paracrine Role for IL6 in Prostate Cancer Patients: Lack of Production by Primary or Metastatic Tumor Cells Open
IL-6 mRNA positive blood vessels in prostate cancer bone metastases. Example of IL-6 positive endothelial cells and IL-6 negative metastatic tumor cells in prostate cancer bone metastases.
View article: Supplementary Figure Legends from A Paracrine Role for IL6 in Prostate Cancer Patients: Lack of Production by Primary or Metastatic Tumor Cells
Supplementary Figure Legends from A Paracrine Role for IL6 in Prostate Cancer Patients: Lack of Production by Primary or Metastatic Tumor Cells Open
Supplementary Figure Legends
View article: Supplementary Figure S2 from A Paracrine Role for IL6 in Prostate Cancer Patients: Lack of Production by Primary or Metastatic Tumor Cells
Supplementary Figure S2 from A Paracrine Role for IL6 in Prostate Cancer Patients: Lack of Production by Primary or Metastatic Tumor Cells Open
IL-6 mRNA positive blood vessels in prostate cancer bone metastases. Example of IL-6 positive endothelial cells and IL-6 negative metastatic tumor cells in prostate cancer bone metastases.
View article: Data from A Paracrine Role for IL6 in Prostate Cancer Patients: Lack of Production by Primary or Metastatic Tumor Cells
Data from A Paracrine Role for IL6 in Prostate Cancer Patients: Lack of Production by Primary or Metastatic Tumor Cells Open
Correlative human studies suggest that the pleiotropic cytokine IL6 contributes to the development and/or progression of prostate cancer. However, the source of IL6 production in the prostate microenvironment in patients has yet to be dete…
View article: Supplementary Fig. S2 from Bacterial Prostatitis Enhances 2-Amino-1-Methyl-6-Phenylimidazo[4,5-<i>b</i>]Pyridine (PhIP)–Induced Cancer at Multiple Sites
Supplementary Fig. S2 from Bacterial Prostatitis Enhances 2-Amino-1-Methyl-6-Phenylimidazo[4,5-<i>b</i>]Pyridine (PhIP)–Induced Cancer at Multiple Sites Open
Supplementary Figure S2. A single E. coli infection of the rat prostate induces long-term chronic inflammation that persists up to 42 weeks.
View article: Supplementary Fig. S3 from Bacterial Prostatitis Enhances 2-Amino-1-Methyl-6-Phenylimidazo[4,5-<i>b</i>]Pyridine (PhIP)–Induced Cancer at Multiple Sites
Supplementary Fig. S3 from Bacterial Prostatitis Enhances 2-Amino-1-Methyl-6-Phenylimidazo[4,5-<i>b</i>]Pyridine (PhIP)–Induced Cancer at Multiple Sites Open
Supplementary Figure S3. Body weight and food intake data.
View article: Supplementary Figure S3 from A Paracrine Role for IL6 in Prostate Cancer Patients: Lack of Production by Primary or Metastatic Tumor Cells
Supplementary Figure S3 from A Paracrine Role for IL6 in Prostate Cancer Patients: Lack of Production by Primary or Metastatic Tumor Cells Open
Western blot on NCI-H460 cells. Western blot on protein lysates from NCI-H460 cells grown without (1) or with (2) protein transport inhibition with monensin (Golgi-Stop{trade mark, serif}). (3) 300 ng recombinant IL-6, positive cont…
View article: Supplementary Figure S4 from A Paracrine Role for IL6 in Prostate Cancer Patients: Lack of Production by Primary or Metastatic Tumor Cells
Supplementary Figure S4 from A Paracrine Role for IL6 in Prostate Cancer Patients: Lack of Production by Primary or Metastatic Tumor Cells Open
IL-6 CISH assay is more sensitive than IL-6 IHC. (A) Standard curve generated using estimated copies of IL-6 cDNA clone expression vector (Origene, SC125236) used to determine IL-6 mRNA copy number in DU145 and PC3 cells. (B)
View article: Supplementary Figure S1 from A Paracrine Role for IL6 in Prostate Cancer Patients: Lack of Production by Primary or Metastatic Tumor Cells
Supplementary Figure S1 from A Paracrine Role for IL6 in Prostate Cancer Patients: Lack of Production by Primary or Metastatic Tumor Cells Open
IL-6 mRNA expression in macrophages and endothelial cells. RNAscope 2-plex assay for IL-6 (red) and CD68 (green) (A) or IL-6 (red) and CD31 (green) (B) indicated that some IL-6 positive cells in the stroma are macropha…
View article: Supplementary Methods from Bacterial Prostatitis Enhances 2-Amino-1-Methyl-6-Phenylimidazo[4,5-<i>b</i>]Pyridine (PhIP)–Induced Cancer at Multiple Sites
Supplementary Methods from Bacterial Prostatitis Enhances 2-Amino-1-Methyl-6-Phenylimidazo[4,5-<i>b</i>]Pyridine (PhIP)–Induced Cancer at Multiple Sites Open
Supplementary Methods file
View article: Data from Bacterial Prostatitis Enhances 2-Amino-1-Methyl-6-Phenylimidazo[4,5-<i>b</i>]Pyridine (PhIP)–Induced Cancer at Multiple Sites
Data from Bacterial Prostatitis Enhances 2-Amino-1-Methyl-6-Phenylimidazo[4,5-<i>b</i>]Pyridine (PhIP)–Induced Cancer at Multiple Sites Open
Dietary carcinogens, such as 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), and chronic inflammation have each been implicated as etiologic agents in prostate cancer. We hypothesized that bacterial prostatitis would acceler…
View article: Supplementary Figure Legends from Bacterial Prostatitis Enhances 2-Amino-1-Methyl-6-Phenylimidazo[4,5-<i>b</i>]Pyridine (PhIP)–Induced Cancer at Multiple Sites
Supplementary Figure Legends from Bacterial Prostatitis Enhances 2-Amino-1-Methyl-6-Phenylimidazo[4,5-<i>b</i>]Pyridine (PhIP)–Induced Cancer at Multiple Sites Open
Supplementary Figure Legends
View article: Supplementary Fig. S3 from Bacterial Prostatitis Enhances 2-Amino-1-Methyl-6-Phenylimidazo[4,5-<i>b</i>]Pyridine (PhIP)–Induced Cancer at Multiple Sites
Supplementary Fig. S3 from Bacterial Prostatitis Enhances 2-Amino-1-Methyl-6-Phenylimidazo[4,5-<i>b</i>]Pyridine (PhIP)–Induced Cancer at Multiple Sites Open
Supplementary Figure S3. Body weight and food intake data.
View article: Supplementary Figure Legends from A Paracrine Role for IL6 in Prostate Cancer Patients: Lack of Production by Primary or Metastatic Tumor Cells
Supplementary Figure Legends from A Paracrine Role for IL6 in Prostate Cancer Patients: Lack of Production by Primary or Metastatic Tumor Cells Open
Supplementary Figure Legends
View article: Supplementary Figure S3 from A Paracrine Role for IL6 in Prostate Cancer Patients: Lack of Production by Primary or Metastatic Tumor Cells
Supplementary Figure S3 from A Paracrine Role for IL6 in Prostate Cancer Patients: Lack of Production by Primary or Metastatic Tumor Cells Open
Western blot on NCI-H460 cells. Western blot on protein lysates from NCI-H460 cells grown without (1) or with (2) protein transport inhibition with monensin (Golgi-Stop{trade mark, serif}). (3) 300 ng recombinant IL-6, positive cont…
View article: Supplementary Fig. S5 from Bacterial Prostatitis Enhances 2-Amino-1-Methyl-6-Phenylimidazo[4,5-<i>b</i>]Pyridine (PhIP)–Induced Cancer at Multiple Sites
Supplementary Fig. S5 from Bacterial Prostatitis Enhances 2-Amino-1-Methyl-6-Phenylimidazo[4,5-<i>b</i>]Pyridine (PhIP)–Induced Cancer at Multiple Sites Open
Supplementary Figure S5. Mast cell quantification in ventral prostates of control versus PhIP-treated rats (n=2) at week 20 of the study (after 20 weeks of receiving dietary PhIP).