Shuhao Zeng
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View article: Apolipoprotein E drives microglia activation in the development of autoimmune uveitis through up-regulation of peptidyl prolyl isomerase F
Apolipoprotein E drives microglia activation in the development of autoimmune uveitis through up-regulation of peptidyl prolyl isomerase F Open
Autoimmune uveitis (AU) is a category of sight-threatening diseases with different pathological causes. Transcriptomic analysis of patients with AU revealed a highly oxidative stress profile as well as an up-regulated apolipoprotein E ( AP…
View article: Muscone Attenuates Uveitis Through the PI3K/AKT Signaling Pathway
Muscone Attenuates Uveitis Through the PI3K/AKT Signaling Pathway Open
In summary, this study establishes the protective efficacy of Muscone against the progression of EAU and provides insights into the molecular mechanisms responsible for its therapeutic action.
View article: BARD1-mediated stabilization of METTL14 promotes retinal neovascularization by m6A-modifying MXD1 mRNA on a YTHDF2-dependent manner
BARD1-mediated stabilization of METTL14 promotes retinal neovascularization by m6A-modifying MXD1 mRNA on a YTHDF2-dependent manner Open
Retinal vascular diseases are typified by the proliferation of irregular and leaky microvessels, resulting in vision impairment. Although the etiology of retinal angiogenesis is not yet fully understood, it is evident that microglia play a…
View article: Revisiting Near-Far Field Boundary in Dual-Polarized XL-MIMO Systems
Revisiting Near-Far Field Boundary in Dual-Polarized XL-MIMO Systems Open
Extremely large-scale multiple-input multiple-output (XL-MIMO) is expected to be an important technology in future sixth generation (6G) networks. Compared with conventional single-polarized XL-MIMO, where signals are transmitted and recei…
View article: Simultaneous Beamforming and Anti-Jamming With Intelligent Omni-Surfaces
Simultaneous Beamforming and Anti-Jamming With Intelligent Omni-Surfaces Open
Wireless transmission is vulnerable to malicious jamming attacks due to the openness of wireless channels, posing a severe threat to wireless communications. Current anti-jamming studies primarily focus on either enhancing desired signals …
View article: Identification and validation of diagnostic genes IFI44 and IRF9 in insomnia-associated autoimmune uveitis
Identification and validation of diagnostic genes IFI44 and IRF9 in insomnia-associated autoimmune uveitis Open
Objective Insomnia is increasingly recognized as a significant factor in the development of various autoimmune diseases, including autoimmune uveitis (AU). We investigated insomnia-associated genes that may contribute to AU pathogenesis an…
View article: Beamforming Design for Wideband Near-Field Communications With Reconfigurable Refractive Surfaces
Beamforming Design for Wideband Near-Field Communications With Reconfigurable Refractive Surfaces Open
To meet the growing demand for high data rates, cellular systems are expected to evolve towards higher carrier frequencies and larger antenna arrays, but conventional phased arrays face challenges in supporting such a prospection due to th…
View article: Dual-Polarized Reconfigurable Intelligent Surface-Based Antenna for Holographic MIMO Communications
Dual-Polarized Reconfigurable Intelligent Surface-Based Antenna for Holographic MIMO Communications Open
Holographic multiple-input-multiple output (HMIMO), which is enabled by large-scale antenna arrays with quasi-continuous apertures, is expected to be an important technology in the forthcoming 6G wireless network. Reconfigurable intelligen…
View article: Autophagy‐mediated activation of the AIM2 inflammasome enhances M1 polarization of microglia and exacerbates retinal neovascularization
Autophagy‐mediated activation of the AIM2 inflammasome enhances M1 polarization of microglia and exacerbates retinal neovascularization Open
Retinopathy of prematurity (ROP) is a retinal neovascularization (RNV) disease that is characterized by abnormal blood vessel development in the retina. Importantly, the etiology of ROP remains understudied. We re‐analyzed previously publi…
View article: Hybrid Near-Far Field Channel Estimation for Holographic MIMO Communications
Hybrid Near-Far Field Channel Estimation for Holographic MIMO Communications Open
Holographic MIMO communications, enabled by large-scale antenna arrays with quasi-continuous apertures, is a potential technology for spectrum efficiency improvement. However, the increased antenna aperture size extends the range of the Fr…
View article: Appetitive Lifestyles and Obesity with Risk of Senile Cataract: An Univariable and Multivariable Mendelian Randomization Study
Appetitive Lifestyles and Obesity with Risk of Senile Cataract: An Univariable and Multivariable Mendelian Randomization Study Open
Objective: To estimate the causal effects of appetitive lifestyles (cigarette smoking, alcohol use, coffee consumption) and obesity on risk of senile cataract (SC) using genetically based approaches. Methods: Single nucleotide polymorphism…
View article: A feedback loop driven by H3K9 lactylation and HDAC2 in endothelial cells regulates VEGF-induced angiogenesis
A feedback loop driven by H3K9 lactylation and HDAC2 in endothelial cells regulates VEGF-induced angiogenesis Open
Background Vascular endothelial growth factor (VEGF) is one of the most powerful proangiogenic factors and plays an important role in multiple diseases. Increased glycolytic rates and lactate accumulation are associated with pathological a…
View article: YY1 Lactylation Aggravates Autoimmune Uveitis by Enhancing Microglial Functions via Inflammatory Genes (Adv. Sci. 19/2024)
YY1 Lactylation Aggravates Autoimmune Uveitis by Enhancing Microglial Functions via Inflammatory Genes (Adv. Sci. 19/2024) Open
YY1 Lactylation Activated microglia in the retina are essential for the development of autoimmune uveitis. The center of this image presents YY1 lactylation (lactylation at 183 lysine of YY1), which stands between the normal microglia (res…
View article: Progress and prospect of 6G wireless air-interface transmission technology research
Progress and prospect of 6G wireless air-interface transmission technology research Open
自20世纪80年代以来,移动通信已彻底改变世界,对人们的生活产生了深远影响。在5G成功商用的今天,人们又开始思考6G会是什么样子。作为下一代移动通信系统,6G不仅在频谱效率、时延、可靠性等通信KPI指标上提出了更高的要求,其内涵也将涉及人工智能、感知等新元素,远超传统意义上移动通信的范畴。为了实现6G愿景,迫切需要业界研究与之相适应的先进无线技术方案。本文重点介绍了6G无线空口多个研究方向的技术趋势和进展,包括:信道编码技术、多址和波形技术、智能超表面技术、智能MIMO技术…
View article: YY1 Lactylation Aggravates Autoimmune Uveitis by Enhancing Microglial Functions via Inflammatory Genes
YY1 Lactylation Aggravates Autoimmune Uveitis by Enhancing Microglial Functions via Inflammatory Genes Open
Activated microglia in the retina are essential for the development of autoimmune uveitis. Yin‐Yang 1 (YY1) is an important transcription factor that participates in multiple inflammatory and immune‐mediated diseases. Here, an increased YY…
View article: Channel Estimation for Holographic Communications in Hybrid Near-Far Field
Channel Estimation for Holographic Communications in Hybrid Near-Far Field Open
To realize holographic communications, a potential technology for spectrum efficiency improvement in the future sixth-generation (6G) network, antenna arrays inlaid with numerous antenna elements will be deployed. However, the increase in …
View article: Near-Far Field Channel Modeling for Holographic MIMO Using Expectation-Maximization Methods
Near-Far Field Channel Modeling for Holographic MIMO Using Expectation-Maximization Methods Open
Holographic Multiple-Input Multiple-Output (HMIMO), which densely integrates numerous antennas into a limited space, is anticipated to provide higher rates for future 6G wireless communications. The increase in antenna aperture size makes …
View article: RIS-based IMT-2030 Testbed for MmWave Multi-stream Ultra-massive MIMO Communications
RIS-based IMT-2030 Testbed for MmWave Multi-stream Ultra-massive MIMO Communications Open
As one enabling technique of the future sixth generation (6G) network, ultra-massive multiple-input-multiple-output (MIMO) can support high-speed data transmissions and cell coverage extension. However, it is hard to realize the ultra-mass…
View article: Global lactylome reveals lactylation-dependent mechanisms underlying T <sub>H</sub> 17 differentiation in experimental autoimmune uveitis
Global lactylome reveals lactylation-dependent mechanisms underlying T <sub>H</sub> 17 differentiation in experimental autoimmune uveitis Open
Dysregulation of CD4 + T cell differentiation is linked to autoimmune diseases. Metabolic reprogramming from oxidative phosphorylation to glycolysis and accumulation of lactate are involved in this process. However, the underlying mechanis…
View article: Intelligent Omni-Surfaces Aided Wireless Communications: Does the Reciprocity Hold?
Intelligent Omni-Surfaces Aided Wireless Communications: Does the Reciprocity Hold? Open
Intelligent omni-surfaces (IOS) have attracted great attention recently due to its potential to achieve full-dimensional communications by simultaneously reflecting and refracting signals toward both sides of the surface. However, it still…
View article: Intelligent Omni-Surfaces: Reflection-Refraction Circuit Model, Full-Dimensional Beamforming, and System Implementation
Intelligent Omni-Surfaces: Reflection-Refraction Circuit Model, Full-Dimensional Beamforming, and System Implementation Open
The intelligent omni-surface (IOS) is a dynamic metasurface that has recently been proposed to achieve full-dimensional communications by realizing the dual function of anomalous reflection and anomalous refraction. Existing research works…
View article: Reconfigurable Refractive Surfaces: An Energy-Efficient Way to Holographic MIMO
Reconfigurable Refractive Surfaces: An Energy-Efficient Way to Holographic MIMO Open
Holographic Multiple Input Multiple Output (HMIMO), which integrates massive antenna elements into a compact space to achieve a spatially continuous aperture, plays an important role in future wireless networks. With numerous antenna eleme…
View article: Intelligent Omni-Surfaces: Reflection-Refraction Circuit Model, Full-Dimensional Beamforming, and System Implementation
Intelligent Omni-Surfaces: Reflection-Refraction Circuit Model, Full-Dimensional Beamforming, and System Implementation Open
The intelligent omni-surface (IOS) is a dynamic metasurface that has recently been proposed to achieve full-dimensional communications by realizing the dual function of anomalous reflection and anomalous refraction. Existing research works…
View article: Intelligent Omni-Surfaces for Full-Dimensional Wireless Communications: Principles, Technology, and Implementation
Intelligent Omni-Surfaces for Full-Dimensional Wireless Communications: Principles, Technology, and Implementation Open
The recent development of metasurfaces has motivated their potential use for improving the performance of wireless communication networks by manipulating the propagation environment through nearly passive sub-wavelength scattering elements…
View article: Intelligent Omni-Surfaces for Full-Dimensional Wireless Communications: Principle, Technology, and Implementation
Intelligent Omni-Surfaces for Full-Dimensional Wireless Communications: Principle, Technology, and Implementation Open
The recent development of metasurfaces has motivated their potential use for improving the performance of wireless communication networks by manipulating the propagation environment through nearly-passive sub-wavelength scattering elements…
View article: Trajectory Optimization and Resource Allocation for OFDMA UAV Relay Networks
Trajectory Optimization and Resource Allocation for OFDMA UAV Relay Networks Open
In this paper, we consider a single-cell multi-user orthogonal frequency division multiple access (OFDMA) network with one unmanned aerial vehicle (UAV), which works as an amplify-and-forward relay to improve the quality-of-service (QoS) o…
View article: Reconfigurable Intelligent Surfaces in 6G: Reflective, Transmissive, or Both?
Reconfigurable Intelligent Surfaces in 6G: Reflective, Transmissive, or Both? Open
Reconfigurable intelligent surfaces (RISs) have attracted wide interest from industry and academia since they can shape the wireless environment into a desirable form with a low cost. In practice, RISs have three types of implementations: …
View article: Reconfigurable Intelligent Surface (RIS) Assisted Wireless Coverage Extension: RIS Orientation and Location Optimization
Reconfigurable Intelligent Surface (RIS) Assisted Wireless Coverage Extension: RIS Orientation and Location Optimization Open
Recently, reconfigurable intelligent surfaces (RIS) have attracted a lot of attention due to their capability of extending cell coverage by reflecting signals toward the receiver. In this letter, we analyze the coverage of a downlink RIS-a…