Shuhua Zheng
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View article: Targeting Survivin: Now I Become Death, the Destroyer of Cells
Targeting Survivin: Now I Become Death, the Destroyer of Cells Open
Survivin (BIRC5) plays a key role in inhibiting apoptosis and is highly expressed in many cancers, including gliomas and breast cancer, where it contributes to tumor progression, therapeutic resistance and poor patient outcomes. With a dua…
View article: <i>Rickettsia heilongjiangensis</i> suppresses RIPK1 kinase-mediated host cell death during the infection
<i>Rickettsia heilongjiangensis</i> suppresses RIPK1 kinase-mediated host cell death during the infection Open
Spotted fever group Rickettsia (SFGR) poses a significant challenge in the field of tick-borne diseases, characterized by its obligate intracellular lifestyle and its ability to disrupt various host cellular pathways. A deeper understandin…
View article: Impact of Curcumin on Frozen Bovine Sperm Quality and In Vitro Bovine Oocyte Maturation
Impact of Curcumin on Frozen Bovine Sperm Quality and In Vitro Bovine Oocyte Maturation Open
This study aimed to analyze the effect of curcumin on the antioxidant properties and fertility of freeze–thawed bovine spermatozoa and bovine oocytes. In this study, curcumin concentrations of 0, 5, 10, 25, and 50 µM were added bovine sper…
View article: Whole exome sequencing of low risk endometrial cancer patients with isolated local recurrences
Whole exome sequencing of low risk endometrial cancer patients with isolated local recurrences Open
NSMP molecular group constitutes the majority of clinically low-risk EC patients with isolated local recurrences. The CTNNB1 alteration was validated as a biomarker in prognostication in this independent cohort and may help guide adjuvant …
View article: <i>Burkholderia pseudomallei</i> BopE suppresses the Rab32-dependent defense pathway to promote its intracellular replication and virulence
<i>Burkholderia pseudomallei</i> BopE suppresses the Rab32-dependent defense pathway to promote its intracellular replication and virulence Open
Melioidosis is a serious infectious disease caused by the Gram-negative bacterium Burkholderia pseudomallei . Recently, Rab32-dependent immune vesicles emerge as a critical defense pathway to restrict the intracellular B. pseudomallei . Ho…
View article: GlioPredictor: a deep learning model for identification of high-risk adult IDH-mutant glioma towards adjuvant treatment planning
GlioPredictor: a deep learning model for identification of high-risk adult IDH-mutant glioma towards adjuvant treatment planning Open
Identification of isocitrate dehydrogenase ( IDH )-mutant glioma patients at high risk of early progression is critical for radiotherapy treatment planning. Currently tools to stratify risk of early progression are lacking. We sought to id…
View article: Race, Prevalence of <i>POLE</i> and <i>POLD1</i> Alterations, and Survival Among Patients With Endometrial Cancer
Race, Prevalence of <i>POLE</i> and <i>POLD1</i> Alterations, and Survival Among Patients With Endometrial Cancer Open
Importance Black patients with endometrial cancer (EC) in the United States have higher mortality than patients of other races with EC. The prevalence of POLE and POLD1 pathogenic alterations in patients of different races with EC are not …
View article: RADT-43. LONG TERM OUTCOMES OF PEDIATRIC AND ADULT CENTRAL NEUROCYTOMA—THE ROLE OF SALVAGE RADIOTHERAPY AND CONSERVATIVE MANAGEMENT
RADT-43. LONG TERM OUTCOMES OF PEDIATRIC AND ADULT CENTRAL NEUROCYTOMA—THE ROLE OF SALVAGE RADIOTHERAPY AND CONSERVATIVE MANAGEMENT Open
INTRODUCTION Central Neurocytoma (CN) is a rare, WHO grade 2 brain tumor that predominantly affects young adults. Gross total resection (GTR) is often curative for CN, but the optimal treatment paradigm following subtotal resection (STR) a…
View article: Integrating <scp><i>POLE</i></scp>/<scp><i>POLD1</i></scp> mutated for immunotherapy treatment planning of advanced stage non‐small cell lung cancer
Integrating <span><i>POLE</i></span>/<span><i>POLD1</i></span> mutated for immunotherapy treatment planning of advanced stage non‐small cell lung cancer Open
Background In this study, we evaluated the potential of DNA polymerase epsilon ( POLE ) and DNA polymerase delta 1 ( POLD1 ) as prognostic biomarkers for immune checkpoint inhibitor (ICI) treatment in patients with advanced stage non‐small…
View article: Editorial: Case reports in molecular and cellular oncology: 2022
Editorial: Case reports in molecular and cellular oncology: 2022 Open
Safety and efficacy of combined treatment of targeted therapy and radiotherapy is not well reported in clinical trials. This Research Topic showed several cases with good outcomes when concurrent or sequential treatment of radiation and ta…
View article: A functional artificial neural network for noninvasive pretreatment evaluation of glioblastoma patients
A functional artificial neural network for noninvasive pretreatment evaluation of glioblastoma patients Open
Background Pretreatment assessments for glioblastoma (GBM) patients, especially elderly or frail patients, are critical for treatment planning. However, genetic profiling with intracranial biopsy carries a significant risk of permanent mor…
View article: Identification of Novel Transcriptome Signature as a Potential Prognostic Biomarker for Anti-Angiogenic Therapy in Glioblastoma Multiforme
Identification of Novel Transcriptome Signature as a Potential Prognostic Biomarker for Anti-Angiogenic Therapy in Glioblastoma Multiforme Open
Glioblastoma multiforme (GBM) is the most common and devastating type of primary brain tumor, with a median survival time of only 15 months. Having a clinically applicable genetic biomarker would lead to a paradigm shift in precise diagnos…
View article: A functional artificial neural network for noninvasive presurgical evaluation of glioblastoma multiforme prognosis and radiosensitivity profiling
A functional artificial neural network for noninvasive presurgical evaluation of glioblastoma multiforme prognosis and radiosensitivity profiling Open
Background and Purpose Genetic profiling for glioblastoma multiforme (GBM) patients with intracranial biopsy carries a significant risk of permanent morbidity. We previously demonstrated that the CUL2 gene, encoding the scaffold cullin2 pr…
View article: Towards the personalized radiotherapy for elderly and/or frail glioblastoma multiforme patients – radiosensitivity profiling using biomarkers and image analyses
Towards the personalized radiotherapy for elderly and/or frail glioblastoma multiforme patients – radiosensitivity profiling using biomarkers and image analyses Open
This a commentary to the article titled "Integrating cullin2-RING E3 ligase as a potential biomarker for glioblastoma multiforme prognosis and radiosensitivity profiling" recently published in the journal Radiotherapy and Oncology (https:/…
View article: Targeting Cullin-RING E3 Ligases for Radiosensitization: From NEDDylation Inhibition to PROTACs
Targeting Cullin-RING E3 Ligases for Radiosensitization: From NEDDylation Inhibition to PROTACs Open
As a dynamic regulator for short-lived protein degradation and turnover, the ubiquitin-proteasome system (UPS) plays important roles in various biological processes, including response to cellular stress, regulation of cell cycle progressi…
View article: <i>Klebsiella pneumoniae</i> invasive syndrome in a diabetic patient with gallbladder abscess
<i>Klebsiella pneumoniae</i> invasive syndrome in a diabetic patient with gallbladder abscess Open
The mortality rates for Klebsiella pneumoniae invasive syndrome range from 4% to 11% with diabetes as a major risk factor. Early diagnosis of KPIS can decrease mortality rate with good outcomes due to sensitivity of K pneumoniae to antibio…
View article: Molecular Mechanism of Anti-Cancer Activity of the Nano-Drug C-PC/CMC-CD59sp NPs in Cervical Cancer
Molecular Mechanism of Anti-Cancer Activity of the Nano-Drug C-PC/CMC-CD59sp NPs in Cervical Cancer Open
The novel tumor targeted nano-drug C-PC/CMC-CD59sp nanoparticles were constructed with carbocymethyl chitosan (CMC), C-phycocyanin (C-PC) and CD59 specific ligand peptide (CD59sp). The anti-tumor drug mechanism of the C-PC/CMC-CD59sp NPs w…
View article: Inhibition of the NEDD8 conjugation pathway induces calcium-dependent compensatory activation of the pro-survival MEK/ERK pathway in acute lymphoblastic leukemia
Inhibition of the NEDD8 conjugation pathway induces calcium-dependent compensatory activation of the pro-survival MEK/ERK pathway in acute lymphoblastic leukemia Open
De novo and acquired drug resistance and subsequent relapse remain major challenges in acute lymphoblastic leukemia (ALL). We previously identified that pevonedistat (TAK-924, MLN4924), a first-in-class inhibitor of NEDD8 activating enzyme…
View article: Evaluation of 3M Molecular Detection System and ANSR Pathogen Detection System for rapid detection of Salmonella from egg products
Evaluation of 3M Molecular Detection System and ANSR Pathogen Detection System for rapid detection of Salmonella from egg products Open
Isothermal amplification assay is a novel simple detection technology that amplifies DNA with high speed, efficiency, and specificity under isothermal conditions. The objective of this study was to evaluate the effectiveness of the 3M Mole…