Shuilian Yu
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View article: From promise to practice: evaluating the clinical impact of FcRn inhibition in IgG-mediated autoimmune rheumatic diseases
From promise to practice: evaluating the clinical impact of FcRn inhibition in IgG-mediated autoimmune rheumatic diseases Open
The neonatal Fragment Crystallizable receptor (FcRn) plays a central role in maintaining immunoglobulin (Ig) G homeostasis by protecting IgG from lysosomal degradation and regulating its transcytosis. In recent years, pharmacological inhib…
View article: The relation between corneal optical quality and clinical ocular surface manifestations in Chinese female with Sjogren's syndrome dry eye.
The relation between corneal optical quality and clinical ocular surface manifestations in Chinese female with Sjogren's syndrome dry eye. Open
Chinese females with DE, and particularly those with concurrent SS, demonstrated poorer ocular surface and corneal optical quality measures than those without DE.
View article: Belimumab-driven reductions in retinal microvascular density assessed by optical coherence tomography angiography: insights from systemic lupus erythematosus patients
Belimumab-driven reductions in retinal microvascular density assessed by optical coherence tomography angiography: insights from systemic lupus erythematosus patients Open
Background Systemic lupus erythematosus (SLE) and lupus nephritis (LN) are associated with retinal microvascular changes that may reflect disease severity. This study aimed to evaluate differences in retinal vascular density (VD) between S…
View article: The neutrophil-to-C3 ratio: unveiling diagnostic efficacy for lupus nephritis and association with reduced retinal vascular density in systemic lupus erythematosus
The neutrophil-to-C3 ratio: unveiling diagnostic efficacy for lupus nephritis and association with reduced retinal vascular density in systemic lupus erythematosus Open
Background Lupus nephritis (LN) frequently manifests as a significant complication in systemic lupus erythematosus (SLE) patients, with emerging research indicating a plausible correlation between subclinical retinal involvement and renal …
View article: Wogonin Modulates Macrophage Polarization and Inflammatory Signaling Through the LSD1-p65 Axis to Alleviate Osteoarthritis
Wogonin Modulates Macrophage Polarization and Inflammatory Signaling Through the LSD1-p65 Axis to Alleviate Osteoarthritis Open
Background: The study elucidates wogonin’s therapeutic mechanisms in osteoarthritis (OA) induced by medial meniscus destabilization (DMM), focusing on macrophage polarization regulation, inflammatory signaling modulation, and cellular cros…
View article: A novel approach with tofacitinib for the management of keratoderma blennorrhagicum in reactive arthritis: a case report
A novel approach with tofacitinib for the management of keratoderma blennorrhagicum in reactive arthritis: a case report Open
Reactive arthritis(ReA), a form of arthritis occurring post-infection, manifests with antecedent infection symptoms, arthritis, and extra-articular manifestations, categorizing it as spondyloarthritis. “Keratoderma blennorrhagicum” (charac…
View article: Bibliometric analysis of global research on air pollution and cardiovascular diseases: 2012–2022
Bibliometric analysis of global research on air pollution and cardiovascular diseases: 2012–2022 Open
The findings presented a notable increase in high-quality publications on this topic over the past 11 years, suggesting a positive outlook for future research. The study concluded with an examination of three key themes in research trends …
View article: Emerging biologic frontiers for Sjogren’s syndrome: Unveiling novel approaches with emphasis on extra glandular pathology
Emerging biologic frontiers for Sjogren’s syndrome: Unveiling novel approaches with emphasis on extra glandular pathology Open
Primary Sjögren’s Syndrome (pSS) is a complex autoimmune disorder characterized by exocrine gland dysfunction, leading to dry eyes and mouth. Despite growing interest in biologic therapies for pSS, FDA approval has proven challenging due t…
View article: Unveiling the nexus: Decoding interactions between regulated cell death and systemic lupus erythematosus pathogenesis for innovative therapeutic avenues
Unveiling the nexus: Decoding interactions between regulated cell death and systemic lupus erythematosus pathogenesis for innovative therapeutic avenues Open
Systemic lupus erythematosus (SLE) is characterized by disruptions in cell death pathways and impaired clearance of apoptotic cells, resulting in immune dysregulation and tissue damage. This review explores the complex interplay of regulat…
View article: Advancements in therapeutic paradigm: Harnessing IL‐17A inhibitor secukinumab to ameliorate psoriasis vulgaris in the presence of resistant pericardial effusion
Advancements in therapeutic paradigm: Harnessing IL‐17A inhibitor secukinumab to ameliorate psoriasis vulgaris in the presence of resistant pericardial effusion Open
We present a case involving a 44-year-old male patient who has suffered from psoriasis for over 30 years and developed recurrent pericardial effusions over the past 4 years. Psoriasis has been linked to an elevated risk of cardiovascular d…
View article: The Neutrophil-to-C3 Ratio: Unveiling Diagnostic Efficacy for Lupus Nephritis and Association with Reduced Retinal Vascular Density in Systemic Lupus Erythematosus
The Neutrophil-to-C3 Ratio: Unveiling Diagnostic Efficacy for Lupus Nephritis and Association with Reduced Retinal Vascular Density in Systemic Lupus Erythematosus Open
Background: Lupus nephritis (LN) frequently manifests as a significant complication in systemic lupus erythematosus (SLE) patients, with emerging research indicating a plausible correlation between subclinical retinal involvement and renal…
View article: Unveiling a Novel Trend: Belimumab Amplifies Retinal Microvascular Density Decline in Lupus Nephritis Patients Revealed by Optical Coherence Tomography Angiography
Unveiling a Novel Trend: Belimumab Amplifies Retinal Microvascular Density Decline in Lupus Nephritis Patients Revealed by Optical Coherence Tomography Angiography Open
Background: In systemic lupus erythematosus (SLE), retinopathy is connected to severe disease and poorer prognosis. This study aimed to investigate changes in retinal vascular density (VD) in SLE and lupus nephritis (LN) patients and to ex…
View article: Deciphering the puzzle: a case report of Tjalma syndrome (pseudo-pseudo Meigs' syndrome) with profoundly elevated CA-125 and pleural effusion
Deciphering the puzzle: a case report of Tjalma syndrome (pseudo-pseudo Meigs' syndrome) with profoundly elevated CA-125 and pleural effusion Open
Elevated CA-125 levels, polyserous effusions (such as pleural effusion, ascites, etc.) in young women with systemic lupus erythematosus (SLE) may signal pseudo-pseudo Meigs’ syndrome (PPMS), after excluding other causes. We describe a 32-y…
View article: Belimumab shows promise in neuropsychiatric lupus: Another challenge to find the offender
Belimumab shows promise in neuropsychiatric lupus: Another challenge to find the offender Open
Introduction Agents that can be used for the treatment of neuropsychiatric lupus (NPSLE) are lacking in the therapeutic armamentarium. Belimumab is a monoclonal antibody targeting the B‐cell activating factor (BAFF) and is approved by the …
View article: Association Between Wait Time of Central Venous Pressure Measurement and Outcomes in Critical Patients With Acute Kidney Injury: A Retrospective Cohort Study
Association Between Wait Time of Central Venous Pressure Measurement and Outcomes in Critical Patients With Acute Kidney Injury: A Retrospective Cohort Study Open
Background Hemodynamic management is of paramount importance in patients with acute kidney injury (AKI). Central venous pressure (CVP) has been used to assess volume status. We intended to identify the optimal time window in which to obtai…
View article: A multicenter study of viral aetiology of Community-Acquired Pneumonia in hospitalized children in mainland China
A multicenter study of viral aetiology of Community-Acquired Pneumonia in hospitalized children in mainland China Open
Background Community-acquired pneumonia (CAP) is one of the leading causes of morbidity and mortality in the children worldwide. In this study, we aim to describe the aetiology of viral infection of pediatric community-acquired pneumonia i…
View article: Serine/threonine phosphatase PP2A is essential for optimal B cell function
Serine/threonine phosphatase PP2A is essential for optimal B cell function Open
Protein phosphatase 2A (PP2A), a serine/threonine phosphatase, has been shown to control T cell function. We found that in vitro-activated B cells and B cells from various lupus-prone mice and patients with systemic lupus erythematosus dis…
View article: Low pretreatment PNI correlates with worse survival in patients with stage III/IV NSCLC who received chemotherapy
Low pretreatment PNI correlates with worse survival in patients with stage III/IV NSCLC who received chemotherapy Open
The aim of this study was to investigate the prognostic value of the prognostic nutritional index (PNI) on the long-term survival of non-small cell lung cancer (NSCLC) patients who received platinum-based chemotherapy. Data on nutritional …
View article: Downregulation of TIM-3 mRNA expression in peripheral blood mononuclear cells from patients with systemic lupus erythematosus
Downregulation of TIM-3 mRNA expression in peripheral blood mononuclear cells from patients with systemic lupus erythematosus Open
The T-cell immunoglobulin and mucin domain (TIM) family is associated with autoimmune diseases, but its expression level in the immune cells of systemic lupus erythematosus (SLE) patients is not known. The aim of this study was to investig…