Shujing Zhang
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View article: Corrigendum to “High humidity exposures and mechanisms in respiratory disease” [Ecotoxicol. Environ. Saf. 305 (2025) 119234]
Corrigendum to “High humidity exposures and mechanisms in respiratory disease” [Ecotoxicol. Environ. Saf. 305 (2025) 119234] Open
View article: Submandibular adenoid cystic carcinoma presenting with liver metastasis as the initial symptom: A case report
Submandibular adenoid cystic carcinoma presenting with liver metastasis as the initial symptom: A case report Open
Adenoid cystic carcinoma (ACC) is a rare and aggressive malignancy characterized by a high incidence of distant metastasis. However, cases of ACC with liver and lymph node metastases are rarely reported and lack a standardized treatment co…
View article: High humidity exposures and mechanisms in respiratory disease
High humidity exposures and mechanisms in respiratory disease Open
Over the past five decades, anthropogenic activities have precipitated a sustained rise in global temperatures. This warming trend enhances the atmosphere's water-holding capacity, thereby elevating atmospheric humidity levels. Prolonged e…
View article: Lactate metabolism and lactylation: Therapeutic and pre-clinical implications in neovascularization in peripheral artery disease
Lactate metabolism and lactylation: Therapeutic and pre-clinical implications in neovascularization in peripheral artery disease Open
View article: Ginsenoside Rg3 Adjunctively Increases the Efficacy of Gefitinib Against NSCLC by Regulating EGFR Copy Number
Ginsenoside Rg3 Adjunctively Increases the Efficacy of Gefitinib Against NSCLC by Regulating EGFR Copy Number Open
Background: Lung cancer has the highest morbidity and mortality of all tumors, and the development of TKI drugs targeting EGFR activating mutations has brought lung cancer treatment into the targeted era. In view of their low efficacy and …
View article: Exploring the Potential of Coix Seeds to Mitigate High Humidity-Induced Gut Inflammation via Microbiota and Metabolite Modulation
Exploring the Potential of Coix Seeds to Mitigate High Humidity-Induced Gut Inflammation via Microbiota and Metabolite Modulation Open
Our findings provide experimental evidence that Coix seed mitigates high humidity-induced gut injury through microbiota remodelling, lipid metabolic regulation and immune modulation.
View article: Metabolic reprogramming in hepatocellular carcinoma: an integrated omics study of lipid pathways and their diagnostic potential
Metabolic reprogramming in hepatocellular carcinoma: an integrated omics study of lipid pathways and their diagnostic potential Open
Metabolic reprogramming is an important cancer hallmark. Recent studies have indicated that lipid metabolic reprogramming play a potential role in the development of hepatocellular carcinoma (HCC). However, the underlying mechanisms remain…
View article: The liprin-α/RIM complex regulates the dynamic assembly of presynaptic active zones via liquid–liquid phase separation
The liprin-α/RIM complex regulates the dynamic assembly of presynaptic active zones via liquid–liquid phase separation Open
Presynaptic scaffold proteins, including liprin-α, RIM, and ELKS, are pivotal to the assembly of the active zone and regulating the coupling of calcium signals and neurotransmitter release, yet the underlying mechanism remains poorly under…
View article: Heterogeneous immune landscapes and macrophage dynamics in primary and lung metastatic adenoid cystic carcinoma of the head and neck
Heterogeneous immune landscapes and macrophage dynamics in primary and lung metastatic adenoid cystic carcinoma of the head and neck Open
Introduction Recurrent or metastatic adenoid cystic carcinoma (ACC) of the head and neck is rare and highly aggressive. Due to the ineffectiveness of immune checkpoint therapies, this study aims to investigate the tumor immune microenviron…
View article: Liprin-α/RIM complex regulates the dynamic assembly of presynaptic active zones via liquid-liquid phase separation
Liprin-α/RIM complex regulates the dynamic assembly of presynaptic active zones via liquid-liquid phase separation Open
Presynaptic scaffold proteins, including liprin-α, RIM, and ELKS, are pivotal to the assembly of the active zone and regulating the coupling of calcium signals and neurotransmitter release, yet the underlying mechanism remains poorly under…
View article: Paeonol and glycyrrhizic acid in combination ameliorate the recurrent nitroglycerin-induced migraine-like phenotype in rats by regulating the GABBR2/TRPM8/PRKACA/TRPV1 pathway
Paeonol and glycyrrhizic acid in combination ameliorate the recurrent nitroglycerin-induced migraine-like phenotype in rats by regulating the GABBR2/TRPM8/PRKACA/TRPV1 pathway Open
Our findings underscore that PAE + GLY ameliorates inflammatory hyperalgesia migraine by upregulating inhibitory neurotransmitters and modulating the GABBR2/TRPM8/PRKACA/TRPV1 pathway.
View article: Active substances and molecular mechanisms of Astragali Radix and Angelicae Sinensis radix against idiopathic pulmonary fibrosis effects by network pharmacology and in vitro experiments
Active substances and molecular mechanisms of Astragali Radix and Angelicae Sinensis radix against idiopathic pulmonary fibrosis effects by network pharmacology and in vitro experiments Open
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive fibrotic disease with an unclear etiology and no effective treatment. This study aims to elucidate the pathogenic mechanism networks involving multiple targets and pathways in I…
View article: Disturbance of gut microbiota aggravates the inflammatory response and damages the vascular endothelial function in patients with preeclampsia
Disturbance of gut microbiota aggravates the inflammatory response and damages the vascular endothelial function in patients with preeclampsia Open
Patients with PE exhibited dysbiosis of intestinal flora, characterized by altered gut microbiota diversity, increased serum pro-inflammatory factors, and impaired vascular endothelial function.
View article: Protective mechanism of Paeoniae Radix Alba against chemical liver injury based on network pharmacology, molecular docking, and in vitro experiments
Protective mechanism of Paeoniae Radix Alba against chemical liver injury based on network pharmacology, molecular docking, and in vitro experiments Open
Objective: To explore and validate the potential targets of Paeoniae Radix Alba (P. Radix, Bai Shao) in protecting against chemical liver injury through network pharmacology, molecular docking technology, and in vitro cell experiments. Met…
View article: Editorial: New insights into dyserythropoiesis: from pathophysiology, molecular mechanisms to treatments for erythroid disorders
Editorial: New insights into dyserythropoiesis: from pathophysiology, molecular mechanisms to treatments for erythroid disorders Open
EDITORIAL article Front. Cell Dev. Biol., 02 November 2023Sec. Stem Cell Research Volume 11 - 2023 | https://doi.org/10.3389/fcell.2023.1321170
View article: Effects of Banxia Xiexin Decoction on apoptosis of interstitial cells of Cajal via regulation of MiR-451-5p: An in vivo and in vitro study
Effects of Banxia Xiexin Decoction on apoptosis of interstitial cells of Cajal via regulation of MiR-451-5p: An in vivo and in vitro study Open
Through this study, we demonstrated that BXD could promote ICCs proliferation and inhibit apoptosis via miR-451-5p and may involve the modulations of SCF/c-kit signaling, thus suggesting a new therapy basis for GI motility dysfunction from…
View article: Cost-Effectiveness of Pembrolizumab as an Adjuvant Treatment in Colombia for Melanoma Patients with Lymph Node Involvement After Complete Resection
Cost-Effectiveness of Pembrolizumab as an Adjuvant Treatment in Colombia for Melanoma Patients with Lymph Node Involvement After Complete Resection Open
Pembrolizumab is cost-effective as an adjuvant treatment compared to watchful waiting among patients with high-risk stage III melanoma after complete resection in Colombia.
View article: Effects of Banxia Xiexin Decoction on Apoptosis of Interstitial Cells of Cajal by Regulation of MiR-451-5p: An In Vivo and In Vitro Study
Effects of Banxia Xiexin Decoction on Apoptosis of Interstitial Cells of Cajal by Regulation of MiR-451-5p: An In Vivo and In Vitro Study Open
View article: Nlrp3 Neuroinflammatory Intervention of Mahuang-Lianqiao-Chixiaodou Decoction for Mental Disorders in Atopic Dermatitis Mice
Nlrp3 Neuroinflammatory Intervention of Mahuang-Lianqiao-Chixiaodou Decoction for Mental Disorders in Atopic Dermatitis Mice Open
View article: High-risk subtype: Clinical manifestations and molecular characteristics of submandibular gland adenoid cystic carcinoma
High-risk subtype: Clinical manifestations and molecular characteristics of submandibular gland adenoid cystic carcinoma Open
Objective Adenoid cystic carcinoma of the head and neck mainly occurs in the major salivary glands, of which the parotid gland and submandibular gland are the most common. The purpose of this study was to clarify the site-specific differen…
View article: Protective effects and mechanism of puerarin targeting PI3K/Akt signal pathway on neurological diseases
Protective effects and mechanism of puerarin targeting PI3K/Akt signal pathway on neurological diseases Open
Neurological diseases impose a tremendous and increasing burden on global health, and there is currently no curative agent. Puerarin, a natural isoflavone extracted from the dried root of Pueraria montana var. Lobata (Willd.) Sanjappa and …
View article: NLRP3 neuroinflammatory factors may be involved in atopic dermatitis mental disorders: an animal study
NLRP3 neuroinflammatory factors may be involved in atopic dermatitis mental disorders: an animal study Open
Background: Numerous clinical studies have shown that atopic dermatitis (AD) is often associated with mental disorders. This could contribute to the overall burden of atopic dermatitis. However, the underlying mechanism of mental health sy…
View article: Real-world Clinical Outcomes of Patients with Stage IIB or IIC Cutaneous Melanoma Treated at US Community Oncology Clinics
Real-world Clinical Outcomes of Patients with Stage IIB or IIC Cutaneous Melanoma Treated at US Community Oncology Clinics Open
Aim: To describe clinical outcomes after complete surgical resection of stage IIB and IIC melanoma. Methods: Adult patients (n = 567) with stage IIB or IIC cutaneous melanoma initially diagnosed and completely resected from 2008-2017 were …
View article: Intervention of the Mahuang Lianqiao Chixiaodou decoction on immune imbalance in atopic dermatitis-like model mice
Intervention of the Mahuang Lianqiao Chixiaodou decoction on immune imbalance in atopic dermatitis-like model mice Open
View article: Symptom burden, family resilience, and functional exercise adherence among postoperative breast cancer patients
Symptom burden, family resilience, and functional exercise adherence among postoperative breast cancer patients Open
Family resilience, as a positive psychological factor, could indirectly impact postoperative breast cancer patients' physical function. Specifically, family resilience can alleviate the patients' symptom burden by strengthening their funct…
View article: Beneficial Effects of Shuyu Decoction on Immune Suppression in Exercise-Induced Fatigued Rats
Beneficial Effects of Shuyu Decoction on Immune Suppression in Exercise-Induced Fatigued Rats Open
View article: Mechanism of mitochondrial protection by the Buyin Qianzheng formula in a Parkin overexpression cell model
Mechanism of mitochondrial protection by the Buyin Qianzheng formula in a Parkin overexpression cell model Open
Objective: To identify the molecular mechanisms of the effects of the Buyin Qianzheng formula (BYQZF) on the mitochondrial dynamics in a Parkin overexpression Parkinson's disease (PD) cell model. Methods: First, a stable Parkin overexpress…
View article: Protective Effects of Yiqi Jiedu Decoction on Ionizing Radiation-Induced Spermatogenic Cell Injury
Protective Effects of Yiqi Jiedu Decoction on Ionizing Radiation-Induced Spermatogenic Cell Injury Open
View article: Mechanism of improving skin barrier function in a mouse model of atopic dermatitis using Mahuang Lianqiao Chixiaodou decoction and its disassembled formula
Mechanism of improving skin barrier function in a mouse model of atopic dermatitis using Mahuang Lianqiao Chixiaodou decoction and its disassembled formula Open
View article: Plasma Metabolomic Profiles in Recovered COVID-19 Patients without Previous Underlying Diseases 3 Months After Discharge
Plasma Metabolomic Profiles in Recovered COVID-19 Patients without Previous Underlying Diseases 3 Months After Discharge Open
We uncovered metabolite clusters pathologically relevant to the recovery state in discharged COVID-19 patients which may provide new insights into the pathogenesis of potential organ damage in recovered patients.