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View article: Synergistic Cationic–Anionic Regulation in Ni-Doped FeSe@C Anodes with Se Vacancies for High-Efficiency Sodium Storage
Synergistic Cationic–Anionic Regulation in Ni-Doped FeSe@C Anodes with Se Vacancies for High-Efficiency Sodium Storage Open
Sodium-ion batteries present an economical energy storage solution, yet their anode kinetics remain slow, impeding rate performance and cyclability. Layered FeSe anodes, characterized by metallic conductivity, hold potential, but structura…
View article: Intestinal deguelin drives resistance to acetaminophen-induced hepatotoxicity in female mice
Intestinal deguelin drives resistance to acetaminophen-induced hepatotoxicity in female mice Open
Acetaminophen (APAP) overdose is a leading cause of drug-induced liver injury (DILI), with gender-specific differences in susceptibility. However, the mechanism underlying this phenomenon remains unclear. Our study reveals that the gender-…
View article: Inhibition of SIRT6 aggravates p53-mediated ferroptosis in acute lung injury in mice
Inhibition of SIRT6 aggravates p53-mediated ferroptosis in acute lung injury in mice Open
Although studies have shown that protein 53 (p53)-mediated ferroptosis is involved in acute lung injury (ALI), the mechanism of its regulation remains unclear. The protective effects of Sirtuin 6 (SIRT6), a histone deacetylase, have been d…
View article: Prognostic and therapeutic significance of microbial cell-free DNA in plasma of people with acute decompensation of cirrhosis
Prognostic and therapeutic significance of microbial cell-free DNA in plasma of people with acute decompensation of cirrhosis Open
A non-hepatotropic virus (NHV) signature, which was similar to that in individuals with sepsis and hematological malignancies, was identified in individuals with acute decompensation of cirrhosis. The detected viral signature had clinical …
View article: Cytosolic p53 Inhibits Parkin-Mediated Mitophagy and Promotes Acute Liver Injury Induced by Heat Stroke
Cytosolic p53 Inhibits Parkin-Mediated Mitophagy and Promotes Acute Liver Injury Induced by Heat Stroke Open
Heat stroke (HS) is a severe condition characterized by increased morbidity and high mortality. Acute liver injury (ALI) is a well-documented complication of HS. The tumor suppressor p53 plays an important role in regulation of mitochondri…
View article: NF‑κB/IκBα signaling pathways are essential for resistance to heat stress‑induced ROS production in pulmonary microvascular endothelial cells
NF‑κB/IκBα signaling pathways are essential for resistance to heat stress‑induced ROS production in pulmonary microvascular endothelial cells Open
The results of a previous study demonstrated that heat stress (HS) triggered oxidative stress, which in turn induced the apoptosis of epithelial cells. These results uncovered a novel mechanism underlying the activation of NF‑κB in primary…
View article: SIRT1 attenuates sepsis-induced acute kidney injury via Beclin1 deacetylation-mediated autophagy activation
SIRT1 attenuates sepsis-induced acute kidney injury via Beclin1 deacetylation-mediated autophagy activation Open
Our previous studies showed that silent mating-type information regulation 2 homologue-1 (SIRT1, a deacetylase) upregulation could attenuate sepsis-induced acute kidney injury (SAKI). Upregulated SIRT1 can deacetylate certain autophagy-rel…
View article: Greenspace exposure and non-injury mortality in UK Biobank
Greenspace exposure and non-injury mortality in UK Biobank Open
Background: Some cohort studies have shown a protective association of greenness and non-injury mortality, after adjustment for personal contextual and area-level confounding factors, though evidence in the UK is predominantly from ecologi…
View article: The Value of Thromboelastography in the Diagnosis of Sepsis-Induced Coagulopathy
The Value of Thromboelastography in the Diagnosis of Sepsis-Induced Coagulopathy Open
Thromboelastography (TEG) is regularly used for monitoring abnormalities of the coagulation system in patients with sepsis. However, it is unclear whether TEG parameters are associated with sepsis-induced coagulopathy (SIC). Thus, we aimed…
View article: Septic Patients in the Intensive Care Unit Present Different Nasal Microbiotas
Septic Patients in the Intensive Care Unit Present Different Nasal Microbiotas Open
Septic patients have three nasal microbiota types, and the nasal microbiota is related to the length of stay and mortality.
View article: SIRT1-mediated HMGB1 deacetylation suppresses sepsis-associated acute kidney injury
SIRT1-mediated HMGB1 deacetylation suppresses sepsis-associated acute kidney injury Open
Sepsis is the leading cause of death in the intensive care unit and continues to lack effective treatment. It is widely accepted that high-mobility group box 1 (HMGB1) is a key inflammatory mediator in the pathogenesis of sepsis. Moreover,…
View article: Genipin alleviates vascular hyperpermeability following hemorrhagic shock by up-regulation of SIRT3/autophagy
Genipin alleviates vascular hyperpermeability following hemorrhagic shock by up-regulation of SIRT3/autophagy Open
Genipin (GP) is commonly used to treat cardiovascular diseases; however, the protective action of GP against vascular hyperpermeability (VH) has not been reported. We previously reported that intrinsic apoptotic signaling (IAS) is involved…
View article: Preparation, characterization, and evaluation of amphotericin B-loaded MPEG-PCL-g-PEI micelles for local treatment of oral Candida albicans
Preparation, characterization, and evaluation of amphotericin B-loaded MPEG-PCL-g-PEI micelles for local treatment of oral Candida albicans Open
Li Zhou,1,* Peipei Zhang,1,* Zhuo Chen,1 Shaona Cai,2 Ting Jing,2 Huihui Fan,2 Fei Mo,2 Jiye Zhang,2 Rong Lin1 1Department of Pharmacology, 2School of Pharmacy, Health Science Center, Xi’an Jiaotong University, Xi’an, P…