Shu‐Ming Li
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View article: Molecular insights into the substrate recognition and quasi-unidirectional catalysis of OpaE, an atypical fungal enzyme from the Asp/Glu racemase family
Molecular insights into the substrate recognition and quasi-unidirectional catalysis of OpaE, an atypical fungal enzyme from the Asp/Glu racemase family Open
Enzymes of the Asp/Glu racemase family, mostly found in bacteria, typically catalyze bidirectional reactions with similar rate because of their pseudosymmetrical structure and minimal differences between substrate isomers. We recently iden…
View article: Tryptophanol, a novel auxin analog found in marine diatoms, enhances nitrogen assimilation
Tryptophanol, a novel auxin analog found in marine diatoms, enhances nitrogen assimilation Open
Diatoms exhibit superior competitive capacity in nitrogen assimilation, largely contributing to their growth, although the mechanisms underpinning their success have not been completely understood. Here, a non-ribosomal peptide synthase-li…
View article: How employees can break out of their learning comfort zone in green innovation scenarios: a nudging experiment based on the pressures of sustainable development in China
How employees can break out of their learning comfort zone in green innovation scenarios: a nudging experiment based on the pressures of sustainable development in China Open
The use of nudging tools to motivate employees to actively participate in corporate green innovation has not yet received sufficient attention. Designing and implementing effective nudging strategies to push employees out of their comfort …
View article: The role of the hippocampus and SLC39A8 in chronic musculoskeletal pain-induced dementia: a Mendelian randomization study
The role of the hippocampus and SLC39A8 in chronic musculoskeletal pain-induced dementia: a Mendelian randomization study Open
Despite observational studies suggesting a link between chronic musculoskeletal pain (CMP) and increased risk of cognitive decline and dementia, the causal nature of this relationship remains uncertain due to potential confounding factors …
View article: Cooperative Redox Reactions Encoded by Two Gene Clusters Enable Intermolecular Cycloaddition Cascade for the Formation of Meroaspochalasins
Cooperative Redox Reactions Encoded by Two Gene Clusters Enable Intermolecular Cycloaddition Cascade for the Formation of Meroaspochalasins Open
Meroaspochalasins (mAPOs) are a group of intricate heteromers comprising two distinct subunits, dienophile aspochalasin, and diene isobenzofuran, of which the biosynthetic mechanism is of great interest yet unrevealed. In this study, two i…
View article: Formation of <i>N</i>-Hydroxyethylisoindolinone Derivatives in Fungi Requires Highly Coordinated Consecutive Oxidation Steps
Formation of <i>N</i>-Hydroxyethylisoindolinone Derivatives in Fungi Requires Highly Coordinated Consecutive Oxidation Steps Open
Gene duplication significantly contributes to the diversification of biosynthetic potential and increases the structural diversity of secondary metabolites. Here, we report the second alkyl salicylaldehyde derivative biosynthetic gene clus…
View article: Geranylation of Cyclic Dipeptides and Naphthols by the Fungal Prenyltransferase CdpC3PT_F253G
Geranylation of Cyclic Dipeptides and Naphthols by the Fungal Prenyltransferase CdpC3PT_F253G Open
Prenyl modification often improves the biological activities of compounds. Prenyltransferases have attracted attention as environmentally friendly biocatalysts for catalyzing prenyl modification of compounds. Compared to dimethylallyl modi…
View article: Exploring the Genetic Links Between Asthma, Gastroesophageal Reflux Disease, and Osteoarthritis Through Mendelian Randomization
Exploring the Genetic Links Between Asthma, Gastroesophageal Reflux Disease, and Osteoarthritis Through Mendelian Randomization Open
To elucidate the bidirectional associations and mechanisms linking the increasingly prevalent conditions of asthma, gastroesophageal reflux disease (GERD), and osteoarthritis (OA), with a focus on exploring the mediating role of Nonsteroid…
View article: Cover Feature: Intramolecular Coupling and Nucleobase Transfer – How Cytochrome P450 Enzymes GymB<sub>x</sub> Establish Their Chemoselectivity (ChemCatChem 10/2024)
Cover Feature: Intramolecular Coupling and Nucleobase Transfer – How Cytochrome P450 Enzymes GymB<sub>x</sub> Establish Their Chemoselectivity (ChemCatChem 10/2024) Open
The Cover Feature shows an overview of the work presented in the Research Article by Shu-Ming Li, Georg Zocher, and co-workers. The authors report the structures of a new class of cyclodipeptide-modifying P450 enzymes named GymBx that are …
View article: Unveiling Novel Dark Matter Particles: Insights from Fractal Quantum Gravity Theory
Unveiling Novel Dark Matter Particles: Insights from Fractal Quantum Gravity Theory Open
As a promising quantum gravity theory, the newly developed fractal quantum gravity theory (FQG) has introduced the smallest constant of the product of space, time and energy of STQAs (Space-Time Quantum of Action).The product of space, tim…
View article: Unraveling New Therapeutic Targets in Ankylosing Spondylitis: Multi-Omics Mendelian Randomization on Immune Cells, Metabolites, and Inflammation Proteins
Unraveling New Therapeutic Targets in Ankylosing Spondylitis: Multi-Omics Mendelian Randomization on Immune Cells, Metabolites, and Inflammation Proteins Open
Objective: To identify novel immunological, metabolic, and inflammatory determinants of Ankylosing Spondylitis (AS) using Mendelian Randomization (MR), offering new insights into its pathogenesis and potential therapeutic interventions. Me…
View article: Intramolecular Coupling and Nucleobase Transfer – How Cytochrome P450 Enzymes GymB<sub>x</sub> Establish Their Chemoselectivity
Intramolecular Coupling and Nucleobase Transfer – How Cytochrome P450 Enzymes GymB<sub>x</sub> Establish Their Chemoselectivity Open
Cyclodipeptides (CDPs) build an important class of secondary metabolites with a plethora of pharmacological impact such as antibiotic, cytotoxic, antifungal properties or even as anti‐Alzheimer drug candidates. The core structure of 2,5‐di…
View article: Various interventions for cancer-related fatigue in patients with breast cancer: a systematic review and network meta-analysis
Various interventions for cancer-related fatigue in patients with breast cancer: a systematic review and network meta-analysis Open
Purpose To investigate the effects of various intervention approaches on cancer-related fatigue (CRF) in patients with breast cancer. Method Computer searches were conducted on PubMed, Embase, Cochrane Library, Web of Science, China Nation…
View article: A simplification strategy for vegetable supply and marketing type problems based on correlation analysis
A simplification strategy for vegetable supply and marketing type problems based on correlation analysis Open
There is a wide variety of vegetables and the connections between single product sales are complex. Solving the problems related to vegetable supply and sales is difficult. Therefore, it is necessary to simplify the handling of vegetable s…
View article: Cupin-domain containing protein is not essential for the alkyl salicylaldehyde formation in <i>Aspergillus ustus</i>
Cupin-domain containing protein is not essential for the alkyl salicylaldehyde formation in <i>Aspergillus ustus</i> Open
The biosynthesis of alkylated salicylaldehyde derivatives usually requires a cupin-domain containing protein. Here, we demonstrate the formation of 6-propyl salicylaldehyde by a gene cluster from Aspergillus ustus without involvement of su…
View article: Investigating Genetic Causality: Mendelian Randomization Study on Gastroesophageal Reflux Disease, Asthma, and Osteoarthritis
Investigating Genetic Causality: Mendelian Randomization Study on Gastroesophageal Reflux Disease, Asthma, and Osteoarthritis Open
Objective To elucidate the bidirectional causal relationships and mechanisms linking the increasingly prevalent conditions of asthma, gastroesophageal reflux disease (GERD), and osteoarthritis (OA). Methods This two-sample Mendelian random…
View article: A basidomycetous hydroxynaphthalene-prenylating enzyme exhibits promiscuity toward prenyl donors
A basidomycetous hydroxynaphthalene-prenylating enzyme exhibits promiscuity toward prenyl donors Open
The fungal prenyltransferase ShPT from Stereum hirsutum was believed to prenylate 4-hydroxybenzyl alcohol and thereby be involved in the vibralactone biosynthesis. In this study, we demonstrate that hydroxynaphthalenes instead of benzyl al…
View article: Space-time curvature and cosmic evolution
Space-time curvature and cosmic evolution Open
In the earlier article, the smallest physical constant was introduced and some new parameters were obtained to describe the elementary particles.1 Based on these new parameters, we have further derived several equations to calculate a part…
View article: Evaluation of herb–drug interactions between compound Danshen dripping pills and clopidogrel based on the pharmacokinetics and pharmacodynamics in rats
Evaluation of herb–drug interactions between compound Danshen dripping pills and clopidogrel based on the pharmacokinetics and pharmacodynamics in rats Open
Compound Danshen dripping pills (CDDP), a well‐known traditional Chinese medicine, is widely used to prevent and treat cardiovascular diseases. CDDP is usually prescribed in combination with clopidogrel (CLP), but the herb–drug interaction…
View article: The smallest constant of physics
The smallest constant of physics Open
This study suggests that the smallest physical constant exists for the product of space interval, time interval, and energy. The integer times of which correspond to the product of the energy, space interval, and time interval of any parti…
View article: Analysis of the Competitiveness and Complementarity between China Japan and other RCEP Member Countries
Analysis of the Competitiveness and Complementarity between China Japan and other RCEP Member Countries Open
Using ESI index, TCI Index and IIT Index to compare the competitiveness, complementarity and Intra-industry trade level between China Japan and other RECP member countries (South Korea, Australia, New Zealand and ASEAN). Both China and Jap…
View article: Natural Gas Price Policy Based on python Data Mining and Measurement
Natural Gas Price Policy Based on python Data Mining and Measurement Open
China is a traditional sense of "rich in coal, short of oil and gas" country. These three energies occupy a high position in China's energy consumption structure. With the increasing proportion of natural gas in the world energy consumptio…
View article: The Fractal Quantum Gravity
The Fractal Quantum Gravity Open
Based on the smallest physical constant of the product of space interval, time interval, and energy, the fractal quantum gravity (FQG) theory has demonstrated that every particle or physical system consists of these smallest units in fract…