Shun Kishimoto
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View article: Improved Tumor Blood Flow Enhances the Abscopal Effect: Preclinical Assessment in Mice Treated with Combined Radiation and PD-1 Blockade Therapy
Improved Tumor Blood Flow Enhances the Abscopal Effect: Preclinical Assessment in Mice Treated with Combined Radiation and PD-1 Blockade Therapy Open
The abscopal effect, where localized radiation therapy induces regression of distant metastatic lesions through immune activation, shows promise for treating metastatic cancer but occurs inconsistently. Here we demonstrate that tumor perfu…
View article: Low Field Magnetic Resonance Imaging to Detect Acute Kidney Injury
Low Field Magnetic Resonance Imaging to Detect Acute Kidney Injury Open
Renal oxygenation is essential for maintaining kidney function. Disruptions in oxygen delivery can lead to renal hypoxia, which can exacerbate kidney injury through multiple pathways, including inflammation, oxidative stress, and ischemia-…
View article: Predicting ADC Map Quality from T2-Weighted MRI: A Deep Learning Approach for Early Quality Assessment to Assist Point-of-Care
Predicting ADC Map Quality from T2-Weighted MRI: A Deep Learning Approach for Early Quality Assessment to Assist Point-of-Care Open
Purpose Poor quality prostate MRI images, especially ADC maps, can lead to missed lesions and unnecessary repeat scans. To address this issue, we aimed to develop an automated method to predict ADC map quality from T2 images acquired earli…
View article: A patient-derived cell model for malignant transformation in IDH-mutant glioma
A patient-derived cell model for malignant transformation in IDH-mutant glioma Open
View article: Pharmacological Ascorbate Induces Transient Hypoxia Sensitizing Pancreatic Ductal Adenocarcinoma to a Hypoxia Activated Prodrug
Pharmacological Ascorbate Induces Transient Hypoxia Sensitizing Pancreatic Ductal Adenocarcinoma to a Hypoxia Activated Prodrug Open
Hypoxic tumor microenvironments pose a significant challenge in cancer treatment. Hypoxia-activated prodrugs like evofosfamide aim to specifically target and eliminate these resistant cells. However, their effectiveness is often limited by…
View article: In vivo deuterium magnetic resonance imaging of xenografted tumors following systemic administration of deuterated water
In vivo deuterium magnetic resonance imaging of xenografted tumors following systemic administration of deuterated water Open
In vivo deuterated water ( 2 H 2 O) labeling leads to deuterium ( 2 H) incorporation into biomolecules of proliferating cells and provides the basis for its use in cell kinetics research. We hypothesized that rapidly proliferating cancer c…
View article: Evaluation of a deuterated triarylmethyl spin probe for in vivo <i>R</i> <sub>2</sub> <i>∗</i> ‐based <scp>EPR</scp> oximetric imaging with enhanced dynamic range
Evaluation of a deuterated triarylmethyl spin probe for in vivo <i>R</i> <sub>2</sub> <i>∗</i> ‐based <span>EPR</span> oximetric imaging with enhanced dynamic range Open
Purpose In this study, we compared two triarylmethyl (TAM) spin probes, Ox071 and Ox063 for their efficacy in measuring tissue oxygen levels under hypoxic and normoxic conditions by R 2 * ‐based EPR oximetry. Methods The R 2 * dependencies…
View article: Evaluation of a deuterated triarylmethyl spin probe for in vivo R2<sup>*</sup>-based EPR oximetric imaging with enhanced dynamic range
Evaluation of a deuterated triarylmethyl spin probe for in vivo R2<sup>*</sup>-based EPR oximetric imaging with enhanced dynamic range Open
Purpose In this study, we compared two triarylmethyl (TAM) spin probes, Ox071 and Ox063 for their efficacy in measuring tissue oxygen concentration by R2*-based oximetry in hypoxic and normoxic conditions. Methods The R2* dependence with s…
View article: In vivo deuterium magnetic resonance imaging of xenografted tumors following systemic administration of deuterated water
In vivo deuterium magnetic resonance imaging of xenografted tumors following systemic administration of deuterated water Open
In vivo deuterated water ( 2 H 2 O) labeling leads to deuterium ( 2 H) incorporation into biomolecules of proliferating cells and provides the basis for its use in cell kinetics research. We hypothesized that rapidly proliferating cancer c…
View article: Evofosfamide and Gemcitabine Act Synergistically in Pancreatic Cancer Xenografts by Dual Action on Tumor Vasculature and Inhibition of Homologous Recombination DNA Repair
Evofosfamide and Gemcitabine Act Synergistically in Pancreatic Cancer Xenografts by Dual Action on Tumor Vasculature and Inhibition of Homologous Recombination DNA Repair Open
Aims: Pancreatic ductal adenocarcinomas (PDACs) form hypovascular and hypoxic tumors, which are difficult to treat with current chemotherapy regimens. Gemcitabine (GEM) is often used as a first-line treatment for PDACs but ha…
View article: Figure S1 from Metabolic and Physiologic Imaging Biomarkers of the Tumor Microenvironment Predict Treatment Outcome with Radiation or a Hypoxia-Activated Prodrug in Mice
Figure S1 from Metabolic and Physiologic Imaging Biomarkers of the Tumor Microenvironment Predict Treatment Outcome with Radiation or a Hypoxia-Activated Prodrug in Mice Open
Immunoblotting of SDHA and SDHB expression in three pancreatic tumors.
View article: Supplementary Data from Multimodal Molecular Imaging Detects Early Responses to Immune Checkpoint Blockade
Supplementary Data from Multimodal Molecular Imaging Detects Early Responses to Immune Checkpoint Blockade Open
Supplementary Data, including figures 1-6 and tables 1-2.
View article: Table S2 from Metabolic and Physiologic Imaging Biomarkers of the Tumor Microenvironment Predict Treatment Outcome with Radiation or a Hypoxia-Activated Prodrug in Mice
Table S2 from Metabolic and Physiologic Imaging Biomarkers of the Tumor Microenvironment Predict Treatment Outcome with Radiation or a Hypoxia-Activated Prodrug in Mice Open
Lactate to pyruvate ratio and kpyr-lac of individual PDAC tumors in hyperpolarized 13C MRI study.
View article: Figure S2 from Metabolic and Physiologic Imaging Biomarkers of the Tumor Microenvironment Predict Treatment Outcome with Radiation or a Hypoxia-Activated Prodrug in Mice
Figure S2 from Metabolic and Physiologic Imaging Biomarkers of the Tumor Microenvironment Predict Treatment Outcome with Radiation or a Hypoxia-Activated Prodrug in Mice Open
Immunostaining of hypoxia marker pimonidazole of three pancreatic tumors. Representative pictures of whole tumor area were shown.
View article: Supplementary Data from Molecular Imaging of the Tumor Microenvironment Reveals the Relationship between Tumor Oxygenation, Glucose Uptake, and Glycolysis in Pancreatic Ductal Adenocarcinoma
Supplementary Data from Molecular Imaging of the Tumor Microenvironment Reveals the Relationship between Tumor Oxygenation, Glucose Uptake, and Glycolysis in Pancreatic Ductal Adenocarcinoma Open
Complete and detailed descriptions of materials and methods are in the supplementary information, including animal studies, image registration, hyperpolarized 13C MRI, 18F-FDG PET, EPR imaging, Western blot, Immunohistochemistry, and stati…
View article: Supplementary Data from Multimodal Molecular Imaging Detects Early Responses to Immune Checkpoint Blockade
Supplementary Data from Multimodal Molecular Imaging Detects Early Responses to Immune Checkpoint Blockade Open
Supplementary Data, including figures 1-6 and tables 1-2.
View article: Figure S3 from Metabolic and Physiologic Imaging Biomarkers of the Tumor Microenvironment Predict Treatment Outcome with Radiation or a Hypoxia-Activated Prodrug in Mice
Figure S3 from Metabolic and Physiologic Imaging Biomarkers of the Tumor Microenvironment Predict Treatment Outcome with Radiation or a Hypoxia-Activated Prodrug in Mice Open
Plots of tumor growth delay vs HF10; pO2; lac/pyr
View article: Data from Molecular Imaging of the Tumor Microenvironment Reveals the Relationship between Tumor Oxygenation, Glucose Uptake, and Glycolysis in Pancreatic Ductal Adenocarcinoma
Data from Molecular Imaging of the Tumor Microenvironment Reveals the Relationship between Tumor Oxygenation, Glucose Uptake, and Glycolysis in Pancreatic Ductal Adenocarcinoma Open
Molecular imaging approaches for metabolic and physiologic imaging of tumors have become important for treatment planning and response monitoring. However, the relationship between the physiologic and metabolic aspects of tumors is not ful…
View article: Table S1 from Metabolic and Physiologic Imaging Biomarkers of the Tumor Microenvironment Predict Treatment Outcome with Radiation or a Hypoxia-Activated Prodrug in Mice
Table S1 from Metabolic and Physiologic Imaging Biomarkers of the Tumor Microenvironment Predict Treatment Outcome with Radiation or a Hypoxia-Activated Prodrug in Mice Open
Median pO2 and HF10 of individual PDAC tumors in EPR oxygen imaging study.
View article: Table S1 from Metabolic and Physiologic Imaging Biomarkers of the Tumor Microenvironment Predict Treatment Outcome with Radiation or a Hypoxia-Activated Prodrug in Mice
Table S1 from Metabolic and Physiologic Imaging Biomarkers of the Tumor Microenvironment Predict Treatment Outcome with Radiation or a Hypoxia-Activated Prodrug in Mice Open
Median pO2 and HF10 of individual PDAC tumors in EPR oxygen imaging study.
View article: Data from Multimodal Molecular Imaging Detects Early Responses to Immune Checkpoint Blockade
Data from Multimodal Molecular Imaging Detects Early Responses to Immune Checkpoint Blockade Open
Immune checkpoint blockade (ICB) has become a standard therapy for several cancers, however, the response to ICB is inconsistent and a method for noninvasive assessment has not been established to date. To investigate the capability of mul…
View article: Figure S3 from Metabolic and Physiologic Imaging Biomarkers of the Tumor Microenvironment Predict Treatment Outcome with Radiation or a Hypoxia-Activated Prodrug in Mice
Figure S3 from Metabolic and Physiologic Imaging Biomarkers of the Tumor Microenvironment Predict Treatment Outcome with Radiation or a Hypoxia-Activated Prodrug in Mice Open
Plots of tumor growth delay vs HF10; pO2; lac/pyr
View article: Figure S1 from Metabolic and Physiologic Imaging Biomarkers of the Tumor Microenvironment Predict Treatment Outcome with Radiation or a Hypoxia-Activated Prodrug in Mice
Figure S1 from Metabolic and Physiologic Imaging Biomarkers of the Tumor Microenvironment Predict Treatment Outcome with Radiation or a Hypoxia-Activated Prodrug in Mice Open
Immunoblotting of SDHA and SDHB expression in three pancreatic tumors.
View article: Figure S2 from Metabolic and Physiologic Imaging Biomarkers of the Tumor Microenvironment Predict Treatment Outcome with Radiation or a Hypoxia-Activated Prodrug in Mice
Figure S2 from Metabolic and Physiologic Imaging Biomarkers of the Tumor Microenvironment Predict Treatment Outcome with Radiation or a Hypoxia-Activated Prodrug in Mice Open
Immunostaining of hypoxia marker pimonidazole of three pancreatic tumors. Representative pictures of whole tumor area were shown.
View article: Table S3 from Metabolic and Physiologic Imaging Biomarkers of the Tumor Microenvironment Predict Treatment Outcome with Radiation or a Hypoxia-Activated Prodrug in Mice
Table S3 from Metabolic and Physiologic Imaging Biomarkers of the Tumor Microenvironment Predict Treatment Outcome with Radiation or a Hypoxia-Activated Prodrug in Mice Open
Benefit of combination therapy over monotherapy.
View article: Supplementary Data from Molecular Imaging of the Tumor Microenvironment Reveals the Relationship between Tumor Oxygenation, Glucose Uptake, and Glycolysis in Pancreatic Ductal Adenocarcinoma
Supplementary Data from Molecular Imaging of the Tumor Microenvironment Reveals the Relationship between Tumor Oxygenation, Glucose Uptake, and Glycolysis in Pancreatic Ductal Adenocarcinoma Open
Complete and detailed descriptions of materials and methods are in the supplementary information, including animal studies, image registration, hyperpolarized 13C MRI, 18F-FDG PET, EPR imaging, Western blot, Immunohistochemistry, and stati…
View article: Data from Multimodal Molecular Imaging Detects Early Responses to Immune Checkpoint Blockade
Data from Multimodal Molecular Imaging Detects Early Responses to Immune Checkpoint Blockade Open
Immune checkpoint blockade (ICB) has become a standard therapy for several cancers, however, the response to ICB is inconsistent and a method for noninvasive assessment has not been established to date. To investigate the capability of mul…
View article: Figure S4 from Metabolic and Physiologic Imaging Biomarkers of the Tumor Microenvironment Predict Treatment Outcome with Radiation or a Hypoxia-Activated Prodrug in Mice
Figure S4 from Metabolic and Physiologic Imaging Biomarkers of the Tumor Microenvironment Predict Treatment Outcome with Radiation or a Hypoxia-Activated Prodrug in Mice Open
Clonogenic assay for Hs766t cells treated with gemcitabine 100 nM in ambient air and anoxic condition
View article: Figure S4 from Metabolic and Physiologic Imaging Biomarkers of the Tumor Microenvironment Predict Treatment Outcome with Radiation or a Hypoxia-Activated Prodrug in Mice
Figure S4 from Metabolic and Physiologic Imaging Biomarkers of the Tumor Microenvironment Predict Treatment Outcome with Radiation or a Hypoxia-Activated Prodrug in Mice Open
Clonogenic assay for Hs766t cells treated with gemcitabine 100 nM in ambient air and anoxic condition
View article: Data from Molecular Imaging of the Tumor Microenvironment Reveals the Relationship between Tumor Oxygenation, Glucose Uptake, and Glycolysis in Pancreatic Ductal Adenocarcinoma
Data from Molecular Imaging of the Tumor Microenvironment Reveals the Relationship between Tumor Oxygenation, Glucose Uptake, and Glycolysis in Pancreatic Ductal Adenocarcinoma Open
Molecular imaging approaches for metabolic and physiologic imaging of tumors have become important for treatment planning and response monitoring. However, the relationship between the physiologic and metabolic aspects of tumors is not ful…