Shuna Chen
YOU?
Author Swipe
View article: Impact of PCSK9 inhibitor on T lymphocyte subsets and cytokines in patients with acute ischemic stroke: an exploratory analysis of a randomized clinical trial
Impact of PCSK9 inhibitor on T lymphocyte subsets and cytokines in patients with acute ischemic stroke: an exploratory analysis of a randomized clinical trial Open
Background PCSK9 inhibitors are lipid-lowering agents with pleiotropic properties including immune-inflammatory modulation. However, the effects of PCSK9 inhibitors on the peripheral immune profile of patients with acute ischemic stroke (A…
View article: Quaternary Layered Boride Ti<sub>4</sub>MoSiB<sub>2</sub>: A Structure‐Function Integrated High‐Temperature Self‐Lubricating and Negative‐Wear Material
Quaternary Layered Boride Ti<sub>4</sub>MoSiB<sub>2</sub>: A Structure‐Function Integrated High‐Temperature Self‐Lubricating and Negative‐Wear Material Open
As a newly emerging class of materials, quaternary layered borides are promising structural–functional integration materials. However, there have been very few systematic and in‐depth studies in many areas of these materials, including hig…
View article: High-entropy diboride: A novel high-temperature self-lubricating ceramic with enhanced mechanical and tribological properties
High-entropy diboride: A novel high-temperature self-lubricating ceramic with enhanced mechanical and tribological properties Open
Ceramic-based lubrication materials are among the best choices for solving high-temperature load-bearing and lubrication problems. However, traditional ceramics achieve self-lubrication by adding lubricating phases, which often leads to si…
View article: Umbilical mesenchymal stem cells mitigate T-cell compartments shift and Th17/Treg imbalance in acute ischemic stroke via mitochondrial transfer
Umbilical mesenchymal stem cells mitigate T-cell compartments shift and Th17/Treg imbalance in acute ischemic stroke via mitochondrial transfer Open
Our comprehensive insights into the key attributes of T-cell compartments in acute ischemic stroke and the immune regulatory mechanisms of UMSCs provide a crucial theoretical foundation for understanding peripheral immune disorders in isch…
View article: A Convolutional Neural Network to Spiking Neural Network Conversion Framework for Seismic Denoising
A Convolutional Neural Network to Spiking Neural Network Conversion Framework for Seismic Denoising Open
This study investigates the application of Spiking Neural Network (SNN) in seismic signal denoising by developing a Convolutional Neural Network (CNN) to SNN conversion framework. We focus on two challenges: optimal spike encoding strategy…
View article: Theaflavin-3,3'-digallate alleviates glucolipotoxicity-induced insulin secretion dysfunction in pancreatic β-TC-6 cells and zebrafish <i>via</i> anti-ferroptotic mechanisms by activating SERCA2
Theaflavin-3,3'-digallate alleviates glucolipotoxicity-induced insulin secretion dysfunction in pancreatic β-TC-6 cells and zebrafish <i>via</i> anti-ferroptotic mechanisms by activating SERCA2 Open
Theaflavins from black tea effectively improve insulin secretion in obesity and diabetes, but the molecular mechanisms are unclear. Here, the palmitic acid (PA)-induced pancreatic β-TC-6 cells and high fat-/high glucose-induced zebrafish w…
View article: High‐entropy (Ti <sub>0.2</sub> V <sub>0.2</sub> Nb <sub>0.2</sub> Mo <sub>0.2</sub> W <sub>0.2</sub> )Si <sub>2</sub> with excellent high‐temperature wear resistance
High‐entropy (Ti <sub>0.2</sub> V <sub>0.2</sub> Nb <sub>0.2</sub> Mo <sub>0.2</sub> W <sub>0.2</sub> )Si <sub>2</sub> with excellent high‐temperature wear resistance Open
The oxidation products (MoO 3 and V 2 O 5 ) have low melting points and tend to sublimate at high temperatures despite that MoSi 2 and VSi 2 may possess good self‐lubricating properties. To cope with this challenge, a high‐entropy transiti…
View article: L-Theanine and Immunity: A Review
L-Theanine and Immunity: A Review Open
L-theanine (N-ethyl-γ-glutamine) is the main amino acid in tea leaves. It not only contributes to tea flavor but also possesses several health benefits. Compared with its sedative and calming activities, the immunomodulatory effects of L-t…
View article: Oscillating Fluid Flow Activated Osteocyte Lysate‐Based Hydrogel for Regulating Osteoblast/Osteoclast Homeostasis to Enhance Bone Repair
Oscillating Fluid Flow Activated Osteocyte Lysate‐Based Hydrogel for Regulating Osteoblast/Osteoclast Homeostasis to Enhance Bone Repair Open
As major regulators on bone formation/resorption in response to mechanical stimuli, osteocytes have shown great promise for restoring bone injury. However, due to the unmanageable and unabiding cell functions in unloading or diseased envir…
View article: Supplementary Figure 2 from Alpha-Melanocyte–Stimulating Hormone Suppresses Oxidative Stress through a p53-Mediated Signaling Pathway in Human Melanocytes
Supplementary Figure 2 from Alpha-Melanocyte–Stimulating Hormone Suppresses Oxidative Stress through a p53-Mediated Signaling Pathway in Human Melanocytes Open
PDF file - 281K, Dose-dependent accumulation of p53 in human melanocytes induced by 18 h incubation with increasing concentrations of nutlin-3
View article: Supplementary Figure 3 from Alpha-Melanocyte–Stimulating Hormone Suppresses Oxidative Stress through a p53-Mediated Signaling Pathway in Human Melanocytes
Supplementary Figure 3 from Alpha-Melanocyte–Stimulating Hormone Suppresses Oxidative Stress through a p53-Mediated Signaling Pathway in Human Melanocytes Open
PDF file - 1.7MB, DNA damage induced by UVR in the presence and absence of nutlin-3 as determined by gamma-H2AX immunofluorescence analyzed by flow cytometer
View article: Supplementary Figure 4 from Alpha-Melanocyte–Stimulating Hormone Suppresses Oxidative Stress through a p53-Mediated Signaling Pathway in Human Melanocytes
Supplementary Figure 4 from Alpha-Melanocyte–Stimulating Hormone Suppresses Oxidative Stress through a p53-Mediated Signaling Pathway in Human Melanocytes Open
PDF file - 15MB, Hydrogen peroxide generation in melanocytes irradiated with 105 mJ/cm2 UVR in the presence and absence of pifithrin-alpha
View article: Supplementary Figure 4 from Alpha-Melanocyte–Stimulating Hormone Suppresses Oxidative Stress through a p53-Mediated Signaling Pathway in Human Melanocytes
Supplementary Figure 4 from Alpha-Melanocyte–Stimulating Hormone Suppresses Oxidative Stress through a p53-Mediated Signaling Pathway in Human Melanocytes Open
PDF file - 15MB, Hydrogen peroxide generation in melanocytes irradiated with 105 mJ/cm2 UVR in the presence and absence of pifithrin-alpha
View article: Supplementary Figure 5 from Alpha-Melanocyte–Stimulating Hormone Suppresses Oxidative Stress through a p53-Mediated Signaling Pathway in Human Melanocytes
Supplementary Figure 5 from Alpha-Melanocyte–Stimulating Hormone Suppresses Oxidative Stress through a p53-Mediated Signaling Pathway in Human Melanocytes Open
PDF file - 364K, Down-regulation of p53 by shRNA and its effect on the expression of p21 in primary cultures of human melanocytes
View article: Supplementary Figure 5 from Alpha-Melanocyte–Stimulating Hormone Suppresses Oxidative Stress through a p53-Mediated Signaling Pathway in Human Melanocytes
Supplementary Figure 5 from Alpha-Melanocyte–Stimulating Hormone Suppresses Oxidative Stress through a p53-Mediated Signaling Pathway in Human Melanocytes Open
PDF file - 364K, Down-regulation of p53 by shRNA and its effect on the expression of p21 in primary cultures of human melanocytes
View article: Supplementary Figure 1 from Alpha-Melanocyte–Stimulating Hormone Suppresses Oxidative Stress through a p53-Mediated Signaling Pathway in Human Melanocytes
Supplementary Figure 1 from Alpha-Melanocyte–Stimulating Hormone Suppresses Oxidative Stress through a p53-Mediated Signaling Pathway in Human Melanocytes Open
PDF file - 3.8MB, Western blott analysis - Absence of p63 isoforms in human melanocytes
View article: Supplementary Figure 2 from Alpha-Melanocyte–Stimulating Hormone Suppresses Oxidative Stress through a p53-Mediated Signaling Pathway in Human Melanocytes
Supplementary Figure 2 from Alpha-Melanocyte–Stimulating Hormone Suppresses Oxidative Stress through a p53-Mediated Signaling Pathway in Human Melanocytes Open
PDF file - 281K, Dose-dependent accumulation of p53 in human melanocytes induced by 18 h incubation with increasing concentrations of nutlin-3
View article: Supplementary Figure 1 from Alpha-Melanocyte–Stimulating Hormone Suppresses Oxidative Stress through a p53-Mediated Signaling Pathway in Human Melanocytes
Supplementary Figure 1 from Alpha-Melanocyte–Stimulating Hormone Suppresses Oxidative Stress through a p53-Mediated Signaling Pathway in Human Melanocytes Open
PDF file - 3.8MB, Western blott analysis - Absence of p63 isoforms in human melanocytes
View article: Supplementary Figure 3 from Alpha-Melanocyte–Stimulating Hormone Suppresses Oxidative Stress through a p53-Mediated Signaling Pathway in Human Melanocytes
Supplementary Figure 3 from Alpha-Melanocyte–Stimulating Hormone Suppresses Oxidative Stress through a p53-Mediated Signaling Pathway in Human Melanocytes Open
PDF file - 1.7MB, DNA damage induced by UVR in the presence and absence of nutlin-3 as determined by gamma-H2AX immunofluorescence analyzed by flow cytometer
View article: Data from Alpha-Melanocyte–Stimulating Hormone Suppresses Oxidative Stress through a p53-Mediated Signaling Pathway in Human Melanocytes
Data from Alpha-Melanocyte–Stimulating Hormone Suppresses Oxidative Stress through a p53-Mediated Signaling Pathway in Human Melanocytes Open
Epidermal melanocytes are skin cells specialized in melanin production. Activation of the melanocortin 1 receptor (MC1R) on melanocytes by α-melanocyte–stimulating hormone (α-MSH) induces synthesis of the brown/black pigment eumelanin that…
View article: Data from Alpha-Melanocyte–Stimulating Hormone Suppresses Oxidative Stress through a p53-Mediated Signaling Pathway in Human Melanocytes
Data from Alpha-Melanocyte–Stimulating Hormone Suppresses Oxidative Stress through a p53-Mediated Signaling Pathway in Human Melanocytes Open
Epidermal melanocytes are skin cells specialized in melanin production. Activation of the melanocortin 1 receptor (MC1R) on melanocytes by α-melanocyte–stimulating hormone (α-MSH) induces synthesis of the brown/black pigment eumelanin that…
View article: Carbon-deficient high-entropy (Zr0.17Nb0.2Ta0.2Mo0.2W0.2)C0.89: A potential high temperature and vacuum wear-resistant material
Carbon-deficient high-entropy (Zr0.17Nb0.2Ta0.2Mo0.2W0.2)C0.89: A potential high temperature and vacuum wear-resistant material Open
High-entropy carbides are promising materials as sliding structural components in ultra-high temperature environments due to their good phase stability and excellent mechanical properties. However, the tribological behaviors under coupling…
View article: Synthesis and mechanical and elevated temperature tribological properties of a novel high-entropy (TiVNbMoW)C <sub>4.375</sub> with carbon stoichiometry deviation
Synthesis and mechanical and elevated temperature tribological properties of a novel high-entropy (TiVNbMoW)C <sub>4.375</sub> with carbon stoichiometry deviation Open
High-entropy carbides are a nascent group of ceramics that are promising for high-temperature applications due to the combination of good stability, high hardness (H), high strength, and superior creep resistance that they display. Due to …
View article: Saponins from Camellia sinensis Seeds Stimulate GIP Secretion in Mice and STC-1 Cells via SGLT1 and TGR5
Saponins from Camellia sinensis Seeds Stimulate GIP Secretion in Mice and STC-1 Cells via SGLT1 and TGR5 Open
Glucose-dependent insulinotropic polypeptide (GIP) is one of the important incretins and possesses lots of physiological activities such as stimulating insulin secretion and maintaining glucose homeostasis. The pentacyclic triterpenoid sap…
View article: Comparative Transcriptome and Phytochemical Analysis Provides Insight into Triterpene Saponin Biosynthesis in Seeds and Flowers of the Tea Plant (Camellia sinensis)
Comparative Transcriptome and Phytochemical Analysis Provides Insight into Triterpene Saponin Biosynthesis in Seeds and Flowers of the Tea Plant (Camellia sinensis) Open
Triterpene saponins exhibit various biological and pharmacological activities. However, the knowledge on saponin biosynthesis in tea plants (Camellia sinensis L.) is still limited. In this work, tea flower and seed samples at different dev…
View article: Influence of binder systems on sintering characteristics, microstructures, and mechanical properties of PcBN composites fabricated by SPS
Influence of binder systems on sintering characteristics, microstructures, and mechanical properties of PcBN composites fabricated by SPS Open
Cubic boron nitride (cBN) with high hardness, thermal conductivity, wear resistance, and chemical inertness has become the most promising abrasive and machining material. Due to the difficulty of fabricating pure cBN body, generally, some …
View article: <i>Ethylene‐responsive factor 4</i> is associated with the desirable rind hardness trait conferring cracking resistance in fresh fruits of watermelon
<i>Ethylene‐responsive factor 4</i> is associated with the desirable rind hardness trait conferring cracking resistance in fresh fruits of watermelon Open
Summary Fruit rind plays a pivotal role in alleviating water loss and disease and particularly in cracking resistance as well as the transportability, storability and shelf‐life quality of the fruit. High susceptibility to cracking due to …