Shunchang Ma
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View article: An MRI radiomics approach using invasion-based weak supervision for identifying and evaluating aggressive PitNETs
An MRI radiomics approach using invasion-based weak supervision for identifying and evaluating aggressive PitNETs Open
Pituitary neuroendocrine tumor (PitNET) aggressiveness critically affects treatment and prognosis, yet reliable noninvasive preoperative tools remain lacking. We developed a deep learning radiomics (DLR) model integrating automatic segment…
View article: Factors Influencing Hormone Remission in Growth Hormone‐Secreting Pituitary Neuroendocrine Tumors With Residual Tumor: A Retrospective Cohort Study
Factors Influencing Hormone Remission in Growth Hormone‐Secreting Pituitary Neuroendocrine Tumors With Residual Tumor: A Retrospective Cohort Study Open
Background Growth hormone‐secreting pituitary neuroendocrine tumors (GH‐secreting PitNETs) pose significant health risks due to hormone‐related complications. Despite transsphenoidal surgical resection being the primary treatment, complete…
View article: Comparison of endoscopic versus microscopic transsphenoidal surgery in patients with pituitary adenomas: a propensity score matched study
Comparison of endoscopic versus microscopic transsphenoidal surgery in patients with pituitary adenomas: a propensity score matched study Open
Background: The comparative efficacy of endoscopic versus microscopic transsphenoidal surgery for patients with pituitary adenoma (PA) remains controversial. Previous retrospective studies have often been limited by inconsistencies in base…
View article: Portable Absorbable Electrical Stimulation System for Enhanced Peripheral Nerve Repair
Portable Absorbable Electrical Stimulation System for Enhanced Peripheral Nerve Repair Open
Peripheral nerve injury significantly impairs sensory and motor functions, leading to diminished quality of life. Traditional treatments like nerve suturing and grafting often have limited efficacy and require long recovery. Recent advance…
View article: Identification of distinct tumor cell patterns with single-cell RNA sequencing integrating primary lung adenocarcinoma and brain metastasis tumor
Identification of distinct tumor cell patterns with single-cell RNA sequencing integrating primary lung adenocarcinoma and brain metastasis tumor Open
scRNA profiling that integrates LUAD BM and primary LUAD can provide information on those malignant cells with BM potential, offering additional prognostic information at cellular level, and may serve as a foundational resource for further…
View article: Treatments for brain metastases from EGFR/ALK-negative/unselected NSCLC: A network meta-analysis
Treatments for brain metastases from EGFR/ALK-negative/unselected NSCLC: A network meta-analysis Open
More clinical evidence is needed regarding the relative priority of treatments for brain metastases (BMs) from EGFR/ALK-negative/unselected non-small cell lung cancer (NSCLC). PubMed, EMBASE, Web of Science, Cochrane Library, and ClinicalT…
View article: Soft and stretchable organic bioelectronics for continuous intra-operative neurophysiological monitoring during microsurgery
Soft and stretchable organic bioelectronics for continuous intra-operative neurophysiological monitoring during microsurgery Open
Continuous intra-operative neurophysiological monitoring (CINM) that provides precise mapping of neural anatomy through the entire microsurgery process is essential to preserve the structural and functional integrity of the nerve. However,…
View article: Surgical Experience of Transcranial Approaches to Large-to-Giant Pituitary Adenomas in Knosp Grade 4
Surgical Experience of Transcranial Approaches to Large-to-Giant Pituitary Adenomas in Knosp Grade 4 Open
Pituitary adenomas in Knosp grade 4 are difficult to resect completely and are generally involved in poor prognosis, because of the close relationship between the tumor and internal carotid. In this study, the authors retrospectively revie…
View article: CTLA4-Mediated Immunosuppression in Glioblastoma is Associated with the Infiltration of Macrophages in the Tumor Microenvironment
CTLA4-Mediated Immunosuppression in Glioblastoma is Associated with the Infiltration of Macrophages in the Tumor Microenvironment Open
These findings implicate that CTLA4 could serve as a novel target for prognosis and therapy in GBM patients. CTLA4-mediated immune suppression may be attributed to the infiltration of macrophages in the tumor microenvironment.
View article: Consistency of pituitary adenomas: Amounts of collagen types I and III and the predictive value of T2WI MRI
Consistency of pituitary adenomas: Amounts of collagen types I and III and the predictive value of T2WI MRI Open
Pituitary adenomas, the most common type of lesion in the sellar region, rank third among all brain tumors, with an incidence of 73-94 cases per 100,000 individuals. Due to its high resolution, MRI is highly efficient in brain imaging and …
View article: MicroRNA-935 Directly Targets FZD6 to Inhibit the Proliferation of Human Glioblastoma and Correlate to Glioma Malignancy and Prognosis
MicroRNA-935 Directly Targets FZD6 to Inhibit the Proliferation of Human Glioblastoma and Correlate to Glioma Malignancy and Prognosis Open
MicroRNAs (miRNAs) are involved in human glioblastoma (GB). MiR-935 has been reported to have both tumor-inhibiting and tumorigenesis effects, but its role in GB remains unclear. Because of the high mortality and morbidity associated with …
View article: Cpne3 Regulates the Cell Proliferation and Apoptosis in Human Gbm via the Activation of Pi3k/akt Signaling Pathway
Cpne3 Regulates the Cell Proliferation and Apoptosis in Human Gbm via the Activation of Pi3k/akt Signaling Pathway Open
Background: Even with decades of intensive study, the signaling regulative network of the progression of GBM remains unclear, a deeper understanding of the molecular crosstalk with pathways in GBM is needed to identify new potential target…
View article: Targeted exome sequencing for the identification of common mutational signatures and potential driver mutations for brain metastases and prognosis.
Targeted exome sequencing for the identification of common mutational signatures and potential driver mutations for brain metastases and prognosis. Open
Brain metastases (BMs) are malignancies in the central nervous system with poor prognosis. Genetic landscapes of the primary tumor sites have been extensively profiled; however, mutations associated with BMs are poorly understood. In the p…
View article: Identification of a Glycolysis-Related LncRNA Signature to Predict Survival in Diffuse Glioma Patients
Identification of a Glycolysis-Related LncRNA Signature to Predict Survival in Diffuse Glioma Patients Open
Glycolysis refers to one of the critical phenotypes of tumor cells, regulating tumor cell phenotypes and generating sufficient energy for glioma cells. A range of noticeable genes [such as isocitrate dehydrogenase (IDH), phosphatase, and t…
View article: CPNE3 regulates the cell proliferation and apoptosis in human Glioblastoma via the activation of PI3K/AKT signaling pathway
CPNE3 regulates the cell proliferation and apoptosis in human Glioblastoma via the activation of PI3K/AKT signaling pathway Open
Background: Even with decades of intensive study, the signaling regulative network of the progression of Glioblastoma (GBM) remains unclear, a deeper understanding of the molecular crosstalk with pathways in GBM is needed to identify new p…
View article: Predicting the likelihood of early recurrence based on mRNA sequencing of pituitary adenomas
Predicting the likelihood of early recurrence based on mRNA sequencing of pituitary adenomas Open
This prediction model derived from mRNA-Seq data may help in identifying the early recurrence of PAs, consequently aiding in the classification of patients with PAs and the administration of the appropriate therapeutic and follow-up strate…
View article: SURG-02. STAGED SURGERY FOR SELECTED GIANT ADULT PITUITARY ADENOMA
SURG-02. STAGED SURGERY FOR SELECTED GIANT ADULT PITUITARY ADENOMA Open
PURPOSE Combined surgical strategy with both trans-cranial surgery and trans-sphenoid surgery is necessary for selected giant pituitary adenoma with both intra-cranial and intra-sphenoidal invasion. Cases of staged surgery were reviewed re…
View article: Primary spinal primitive neuroectodermal tumor: A single center series with literature review
Primary spinal primitive neuroectodermal tumor: A single center series with literature review Open
Context: Primary spinal primitive neuroectodermal tumor (PNET) of the central nervous system has a low incidence. The intraspinal case is very rare. Around 30 cases have been reported so far. We summarized the cases of primary spinal PNET …
View article: Clinical Features and Prognostic Risk Factors of Choroid Plexus Tumors in Children
Clinical Features and Prognostic Risk Factors of Choroid Plexus Tumors in Children Open
Our results indicated that CPP in the fourth ventricle could trigger serious clinical symptoms at an early stage, requiring early intervention. Adjuvant treatment might be necessary for patients with partially resected CPP, aCPP, and CPC t…
View article: Indications and Safety of the Zygomatic Osteotomy in Middle Cranial Fossa Surgery: A Retrospective Cohort Review
Indications and Safety of the Zygomatic Osteotomy in Middle Cranial Fossa Surgery: A Retrospective Cohort Review Open
Background Zygomatic osteotomy, an adjunct to middle cranial fossa (MCF) surgical approaches, improves the superior-inferior angle of approach and minimizes temporal lobe retraction. However, a decision-making algorithm for selective use o…
View article: The Zygomatic Osteotomy in Middle Cranial Fossa Surgery: A Retrospective Cohort Review
The Zygomatic Osteotomy in Middle Cranial Fossa Surgery: A Retrospective Cohort Review Open
Background The zygomatic osteotomy, an adjunct to middle cranial fossa (MCF) surgical approaches, improves the superior–inferior angle of approach and minimizes temporal lobe retraction. However, the impact of the zygomatic osteotomy on ap…
View article: Downregulation of the long non-coding RNA taurine-upregulated gene 1 inhibits glioma cell proliferation and invasion and promotes apoptosis
Downregulation of the long non-coding RNA taurine-upregulated gene 1 inhibits glioma cell proliferation and invasion and promotes apoptosis Open
Expression of the long non-coding RNA taurine-upregulated gene 1 (TUG1) is associated with various aggressive tumors. The present study aimed to investigate the biological function of TUG1 in regulating apoptosis, proliferation, invasion a…
View article: CLDN5 affects lncRNAs acting as ceRNA dynamics contributing to regulating blood‑brain barrier permeability in tumor brain metastasis
CLDN5 affects lncRNAs acting as ceRNA dynamics contributing to regulating blood‑brain barrier permeability in tumor brain metastasis Open
The blood‑brain barrier (BBB) constitutes an efficient organization of tight junctions that limits the delivery of tumor to the brain. The principal tight junction protein in BBB is claudin‑5 (CLDN5), but its mechanism of action remains la…