Shunchuan Zhang
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View article: Hematopoietic cell-mediated dissemination of murine cytomegalovirus is regulated by NK cells and immune evasion
Hematopoietic cell-mediated dissemination of murine cytomegalovirus is regulated by NK cells and immune evasion Open
Cytomegalovirus (CMV) causes clinically important diseases in immune compromised and immune immature individuals. Based largely on work in the mouse model of murine (M)CMV, there is a consensus that myeloid cells are important for dissemin…
View article: The discovery and development of oncolytic viruses: are they the future of cancer immunotherapy?
The discovery and development of oncolytic viruses: are they the future of cancer immunotherapy? Open
Introduction: Despite diverse treatment modalities and novel therapies, many cancers and patients are not effectively treated. Cancer immunotherapy has recently achieved breakthrough status yet is not effective in all cancer types or patie…
View article: α2β1 Integrin Is Required for Optimal NK Cell Proliferation during Viral Infection but Not for Acquisition of Effector Functions or NK Cell–Mediated Virus Control
α2β1 Integrin Is Required for Optimal NK Cell Proliferation during Viral Infection but Not for Acquisition of Effector Functions or NK Cell–Mediated Virus Control Open
NK cells play an important role in antiviral resistance. The integrin α2, which dimerizes with integrin β1, distinguishes NK cells from innate lymphoid cells 1 and other leukocytes. Despite its use as an NK cell marker, little is known abo…
View article: NK cells force cytomegalovirus to use hematopoietic cells and immune evasion for dissemination after mucosal infection
NK cells force cytomegalovirus to use hematopoietic cells and immune evasion for dissemination after mucosal infection Open
Cytomegalovirus (CMV) infects most people in the world and causes clinically important disease in immune compromised and immune immature individuals. How the virus disseminates from the initial site of infection is poorly understood. We us…